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BMB Reports, ISSN 1976-6696, 2018, Volume 51, Issue 5, pp. 219 - 224
Necroptosis is an emerging form of programmed cell death occurring via active and well-regulated necrosis, distinct from apoptosis morphologically, and... 
Regulator | Necroptosis | Necroptosis modulator | Apoptosis | Cancer
Journal Article
Pharmacological Research, ISSN 1043-6618, 10/2019, Volume 148, p. 104439
The apoptosis alternate cell death pathways are extensively studied in recent years and their significance has been well recognized. With identification of... 
RIPK3 | MLKL | Necroptosis
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 12/2013, Volume 1833, Issue 12, pp. 3448 - 3459
Journal Article
Cell Death and Disease, 06/2012, Volume 3, Issue 6, p. e320
Journal Article
Oncotarget, ISSN 1949-2553, 03/2018, Volume 9, Issue 24, pp. 16744 - 16757
has traditionally been used to treat various medical problems. In this report, we introduce cis-khellactone as a new anti-cancer agent, which was isolated from... 
Angelica amurensis | Necrosis/ necroptosis | Cis-khellactone | Anti-cancer drug | Apoptosis, autophagy-mediated cell death
Journal Article
Cancer Letters, ISSN 0304-3835, 12/2019, Volume 467, pp. 58 - 71
Chromatinolysis refers to enzymatic degradation of nuclear DNA and is regarded as one of the crucial events leading to cell death. Mixed-lineage kinase... 
MLKL | Glioma | Necroptosis | Shikonin | Chromatinolysis
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2018, Volume 61, Issue 24, pp. 11398 - 11414
We herein report the structural optimization and structure–activity relationship studies of 5-(2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo­[2,3-d]­pyrimidin-4-amine... 
DESIGN | CHEMISTRY, MEDICINAL | OPTIMIZATION | NECROPTOSIS | DISCOVERY | INSIGHTS
Journal Article
Seminars in Cell and Developmental Biology, ISSN 1084-9521, 11/2014, Volume 35, pp. 14 - 23
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 02/2013, Volume 20, Issue 2, pp. 188 - 197
Journal Article
Journal Article
Genes and Cancer, ISSN 1947-6019, 09/2017, Volume 8, Issue 9-10, pp. 682 - 694
Jun N-terminal kinases or JNKs have been shown to be involved in a wide array of signaling events underlying tumorigenesis and tumor progression. Through its... 
Ferroptosis | Cell death | Necroptosis | JNK | Apoptosis | apoptosis | ferroptosis | Review | cell death | necroptosis
Journal Article
Histology and Histopathology, ISSN 0213-3911, 08/2018, Volume 33, Issue 8, pp. 773 - 789
Necroptosis is programmed necrosis, a process which has been studied for over a decade. The most common accepted mechanism is through the RIP1-RIP3-MLKL axis... 
Drugs | Disease therapy | RIP3 | Necroptosis | RIP1 | INDUCED CELL-DEATH | DOMAIN-LIKE PROTEIN | MIXED LINEAGE KINASE | MLKL-DRIVEN NECROPTOSIS | PROGRAMMED NECROSIS | DEPENDENT NECROPTOSIS | PATHOLOGY | CELL BIOLOGY | ISCHEMIA-REPERFUSION INJURY | TUMOR-NECROSIS-FACTOR | RECEPTOR-INTERACTING PROTEIN | MOTOR-NEURON DEATH
Journal Article