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Journal Article
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2006, Volume 394, Issue 2, pp. 501 - 509
PS (presenilin)-dependent gamma-secretase occurs as a high-molecular-mass complex composed of either PS1 or PS2 associated with Nct (nicastrin), PEN2... 
γ-secretase complex | Nicastrin | Anterior pharynx defective 1 homologue (APH1a) | Presenilin enhancer 2 homologue (PEN2) | Presenilins | Proteasome | nicastrin | PRESENILIN | proteasome | WILD-TYPE | APH-1 INTERACTS | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMYLOID PRECURSOR PROTEIN | anterior pharynx defective 1 homologue (APH1a) | gamma-secretase complex | IN-VIVO | BETA-APP | ENDOPLASMIC-RETICULUM | presenilins | presenilin enhancer 2 homologue (PEN2) | Cell Line | Endopeptidases - metabolism | Gene Expression | Membrane Proteins - genetics | Receptors, Notch - metabolism | Humans | Receptors, Notch - genetics | Proteins - genetics | Animals | Endopeptidases - genetics | Proteins - metabolism | Transfection | Cattle | Gene Deletion | Membrane Proteins - metabolism | Mice | Neurons - metabolism | Proteasome Endopeptidase Complex - metabolism | Proteasome Inhibitors | Fibroblasts - metabolism | Index Medicus | Z, benzylocarbonyl | ZL, Z-Leu-leucinal | Ac-DEVD-al, acetyl-Asp-Glu-Val-Asp-aldehyde | ZIE, Z-Ile-Leu-(OBut)-Ala-leucinal | DTT, dithiothreitol | βAPP, β-amyloid precursor protein | PEN2, presenilin enhancer 2 homologue | AEBSF, 4-(2-aminoethyl)benzenesulphonyl fluoride hydrochloride | PS, presenilin | CMV, cytomegalovirus | E-64, trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane | Aβ, amyloid β-peptide | 7AMC, 7-amino-4-methylcoumarin | Nct, nicastrin | APH1, anterior pharynx defective 1 homologue | SV40, simian virus 40
Journal Article
Journal Article
Current Opinion in Neurobiology, ISSN 0959-4388, 2004, Volume 14, Issue 3, pp. 379 - 383
γ-Secretase is a membrane protease complex that possesses presenilin as a catalytic subunit. Presenilin generates amyloid β peptides in the brains of... 
nicastrin | APP | notch intracellular domain | FAD | presenilin enhancer | Drosophila presenilin | Psn | familial AD | Psn FL | HMW | high molecular weight | amyloid β peptides | NICD | pen | β-amyloid precursor protein | Alzheimer's disease | NCT | PRESENILIN | ENDOPROTEOLYSIS | APH-1 | BETA-APP | NICASTRIN | NOTCH | PEN-2 | AMYLOID PRECURSOR PROTEIN | ACCUMULATION | CLEAVAGE | NEUROSCIENCES
Journal Article
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