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PLoS ONE, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, p. e0180154
Ion channels regulate a variety of physiological processes and represent an important class of drug target. Among the many methods of studying ion channel... 
TARGET | DYE | KV1.3 | NA(V)1.7 | MODULATORS | MULTIDISCIPLINARY SCIENCES | EXTREME PAIN DISORDER | PATCH-CLAMP | MUTATIONS | Cricetulus | High-Throughput Screening Assays - instrumentation | NAV1.3 Voltage-Gated Sodium Channel - genetics | NAV1.1 Voltage-Gated Sodium Channel - genetics | NAV1.5 Voltage-Gated Sodium Channel - metabolism | NAV1.1 Voltage-Gated Sodium Channel - metabolism | NAV1.4 Voltage-Gated Sodium Channel - metabolism | Kv1.3 Potassium Channel - genetics | NAV1.2 Voltage-Gated Sodium Channel - metabolism | NAV1.3 Voltage-Gated Sodium Channel - metabolism | Patch-Clamp Techniques - methods | Kv1.3 Potassium Channel - deficiency | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Sodium Channels - metabolism | NAV1.7 Voltage-Gated Sodium Channel - genetics | NAV1.5 Voltage-Gated Sodium Channel - genetics | Drug Evaluation, Preclinical | Transgenes | Potassium Channel Blockers - pharmacology | CHO Cells | High-Throughput Screening Assays - methods | Gene Expression | NAV1.4 Voltage-Gated Sodium Channel - genetics | NAV1.2 Voltage-Gated Sodium Channel - genetics | Rats | Sodium Channel Blockers - pharmacology | Membrane Potentials - physiology | Animals | T-Lymphocytes - cytology | NAV1.6 Voltage-Gated Sodium Channel - metabolism | NAV1.7 Voltage-Gated Sodium Channel - metabolism | NAV1.6 Voltage-Gated Sodium Channel - genetics | Sodium Channels - genetics | Primary Cell Culture | Patch-Clamp Techniques - instrumentation | Ion channels | Information management | Drug discovery | T cells | Modules | Electrophysiology | Patching | Lymphocytes T | Boundaries | Assaying | Channels | Step voltage | Immunology | Pain | Lymphocytes | Sodium channels (voltage-gated) | Physiology | Potassium channels (voltage-gated) | Gold | Platforms | Data points | Automation | Cloning | Pharmacology | Sodium | Antigen-presenting cells | Ligands | Mutation | Recording | Potassium
Journal Article
European Journal of Human Genetics, ISSN 1018-4813, 02/2017, Volume 25, Issue 2, pp. 176 - 182
Journal Article
Journal Article
Neuron, ISSN 0896-6273, 09/2018, Volume 99, Issue 5, pp. 905 - 913.e7
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2013, Volume 288, Issue 34, pp. 24316 - 24331
Voltage-gated sodium channel (NaV) trafficking is incompletely understood. Post-translational modifications of NaVs and/or auxiliary subunits and... 
SPINAL SENSORY NEURONS | NEUROPATHIC PAIN | TRAUMATIC BRAIN-INJURY | RESPONSE MEDIATOR PROTEIN-2 | ROOT GANGLION NEURONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GATED SODIUM-CHANNELS | SLOW INACTIVATION | ANTICONVULSANT LACOSAMIDE | SUMO MODIFICATION | GROWTH CONE COLLAPSE | NAV1.3 Voltage-Gated Sodium Channel - genetics | Humans | NAV1.1 Voltage-Gated Sodium Channel - genetics | Multienzyme Complexes - metabolism | Protein Transport - physiology | NAV1.1 Voltage-Gated Sodium Channel - metabolism | Protein Transport - drug effects | Sumoylation - physiology | Mutation, Missense | NAV1.3 Voltage-Gated Sodium Channel - metabolism | Sumoylation - drug effects | Intercellular Signaling Peptides and Proteins - metabolism | Cysteine Endopeptidases - metabolism | SUMO-1 Protein - genetics | HEK293 Cells | Sodium Channels - metabolism | NAV1.7 Voltage-Gated Sodium Channel - genetics | Sensory Receptor Cells - metabolism | Cell Differentiation - physiology | Endopeptidases - metabolism | Intercellular Signaling Peptides and Proteins - genetics | Ubiquitin-Conjugating Enzymes - genetics | Multienzyme Complexes - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Endopeptidases - genetics | Sensory Receptor Cells - cytology | Cell Differentiation - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Cysteine Endopeptidases - genetics | NAV1.7 Voltage-Gated Sodium Channel - metabolism | SUMO-1 Protein - metabolism | Sodium Channels - genetics | Catecholamines - pharmacology | Amino Acid Substitution | Signaling | Patch Clamp Electrophysiology | Signal Transduction | Post-translational Modification | Trafficking | CRMP2 | Sodium Channels | Sumoylation | NaV1.1 | NaV1.7
Journal Article
Journal Article