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PLoS ONE, ISSN 1932-6203, 08/2018, Volume 13, Issue 8, p. e0201220
In recent years, immunogenic cell death (ICD) has emerged as a revolutionary concept in the development of novel anticancer therapies. This particular form of... 
CALRETICULIN EXPOSURE | KILLS CANCER-CELLS | THERAPY | MELANOMA | PROTEIN | MULTIDISCIPLINARY SCIENCES | LTX-315 | RELEASE | TARGETING AAC-11 | EXPRESSION | TUMORS | Apoptosis Regulatory Proteins - pharmacology | Recombinant Fusion Proteins - pharmacology | Humans | Cell Death - immunology | Nuclear Proteins - pharmacology | Peptide Fragments - pharmacology | Sarcoma, Experimental - immunology | Cell-Penetrating Peptides - pharmacology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Cell-Penetrating Peptides - chemistry | Amino Acid Sequence | Jurkat Cells | Apoptosis Regulatory Proteins - chemistry | Mice, Inbred C57BL | Recombinant Fusion Proteins - chemistry | Antineoplastic Agents - chemistry | Nuclear Proteins - chemistry | Sarcoma, Experimental - pathology | Sarcoma, Experimental - drug therapy | Xenograft Model Antitumor Assays | Peptide Fragments - chemistry | Animals | Cell Line, Tumor | HL-60 Cells | Mice | Care and treatment | Peptides | Cell death | Analysis | Cancer cells | Research | Cancer | Dehydrogenases | Vaccination | Inflammatory response | Lymphocytes T | Leucine | Kinases | HMGB1 protein | Blood | Metastases | Anticancer properties | Proteins | Calreticulin | Immunology | Gangrene | Immune system | Medical research | Cell survival | Immune response | Mortality | Melanoma | Hazards | Inflammation | Mode of action | Immunogenicity | Antitumor activity | Infiltration | Chemokines | Apoptosis | Tumors
Journal Article
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 12/2012, Volume 19, Issue 12, pp. 2003 - 2014
Although TRAIL (tumor necrosis factor (TNF)-related apoptosis inducing ligand) is a well-known apoptosis inducer, we have previously demonstrated that acidic... 
RIPK1/RIPK3 | TRAIL | hepatitis | concanavalin A | colon cancer | necroptosis | APOPTOSIS | MITOCHONDRIAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROGRAMMED NECROSIS | RECEPTOR | CELL BIOLOGY | TUMOR-NECROSIS-FACTOR | INFLAMMATION | NECROTIC CELL-DEATH | LIGAND | EXTRACELLULAR PH | T-CELLS | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Hepatocytes - metabolism | TNF-Related Apoptosis-Inducing Ligand - pharmacology | RNA Interference | Adenosine Triphosphate - metabolism | Killer Cells, Natural - immunology | Indoles - pharmacology | Hepatocytes - drug effects | Disease Models, Animal | Cell Line | Imidazoles - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors | Hep G2 Cells | HT29 Cells | Phenanthrenes - pharmacology | Poly(ADP-ribose) Polymerases - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Killer Cells, Natural - drug effects | Mice | Killer Cells, Natural - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors | Hydrogen-Ion Concentration | RNA, Small Interfering - metabolism | Killer Cells, Natural | Poly(ADP-ribose) Polymerases | Reactive Oxygen Species | Receptor-Interacting Protein Serine-Threonine Kinases | Biochemistry, Molecular Biology | Adenosine Triphosphate | Life Sciences | Phenanthrenes | Imidazoles | TNF-Related Apoptosis-Inducing Ligand | Hepatocytes | RNA, Small Interfering | Indoles | Apoptosis | RIPK3 | Original Paper | RIPK1
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2016, Volume 11, Issue 4, pp. e0154612 - e0154612
Glioblastoma is the most frequent and malignant brain tumor. Treatment includes chemotherapy with temozolomide concomitant with surgical resection and/or... 
GLIOMA-CELLS | CANCER-CELLS | PROSTATE | APOPTOSIS | ANTAGONIST DOXAZOSIN | IN-VITRO | O-6-METHYLGUANINE DNA-METHYLTRANSFERASE | MULTIDISCIPLINARY SCIENCES | GROWTH | KINASE INHIBITORS | TEMOZOLOMIDE | Tumor Suppressor Protein p53 - biosynthesis | Doxazosin - pharmacology | Rats, Wistar | Apoptosis - drug effects | Glycogen Synthase Kinase 3 beta - biosynthesis | Humans | Caspase 3 - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Hippocampus - drug effects | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Lapatinib | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Astrocytes - drug effects | Doxazosin - toxicity | Morpholines - pharmacology | Rats | Brain Neoplasms - drug therapy | Enzyme Activation - drug effects | Animals | Cell Line, Tumor | Cell Proliferation - drug effects | G1 Phase Cell Cycle Checkpoints - drug effects | Glioblastoma - drug therapy | Quinazolines - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Chemotherapy | Usage | Doxazosin | Dosage and administration | Research | Glioblastoma multiforme | Cancer | Brain | Cell culture | p53 Protein | Brain cancer | AKT protein | Metastasis | Confocal | Drug development | Caspase-3 | Cancer therapies | Proteins | Cell activation | Surgery | Tumorigenesis | Inhibition | Protein-tyrosine kinase | Tyrosine | Medical research | Astrocytes | Mortality | Cultures | 1-Phosphatidylinositol 3-kinase | Inhibitors | Irradiation | Temozolomide | Hippocampus | Cell proliferation | Drugs | Flow cytometry | Brain tumors | Glioblastoma | Confocal microscopy | Kinases | Neurotoxicity | Cell cycle | G1 phase | Tumor cells | Caspase | Pharmacology | Chemical compounds | Cytometry | Brain research | Microscopy | Cell death | Medical prognosis | Glioblastoma cells | Laboratory animals | Prostate cancer | Tumors | Apoptosis | Index Medicus
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 10/2017, Volume 47, Issue 4, pp. 621 - 634
Atherosclerosis is an arterial disease process characterized by the focal subendothelial accumulation of apolipoprotein-B-containing lipoproteins, immune and... 
Innate and adaptive inflammatory responses drive the progression of atherosclerosis | which is the root cause of most cardiovascular disease. Tabas and Lichtman review the roles and regulation of monocyte-macrophages and T cells during the various stages of atherosclerosis and discuss how this knowledge suggests new therapeutic approaches.atherosclerosis | innate immunity | inflammation | T cell | monocyte | macrophage | effector T cell | adaptive immunity | regulatory T cell | regulatory T cell | effector T cell | STRESS PROMOTES ATHEROSCLEROSIS | LY-6C(HIGH) MONOCYTES | MERTK RECEPTOR | CLONAL HEMATOPOIESIS | INSULIN-RESISTANCE | NECROTIC CORE | VASCULAR INFLAMMATION | ACUTE CORONARY SYNDROMES | IMMUNOLOGY | BINDING CASSETTE TRANSPORTERS | RECEPTOR TYROSINE KINASE | Immunity, Innate - immunology | Models, Immunological | Animals | Atherosclerosis - immunology | Humans | T-Lymphocytes - immunology | Monocytes - immunology | Adaptive Immunity - immunology | Lipoproteins - immunology | Macrophages - immunology | T cells | Macrophages | Atherosclerosis | Development and progression | Inflammation | Blood lipids | Apolipoproteins | Effector cells | Smooth muscle | Lymphocytes T | Retention | Cell activation | Lymphocytes | Hematopoiesis | Aging | Extracellular matrix | ABC transporters | Lipid metabolism | Thromboembolism | Immune system | Immune response | Neutrophils | Aging (artificial) | Phenotypic plasticity | Metabolism | Thrombosis | Cholesterol | Cells | Hemopoiesis | Damage patterns | Studies | Monocytes | Lipoproteins | Arteriosclerosis | Infarction | Diabetes | Plastic foam
Journal Article
The Journal of Immunology, ISSN 0022-1767, 06/2005, Volume 174, Issue 12, pp. 7506 - 7515
Journal Article