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Nucleic Acids Research, ISSN 0305-1048, 03/2018, Volume 46, Issue 5, pp. 2145 - 2158
Abstract Exonic splicing enhancer (ESE) sequences are bound by serine & arginine-rich (SR) proteins, which in turn enhance the recruitment of splicing factors.... 
NAR Breakthrough
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 12/2018, Volume 46, Issue 22, pp. 11659 - 11670
Abstract N 6-methyldeoxyadenosine (6mA) is a well-characterized DNA modification in prokaryotes but reports on its presence and function in mammals have been... 
NAR Breakthrough
Journal Article
Nucleic acids research, ISSN 0305-1048, 08/2019, Volume 47, Issue 17, pp. 8927 - 8940
The maintenance of telomere length is critical to longevity and survival. Specifically, the failure to properly replicate, resect, and/or form appropriate... 
NAR Breakthrough
Journal Article
Nucleic acids research, ISSN 0305-1048, 07/2019, Volume 47, Issue 15, pp. 7719 - 7733
N6-methyladenosine (m6A) has recently been found abundantly on messenger RNA and shown to regulate most steps of mRNA metabolism. Several important m6A... 
NAR Breakthrough
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 11/2018, Volume 46, Issue 20, pp. 10535 - 10545
Abstract Retroviruses package two complete RNA genomes into a viral particle but generate only one provirus after each infection. This pseudodiploid... 
HIGH NEGATIVE INTERFERENCE | RNA | REVERSE TRANSCRIPTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | FREQUENCY | IMMUNODEFICIENCY-VIRUS TYPE-1 | MURINE LEUKEMIA-VIRUS | GENETIC-RECOMBINATION | RETROVIRAL RECOMBINATION | MUTATIONS | NAR Breakthrough
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 01/2019, Volume 47, Issue D1, pp. D859 - D866
Abstract Understanding anatomical structures and biological functions based on gene expression is critical in a systemic approach to address the complexity of... 
ATLAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NAR Breakthrough
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 02/2018, Volume 46, Issue 3, pp. 1007 - 1020
Abstract The CRISPR-Cas system for prokaryotic adaptive immunity provides RNA-mediated protection from viruses and mobile genetic elements. Adaptation is... 
ARCHAEAL | CHROMATIN PROTEIN | FOREIGN DNA | SULFOLOBUS | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADAPTATION | BINDING-PROTEIN | HOST FACTOR | CAS SYSTEM | SPACER ACQUISITION | NAR Breakthrough
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 02/2018, Volume 46, Issue 4, pp. 1565 - 1583
Abstract Modified uridine containing taurine, 5-taurinomethyluridine (τm5U), is found at the anticodon first position of mitochondrial (mt-)transfer RNAs... 
JAPANESE FLOUNDER | HYPERTROPHIC CARDIOMYOPATHY | WOBBLE MODIFICATION DEFICIENCY | MUTANT TRANSFER-RNAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MODIFICATION DEFECT | MITOCHONDRIAL TRANSFER-RNAS | STROKE-LIKE EPISODES | LACTIC-ACIDOSIS | CLINICAL-FEATURES | ONE-CARBON METABOLISM | NAR Breakthrough
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 01/2019, Volume 47, Issue 1, pp. 3 - 14
Abstract RNA modifications are present in all classes of RNAs. They control the fate of mRNAs by affecting their processing, translation, or stability. Inosine... 
CODON | ADENOSINE-DEAMINASE | GENE | LETHALITY | DEOXYINOSINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CONSTRUCTION | DEFICIENT | RNA EDITING SITES | IDENTIFICATION | ADAR3 | NAR Breakthrough
Journal Article
NUCLEIC ACIDS RESEARCH, ISSN 0305-1048, 06/2019, Volume 47, Issue 11, pp. 5465 - 5479
Phosphorothioate-modified antisense oligonucleotides (PS-ASOs) interact with a host of plasma, cell-surface and intracellular proteins which govern their... 
STABILIN-2 | MESSENGER-RNA | NUCLEOSIDE ANALOGS | RECOGNITION | POTENCY | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEQUENCE | TOXICITY | HEPATOTOXICITY | ANTISENSE OLIGONUCLEOTIDES | RNA/DNA HYBRID | NAR Breakthrough
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 04/2019, Volume 47, Issue 6, pp. 2703 - 2715
Abstract P53-binding protein 1 (53BP1) mediates DNA repair pathway choice and promotes checkpoint activation. Chromatin marks induced by DNA double-strand... 
CELLS | RECRUITMENT | CHROMATIN | CELLULAR-RESPONSES | DAMAGE-RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR | DIFFUSION | HOMOLOGOUS RECOMBINATION | BINDING | TELOMERES | NAR Breakthrough
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 11/2018, Volume 46, Issue 21, pp. 11129 - 11143
Abstract H2B ubiquitylation (H2Bub)-dependent H3K4 methylation is mediated by the multisubunit Set1 complex (Set1C) in yeast, but precisely how Set1C subunits... 
COMPASS | UBIQUITINATION | DOMAIN | METHYLTRANSFERASE | HISTONE H2B | ROLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRITHORAX | DISEASE | SPP1 | NAR Breakthrough
Journal Article
15.