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Tetrahedron, ISSN 0040-4020, 02/2018, Volume 74, Issue 5, pp. 549 - 555
One important class of HDAC (histone deacetylation enzymes) inhibitors is the sulfur-containing marine natural products with structural diversity. Inspired by... 
Psammaplin A | Hybrid | Largazole | HDAC inhibitors | Marine natural product | HDACS | ANALOGS | CHROMOBACTERIUM-VIOLACEUM NO-968 | CHEMISTRY, ORGANIC | FR901228 | HISTONE-DEACETYLASE INHIBITORS | DISCOVERY | Sulfur compounds | Enzymes | Malic acid | Biological products | Olefins
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2018, Volume 143, pp. 2005 - 2014
Recent studies have demonstrated enhanced anticancer effects of combination therapy consisting of camptothecin derivatives and HDAC inhibitors. To exploit this... 
Camptothecin | Dual-action inhibitors | Antitumor activity | Psammaplin | HDAC inhibitors | Antiproliferative activity | CHEMISTRY, MEDICINAL | ANTITUMOR-ACTIVITY | NATURAL-PRODUCT PSAMMAPLIN | CELL LUNG-CANCER | 5-FLUOROURACIL | SPONGE | BIOLOGICAL-ACTIVITY | FORCE-FIELD | AGENTS | HISTONE DEACETYLASE INHIBITORS | DERIVATIVES | Tyrosine - pharmacology | Camptothecin - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Tyrosine - analogs & derivatives | Dose-Response Relationship, Drug | Neoplasms, Experimental - pathology | Histone Deacetylase Inhibitors - chemical synthesis | Topoisomerase I Inhibitors - pharmacology | Disulfides - chemistry | Disulfides - pharmacology | Antineoplastic Agents - pharmacology | Molecular Structure | Topoisomerase I Inhibitors - chemistry | Tyrosine - chemistry | DNA Topoisomerases, Type I - metabolism | Cells, Cultured | Models, Molecular | Histone Deacetylases - metabolism | Antineoplastic Agents - chemistry | Histone Deacetylase Inhibitors - chemistry | Topoisomerase I Inhibitors - chemical synthesis | Animals | Mice, Nude | Histone Deacetylase Inhibitors - pharmacology | Cell Proliferation - drug effects | Mice | Camptothecin - pharmacology | Neoplasms, Experimental - drug therapy | Drug Screening Assays, Antitumor | Molecular biology
Journal Article
by Jing, QX and Hu, X and Ma, YZ and Mu, JH and Liu, WW and Xu, FX and Li, ZL and Bai, J and Hua, HM and Li, DH
MARINE DRUGS, ISSN 1660-3397, 07/2019, Volume 17, Issue 7, p. 384
Marine natural products are considered to be valuable resources that are furnished with diverse chemical structures and various bioactivities. To date, there... 
METABOLITES | CHEMISTRY, MEDICINAL | biological activity | ANALOGS | DRUG DISCOVERY | RESISTANT STAPHYLOCOCCUS-AUREUS | structural modification | CHITINASE INHIBITORS | psammaplin A | SPONGE | EVOLVING ROLE | marine natural product | PRODUCT PSAMMAPLIN | DERIVATIVES | HISTONE DEACETYLASE
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2019, Volume 29, Issue 4, pp. 614 - 618
Synthesis of psammaplin A analogues is described. Screening for antibiofilm activity of the targeted library afford some interesting elements in terms of... 
Psammaplin A | Anti-biofilm | 1,2,3-Triazole | Click chemistry | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | COLONIZATION | DISCOVERY | MARINE NATURAL-PRODUCTS | SPONGE | ANTI-BIOFILM COMPOUNDS | CLICK-BASED SYNTHESIS | ANTIFOULING COMPOUNDS | Ampicillin | Triazoles | Libraries
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2012, Volume 55, Issue 22, pp. 9467 - 9491
Journal Article
Tetrahedron, ISSN 0040-4020, 12/2014, Volume 70, Issue 51, pp. 9702 - 9708
An innovative synthesis of psammaplin-like structure is proposed based on original methodologies using superacid, microwaves, and S-ene chemistry. The new... 
Superacid | Psammaplin | S-Ene chemistry | Microwaves | Cancer | HISTONE DEACETYLASE INHIBITOR | METABOLITES | CHEMISTRY, ORGANIC | MALIGNANT PLEURAL MESOTHELIOMA | T-CELL LYMPHOMA | RESISTANT STAPHYLOCOCCUS-AUREUS | NATURAL-PRODUCT PSAMMAPLIN | SPONGE | PRODRUG | GENE-EXPRESSION | DERIVATIVES | Analysis | Thiols | Inhibitors | Synthesis | Disulfides | Tetrahedrons | Histones | Chemical compounds | Tumors | Chemical Sciences
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2011, Volume 19, Issue 12, pp. 3637 - 3649
Journal Article
Molecular Medicine Reports, ISSN 1791-2997, 09/2016, Volume 14, Issue 3, pp. 2691 - 2696
Vibrio vulnificus is known to induce severely fulminant and fatal septicemia in susceptible hosts. In the present study, the antimicrobial activity of natural... 
Psammaplin A | Antimicrobial activity | Vibrio vulnificus | MEDICINE, RESEARCH & EXPERIMENTAL | NECROSIS-FACTOR-ALPHA | antimicrobial activity | RESISTANT STAPHYLOCOCCUS-AUREUS | IDENTIFICATION | VIRULENCE | INTESTINAL EPITHELIAL-CELLS | psammaplin A | CAPSULAR POLYSACCHARIDE | PATHOGENESIS | SPONGE | ONCOLOGY | INFECTION | ASSOCIATION | Index Medicus
Journal Article
by Zhang, BB and Shan, GS and Zheng, YY and Yu, XL and Ruan, ZW and Li, Y and Lei, XS
MARINE DRUGS, ISSN 1660-3397, 06/2019, Volume 17, Issue 6, p. 333
Largazole, isolated from a marine Cyanobacterium of the genus Symploca, is a potent and selective Class I HDAC (histone deacetylation enzymes) inhibitor. This... 
CHEMISTRY, MEDICINAL | HDACS | ACID | CHROMOBACTERIUM-VIOLACEUM NO-968 | HDAC inhibitors | HISTONE-DEACETYLASE INHIBITORS | DISCOVERY | Psammaplin A | POTENT | Largazole | FR901228 | marine natural product | SELECTIVITY | luoro olefin | Histone deacetylase | Similarity | Bioassays | Chains | Alcohol | Sulphur | Zinc | Chromatography | Analogs | Chemistry | Acids | Deacetylation | Natural products | Histones | Sulfur
Journal Article
Beilstein Journal of Organic Chemistry, ISSN 1860-5397, 01/2013, Volume 9, Issue 1, pp. 81 - 88
There has been significant interest in the bioactivity of the natural product psammaplin A, most recently as a potent and isoform selective HDAC inhibitor.... 
Psammaplin A | Epigenetics | Natural product | Histone deacetylase | Prodrug | Thioester | prodrug | DRUG | METABOLITES | DESIGN | thioester | MECHANISM | natural product | CHEMISTRY, ORGANIC | T-CELL LYMPHOMA | FUTURE | histone deacetylase | CANCER | epigenetics | VORINOSTAT | psammaplin A | SPONGE
Journal Article
Journal Article
by Li, M and Miao, Z.-H and Chen, Z and Chen, Q and Gui, M and Lin, L.-P and Sun, P and Yi, Y.-H and Ding, J
Annals of Oncology, ISSN 0923-7534, 3/2010, Volume 21, Issue 3, pp. 597 - 607
Background: Echinoside A was isolated from sea cucumber. This study demonstrates its anticancer effects and its mechanisms of action. Materials and methods:... 
Marine-derived anticancer drugs | Echinoside A | Topoisomerase2 inhibitor | DNA damage | Catalytic cycle | CANCER-CELLS | APOPTOSIS | II INHIBITORS | topoisomerase2 inhibitor | NATURAL-PRODUCTS | marine-derived anticancer drugs | PSAMMAPLIN | catalytic cycle | echinoside A | ONCOLOGY | CLEAVAGE COMPLEXES | IN-VIVO | DRUGS | MULTIDRUG-RESISTANCE | DERIVATIVES
Journal Article