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Scandinavian Journal of Gastroenterology, ISSN 0036-5521, 08/2010, Volume 45, Issue 7-8, pp. 898 - 908
Abstract Objective. N-myc downstream regulated gene-1 (NDRG1) is known as a differentiation-related gene that plays important roles in cell differentiation, organ formation, and embryonic development... 
gastric cancer | invasion | proliferation | metastasis | NDRG1 | Apoptosis | Metastasis | Proliferation | Gastric cancer | Invasion | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Stomach Neoplasms - genetics | Prognosis | Stomach Neoplasms - diagnosis | Down-Regulation | Humans | Middle Aged | Cell Cycle Proteins - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Aged, 80 and over | Biomarkers | Female | Aged | Index Medicus
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 01/2016, Volume 291, Issue 3, pp. 1029 - 1052
N-MYC downstream-regulated gene-1 (NDRG1) is a potent growth and metastasis suppressor that acts through its inhibitory effects on a wide variety of cellular signaling pathways, including the TGF-beta pathway, protein kinase B (AKT... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Receptor, ErbB-3 - metabolism | Pancreatic Neoplasms - metabolism | Receptor, ErbB-2 - genetics | Humans | Antineoplastic Agents - therapeutic use | Intracellular Signaling Peptides and Proteins - metabolism | Antineoplastic Agents - administration & dosage | Colonic Neoplasms - metabolism | RNA Interference | Receptor, ErbB-2 - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - genetics | ErbB Receptors - antagonists & inhibitors | Pancreatic Neoplasms - pathology | Cell Cycle Proteins - metabolism | Receptor, ErbB-3 - antagonists & inhibitors | Recombinant Proteins - chemistry | Random Allocation | Receptor, ErbB-3 - agonists | Receptor, ErbB-3 - genetics | Mice, Nude | Cell Line, Tumor | Receptor, ErbB-2 - agonists | Colonic Neoplasms - drug therapy | ErbB Receptors - genetics | Receptor, ErbB-2 - metabolism | Cell Cycle Proteins - antagonists & inhibitors | Pancreatic Neoplasms - drug therapy | Cell Cycle Proteins - genetics | Female | Antineoplastic Agents - pharmacology | Thiosemicarbazones - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Pyridines - therapeutic use | Recombinant Proteins - metabolism | ErbB Receptors - metabolism | Epidermal Growth Factor - genetics | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Epidermal Growth Factor - metabolism | Cell Cycle Proteins - agonists | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Thiosemicarbazones - therapeutic use | Tumor Burden - drug effects | Colonic Neoplasms - pathology | Intracellular Signaling Peptides and Proteins - agonists | Epidermal Growth Factor - antagonists & inhibitors | Pyridines - pharmacology | ErbB Receptors - agonists | Index Medicus | Molecular Bases of Disease | cancer therapy | anticancer drug | pharmaceutics | metastasis suppressor | molecular pharmacology | pharmacology | thiosemicarbazones | tumor cell biology | NDRG1 | Dp44mT
Journal Article
Biochemical journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC (protein kinase A/protein kinase G/protein... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | Index Medicus | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | kinase inhibitor | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | cancer | serum and glucocorticoid protein kinase (SGK) | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical journal, ISSN 1470-8728, 10/2014, Volume 463, Issue 3, pp. 413 - 427
We characterize VPS34-IN, a potent and selective inhibitor of class III Vps34 PI3K. Using VPS34-IN1, we demonstrate that PtdIns(3)P, produced by Vps34 controls... 
Mammalian target of rapamycin (mTOR) | Phosphoinositide 3-kinase (PI3K) | Protein kinase inhibitor | Signal transduction inhibitor | N-Myc downstream-regulated gene-1 (NDRG1) | Protein Structure, Tertiary | Cell Line | Phosphorylation | Class II Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol Phosphates - metabolism | Class I Phosphatidylinositol 3-Kinases - metabolism | Class II Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Humans | Inositol Polyphosphate 5-Phosphatases | Class III Phosphatidylinositol 3-Kinases - metabolism | Pyrimidines - pharmacology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Endosomes - metabolism | Amino Acid Motifs | Aminopyridines - pharmacology | Hydrophobic and Hydrophilic Interactions | Protein Binding | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | Protein-Serine-Threonine Kinases - metabolism | Index Medicus | SGK3, serum- and glucocorticoid-regulated kinase-3 | signal transduction inhibitor | PI3K, phosphoinositide 3-kinase | ITC, isothermal titration calorimetry | SHIP1 | mTORC, mammalian target of rapamycin complex | EEA1, early endosome antigen 1 | INPP4B, inositol polyphosphate 4-phosphatase type II | TSC2, tuberous sclerosis complex 2 | phosphoinositide 3-kinase (PI3K) | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | DMEM, Dulbecco's modified Eagle's medium | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | IP1, inositol phosphate | 4E-BP1, eukaryotic initiation factor 4E-binding protein 1 | PX, Phox homology | mammalian target of rapamycin (mTOR) | Accelerated Publication | PH, pleckstrin homology | PtdIns, phosphatidylinositol | PRAS40, proline-rich Akt substrate 40 kDa | protein kinase inhibitor | 2, Src homology 2-domain-containing inositol phosphatase 1 | Vps34, vacuolar protein sorting 34 | VSV-G, vesicular stomatitis virus glycoprotein
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