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Science, ISSN 0036-8075, 5/2010, Volume 328, Issue 5980, pp. 906 - 909
Journal Article
Journal Article
Journal Article
蛋白质与细胞:英文版, ISSN 1674-800X, 2017, Volume 8, Issue 6, pp. 401 - 438
Journal Article
BBA - Biomembranes, ISSN 0005-2736, 07/2015, Volume 1848, Issue 7, pp. 1545 - 1551
With the ultimate goal of detailed structural analysis of mammalian and particularly human voltage-gated sodium channels (VGSCs), we have investigated the... 
Radioligand-binding assay | Human voltage-gated sodium channel | Membrane protein stability | Rat VGSC | Structural biology | Electrophorus electricus | RAT SKELETAL-MUSCLE | ELECTROPHORUS-ELECTRICUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | VALIDATION | RECEPTOR | MECHANISMS | MICROSCOPY | BIOPHYSICS | NA+ CHANNEL | SAXITOXIN | MEMBRANE-PROTEINS | BINDING | Temperature | Cricetulus | Detergents - chemistry | Humans | Crystallography, X-Ray | NAV1.1 Voltage-Gated Sodium Channel - metabolism | NAV1.1 Voltage-Gated Sodium Channel - chemistry | NAV1.2 Voltage-Gated Sodium Channel - metabolism | NAV1.3 Voltage-Gated Sodium Channel - metabolism | NAV1.1 Voltage-Gated Sodium Channel - ultrastructure | Membrane Proteins - ultrastructure | Voltage-Gated Sodium Channels - ultrastructure | HEK293 Cells | Membrane Proteins - metabolism | NAV1.3 Voltage-Gated Sodium Channel - ultrastructure | NAV1.2 Voltage-Gated Sodium Channel - ultrastructure | CHO Cells | Toxins, Biological - pharmacology | Cricetinae | Solubility | Benchmarking - methods | Rats | Cryoelectron Microscopy | NAV1.2 Voltage-Gated Sodium Channel - chemistry | Animals | Membrane Proteins - chemistry | Protein Stability - drug effects | Toxins, Biological - metabolism | NAV1.3 Voltage-Gated Sodium Channel - chemistry | Eels - metabolism | Voltage-Gated Sodium Channels - chemistry | Voltage-Gated Sodium Channels - metabolism | Benchmarks | Detergents, Synthetic | Analysis | Eels
Journal Article
MARINE DRUGS, ISSN 1660-3397, 09/2017, Volume 15, Issue 9
Ciguatoxins (CTXs) are marine toxins that cause ciguatera fish poisoning, a debilitating disease dominated by sensory and neurological disturbances that... 
TRPC5 | CHEMISTRY, MEDICINAL | GENE-RELATED PEPTIDE | TRPA1 | ciguatera | neurogenic inflammation | neuropathic pain | PACIFIC CIGUATOXIN-1 | IN-VITRO | 5 TRPC5 | voltage-gated calcium channels | TTX | P-CTX-1 | tetrodotoxin | TRPM8 | PRIMARY SENSORY NEURONS | COLD | SUBSTANCE-P | RESISTANT NA+ CURRENT | PROSTAGLANDIN E-2 | calcitonin-gene related peptide
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2004, Volume 101, Issue 30, pp. 11147 - 11152
Journal Article
Pharmacogenetics and Genomics, ISSN 1744-6872, 11/2008, Volume 18, Issue 11, pp. 989 - 998
Journal Article
Channels, ISSN 1933-6950, 01/2018, Volume 12, Issue 1, pp. 367 - 377
Voltage-gated sodium channels are key contributors to membrane excitability. These channels are expressed in a tissue-specific manner. Mutations and modulation... 
pH | electrophysiology | Nav1.3 | Acidosis | Nav1.1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | SENSOR | Nav1 | CURRENTS | 1 | SKELETAL-MUSCLE | 3 | STRUCTURAL BASIS | CA2 | PORE | NA+ | EXPRESSION | MODULATION | Patch-Clamp Techniques | Animals | Cricetulus | Cells, Cultured | Neurons - metabolism | Voltage-Gated Sodium Channels - metabolism | CHO Cells
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2009, Volume 284, Issue 26, pp. 17883 - 17896
Voltage-gated sodium channels (Na v ) produce sodium currents that underlie the initiation and propagation of action potentials in nerve and muscle cells.... 
MICE LACKING FIBROBLAST-GROWTH-FACTOR-14 | NERVOUS-SYSTEM | LINKED MENTAL-RETARDATION | GENE | FGF | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTATION | INACTIVATION GATE | FACTOR 1B | NEURONAL EXCITABILITY | EXPRESSION | Humans | Fibroblast Growth Factors - genetics | Molecular Sequence Data | Crystallography, X-Ray | Neurons - cytology | Structure-Activity Relationship | Fibroblast Growth Factors - chemistry | Fibroblast Growth Factors - metabolism | Nerve Tissue Proteins - chemistry | Sodium Channels - metabolism | Neurons - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Mutagenesis, Site-Directed | Rats | Hippocampus - cytology | Mutation - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Sequence Homology, Amino Acid | Hippocampus - metabolism | NAV1.1 Voltage-Gated Sodium Channel | Animals | Sodium Channels - chemistry | Protein Isoforms | Protein Binding | Sodium Channels - genetics | Index Medicus | HUMAN POPULATIONS | MUTAGENESIS | SODIUM | BASIC BIOLOGICAL SCIENCES | NERVES | STOWING | INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY | CRYSTAL STRUCTURE | national synchrotron light source | MATERIALS SCIENCE | IN VIVO | POTENTIALS | FIBROBLASTS | INACTIVATION | GROWTH FACTORS | DATA | IN VITRO | GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE | CRYSTALS | MUTATIONS | MODULATION | MUSCLES | NERVE CELLS | SURFACES | Protein Structure and Folding
Journal Article