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Molecular Cell, ISSN 1097-2765, 04/2014, Volume 54, Issue 1, pp. 43 - 55
The rapid production of reactive oxygen species (ROS) burst is a conserved signaling output in immunity across kingdoms. In plants, perception of... 
PLASMA-MEMBRANE PROTEINS | OXYGEN SPECIES PRODUCTION | NICOTIANA-BENTHAMIANA | ARABIDOPSIS-THALIANA | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELICITED TOBACCO CELLS | OXIDATIVE BURST | PHYTOPHTHORA-INFESTANS | DISEASE RESISTANCE | PSEUDOMONAS-SYRINGAE EFFECTOR | INNATE IMMUNITY | CELL BIOLOGY | Protein Kinases - metabolism | Plant Immunity | Phosphorylation | Arabidopsis - enzymology | Multienzyme Complexes | Reactive Oxygen Species - metabolism | Receptors, Pattern Recognition - immunology | Arabidopsis - immunology | Molecular Sequence Data | NADPH Oxidases - immunology | Plant Stomata - metabolism | Plant Stomata - immunology | Tobacco - immunology | Arabidopsis Proteins - metabolism | Receptors, Pattern Recognition - metabolism | Flagellin - metabolism | Gene Expression Regulation, Plant | NADPH Oxidases - genetics | Protein-Serine-Threonine Kinases - metabolism | Amino Acid Sequence | Cell Line | Arabidopsis Proteins - genetics | Flagellin - immunology | Peptide Elongation Factor Tu - immunology | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Arabidopsis Proteins - immunology | Immunity, Innate | Arabidopsis - genetics | Gene Expression Regulation, Enzymologic | Peptide Elongation Factor Tu - metabolism | Arabidopsis - microbiology | Protein Kinases - immunology | Tobacco - genetics | Ligands | Tobacco - microbiology | Enzyme Activation | Tobacco - enzymology | Receptors, Immunologic - metabolism | Oxidases | Phosphotransferases | Arabidopsis thaliana | Protein kinases | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2013, Volume 110, Issue 21, pp. 8744 - 8749
In animals and plants, pathogen recognition triggers the local activation of intracellular signaling that is prerequisite for mounting systemic defenses in the... 
Proteins | Oxidases | Pathogens | Enzymes | Phosphorylation | Reactive oxygen species | Calcium | Plant propagation | Protoplasts | Biochemistry | ANION CHANNEL | ABIOTIC STRESS | PATHOGEN | MULTIDISCIPLINARY SCIENCES | ROS signaling | RECEPTOR | IMMUNE | disease resistance | plant innate immunity | CA2 | ROS | RESISTANCE | ACCUMULATION | KINASES | Arabidopsis - enzymology | Reactive Oxygen Species - metabolism | NADPH Oxidases - metabolism | Arabidopsis - immunology | NADPH Oxidases - immunology | Cell Communication - physiology | Enzyme Activation - immunology | Tobacco - immunology | Arabidopsis Proteins - metabolism | Reactive Oxygen Species - immunology | NADPH Oxidases - genetics | Calcium-Calmodulin-Dependent Protein Kinases - immunology | Arabidopsis Proteins - genetics | Calcium-Calmodulin-Dependent Protein Kinases - genetics | Plants, Genetically Modified - genetics | Plants, Genetically Modified - immunology | Plants, Genetically Modified - enzymology | Plant Immunity - physiology | Arabidopsis Proteins - immunology | Arabidopsis - genetics | Tobacco - genetics | Signal Transduction - physiology | Mutation | Plant Diseases | Enzyme Activation - genetics | Tobacco - enzymology | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Arabidopsis thaliana | Physiological aspects | Research | Protein kinases | Plant immunology | Flowers & plants | Kinases | Gene expression | Cells | Index Medicus | Biological Sciences
Journal Article
Nature Immunology, ISSN 1529-2908, 05/2010, Volume 11, Issue 5, pp. 411 - 418
Sensors of pathogens, such as Toll-like receptors (TLRs), detect microbes to activate transcriptional programs that orchestrate adaptive responses to specific... 
UNFOLDED PROTEIN RESPONSE | PATHWAY | ER STRESS | HOST-DEFENSE | ENDOPLASMIC-RETICULUM STRESS | FRANCISELLA-TULARENSIS INFECTION | IMMUNOLOGY | LIVE VACCINE STRAIN | INFLAMMATORY RESPONSE | NEGATIVE REGULATOR | SYSTEMS BIOLOGY | RNA, Small Interfering - genetics | Endoribonucleases - genetics | Tularemia - metabolism | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - metabolism | Lipopeptides - pharmacology | Transcriptional Activation - drug effects | NADPH Oxidases - metabolism | Tularemia - genetics | Protein Splicing - genetics | Transcriptional Activation - immunology | X-Box Binding Protein 1 | Protein Splicing - drug effects | NADPH Oxidases - genetics | Stress, Physiological - drug effects | TNF Receptor-Associated Factor 6 - genetics | Transcription Factor CHOP - biosynthesis | Transcription Factors - immunology | Cytokines - genetics | Protein-Serine-Threonine Kinases - metabolism | DNA-Binding Proteins - immunology | Endoribonucleases - metabolism | Macrophages - pathology | Stress, Physiological - genetics | Myeloid Differentiation Factor 88 - genetics | Toll-Like Receptor 4 - genetics | Signal Transduction - genetics | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Macrophages - metabolism | Signal Transduction - drug effects | Tunicamycin - pharmacology | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | Mice | Stress, Physiological - immunology | Endoribonucleases - immunology | Transcription Factor CHOP - genetics | NADPH Oxidases - immunology | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | Macrophages - virology | Mice, Mutant Strains | Tularemia - immunology | Membrane Glycoproteins - immunology | Macrophages - immunology | Cytokines - immunology | Cell Line | Francisella tularensis - immunology | Protein Splicing - immunology | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Immunity, Innate | NADPH Oxidase 2 | Regulatory Factor X Transcription Factors | Mice, Inbred C3H | Membrane Glycoproteins - genetics | Transcription Factors - metabolism | Animals | TNF Receptor-Associated Factor 6 - metabolism | Macrophages - drug effects | Protein-Serine-Threonine Kinases - immunology | Francisella tularensis - pathogenicity | Myeloid Differentiation Factor 88 - metabolism | Cytokines - biosynthesis | Cell receptors | Transcription factors | Immune response | Physiological aspects | Genetic aspects | Research | Health aspects | Francisella tularensis | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2016, Volume 291, Issue 38, pp. 20030 - 20041
Journal Article
Nature Immunology, ISSN 1529-2908, 06/2013, Volume 14, Issue 6, pp. 543 - 553
Phagocytosis is a fundamental cellular process that is pivotal for immunity as it coordinates microbial killing, innate immune activation and antigen... 
PROTEOLYTIC CLEAVAGE | H+-ATPASE ACTIVITY | DENDRITIC CELLS | TOLL-LIKE RECEPTOR | BACTERIAL LIGANDS | ACIDIFICATION | INNATE IMMUNE-SYSTEM | STAPHYLOCOCCUS-AUREUS | IMMUNOLOGY | MATURATION | NALP3 INFLAMMASOME | Phagosomes - microbiology | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Membrane Glycoproteins - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Staphylococcus aureus - physiology | Humans | NADPH Oxidases - metabolism | NADPH Oxidases - immunology | Caspase 1 - metabolism | Immunoblotting | Caspase 1 - immunology | Mice, 129 Strain | Enzyme Activation - immunology | Host-Pathogen Interactions - immunology | Phagosomes - immunology | Flow Cytometry | Reactive Oxygen Species - immunology | HEK293 Cells | Phagosomes - ultrastructure | Membrane Glycoproteins - immunology | Carrier Proteins - immunology | Macrophages - immunology | Macrophages - microbiology | Mice, Inbred C57BL | Phagosomes - metabolism | Cells, Cultured | Phagocytosis - immunology | Mice, Transgenic | Microscopy, Electron | NADPH Oxidase 2 | Mice, Knockout | Microscopy, Confocal | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Inflammasomes - immunology | Staphylococcus aureus - immunology | Mice | Hydrogen-Ion Concentration | Oxidases | Physiological aspects | Phagosomes | Bacteria | Genetic aspects | Research | Health aspects | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 06/2014, Volume 192, Issue 11, pp. 5314 - 5323
Journal Article
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 11/2015, Volume 6, Issue 1, pp. 8819 - 8819
Interferon gamma (IFNg)-producing CD8(+) T cells (Tc1) play important roles in immunological disease. We now report that CD3/CD28-mediated stimulation of... 
ACTIVATION | INFLAMMATORY-BOWEL-DISEASE | INHIBITION | IMMUNE SUPPRESSION | MURINE COLITIS | NOX FAMILY | MULTIDISCIPLINARY SCIENCES | MICE | DIFFERENTIATION | SEVERE CROHNS-DISEASE | NF-KAPPA-B | Colon - cytology | Antigens, CD - immunology | Immunosuppressive Agents | Reactive Oxygen Species | Humans | Middle Aged | Multienzyme Complexes - immunology | NADPH Oxidases - metabolism | NF-kappa B - immunology | Multienzyme Complexes - metabolism | NADPH Oxidases - immunology | Colon - immunology | Male | NF-kappa B - metabolism | Interferon-gamma - metabolism | MAP Kinase Signaling System - immunology | Antigens, CD - metabolism | Intestinal Mucosa - cytology | Young Adult | Flow Cytometry | Chromatin Immunoprecipitation | Intestinal Mucosa - immunology | Leukocytes, Mononuclear - immunology | CD8-Positive T-Lymphocytes - metabolism | Adult | Female | NADH, NADPH Oxidoreductases - metabolism | T-Lymphocytes, Cytotoxic - immunology | CD3 Complex | Apyrase - metabolism | Apyrase - immunology | Reverse Transcriptase Polymerase Chain Reaction | Crohn Disease - immunology | Blotting, Western | T-Lymphocytes, Cytotoxic - metabolism | CD28 Antigens | Interferon-gamma - immunology | Adenosine - metabolism | NADH, NADPH Oxidoreductases - immunology | Aged | Receptors, Purinergic P1 - metabolism | CD8-Positive T-Lymphocytes - immunology | Adenosine | Adenosine receptors | CD8 antigen | Paracrine signalling | Crohn's disease | Lymphocytes T | CD3 antigen | CD28 antigen | NAD(P)H oxidase | NADH oxidase | Signal transduction | Receptors | Immunological diseases | Immunology | NADH | Lymphocytes | γ-Interferon | Nicotinamide adenine dinucleotide | Transduction | Interferon | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2014, Volume 192, Issue 7, pp. 3301 - 3307
Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as a leading contributor to mortality during recent influenza pandemics. The mechanism for this... 
UNITED-STATES | LUNG | COMMUNITY-ACQUIRED PNEUMONIA | STREPTOCOCCUS-PNEUMONIAE | VIRUS | NITRIC-OXIDE | PNEUMOCOCCAL PNEUMONIA | COINFECTION | NEUTROPHILS | MICE | IMMUNOLOGY | Influenza A Virus, H1N1 Subtype - immunology | Lung - microbiology | Reactive Oxygen Species - metabolism | Influenza A Virus, H1N1 Subtype - physiology | NADPH Oxidases - metabolism | NADPH Oxidases - immunology | Male | Host-Pathogen Interactions - immunology | Orthomyxoviridae Infections - genetics | NADPH Oxidases - deficiency | Lung - virology | Flow Cytometry | Reactive Oxygen Species - immunology | NADPH Oxidases - genetics | Female | Staphylococcal Infections - microbiology | Membrane Glycoproteins - immunology | Neutrophils - metabolism | Macrophages, Alveolar - immunology | Methicillin-Resistant Staphylococcus aureus - physiology | Cytotoxicity, Immunologic - genetics | Staphylococcal Infections - genetics | Staphylococcal Infections - immunology | Mice, Inbred C57BL | Neutrophils - immunology | Methicillin-Resistant Staphylococcus aureus - immunology | Phagocytes - metabolism | Phagocytes - immunology | NADPH Oxidase 2 | Cells | Membrane Glycoproteins - genetics | Mice, Knockout | Animals | Mice | Macrophages, Alveolar - metabolism | Cytotoxicity, Immunologic - immunology | Orthomyxoviridae Infections - virology | Lung - immunology | Membrane Glycoproteins - deficiency | Orthomyxoviridae Infections - immunology | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 131, Issue 2, pp. 549 - 561
Background Allergic rhinitis (AR) and asthma are 2 entities of allergic airway diseases that frequently occur together, which is referred to as united airways... 
Allergy and Immunology | pathogen associated molecular pattern | allergic asthma | innate immunity | house dust mite | Allergic rhinitis | reactive oxygen species | epithelium | β-glucans | dual oxidase 2 | Toll-like receptor | ACTIVATION | beta-glucans | DENDRITIC CELLS | IMMUNOLOGY | DECTIN-1 | RHINITIS | TOLL-LIKE RECEPTOR-2 | RESPONSES | EPITHELIAL-CELLS | ALLERGY | INFLAMMATION | LIPID RAFTS | ASTHMA | Asthma - metabolism | Epithelial Cells - metabolism | Reactive Oxygen Species - metabolism | Rhinitis, Allergic | NADPH Oxidases - metabolism | Hypersensitivity - immunology | NADPH Oxidases - immunology | Lipopolysaccharides - immunology | Rhinitis, Allergic, Perennial - metabolism | Hypersensitivity - metabolism | Reactive Oxygen Species - immunology | Respiratory Mucosa - immunology | Asthma - immunology | Lung - metabolism | Nasal Mucosa - metabolism | beta-Glucans - immunology | Respiratory System - immunology | Rhinitis, Allergic, Perennial - immunology | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Immunity, Innate - immunology | beta-Glucans - metabolism | Animals | Nasal Mucosa - immunology | Respiratory System - metabolism | Epithelial Cells - immunology | Toll-Like Receptor 2 - immunology | Mice | Respiratory Mucosa - metabolism | Dual Oxidases | Lung - immunology | Pyroglyphidae - immunology | Medical colleges | Asthma | Lipids | Gene expression | Allergies | Immune system | Index Medicus | Abridged Index Medicus
Journal Article