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Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 9, pp. 1471 - 1474
Escitalopram, a selective serotonin reuptake inhibitor (SSRI), may induce seizures, particularly in epileptic patients. In this study, we investigated the... 
Nav1.2 voltage-gated sodium channels (VGSCs) | escitalopram | HEK293 | 1.2 voltage-gated sodium channels (VGSCs) | Escitalopram
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2016, Volume 291, Issue 13, pp. 7205 - 7220
Journal Article
BBA - Biomembranes, ISSN 0005-2736, 07/2015, Volume 1848, Issue 7, pp. 1545 - 1551
With the ultimate goal of detailed structural analysis of mammalian and particularly human voltage-gated sodium channels (VGSCs), we have investigated the... 
Radioligand-binding assay | Human voltage-gated sodium channel | Membrane protein stability | Rat VGSC | Structural biology | Electrophorus electricus | RAT SKELETAL-MUSCLE | ELECTROPHORUS-ELECTRICUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | VALIDATION | RECEPTOR | MECHANISMS | MICROSCOPY | BIOPHYSICS | NA+ CHANNEL | SAXITOXIN | MEMBRANE-PROTEINS | BINDING | Temperature | Cricetulus | Detergents - chemistry | Humans | Crystallography, X-Ray | NAV1.1 Voltage-Gated Sodium Channel - metabolism | NAV1.1 Voltage-Gated Sodium Channel - chemistry | NAV1.2 Voltage-Gated Sodium Channel - metabolism | NAV1.3 Voltage-Gated Sodium Channel - metabolism | NAV1.1 Voltage-Gated Sodium Channel - ultrastructure | Membrane Proteins - ultrastructure | Voltage-Gated Sodium Channels - ultrastructure | HEK293 Cells | Membrane Proteins - metabolism | NAV1.3 Voltage-Gated Sodium Channel - ultrastructure | NAV1.2 Voltage-Gated Sodium Channel - ultrastructure | CHO Cells | Toxins, Biological - pharmacology | Cricetinae | Solubility | Benchmarking - methods | Rats | Cryoelectron Microscopy | NAV1.2 Voltage-Gated Sodium Channel - chemistry | Animals | Membrane Proteins - chemistry | Protein Stability - drug effects | Toxins, Biological - metabolism | NAV1.3 Voltage-Gated Sodium Channel - chemistry | Eels - metabolism | Voltage-Gated Sodium Channels - chemistry | Voltage-Gated Sodium Channels - metabolism | Benchmarks | Detergents, Synthetic | Analysis | Eels
Journal Article
Channels, ISSN 1933-6950, 05/2014, Volume 8, Issue 3, pp. 264 - 277
Eukaryotic voltage-gated sodium channels (VGSCs) are essential for the initiation and propagation of action potentials in electrically excitable cells, and are... 
Nav1.4 | local anesthetic | ion channel | Nav1.2 | fenestrations | molecular dynamics | Voltage-gated sodium channel | Local anesthetic | Fenestrations | Molecular dynamics | Ion channel | DOMAIN | DETERMINANTS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NA+ CHANNELS | BENZOCAINE | INHIBITION | LOCAL-ANESTHETICS | STATE-DEPENDENT BLOCK | RESIDUES | CHANNELOPATHIES | Research Paper
Journal Article
Molecular and Cellular Proteomics, ISSN 1535-9476, 05/2015, Volume 14, Issue 5, pp. 1288 - 1300
Voltage-gated sodium channels (Nav1.1-Nav1.9) are responsible for the initiation and propagation of action potentials in neurons, controlling firing patterns,... 
IQ-MOTIF | NA(V)1.6 | NERVOUS-SYSTEM | FACTOR HOMOLOGOUS FACTOR | CALMODULIN | BIOCHEMICAL RESEARCH METHODS | INITIAL SEGMENT | SUBUNITS | ION CHANNELS | IDENTIFICATION | MODULATION | Cell Membrane | Proteome - genetics | Immunoprecipitation | Humans | Fibroblast Growth Factors - genetics | Neurons - cytology | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - pharmacology | NAV1.2 Voltage-Gated Sodium Channel - metabolism | Brain - metabolism | Fibroblast Growth Factors - chemistry | Fibroblast Growth Factors - metabolism | HEK293 Cells | Neurons - metabolism | Neurons - drug effects | Action Potentials - drug effects | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Recombinant Proteins - metabolism | Brain - cytology | Gene Expression | Molecular Sequence Annotation | NAV1.2 Voltage-Gated Sodium Channel - genetics | Rats | Recombinant Proteins - chemistry | Fibroblast Growth Factors - pharmacology | Recombinant Proteins - genetics | Rats, Sprague-Dawley | Action Potentials - physiology | Brain - drug effects | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | NAV1.2 Voltage-Gated Sodium Channel - chemistry | Patch-Clamp Techniques | Animals | Neuronal Plasticity | Protein Binding | Proteome - metabolism | Index Medicus | Research | Brain | Neurons | Proteome | Recombinant Proteins | Journal Article | Research Support, N.I.H., Extramural | Action Potentials | Research Support, Non-U.S. Gov't | Fibroblast Growth Factors | Calcium-Calmodulin-Dependent Protein Kinase Type 2 | NAV1.2 Voltage-Gated Sodium Channel
Journal Article
Pharmacogenetics and Genomics, ISSN 1744-6872, 11/2008, Volume 18, Issue 11, pp. 989 - 998
Journal Article
Journal Article