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mln4924 (23) 23
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Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2016, Volume 22, Issue 1, pp. 34 - 43
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 03/2015, Volume 16, Issue 3, pp. 420 - 429
Journal Article
Veterinary and Comparative Oncology, ISSN 1476-5810, 12/2018, Volume 16, Issue 4, pp. 606 - 615
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2011, Volume 52, Issue 15, pp. 1807 - 1810
Synthesis of two isotopically labeled versions of NAE inhibitor—MLN4924. The synthesis of two isotopically labeled versions of an investigational NAE inhibitor... 
NAE inhibitor | 14C-6-chloro-7-deazapurine | MLN4924 | D 8-( S)-1-aminoindan | C-6-chloro-7-deazapurine | (S)-1-aminoindan | CHEMISTRY, ORGANIC | C-14-6-chloro-7-deazapurine D-8-(S)-1-aminoindan | Tetrahedrons | Enzymes | Synthesis (chemistry) | Inhibitors
Journal Article
CELL CYCLE, ISSN 1538-4101, 09/2019, Volume 18, Issue 18, pp. 2307 - 2322
The BCR-ABL1 fusion gene is the driver oncogene in chronic myeloid leukemia (CML) and Philadelphia-chromosome positive (Ph+) acute lymphoblastic leukemia... 
CHRONIC PHASE | DNA damage | TYROSINE KINASE | BLAST CRISIS | Neddylation | DOMAIN MUTATIONS | CHRONIC MYELOID-LEUKEMIA | CELL BIOLOGY | NAE INHIBITOR | ACUTE LYMPHOBLASTIC-LEUKEMIA | MYELOGENOUS LEUKEMIA | Ph plus leukemia | UP-REGULATION | IMATINIB MESYLATE
Journal Article
Cellular Signalling, ISSN 0898-6568, 04/2018, Volume 44, pp. 92 - 102
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2012, Volume 441, Issue 3, pp. 927 - 936
Ubiquitin and UBL (ubiquitin-like) modifiers are small proteins that covalently modify other proteins to alter their properties or behaviours. Ubiquitin... 
Ubiquitin-activating enzyme | MG132 | Bortezomib | MLN4924 | Neural-precursor-cell-expressed developmentally down-regulated 8 (NEDD8)-activating enzyme (NAE) | Proteasome | proteasome | PROTEIN | ubiquitin-activating enzyme | BIOCHEMISTRY & MOLECULAR BIOLOGY | CUL1 | neural-precursor-cell-expressed developmentally down-regulated 8 (NEDD8)-activating enzyme (NAE) | P53 | E3 LIGASE | CONJUGATION | PATHWAY | CHAINS | bortezomib | INHIBITOR | BINDING | Ubiquitin - analysis | Cricetinae | Cricetulus | Ubiquitins - genetics | Humans | Cells, Cultured | Enzyme Inhibitors - pharmacology | Ubiquitin - metabolism | Ubiquitin-Protein Ligases - metabolism | Animals | Transfection | Ubiquitination - drug effects | HEK293 Cells | Ubiquitins - analysis | HeLa Cells | Ubiquitination - physiology | Pyrazines - pharmacology | Ubiquitin-Protein Ligases - genetics | Ubiquitins - metabolism | NEDD8 Protein | Ubiquitination - genetics | Boronic Acids - pharmacology | CHO Cells | ubiquitinactivating enzyme | WT, wild-type | LDS, lithium dodecyl sulfate | FBS, fetal bovine serum | BCA3, breast cancer-associated gene 3 | UBL, ubiquitin-like | EGFR, epidermal growth factor receptor | HA, haemagglutinin | NAE, NEDD8-activating enzyme | siRNA, small interfering RNA | HRP, horseradish peroxidase | CHO, Chinese-hamster ovary | CRL, cullin-RING ubiquitin ligase | NEDD8, neural-precursor-cell-expressed developmentally down-regulated 8 | TCA, trichloroacetic acid | SUMO, small ubiquitin-like modifier
Journal Article