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PLoS ONE, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, p. e0180154
Ion channels regulate a variety of physiological processes and represent an important class of drug target. Among the many methods of studying ion channel... 
TARGET | DYE | KV1.3 | NA(V)1.7 | MODULATORS | MULTIDISCIPLINARY SCIENCES | EXTREME PAIN DISORDER | PATCH-CLAMP | MUTATIONS | Cricetulus | High-Throughput Screening Assays - instrumentation | NAV1.3 Voltage-Gated Sodium Channel - genetics | NAV1.1 Voltage-Gated Sodium Channel - genetics | NAV1.5 Voltage-Gated Sodium Channel - metabolism | NAV1.1 Voltage-Gated Sodium Channel - metabolism | NAV1.4 Voltage-Gated Sodium Channel - metabolism | Kv1.3 Potassium Channel - genetics | NAV1.2 Voltage-Gated Sodium Channel - metabolism | NAV1.3 Voltage-Gated Sodium Channel - metabolism | Patch-Clamp Techniques - methods | Kv1.3 Potassium Channel - deficiency | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Sodium Channels - metabolism | NAV1.7 Voltage-Gated Sodium Channel - genetics | NAV1.5 Voltage-Gated Sodium Channel - genetics | Drug Evaluation, Preclinical | Transgenes | Potassium Channel Blockers - pharmacology | CHO Cells | High-Throughput Screening Assays - methods | Gene Expression | NAV1.4 Voltage-Gated Sodium Channel - genetics | NAV1.2 Voltage-Gated Sodium Channel - genetics | Rats | Sodium Channel Blockers - pharmacology | Membrane Potentials - physiology | Animals | T-Lymphocytes - cytology | NAV1.6 Voltage-Gated Sodium Channel - metabolism | NAV1.7 Voltage-Gated Sodium Channel - metabolism | NAV1.6 Voltage-Gated Sodium Channel - genetics | Sodium Channels - genetics | Primary Cell Culture | Patch-Clamp Techniques - instrumentation | Ion channels | Information management | Drug discovery | T cells | Modules | Electrophysiology | Patching | Lymphocytes T | Boundaries | Assaying | Channels | Step voltage | Immunology | Pain | Lymphocytes | Sodium channels (voltage-gated) | Physiology | Potassium channels (voltage-gated) | Gold | Platforms | Data points | Automation | Cloning | Pharmacology | Sodium | Antigen-presenting cells | Ligands | Mutation | Recording | Potassium
Journal Article
BBA - Biomembranes, ISSN 0005-2736, 07/2015, Volume 1848, Issue 7, pp. 1545 - 1551
With the ultimate goal of detailed structural analysis of mammalian and particularly human voltage-gated sodium channels (VGSCs), we have investigated the... 
Radioligand-binding assay | Human voltage-gated sodium channel | Membrane protein stability | Rat VGSC | Structural biology | Electrophorus electricus | RAT SKELETAL-MUSCLE | ELECTROPHORUS-ELECTRICUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | VALIDATION | RECEPTOR | MECHANISMS | MICROSCOPY | BIOPHYSICS | NA+ CHANNEL | SAXITOXIN | MEMBRANE-PROTEINS | BINDING | Temperature | Cricetulus | Detergents - chemistry | Humans | Crystallography, X-Ray | NAV1.1 Voltage-Gated Sodium Channel - metabolism | NAV1.1 Voltage-Gated Sodium Channel - chemistry | NAV1.2 Voltage-Gated Sodium Channel - metabolism | NAV1.3 Voltage-Gated Sodium Channel - metabolism | NAV1.1 Voltage-Gated Sodium Channel - ultrastructure | Membrane Proteins - ultrastructure | Voltage-Gated Sodium Channels - ultrastructure | HEK293 Cells | Membrane Proteins - metabolism | NAV1.3 Voltage-Gated Sodium Channel - ultrastructure | NAV1.2 Voltage-Gated Sodium Channel - ultrastructure | CHO Cells | Toxins, Biological - pharmacology | Cricetinae | Solubility | Benchmarking - methods | Rats | Cryoelectron Microscopy | NAV1.2 Voltage-Gated Sodium Channel - chemistry | Animals | Membrane Proteins - chemistry | Protein Stability - drug effects | Toxins, Biological - metabolism | NAV1.3 Voltage-Gated Sodium Channel - chemistry | Eels - metabolism | Voltage-Gated Sodium Channels - chemistry | Voltage-Gated Sodium Channels - metabolism | Benchmarks | Detergents, Synthetic | Analysis | Eels
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2016, Volume 291, Issue 13, pp. 7205 - 7220
Journal Article
Molecular and Cellular Proteomics, ISSN 1535-9476, 05/2015, Volume 14, Issue 5, pp. 1288 - 1300
Voltage-gated sodium channels (Nav1.1-Nav1.9) are responsible for the initiation and propagation of action potentials in neurons, controlling firing patterns,... 
IQ-MOTIF | NA(V)1.6 | NERVOUS-SYSTEM | FACTOR HOMOLOGOUS FACTOR | CALMODULIN | BIOCHEMICAL RESEARCH METHODS | INITIAL SEGMENT | SUBUNITS | ION CHANNELS | IDENTIFICATION | MODULATION | Cell Membrane | Proteome - genetics | Immunoprecipitation | Humans | Fibroblast Growth Factors - genetics | Neurons - cytology | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - pharmacology | NAV1.2 Voltage-Gated Sodium Channel - metabolism | Brain - metabolism | Fibroblast Growth Factors - chemistry | Fibroblast Growth Factors - metabolism | HEK293 Cells | Neurons - metabolism | Neurons - drug effects | Action Potentials - drug effects | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Recombinant Proteins - metabolism | Brain - cytology | Gene Expression | Molecular Sequence Annotation | NAV1.2 Voltage-Gated Sodium Channel - genetics | Rats | Recombinant Proteins - chemistry | Fibroblast Growth Factors - pharmacology | Recombinant Proteins - genetics | Rats, Sprague-Dawley | Action Potentials - physiology | Brain - drug effects | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | NAV1.2 Voltage-Gated Sodium Channel - chemistry | Patch-Clamp Techniques | Animals | Neuronal Plasticity | Protein Binding | Proteome - metabolism | Index Medicus | Research | Brain | Neurons | Proteome | Recombinant Proteins | Journal Article | Research Support, N.I.H., Extramural | Action Potentials | Research Support, Non-U.S. Gov't | Fibroblast Growth Factors | Calcium-Calmodulin-Dependent Protein Kinase Type 2 | NAV1.2 Voltage-Gated Sodium Channel
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