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Nature communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, p. 8819
...) and augments expression of CD39. Inhibition of NADPH oxidases or knockdown of gp91phox in CD8... 
ACTIVATION | INFLAMMATORY-BOWEL-DISEASE | INHIBITION | IMMUNE SUPPRESSION | MURINE COLITIS | NOX FAMILY | MULTIDISCIPLINARY SCIENCES | MICE | DIFFERENTIATION | SEVERE CROHNS-DISEASE | NF-KAPPA-B | Colon - cytology | Antigens, CD - immunology | Immunosuppressive Agents | Reactive Oxygen Species | Humans | Middle Aged | Multienzyme Complexes - immunology | NADPH Oxidases - metabolism | NF-kappa B - immunology | Multienzyme Complexes - metabolism | NADPH Oxidases - immunology | Colon - immunology | Male | NF-kappa B - metabolism | Interferon-gamma - metabolism | MAP Kinase Signaling System - immunology | Antigens, CD - metabolism | Intestinal Mucosa - cytology | Young Adult | Flow Cytometry | Chromatin Immunoprecipitation | Intestinal Mucosa - immunology | Leukocytes, Mononuclear - immunology | CD8-Positive T-Lymphocytes - metabolism | Adult | Female | NADH, NADPH Oxidoreductases - metabolism | T-Lymphocytes, Cytotoxic - immunology | CD3 Complex | Apyrase - metabolism | Apyrase - immunology | Reverse Transcriptase Polymerase Chain Reaction | Crohn Disease - immunology | Blotting, Western | T-Lymphocytes, Cytotoxic - metabolism | CD28 Antigens | Interferon-gamma - immunology | Adenosine - metabolism | NADH, NADPH Oxidoreductases - immunology | Aged | Receptors, Purinergic P1 - metabolism | CD8-Positive T-Lymphocytes - immunology | Adenosine | Adenosine receptors | CD8 antigen | Paracrine signalling | Crohn's disease | Lymphocytes T | CD3 antigen | CD28 antigen | NAD(P)H oxidase | NADH oxidase | Signal transduction | Receptors | Immunological diseases | Immunology | NADH | Lymphocytes | γ-Interferon | Nicotinamide adenine dinucleotide | Interferon | Reactive oxygen species | Oxidase | Signaling | Ectonucleotidase
Journal Article
Nature immunology, ISSN 1529-2916, 2013, Volume 14, Issue 6, pp. 543 - 553
.... Active caspase-1 accumulates on phagosomes and acts locally to control the pH by modulating buffering by the NADPH oxidase NOX2... 
PROTEOLYTIC CLEAVAGE | H+-ATPASE ACTIVITY | DENDRITIC CELLS | TOLL-LIKE RECEPTOR | BACTERIAL LIGANDS | ACIDIFICATION | INNATE IMMUNE-SYSTEM | STAPHYLOCOCCUS-AUREUS | IMMUNOLOGY | MATURATION | NALP3 INFLAMMASOME | Phagosomes - microbiology | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Membrane Glycoproteins - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Staphylococcus aureus - physiology | Humans | NADPH Oxidases - metabolism | NADPH Oxidases - immunology | Caspase 1 - metabolism | Immunoblotting | Caspase 1 - immunology | Mice, 129 Strain | Enzyme Activation - immunology | Host-Pathogen Interactions - immunology | Phagosomes - immunology | Flow Cytometry | Reactive Oxygen Species - immunology | HEK293 Cells | Phagosomes - ultrastructure | Membrane Glycoproteins - immunology | Carrier Proteins - immunology | Macrophages - immunology | Macrophages - microbiology | Mice, Inbred C57BL | Phagosomes - metabolism | Cells, Cultured | Phagocytosis - immunology | Mice, Transgenic | Microscopy, Electron | NADPH Oxidase 2 | Mice, Knockout | Microscopy, Confocal | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Inflammasomes - immunology | Staphylococcus aureus - immunology | Mice | Hydrogen-Ion Concentration | Oxidases | Physiological aspects | Phagosomes | Bacteria | Genetic aspects | Research | Health aspects
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 5/2013, Volume 110, Issue 21, pp. 8744 - 8749
...). Using selected reaction monitoring MS, we identified the plant NADPH oxidase, respiratory burst oxidase homolog D (RBOHD... 
Proteins | Oxidases | Pathogens | Enzymes | Phosphorylation | Reactive oxygen species | Calcium | Plant propagation | Protoplasts | Biochemistry | ANION CHANNEL | ABIOTIC STRESS | PATHOGEN | MULTIDISCIPLINARY SCIENCES | ROS signaling | RECEPTOR | IMMUNE | disease resistance | plant innate immunity | CA2 | ROS | RESISTANCE | ACCUMULATION | KINASES | Arabidopsis - enzymology | Reactive Oxygen Species - metabolism | NADPH Oxidases - metabolism | Arabidopsis - immunology | NADPH Oxidases - immunology | Cell Communication - physiology | Enzyme Activation - immunology | Tobacco - immunology | Arabidopsis Proteins - metabolism | Reactive Oxygen Species - immunology | NADPH Oxidases - genetics | Calcium-Calmodulin-Dependent Protein Kinases - immunology | Arabidopsis Proteins - genetics | Calcium-Calmodulin-Dependent Protein Kinases - genetics | Plants, Genetically Modified - genetics | Plants, Genetically Modified - immunology | Plants, Genetically Modified - enzymology | Plant Immunity - physiology | Arabidopsis Proteins - immunology | Arabidopsis - genetics | Tobacco - genetics | Signal Transduction - physiology | Mutation | Plant Diseases | Enzyme Activation - genetics | Tobacco - enzymology | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Arabidopsis thaliana | Physiological aspects | Research | Protein kinases | Plant immunology | Biological Sciences
Journal Article
Nature immunology, ISSN 1529-2916, 2010, Volume 11, Issue 5, pp. 411 - 418
Sensors of pathogens, such as Toll-like receptors (TLRs), detect microbes to activate transcriptional programs that orchestrate adaptive responses to specific... 
UNFOLDED PROTEIN RESPONSE | PATHWAY | ER STRESS | HOST-DEFENSE | ENDOPLASMIC-RETICULUM STRESS | FRANCISELLA-TULARENSIS INFECTION | IMMUNOLOGY | LIVE VACCINE STRAIN | INFLAMMATORY RESPONSE | NEGATIVE REGULATOR | SYSTEMS BIOLOGY | RNA, Small Interfering - genetics | Endoribonucleases - genetics | Tularemia - metabolism | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - metabolism | Lipopeptides - pharmacology | Transcriptional Activation - drug effects | NADPH Oxidases - metabolism | Tularemia - genetics | Protein Splicing - genetics | Transcriptional Activation - immunology | X-Box Binding Protein 1 | Protein Splicing - drug effects | NADPH Oxidases - genetics | Stress, Physiological - drug effects | TNF Receptor-Associated Factor 6 - genetics | Transcription Factor CHOP - biosynthesis | Transcription Factors - immunology | Cytokines - genetics | Protein-Serine-Threonine Kinases - metabolism | DNA-Binding Proteins - immunology | Endoribonucleases - metabolism | Macrophages - pathology | Stress, Physiological - genetics | Myeloid Differentiation Factor 88 - genetics | Toll-Like Receptor 4 - genetics | Signal Transduction - genetics | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Macrophages - metabolism | Signal Transduction - drug effects | Tunicamycin - pharmacology | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | Mice | Stress, Physiological - immunology | Endoribonucleases - immunology | Transcription Factor CHOP - genetics | NADPH Oxidases - immunology | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | Macrophages - virology | Mice, Mutant Strains | Tularemia - immunology | Membrane Glycoproteins - immunology | Macrophages - immunology | Cytokines - immunology | Cell Line | Francisella tularensis - immunology | Protein Splicing - immunology | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Immunity, Innate | NADPH Oxidase 2 | Regulatory Factor X Transcription Factors | Mice, Inbred C3H | Membrane Glycoproteins - genetics | Transcription Factors - metabolism | Animals | TNF Receptor-Associated Factor 6 - metabolism | Macrophages - drug effects | Protein-Serine-Threonine Kinases - immunology | Francisella tularensis - pathogenicity | Myeloid Differentiation Factor 88 - metabolism | Cytokines - biosynthesis | Cell receptors | Transcription factors | Immune response | Physiological aspects | Genetic aspects | Research | Health aspects | Francisella tularensis
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2014, Volume 192, Issue 11, pp. 4989 - 5001
.... The antimicrobial effector NADPH oxidase (NOX2), which generates superoxide within maturing phagosomes, has also been shown to regulate activities of cysteine cathepsins through modulation of the lumenal redox potential... 
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | LYSOSOMAL THIOL REDUCTASE | DENDRITIC CELLS | MULTIPLE-SCLEROSIS | CHRONIC GRANULOMATOUS-DISEASE | IMMUNE-RESPONSES | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | T-CELL-ACTIVATION | CENTRAL-NERVOUS-SYSTEM | IMMUNOLOGY | CONTROLS PHAGOSOMAL PH | Myelin-Oligodendrocyte Glycoprotein - immunology | Cathepsin L - genetics | Myelin-Oligodendrocyte Glycoprotein - genetics | Cathepsin L - immunology | Encephalomyelitis, Autoimmune, Experimental - immunology | NADPH Oxidases - immunology | Epitopes, T-Lymphocyte - genetics | Antigen-Presenting Cells - pathology | Bone Marrow Cells - immunology | NADPH Oxidases - genetics | CD4-Positive T-Lymphocytes | Encephalomyelitis, Autoimmune, Experimental - genetics | Epitopes, T-Lymphocyte - immunology | Membrane Glycoproteins - immunology | Macrophages - immunology | Cathepsins - immunology | Cell Line | Encephalomyelitis, Autoimmune, Experimental - pathology | Macrophages - pathology | Oxidation-Reduction | Bone Marrow Cells - pathology | Antigen-Presenting Cells - immunology | NADPH Oxidase 2 | Membrane Glycoproteins - genetics | Mice, Knockout | Animals | Histocompatibility Antigens Class II - immunology | Cathepsins - genetics | Mice | Histocompatibility Antigens Class II - genetics
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2013, Volume 131, Issue 2, pp. 549 - 561
Background Allergic rhinitis (AR) and asthma are 2 entities of allergic airway diseases that frequently occur together, which is referred to as united airways... 
Allergy and Immunology | pathogen associated molecular pattern | allergic asthma | innate immunity | house dust mite | Allergic rhinitis | reactive oxygen species | epithelium | β-glucans | dual oxidase 2 | Toll-like receptor | ACTIVATION | beta-glucans | DENDRITIC CELLS | IMMUNOLOGY | DECTIN-1 | RHINITIS | TOLL-LIKE RECEPTOR-2 | RESPONSES | EPITHELIAL-CELLS | ALLERGY | INFLAMMATION | LIPID RAFTS | ASTHMA | Asthma - metabolism | Epithelial Cells - metabolism | Reactive Oxygen Species - metabolism | Rhinitis, Allergic | NADPH Oxidases - metabolism | Hypersensitivity - immunology | NADPH Oxidases - immunology | Lipopolysaccharides - immunology | Rhinitis, Allergic, Perennial - metabolism | Hypersensitivity - metabolism | Reactive Oxygen Species - immunology | Respiratory Mucosa - immunology | Asthma - immunology | Lung - metabolism | Nasal Mucosa - metabolism | beta-Glucans - immunology | Respiratory System - immunology | Rhinitis, Allergic, Perennial - immunology | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Immunity, Innate - immunology | beta-Glucans - metabolism | Animals | Nasal Mucosa - immunology | Respiratory System - metabolism | Epithelial Cells - immunology | Toll-Like Receptor 2 - immunology | Mice | Respiratory Mucosa - metabolism | Dual Oxidases | Lung - immunology | Pyroglyphidae - immunology | Medical colleges | Asthma | Lipids | Gene expression | Allergies | Immune system
Journal Article
Scientific reports, ISSN 2045-2322, 2015, Volume 5, Issue 1, p. 18302
...) generation by NADPH oxidase and also chromatin decondensation dependent upon the enzymes (PAD4), neutrophil elastase... 
INACTIVATION | NADPH OXIDASE | MYELOPEROXIDASE | ACTIVATION | PROTEIN | MECHANISM | NITRIC-OXIDE SYNTHASE | NET FORMATION | MULTIDISCIPLINARY SCIENCES | INHIBITORS | EXPRESSION | Leukocyte Elastase - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Extracellular Traps - metabolism | Humans | NADPH Oxidases - metabolism | NADPH Oxidases - immunology | Mitochondria - immunology | Leukocyte Elastase - antagonists & inhibitors | Neutrophils - parasitology | Extracellular Traps - immunology | Time Factors | Reactive Oxygen Species - immunology | Oxidation-Reduction - drug effects | Neutrophils - metabolism | Hydrolases - metabolism | Peroxidase - antagonists & inhibitors | Peroxidase - immunology | NADPH Oxidases - antagonists & inhibitors | Cells, Cultured | Enzyme Inhibitors - pharmacology | Neutrophils - immunology | Host-Parasite Interactions - immunology | Mitochondria - metabolism | Mitochondria - drug effects | Leishmania - immunology | Apoptosis - immunology | Hydrolases - immunology | Leishmania - physiology | Leukocyte Elastase - immunology | Microscopy, Fluorescence | Protein-Arginine Deiminases | Hydrolases - antagonists & inhibitors | Peroxidase - metabolism | Enzymes | Chromatin | Promastigotes | Neutrophils | Leukocytes (neutrophilic) | Leishmaniasis | Parasites | NAD(P)H oxidase | Microorganisms | Cell activation | Microbicides | Peroxidase | Elastase | Immune system
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 6/2011, Volume 108, Issue 23, pp. 9548 - 9553
Emerging evidence indicates that NADPH oxidase (NOX) and its reactive oxygen species (ROS... 
T lymphocytes | Oxidases | Myeloid cells | Reactive oxygen species | Spleen cells | Cytokines | Chondrocytes | Arthritis | Mice | Bone marrow cells | Rheumatoid arthritis | Myeloid-derived suppressor cell | RHEUMATOID-ARTHRITIS | ENCEPHALOMYELITIS | CHRONIC GRANULOMATOUS-DISEASE | MULTIDISCIPLINARY SCIENCES | rheumatoid arthritis | DESTRUCTION | REACTIVE OXYGEN | RECEPTOR STIMULATION | AUTOIMMUNITY | myeloid-derived suppressor cell | MICE | SUPPRESSOR-CELLS | TH17 | T-Lymphocytes, Regulatory - metabolism | Arthritis - metabolism | Interleukin-17 - immunology | NADPH Oxidases - immunology | Male | Adoptive Transfer | Interferon-gamma - metabolism | Arthritis - genetics | X-Ray Microtomography | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | NADPH Oxidases - deficiency | Aging - immunology | Flow Cytometry | T-Lymphocytes, Helper-Inducer - immunology | Bone and Bones - metabolism | Arthritis - immunology | NADPH Oxidases - genetics | Female | Membrane Glycoproteins - immunology | Bone Density | T-Lymphocytes, Helper-Inducer - metabolism | CD11b Antigen - immunology | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | NADPH Oxidase 2 | Membrane Glycoproteins - genetics | Mice, Knockout | Cell Differentiation - immunology | Interleukin-17 - metabolism | Animals | CD4-Positive T-Lymphocytes - transplantation | Interferon-gamma - immunology | CD11b Antigen - metabolism | Bone and Bones - abnormalities | Membrane Glycoproteins - deficiency | Biological Sciences
Journal Article