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FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ISSN 0892-6638, 02/2019, Volume 33, Issue 2, pp. 2422 - 2434
The importance of proteostasis in preventing cellular senescence has been well recognized. However, the exact mechanism by which the loss of proteostasis or... 
Ras | NADPH oxidase | oxidative stress | NBR1 | p53
Journal Article
Current Opinion in Immunology, ISSN 0952-7915, 2011, Volume 24, Issue 1, pp. 21 - 31
Highlights ► Autophagy is a developing immunological paradigm with vertical and lateral connections in innate immunity. ► Sequestosome 1/p62-like adaptors... 
Allergy and Immunology | APOPTOSIS | PHOSPHORYLATION | INFLAMMATION | REGULATES AUTOPHAGY | ADAPTER | NBR1 | PHAGOPHORE | HMGB1 | INDUCTION | IMMUNOLOGY | P62 | Autophagy - immunology | Animals | Receptors, Pattern Recognition - immunology | Immunity, Innate - physiology | Humans | Cameras
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 02/2014, Volume 67, pp. 292 - 303
Emerging evidence indicates that oxidative stress instigates the formation of ubiquitin (Ub) aggregates, substrates of autophagy, through a process requiring... 
PDT | Free radicals | Proteotoxicity | ROS | NBR1 | ER stress | Photodynamic stress | p62 | Autophagy
Journal Article
Autophagy, ISSN 1554-8627, 08/2018, Volume 14, Issue 8, pp. 1465 - 1466
Macroautophagy/autophagy and the ubiquitin-proteasome system (UPS) are major proteolytic pathways that are increasingly recognized as battlegrounds during... 
Innate immunity | plant bacterium | proteaphagy | Pseudomonas syringae | NBR1 | selective autophagy | CELL BIOLOGY
Journal Article
Journal of Cell Science, ISSN 0021-9533, 02/2013, Volume 126, Issue 4, pp. 939 - 952
Selective macro-autophagy is an intracellular process by which large cytoplasmic materials are selectively sequestered and degraded in the lysosomes. Substrate... 
Peroxisomes | Autophagy receptors | Selective autophagy | Pexophagy | p62 | NBR1 | DOMAIN | ADAPTER PROTEINS | UBIQUITIN | P62/SQSTM1 | MITOCHONDRIA | MITOPHAGY | TAGS PEROXISOMES | CELL BIOLOGY | DEGRADATION | NDP52 | Cell Line | Microscopy, Confocal | Proteins - metabolism | Humans | Autophagy - physiology | HeLa Cells | Microscopy, Electron | Blotting, Western | Peroxisomes - metabolism | Peroxisomes - ultrastructure
Journal Article
Journal of Cell Science, ISSN 0021-9533, 2016, Volume 129, Issue 20, pp. 3685 - 3693
Autophagy, a pathway for lysosomal-mediated cellular degradation, has recently been described as a regulator of cell migration. Although the molecular... 
Autophagy | Migration | Focal adhesion | NBR1 | PAXILLIN | MICROTUBULES | PHOSPHORYLATION | UBIQUITIN | KINASE | CELL BIOLOGY | PINK1 | CELL-MIGRATION | DEGRADATION | TALIN | PROMOTES | Animals | Focal Adhesions - metabolism | Humans | Cell Adhesion | Integrins - metabolism | Cell Movement | Protein Transport | 131
Journal Article
Autophagy, ISSN 1554-8627, 05/2015, Volume 11, Issue 5, pp. 812 - 832
By monitoring the fragmentation of a GST-BHMT (a protein fusion of glutathionine S-transferase N-terminal to betaine-homocysteine S-methyltransferase) reporter... 
GST-BHMT, a fusion protein of glutathionine S-transferase N-terminal to betaine-homocysteine S-methyltransferase | ATF4, activating transcription factor 4 | MTORC1, MTOR complex 1 | LSCS, linker-specific cleavage site | selective macroautophagy | RPS6KB1, ribosomal protein S6 kinase, 70kDa, polypeptide 1 | UPR, unfolded protein response | ATG7, autophagy-related 7 | ULK1, unc-51 like autophagy activating kinase 1 | TSC1/2, tuberous sclerosis 1/2 | BCL2, B-cell CLL/lymphoma 2 | XBP1, X-box binding protein 1 | ACACA/B, acetyl-CoA carboxylase α/β | BECN1, Beclin 1, autophagy-related | MTOR, mechanistic target of rapamycin (serine/threonine kinase) | 1 | SQSTM1, sequestosome 1 | HA, hemagglutinin | BHMT, betaine-homocysteine S-methyltransferase | GST-BHMT | DDIT3, DNA-damage-inducible transcript 3 | ATF6, activating transcription factor 6 | EBSS, Earle's Balanced Salt Solution | Cvt, cytoplasm-to-vacuole-targeting | RM, rich medium | proteasome inhibition | GST, glutathionine S-transferase | FRAG | MAP1LC3, microtubule-associated protein 1 light chain 3 | PRKAA, protein kinase, AMP-activated, α catalytic subunit | an autophagy-mediated cleavage product of the GST-BHMT reporter | NBR1, neighbor of BRCA1 gene 1 | ERN1, endoplasmic reticulum to nucleus signaling 1 | P4HB, prolyl 4-hydroxylase, β polypeptide | MAP2K7, mitogen-activated protein kinase kinase 7 | Baf A1, bafilomycin A | UPS, ubiquitin proteasome system | PRKAA/AMPK | EIF4EBP1, eukaryotic translation initiation factor 4E binding protein 1 | ACTB, actin, β | HSPA5, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | MTOR | BHMT | EIF2AK3, eukaryotic translation initiation factor 2-α, kinase 3 | RHEB, Ras homolog enriched in brain | MAPK8, mitogen-activated protein kinase 8 | cargo receptors SQSTM1/p62 and NBR1 | ER, endoplasmic reticulum | CTNNB1, catenin (cadherin-associated protein), β 1, 88kDa | SIGNALING PATHWAYS | ER STRESS | KINASE | ENDOPLASMIC-RETICULUM STRESS | SELECTIVE AUTOPHAGY | CELL BIOLOGY | UNFOLDED PROTEIN RESPONSE | MONITORING AUTOPHAGY | FUSION PROTEIN | BETAINE HOMOCYSTEINE METHYLTRANSFERASE | MAINTAINS ENERGY | AMP-Activated Protein Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Sequestosome-1 Protein | Humans | Recombinant Fusion Proteins - metabolism | Autophagy - drug effects | Lysosomes - metabolism | Ubiquitination - drug effects | Protein Processing, Post-Translational - drug effects | Protein Binding - drug effects | HEK293 Cells | Membrane Proteins - metabolism | Betaine-Homocysteine S-Methyltransferase - metabolism | Protein-Serine-Threonine Kinases - metabolism | Beclin-1 | Lysosomes - drug effects | Protein Structure, Tertiary | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | Proteasome Inhibitors - pharmacology | Mitogen-Activated Protein Kinase 8 - metabolism | Glutathione Transferase - metabolism | Apoptosis Regulatory Proteins - metabolism | Leupeptins - pharmacology | Proteins - metabolism | Signal Transduction - drug effects | HeLa Cells | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Protein Multimerization - drug effects
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2012, Volume 441, Issue 2, pp. 523 - 540
Reactive oxygen and nitrogen species change cellular responses through diverse mechanisms that are now being defined. At low levels, they are signalling... 
Mitochondrion | Oxidative stress | Redox signalling | Neurodegeneration | Autophagy | Nitrative stress | autophagy | CHAPERONE-MEDIATED AUTOPHAGY | ANTIOXIDANT RESPONSIVE ELEMENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIPOFUSCINOSES BATTEN-DISEASE | neurodegeneration | AMYOTROPHIC-LATERAL-SCLEROSIS | mitochondrion | redox signalling | MOTOR-NEURON DEGENERATION | MANGANESE SUPEROXIDE-DISMUTASE | nitrative stress | SMOOTH-MUSCLE-CELLS | PATHOGENIC DJ-1 MUTATIONS | HYPOXIA-INDUCED AUTOPHAGY | oxidative stress | COMPLEX-I DEFICIENCY | Protein Kinases - metabolism | Transcription, Genetic - drug effects | Cardiovascular Diseases - physiopathology | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Reactive Nitrogen Species - metabolism | Humans | Oxidative Stress - physiology | Hydrogen Peroxide - pharmacology | Oncogene Proteins - metabolism | Nitric Oxide - physiology | Autophagy - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Mitochondria - metabolism | Mitochondria - pathology | Parkinson Disease - physiopathology | Lysosomes - physiology | Protein Deglycase DJ-1 | Animals | Signal Transduction - physiology | TOR Serine-Threonine Kinases - physiology | Neoplasms - physiopathology | AMPK, 5′-AMP-activated protein kinase | NBR1, neighbour of BRCA1 (breast cancer early-onset 1) | NGF, nerve growth factor | LC3, light chain 3 | NOX, NADPH oxidase | EM, electron microscopy | TOR, target of rapamycin | ULK, unc (unco-ordinated family member)-51-like kinase | mtDNA, mitochondrial DNA | mTOR, mammalian target of rapamycin | IKKβ, IκB kinase β | LRRK2, leucine-rich repeat kinase 2 | NAC, N-acetyl-L-cysteine | Nrf2, nuclear factor-erythroid 2-related factor 2 | PI3P, phosphatidylinositol 3-phosphate | ECH, enoyl-CoA hydratase | BNIP3L, BNIP3-like | Drp1, dynamin-related protein 1 | tfLC3, tandem fluorescently tagged LC3 | NF-κB, nuclear factor κB | BAG, Bcl-2-associated athanogene | Keap1, Kelch-like ECH-associated protein 1 | PE, phosphatidylethanolamine | 3-MA, 3-methyladenine | UCP, uncoupling protein | IκB, inhibitor of nuclear factor κB | FIP200, focal adhesion kinase family-interacting protein of 200 kDa | PI3K, phosphoinositide 3-kinase | HNE, 4-hydroxynonenal | Review | ALS, amyotrophic lateral sclerosis | ATG, AuTophaGy-related | adenovirus E18 19-kDa-interacting protein | Tzb, trastuzumab | mETC, mitochondrial electron-transport chain | Rubicon, RUN domain- and cysteine-rich domain-containing beclin-1-interacting protein | VDAC, voltage-dependent anion channel | IP3, inositol 1,4,5-trisphosphate | RFP, red fluorescent protein | ROS, reactive oxygen species | TNFα, tumour necrosis factor α | PINK1, PTEN (phosphatase and tensin homologue deleted on chromosome 10)-induced kinase 1 | GFP, green fluorescent protein | LAMP, lysosome-associated membrane protein | JNK1, c-Jun N-terminal kinase 1 | TAC, transverse aortic constriction | GABARAP, GABAA (γ-aminobutyric acid type A)-receptor-associated protein | HIF-1, hypoxia-inducible factor 1 | NOS, nitric oxide synthase | siRNA, small interfering RNA | SOD, superoxide dismutase | RLS, reactive lipid species | RNS, reactive nitrogen species | ER, endoplasmic reticulum | TIGAR, TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator | Vps34, vacuolar protein sorting 34 | BNIP, Bcl-2
Journal Article
Autophagy, ISSN 1554-8627, 07/2009, Volume 5, Issue 5, pp. 732 - 733
Selective degradation of intracellular targets, such as misfolded proteins and damaged organelles, is an important homeostatic function that autophagy has... 
Ubiquitin | Selective autophagy | LIR | p62 | Protein aggregates | NBR1 | selective autophagy | protein aggregates | ubiquitin | CELL BIOLOGY | Ubiquitination | Proteins - metabolism | Sequestosome-1 Protein | Humans | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Autophagy
Journal Article
Frontiers in Plant Science, ISSN 1664-462X, 04/2014, Volume 5, p. 174
As sessile organisms, plants are constantly exposed to a wide spectrum of stress conditions such as high temperature, which causes protein misfolding.... 
WRKY33 | NBR1 | Heat tolerance | Tomato | ATG7 | Autophagy | ATG5 | heat tolerance | PATHWAYS | autophagy | TOLERANCE | tomato | NECROTROPHIC FUNGAL PATHOGENS | WRKY33 TRANSCRIPTION FACTOR | MONODANSYLCADAVERINE | SELECTIVE AUTOPHAGY | PLANT SCIENCES | RESISTANCE | DEGRADATION | ARABIDOPSIS | PROTEINS | nbr1 | Atg5
Journal Article
Oncotarget, ISSN 1949-2553, 11/2017, Volume 8, Issue 55, p. 94819
To study the expression of Neighbor of Brca1 gene (NBR1) in clear cell renal cell carcinoma (ccRCC), renal cancer cells and the chemoresistance cells and to... 
Journal Article