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Cancer Letters, ISSN 0304-3835, 12/2014, Volume 355, Issue 2, pp. 242 - 252
Oral squamous cell carcinoma (OSCC) is the most common phenotype of oral cancer. N-myc downstream regulated gene 1 (NDRG1) is a modulator for cell... 
OSCC | MMP-2 | NDRG1 | EMT | MMP-9 | Invasion
Journal Article
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 12, pp. 10470 - 10482
Hypoxia can lead to solid tumor aggressiveness by driving multiple signaling pathways. Long non-coding RNAs respond to several extrinsic stimuli, causing... 
LncRNA | Hypoxia | Ubiquitination | NDRG1 | NDRG1-OT1
Journal Article
Genetics and Molecular Biology, ISSN 1415-4757, 10/2015, Volume 38, Issue 4, pp. 527 - 533
Valproic acid (VPA) is a clinically available histone deacetylase inhibitor with promising anticancer attributes. Recent studies have demonstrated the... 
Prostate cancer cells | NDRG1 | VPA | prostate cancer cells
Journal Article
Biochemical Journal, ISSN 0264-6021, 11/2014, Volume 463, Issue 3, pp. 413 - 427
The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to... 
Mammalian target of rapamycin (mTOR) | Phosphoinositide 3-kinase (PI3K) | Protein kinase inhibitor | Signal transduction inhibitor | N-Myc downstream-regulated gene-1 (NDRG1) | Protein Structure, Tertiary | Cell Line | Phosphorylation | Class II Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol Phosphates - metabolism | Class I Phosphatidylinositol 3-Kinases - metabolism | Class II Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Humans | Inositol Polyphosphate 5-Phosphatases | Class III Phosphatidylinositol 3-Kinases - metabolism | Pyrimidines - pharmacology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Endosomes - metabolism | Amino Acid Motifs | Aminopyridines - pharmacology | Hydrophobic and Hydrophilic Interactions | Protein Binding | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | Protein-Serine-Threonine Kinases - metabolism | SGK3, serum- and glucocorticoid-regulated kinase-3 | signal transduction inhibitor | PI3K, phosphoinositide 3-kinase | ITC, isothermal titration calorimetry | SHIP1 | mTORC, mammalian target of rapamycin complex | EEA1, early endosome antigen 1 | INPP4B, inositol polyphosphate 4-phosphatase type II | TSC2, tuberous sclerosis complex 2 | phosphoinositide 3-kinase (PI3K) | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | DMEM, Dulbecco's modified Eagle's medium | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | IP1, inositol phosphate | 4E-BP1, eukaryotic initiation factor 4E-binding protein 1 | PX, Phox homology | mammalian target of rapamycin (mTOR) | Accelerated Publication | PH, pleckstrin homology | PtdIns, phosphatidylinositol | PRAS40, proline-rich Akt substrate 40 kDa | protein kinase inhibitor | 2, Src homology 2-domain-containing inositol phosphatase 1 | Vps34, vacuolar protein sorting 34 | VSV-G, vesicular stomatitis virus glycoprotein
Journal Article
Cancer Research, ISSN 0008-5472, 03/2009, Volume 69, Issue 6, pp. 2638 - 2646
Hypoxia-inducible factor-1 (HIF-1) is a known cancer progression factor, promoting growth, spread, and metastasis. However, in selected contexts, HIF-1 is a... 
FACTOR 1-ALPHA | ONCOLOGY | NDRG1 GENE | PROSTATE-CANCER CELLS | C-MYC | PREDICTS SURVIVAL | TUMOR ANGIOGENESIS | E-CADHERIN | HIF-1-ALPHA | SELENIUM-BINDING-PROTEIN | EXPRESSION | HIF-1alpha | carcinogenesis | selenium | EMT | NDRG1
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2013, Volume 452, Issue 3, pp. 499 - 508
The majority of human cancers harbour mutations promoting activation of the Ala protein kinase, and Akt inhibitors are being evaluated in clinical trials. An... 
Mammalian target of rapamycin (mTOR) | Phosphoinositide 3-kinase (PI3K) | Protein kinase inhibitor | Signal transduction inhibitor | N-Myc downstream-regulated gene 1 (NDRG1) | signal transduction inhibitor | ACTIVATION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | mammalian target of rapamycin (mTOR) | SERUM | ANTITUMOR-ACTIVITY | FAMILY | phosphoinositide 3-kinase (PI3K) | IN-VITRO | THREONINE PROTEIN-KINASE | 3-KINASE PATHWAY | protein kinase inhibitor | MTOR COMPLEX | PDK1 | Amino Acid Sequence | Predictive Value of Tests | Cell Proliferation | Humans | Immediate-Early Proteins - biosynthesis | Molecular Sequence Data | Proto-Oncogene Proteins c-akt - physiology | Breast Neoplasms - drug therapy | Breast Neoplasms - metabolism | Protein-Serine-Threonine Kinases - biosynthesis | Growth Inhibitors - therapeutic use | Breast Neoplasms - enzymology | Drug Resistance, Neoplasm - genetics | Animals | Protein Kinase Inhibitors - therapeutic use | HEK293 Cells | Cell Line, Tumor | Female | Sheep | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | PI3K, phosphoinositide 3-kinase | SGK, serum- and glucocorticoid-regulated kinase | HEK, human embryonic kidney | MTS, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium | mTORC, mTOR complex | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | mTOR, mammalian target of rapamycin | FOXO, forkhead box O | GI50, growth inhibition by 50 | FBS, fetal bovine serum | qRT-PCR, quantitative reverse transcription–PCR | GSK3, glycogen synthase kinase 3 | PRAS40, proline-rich Akt substrate of 40 kDa | N-Myc, neuroblastoma-derived Myc | NDRG1, N-Myc downstream-regulated gene 1 | PH, pleckstrin homology | TBST, Tris-buffered saline-Tween | shRNA, short hairpin RNA
Journal Article
Oncology Letters, ISSN 1792-1074, 05/2017, Volume 13, Issue 5, pp. 3599 - 3607
N-myc downstream-regulated gene 1 (NDRG1) is a multifunctional protein associated with carcinogenesis and tumor progression. The function of NDRG1 in... 
HCC | Metastasis | Proliferation | NDRG1 | ITGB3 | Invasion
Journal Article
Journal Article
Cell Biology International, ISSN 1065-6995, 07/2017, Volume 41, Issue 7, pp. 716 - 725
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 31, pp. 12772 - 12782
The iron-regulated metastasis suppressor N-myc downstream-regulated gene 1 (NDRG1) has been shown to inhibit numerous oncogenic signaling pathways in cancer... 
ANTIPROLIFERATIVE ACTIVITY | TGF-BETA | epidermal growth factor receptor (EGFR) | BIOCHEMISTRY & MOLECULAR BIOLOGY | PANCREATIC-CANCER | TYROSINE KINASES | NDRG1 | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | cancer therapy | TUMOR-CELL MIGRATION | metastasis | cell signaling | PROSTATE-CANCER | GENE-1 NDRG1 | iron | SELECTIVE ANTITUMOR-ACTIVITY | Receptor, ErbB-3 - metabolism | Humans | Protein Multimerization | Receptor, ErbB-2 - chemistry | Receptor, ErbB-2 - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Receptor, ErbB-3 - chemistry | Receptors, Transferrin - agonists | Carcinogenesis | Antigens, CD - metabolism | Cell Cycle Proteins - chemistry | Endocytosis | Receptor, Epidermal Growth Factor - metabolism | Clathrin-Coated Vesicles | Proteolysis | Receptor, ErbB-2 - antagonists & inhibitors | Signal Transduction | Cell Cycle Proteins - metabolism | Receptor, ErbB-3 - antagonists & inhibitors | Receptor, ErbB-3 - agonists | Iron - metabolism | Receptors, Transferrin - metabolism | Receptor, Epidermal Growth Factor - chemistry | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Models, Biological | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Ligands | Endosomes - enzymology | Receptor, ErbB-2 - agonists | Transferrin - metabolism | Index Medicus | Minireviews
Journal Article
EMBO MOLECULAR MEDICINE, ISSN 1757-4676, 02/2012, Volume 4, Issue 2, pp. 93 - 108
Wnt signalling has pivotal roles in tumour progression and metastasis; however, the exact molecular mechanism of Wnt signalling in the metastatic process is as... 
PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | IRON CHELATORS | breast cancer | TRANSDUCTION | metastasis suppressor gene | BETA-CATENIN | NDRG1 | CANCER | prostate cancer | metastasis | MECHANISTIC INSIGHTS | TUMOR-METASTASIS | GROWTH | EXPRESSION
Journal Article
Biomedical Research (India), ISSN 0970-938X, 2017, Volume 28, Issue 21, pp. 9352 - 9357
Journal Article
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