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Molecular Plant, ISSN 1674-2052, 05/2012, Volume 5, Issue 3, pp. 750 - 762
Ubiquitin-26S proteasome system (UPS) has been shown to play central roles in light and hormone-regulated plant growth and development. Previously, we have... 
photomorphogenesis | Arabidopsis | strigolactone | protein degradation | F-box protein | SCF complex | ARABIDOPSIS-THALIANA | SEED-GERMINATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PIL5 | HELIX TRANSCRIPTION FACTOR | NEGATIVE REGULATOR | PLANT SCIENCES | AUXIN TRANSPORT | PHYTOCHROME-INTERACTING FACTORS | DEGRADATION | LIGHT SIGNAL-TRANSDUCTION | Organ Specificity - drug effects | Seeds - radiation effects | Arabidopsis - growth & development | Epistasis, Genetic - drug effects | Lactones - pharmacology | Seedlings - growth & development | Arabidopsis Proteins - metabolism | Arabidopsis - radiation effects | Biosynthetic Pathways - radiation effects | Seeds - growth & development | Biological Transport - radiation effects | Light | Biological Transport - drug effects | Germination - radiation effects | Germination - drug effects | Gene Expression Regulation, Plant - radiation effects | Arabidopsis - drug effects | Indoleacetic Acids - metabolism | Morphogenesis - radiation effects | Seeds - drug effects | Ubiquitin-Protein Ligases - metabolism | Seedlings - drug effects | Mutation - genetics | Abscisic Acid - pharmacology | Gene Expression Regulation, Plant - drug effects | Organ Specificity - radiation effects | Phenotype | Biosynthetic Pathways - drug effects | Carrier Proteins - metabolism | Epistasis, Genetic - radiation effects | Genes, Plant - genetics | Gibberellins - pharmacology | Morphogenesis - drug effects | Plant Growth Regulators - metabolism | Seedlings - radiation effects | Seeds | Hormones | Plant growth | Index Medicus
Journal Article
Plant Physiology, ISSN 0032-0889, 10/2013, Volume 163, Issue 2, pp. 857 - 866
Light and the phytohormone abscisic acid (ABA) regulate overlapping processes in plants, such as seed germination and seedling development. However, the... 
Transcription factors | Plant growth regulators | Genes | Germination | Root growth | SIGNALING AND RESPONSE | Plants | Drought | Seedlings | Seed germination | Plant cells | CIRCADIAN CLOCK | SEED-GERMINATION | PROTEIN | ABI5 | THALIANA | GENE-EXPRESSION | TRANSDUCTION | FHY3 | PHYTOCHROME | NEGATIVE REGULATOR | PLANT SCIENCES | Basic-Leucine Zipper Transcription Factors - metabolism | Up-Regulation - radiation effects | Adaptation, Physiological - drug effects | Plant Roots - genetics | Stress, Physiological - radiation effects | Plant Roots - drug effects | Arabidopsis Proteins - metabolism | Arabidopsis - radiation effects | Seeds - growth & development | Adaptation, Physiological - genetics | Droughts | Germination - genetics | Light | Phytochrome - metabolism | Plant Stomata - drug effects | Osmotic Pressure - radiation effects | Abscisic Acid - metabolism | Stress, Physiological - drug effects | Signal Transduction - radiation effects | Plant Roots - growth & development | Germination - drug effects | Arabidopsis Proteins - genetics | Gene Expression Regulation, Plant - radiation effects | Arabidopsis - drug effects | Seeds - drug effects | Stress, Physiological - genetics | Nuclear Proteins - metabolism | Up-Regulation - genetics | Signal Transduction - genetics | Adaptation, Physiological - radiation effects | Basic-Leucine Zipper Transcription Factors - genetics | Gene Knockout Techniques | Mutation - genetics | Arabidopsis - metabolism | Salinity | Arabidopsis - genetics | Transcription Factors - metabolism | Up-Regulation - drug effects | Abscisic Acid - pharmacology | Gene Expression Regulation, Plant - drug effects | Phenotype | Signal Transduction - drug effects | Osmotic Pressure - drug effects | Plant Stomata - physiology | Plant Roots - radiation effects | Arabidopsis thaliana | Photoreception | Physiological aspects | Abscisic acid | Genetic aspects | Cellular signal transduction | Research | Index Medicus
Journal Article
The Plant Cell, ISSN 1040-4651, 9/2014, Volume 26, Issue 9, pp. 3630 - 3645
Arabidopsis thatiana seedlings undergo photomorphogenic development even in darkness when the function of DEETIOLATED1 (DET1), a repressor of... 
Phenotypes | Transcription factors | Hypocotyls | Cocktails | RESEARCH ARTICLES | Genes | Gene expression regulation | Physiological regulation | Plants | Seedlings | Plant cells | PHOTOACTIVATED PHYTOCHROMES | SEEDLING DEVELOPMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLANT DEVELOPMENT | NEGATIVE REGULATOR | PLANT SCIENCES | CELL BIOLOGY | LIGHT-SIGNAL-TRANSDUCTION | LOOP-HELIX PROTEIN | COP9 SIGNALOSOME | CHLOROPLAST DEVELOPMENT | TRANSCRIPTION FACTOR | E3 UBIQUITIN LIGASE | Darkness | Cell Wall - radiation effects | Arabidopsis - growth & development | Genes, Plant | Etiolation - drug effects | Arabidopsis Proteins - metabolism | Arabidopsis - radiation effects | Cell Wall - drug effects | Light | Protein Binding - drug effects | Protein Binding - radiation effects | Photosynthesis - radiation effects | Gene Expression Regulation, Plant - radiation effects | Arabidopsis - drug effects | Morphogenesis - radiation effects | Proteasome Inhibitors - pharmacology | Etiolation - radiation effects | Nuclear Proteins - metabolism | Transcriptome - genetics | Seedlings - drug effects | Mutation - genetics | Arabidopsis - metabolism | Gene Expression Regulation, Plant - drug effects | Phenotype | Indoleacetic Acids - pharmacology | Models, Biological | Photosynthesis - drug effects | Morphogenesis - drug effects | Seedlings - radiation effects | Seedlings - metabolism | Arabidopsis thaliana | Botanical research | Physiological aspects | Photoreceptors | Research | Photomorphogenesis | Index Medicus
Journal Article
The Plant Cell, ISSN 1040-4651, 4/2012, Volume 24, Issue 4, pp. 1398 - 1419
Plants respond to shade-modulated light signals via phytochrome (phy)-induced adaptive changes, termed shade avoidance. To examine the roles of... 
Datasets | Hypocotyls | Phenotypes | Genes | Auxins | Gene expression regulation | Plants | Repression | Seedlings | Plant cells | AVOIDANCE-RESPONSE | SEED-GERMINATION | REGULATED GENE-EXPRESSION | RED-LIGHT | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHLOROPHYLL BIOSYNTHESIS | MEDIATED DEGRADATION | NEGATIVE REGULATOR | PLANT SCIENCES | CELL BIOLOGY | SIGNAL-TRANSDUCTION | CHLOROPLAST DEVELOPMENT | INTERACTING FACTOR-3 | Transcription, Genetic - drug effects | Arabidopsis - growth & development | Nucleotide Motifs - genetics | Transcription, Genetic - radiation effects | Gene Regulatory Networks - drug effects | Light Signal Transduction - radiation effects | Promoter Regions, Genetic - genetics | Seedlings - growth & development | Arabidopsis Proteins - metabolism | Arabidopsis - radiation effects | Basic Helix-Loop-Helix Transcription Factors - metabolism | Light Signal Transduction - drug effects | Light | Phytochrome - metabolism | Arabidopsis Proteins - genetics | Gene Expression Regulation, Plant - radiation effects | Arabidopsis - drug effects | Basic Helix-Loop-Helix Transcription Factors - genetics | Gene Regulatory Networks - genetics | Morphogenesis - radiation effects | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Seedlings - drug effects | Mutation - genetics | Arabidopsis - genetics | Gene Expression Regulation, Plant - drug effects | Phenotype | Genes, Plant - genetics | Indoleacetic Acids - pharmacology | Gene Regulatory Networks - radiation effects | Morphogenesis - drug effects | Seedlings - radiation effects | Seedlings - metabolism | Arabidopsis | Plant genetics | Phytochrome | Physiological aspects | Genetic aspects | Genetic transcription | Research | Index Medicus
Journal Article
British Journal of Cancer, ISSN 0007-0920, 01/2016, Volume 114, Issue 2, pp. 177 - 187
Background: Oestrogen receptor-negative (ER-) breast cancer is intrinsically sensitive to chemotherapy. However, tumour response is often incomplete, and... 
CELLS | REDUCES TUMOR-GROWTH | STAT1 | DNA-DAMAGE | chemotherapy | IFN | THERAPY | NEOADJUVANT CHEMOTHERAPY | ONCOLOGY | ER-negative breast cancer | GENE-EXPRESSION | RESISTANCE | PATHWAY ANALYSIS | predictive signature | XENOGRAFTS | Caspase 7 - metabolism | Immunohistochemistry | Receptors, Estrogen - metabolism | Cytoskeletal Proteins - genetics | Humans | Intracellular Signaling Peptides and Proteins - drug effects | Caspase 3 - metabolism | Gene Expression Profiling | Intracellular Signaling Peptides and Proteins - metabolism | Interferon-gamma - metabolism | Carrier Proteins - drug effects | Mitochondrial Proteins - drug effects | STAT1 Transcription Factor - metabolism | Mitochondrial Proteins - metabolism | Caspase 3 - genetics | Interferon-beta - genetics | Cytokines - genetics | Intracellular Signaling Peptides and Proteins - genetics | Real-Time Polymerase Chain Reaction | Ubiquitins - metabolism | Caspase 7 - drug effects | Antigens - drug effects | Caspase 7 - genetics | Membrane Proteins - genetics | Myxovirus Resistance Proteins - drug effects | Capecitabine - pharmacology | STAT1 Transcription Factor - genetics | Breast Neoplasms - drug therapy | Blotting, Western | Breast Neoplasms - genetics | Interferon-beta - metabolism | Signal Transduction - drug effects | Mice, Nude | Membrane Proteins - drug effects | Mice | Myxovirus Resistance Proteins - genetics | Ubiquitins - drug effects | Antigens - genetics | Neoplasm Transplantation | Phosphorylation | Ubiquitins - genetics | Gene Expression Regulation, Neoplastic | Interferon-gamma - drug effects | STAT1 Transcription Factor - drug effects | Mitochondrial Proteins - genetics | Interferon-beta - drug effects | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Breast Neoplasms - metabolism | In Situ Hybridization | Caspase 3 - drug effects | Cytoskeletal Proteins - metabolism | Female | Cytoskeletal Proteins - drug effects | Membrane Proteins - metabolism | Interferon-gamma - genetics | Cytokines - metabolism | Antigens - metabolism | Cisplatin - pharmacology | Xenograft Model Antitumor Assays | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Cytokines - drug effects | Myxovirus Resistance Proteins - metabolism | Index Medicus | Translational Therapeutics
Journal Article
Journal Article
Journal Article
Nature, ISSN 0028-0836, 01/2016, Volume 529, Issue 7586, pp. 413 - 417
Triple-negative breast cancer (TNBC) is a heterogeneous and clinically aggressive disease for which there is no targeted therapy(1-3). BET bromodomain... 
SELECTIVE-INHIBITION | SUPER-ENHANCERS | RNA-SEQ | SUBTYPES | INFLAMMATION | STRATEGY | MULTIDISCIPLINARY SCIENCES | CELL IDENTITY | C-MYC | PP2A | LEUKEMIA | Chromatin - metabolism | Transcription, Genetic - drug effects | Humans | Transcription Factors - deficiency | Triple Negative Breast Neoplasms - drug therapy | Genome, Human - drug effects | Nuclear Proteins - deficiency | Protein Binding - drug effects | Triple Negative Breast Neoplasms - pathology | Female | Epigenesis, Genetic - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Nuclear Proteins - genetics | Triazoles - therapeutic use | Cell Proliferation - genetics | Mediator Complex Subunit 1 - metabolism | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Phosphoserine - metabolism | Genome, Human - genetics | Azepines - therapeutic use | Azepines - pharmacology | Binding, Competitive - drug effects | Transcription Factors - metabolism | Triazoles - pharmacology | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Triple Negative Breast Neoplasms - genetics | Epigenesis, Genetic - genetics | Triple Negative Breast Neoplasms - metabolism | Nuclear Proteins - antagonists & inhibitors | Protein Phosphatase 2 - metabolism | Proteomics | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Chromatin - genetics | Casein Kinase II - metabolism | Drug Resistance, Neoplasm - drug effects | Protein Structure, Tertiary - drug effects | Antimitotic agents | Enzyme inhibitors | Patient outcomes | Breast cancer | Dosage and administration | Drug therapy | Antineoplastic agents | Studies | Inhibitor drugs | Drug resistance | Gene expression | Drug dosages | Index Medicus
Journal Article