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animals (11) 11
ndrg (10) 10
biochemistry & molecular biology (9) 9
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expression (7) 7
analysis (6) 6
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mice (6) 6
oncology (6) 6
phosphorylation (6) 6
cell cycle proteins - metabolism (5) 5
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mapk, mitogen-activated protein kinase (5) 5
myc (5) 5
proteins (5) 5
amino acid sequence (4) 4
cell biology (4) 4
cell line, tumor (4) 4
cell proliferation (4) 4
cells (4) 4
colorectal cancer (4) 4
down-regulation (4) 4
erk, extracellular-signal-regulated kinase (4) 4
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immunohistochemistry (4) 4
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n-myc (4) 4
ndrg, n-myc downstream-regulated gene (4) 4
pkb, protein kinase b (4) 4
prognosis (4) 4
rodents (4) 4
tumor suppressor proteins - metabolism (4) 4
apoptosis (3) 3
biophysics (3) 3
candidate tumor-suppressor (3) 3
carcinoma (3) 3
cell cycle proteins - genetics (3) 3
cell differentiation - physiology (3) 3
colorectal-cancer (3) 3
differentiation (3) 3
family (3) 3
gene expression (3) 3
genes (3) 3
gsk3, glycogen synthase kinase 3 (3) 3
hypoxia (3) 3
intracellular signaling peptides and proteins - metabolism (3) 3
kinases (3) 3
metastasis (3) 3
mice, knockout (3) 3
molecular sequence data (3) 3
muscle proteins (3) 3
myc protein (3) 3
ndrg gene family (3) 3
ndrg1 (3) 3
ndrg2 (3) 3
neurosciences (3) 3
original (3) 3
pdk1, 3-phosphoinositide-dependent kinase 1 (3) 3
pharmacology & pharmacy (3) 3
poor-prognosis (3) 3
proteins - genetics (3) 3
proteins - metabolism (3) 3
research article (3) 3
rsk, p90 ribosomal s6 kinase (3) 3
sapk, stress-activated protein kinase (3) 3
serum (3) 3
studies (3) 3
survival (3) 3
tumor suppressor proteins - genetics (3) 3
tumor-metastasis (3) 3
up-regulation (3) 3
activation (2) 2
apoptosis - physiology (2) 2
beta-catenin (2) 2
biomarkers (2) 2
blotting, western (2) 2
brain - metabolism (2) 2
breast cancer (2) 2
breast-cancer (2) 2
c-myc (2) 2
cancer cells (2) 2
cap43 (2) 2
cdk, cyclin-dependent protein kinase (2) 2
cell differentiation (2) 2
cell differentiation - genetics (2) 2
cell line (2) 2
clinical neurology (2) 2
colorectal neoplasms - metabolism (2) 2
cytoskeleton (2) 2
development and progression (2) 2
disease progression (2) 2
dna methylation (2) 2
egf, epidermal growth factor (2) 2
fucoidan (2) 2
gastroenterology & hepatology (2) 2
gene expression regulation, neoplastic (2) 2
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International Journal of Developmental Biology, ISSN 0214-6282, 2015, Volume 59, Issue 10-12, pp. 511 - 517
The N-myc downstream regulated gene (Ndrg) family consists of four main members Ndrg1,2,3, and 4. The Ndrggenes are involved in many vital biological events... 
N-myc downstream regulated gene (Ndrg) family | Embryogenesis | Expression pattern | Xenopus tropicalis | SUPPRESSOR | expression pattern | embryogenesis | DEVELOPMENTAL BIOLOGY | IDENTIFICATION | CANCER
Journal Article
Journal Article
PROTEOMICS, ISSN 1615-9853, 01/2013, Volume 13, Issue 1, pp. 134 - 141
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2004, Volume 384, Issue 3, pp. 477 - 488
We detected a protein in rabbit skeletal muscle extracts that was phosphorylated rapidly by SGK1 (serum- and glucocorticoid-induced kinase 1), but not by... 
Phosphorylation | Glycogen synthase kinase 3 (GSK3) | N-myc down-stream-regulated gene (NDRG) | p53 | Serum- and glucocorticoid-induced kinase 1 (SGK1) | glycogen synthase kinase 3 (GSK3) | EPITHELIAL NA+ CHANNEL | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLYCOGEN-SYNTHASE KINASE-3 | TRANSCRIPTION | SERUM | P70 S6 KINASE | n-myc downstream-regulated gene (NDRG) | IN-VIVO | GENE FAMILY | serum- and glucocorticoid-induced kinase 1 (SGK1) | MAPKAP KINASE-1 | phosphorylation | Antibody Specificity | Multigene Family | Molecular Weight | Humans | Molecular Sequence Data | Substrate Specificity | Cell Cycle Proteins - classification | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Immediate-Early Proteins | Cell Cycle Proteins - immunology | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Antibodies - immunology | Cell Cycle Proteins - genetics | Proteins - classification | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Cell Line | Rabbits | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Intracellular Signaling Peptides and Proteins | Nuclear Proteins - metabolism | Glycogen Synthase Kinase 3 - metabolism | Phosphoserine - metabolism | Proteins - immunology | Proteins - genetics | Proto-Oncogene Proteins c-akt | Animals | Proteins - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Mice | HeLa Cells | Tumor Suppressor Proteins | Index Medicus | SGK1, serum- and glucocorticoid-induced kinase 1 | PDK1, 3-phosphoinositide-dependent kinase 1 | LDS, lithium dodecyl sulphate | RSK, p90 ribosomal S6 kinase | ENaC, epithelial sodium channel | FOXO3a, forkhead box O3a | ERK, extracellular-signal-regulated kinase | MALDI-TOF, matrix-assisted laser-desorption ionization–time-of-flight | PKB, protein kinase B | SAPK, stress-activated protein kinase | CDK, cyclin-dependent kinase | IGF-1, insulin-like growth factor-1 | DYRK1A, dual-specificity tyrosine phosphorylated and regulated kinase 1A | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | GSK3, glycogen synthase kinase 3 | siRNA, small interfering RNA | KESTREL, kinase substrate tracking and elucidation | MAPK, mitogen-activated protein kinase | NDRG, n-myc downstream-regulated gene
Journal Article
FEBS Letters, ISSN 0014-5793, 11/2012, Volume 586, Issue 22, pp. 3962 - 3968
► NDRG2 mRNA and protein levels are downregulated in colorectal cancer tissue. ► Yeast two-hybrid screening shows that NDRG2 and PRA1 physically interact. ►... 
Cell proliferation | Promoter inhibition | Yeast two-hybrid screen | Protein–protein interaction | PRA1 | NDRG | colorectal cancer | hemagglutinin | T-cell factor | GST | green fluorescent protein | GFP | N-myc downstream regulated gene | CRC | glutathione S-transferase | TCF | prenylated Rab acceptor-1 | endoplasmic reticulum | Protein-protein interaction | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR GENE | BETA-CATENIN | FAMILY | CELL BIOLOGY | BIOPHYSICS | COLORECTAL-CANCER | MYC | PROSTATE-CANCER CELLS | GROWTH | DIFFERENTIATION | EXPRESSION | COLON-CARCINOMA | Phosphorylation | Vesicular Transport Proteins - metabolism | Colorectal Neoplasms - genetics | Humans | Glycogen Synthase Kinase 3 beta | Green Fluorescent Proteins - genetics | GTP-Binding Proteins - genetics | Promoter Regions, Genetic - genetics | Cell Nucleus - metabolism | Tumor Suppressor Proteins - genetics | Active Transport, Cell Nucleus | Colorectal Neoplasms - metabolism | Green Fluorescent Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | HCT116 Cells | Vesicular Transport Proteins - genetics | Gene Expression Regulation | Binding Sites - genetics | Glycogen Synthase Kinase 3 - metabolism | beta Catenin - metabolism | Blotting, Western | Microscopy, Confocal | Two-Hybrid System Techniques | Protein Binding | Mutation | Colorectal Neoplasms - pathology | TCF Transcription Factors - genetics | GTP-Binding Proteins - metabolism | Index Medicus
Journal Article
Acta Pharmaceutica Sinica B, ISSN 2211-3835, 11/2015, Volume 5, Issue 6, pp. 544 - 553
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2006, Volume 393, Issue 1, pp. 1 - 6
The identification of all the substrates of every protein kinase is one of the major challenges of post-genomic research. Here we review a powerful method for... 
Mitogen-activated-protein-kinase-activated protein kinase-2 (MAPKAP-K2) | Protein kinase B (PKB) | Glycogen synthase kinase 3 (GSK3) | Serum- and glucocorticoid-induced protein kinase (SGK) | Kinase substrate tracking and elucidation (KESTREL) | CELLS | glycogen synthase kinase 3 (GSK3) | DOMAIN | SPECIFICITY | PHOSPHORYLATION | PKB | BIOCHEMISTRY & MOLECULAR BIOLOGY | SERUM | IDENTIFICATION | IN-VITRO | protein kinase B (PKB) | kinase substrate tracking and elucidation (KESTREL) | mitogen-activated-protein-kinase-activated protein kinase-2 (MAPKAP-K2) | TRANSFER-RNA | STRESS | serum- and glucocorticoid-induced protein kinase (SGK) | Protein Kinases - metabolism | Phosphorylation | Protein Kinases - genetics | Reproducibility of Results | Animals | Peptide Mapping | Biochemistry - methods | Substrate Specificity | Protein Kinases - deficiency | Index Medicus | CRMP, collapsin-response mediator protein | PI3K, phosphoinositide 3-kinase | SAKS1, SAPK-substrate 1 | TNF, tumour necrosis factor | hnRNP, heterogeneous nuclear ribonucleoprotein | PNGase, peptide N-glycanase | PDK1, 3-phosphoinositide-dependent kinase 1 | HEK, human embryonic kidney | Review | JNK, c-Jun N-terminal kinase | EF2, elongation factor 2 | UBA, ubiquitin-associated | KSHV, Kaposi sarcoma-associated herpesvirus | UBX, ubiquitin-like | ERK, extracellular-signal-regulated kinase | PKB, protein kinase B | SAPK, stress-activated protein kinase | MKK1, MAPK kinase-1 | EF2K, EF2 kinase | HSP27, heat-shock protein of 27 kDa | METTL1, methyltransferase-like protein 1 | FLNc, filamin C | NDRG, N-myc downstream-regulated gene product | VCP, valosin-containing protein | GSK3, glycogen synthase kinase 3 | SGK, serum- and glucocorticoid-induced protein kinase | IGF-1, insulin-like growth factor 1 | KESTREL, kinasesubstrate tracking and elucidation | MAPKAP-K2, MAPK-activated protein kinase-2 | CDK, cyclin-dependent protein kinase | CRHSP24, calcium-regulated heatshock protein of 24 kDa | PIC, pro-inflammatory cytokine | LPS, lipopolysaccharide | ARE, AU-rich element | CapZIP, CapZ-interacting protein | MAPK, mitogen-activated protein kinase
Journal Article
Cancer Letters, ISSN 0304-3835, 2016, Volume 375, Issue 1, pp. 142 - 151
Journal Article
Neurogastroenterology and motility, ISSN 1350-1925, 2017, Volume 29, Issue 9, pp. e13095 - n/a
Journal Article
by Yu, CR and Hao, XH and Zhang, S and Hu, WJ and Li, JW and Sun, J and Zheng, MH
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY, ISSN 1756-2848, 07/2019, Volume 12, pp. 175628481985850 - 1756284819858507
Background: The N-myc downstream-regulated gene (NDRG) family, NDRG1-4, has been involved in a wide spectrum of biological functions in multiple cancers.... 
SURVIVAL | POTENTIAL BIOMARKER | gastric cancer | DNA METHYLATION | DOWN-REGULATION | prognosis | TCGA | METASTASIS SUPPRESSOR | INVASION | methylation | NDRG family | POOR-PROGNOSIS | CANDIDATE TUMOR-SUPPRESSOR | GENE-EXPRESSION | HER2 | GASTROENTEROLOGY & HEPATOLOGY | WEB SERVER
Journal Article
CNS Neuroscience & Therapeutics, ISSN 1755-5930, 08/2017, Volume 23, Issue 8, pp. 667 - 679
Journal Article