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chemistry, organic (17) 17
neodysiherbaine-a (15) 15
dysiherbaine (9) 9
marine sponge (9) 9
sponge dysidea-herbacea (9) 9
amino-acid (8) 8
alanine - analogs & derivatives (6) 6
biological evaluation (6) 6
kainate receptors (6) 6
alanine - chemical synthesis (5) 5
alanine - pharmacology (5) 5
analogs (5) 5
animals (5) 5
bridged bicyclo compounds, heterocyclic - chemical synthesis (5) 5
bridged bicyclo compounds, heterocyclic - pharmacology (5) 5
excitatory amino-acids (5) 5
amino acids (4) 4
chemistry, multidisciplinary (4) 4
glutamate (4) 4
marine toxin neodysiherbaine (4) 4
molecular structure (4) 4
natural products (4) 4
neodysiherbaine (4) 4
neodysiherbaine a (4) 4
stereoisomerism (4) 4
structure-activity relationship (4) 4
alanine - chemistry (3) 3
bridged bicyclo compounds, heterocyclic - chemistry (3) 3
chemical properties (3) 3
chemical synthesis (3) 3
chemistry, medicinal (3) 3
enantioselective synthesis (3) 3
glutamate receptors (3) 3
metathesis (3) 3
mice (3) 3
models, molecular (3) 3
neurosciences (3) 3
receptor ion channels (3) 3
receptors, kainic acid - drug effects (3) 3
receptors, kainic acid - metabolism (3) 3
stereoselective-synthesis (3) 3
synthesis (3) 3
-dysiherbaine (2) 2
1,5-dienes (2) 2
acid (2) 2
alpha-amino-acids (2) 2
binding sites (2) 2
biochemistry & molecular biology (2) 2
biological products - chemical synthesis (2) 2
biological products - chemistry (2) 2
discovery (2) 2
domino metathesis (2) 2
domino reaction (2) 2
dose-response relationship, drug (2) 2
drug design (2) 2
drug evaluation, preclinical (2) 2
excitatory amino acid (2) 2
excitatory amino acid agonists - pharmacology (2) 2
glutamate receptor (2) 2
glycosylation (2) 2
humans (2) 2
ligand-binding core (2) 2
ligand-binding domain (2) 2
ligands (2) 2
lycoperdic acid (2) 2
magnetic resonance spectroscopy (2) 2
methods (2) 2
organic compounds (2) 2
oxidative cyclisation (2) 2
oxidative cyclization (2) 2
pharmacology & pharmacy (2) 2
receptors, glutamate - drug effects (2) 2
receptors, kainic acid - agonists (2) 2
receptors, kainic acid - chemistry (2) 2
stereochemistry (2) 2
stereocontrolled total-synthesis (2) 2
stereoselective synthesis (2) 2
stereoselectivity (2) 2
structure (2) 2
tetrahydrofuran (2) 2
total synthesis (2) 2
- (1) 1
-alpha-kainic acid (1) 1
-cis-sylvaticin (1) 1
-pyroglutamic acid (1) 1
1,3-dipolar cycloaddition reactions (1) 1
2,4-syn-functionalized-glutamate analogs (1) 1
2-b]pyran (1) 1
4 dictyoceratid sponges (1) 1
4-fluoroglutamic acids (1) 1
7-oxabicyclo<2.2.1>hept-2-ene derivatives (1) 1
7-oxanorbornene (1) 1
access (1) 1
accountants (1) 1
acting dpp-4 inhibitor (1) 1
agonist dysiherbaine (1) 1
aldol reaction (1) 1
alkenes (1) 1
alkenes - chemistry (1) 1
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Organic & biomolecular chemistry, ISSN 1477-0539, 2018, Volume 16, Issue 11, pp. 1791 - 1806
-Glycosylation has found widespread use in the synthesis of biomedically important natural products and pharmaceuticals. Chemical -glycosylation has been well... 
GLYCOSIDES | SGLT2 INHIBITOR | ALLYLATION | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | GLUCOSIDE | NEODYSIHERBAINE | COTRANSPORTER 2 INHIBITOR | TYPE-2 DIABETES-MELLITUS | DISCOVERY | HOMOMANGIFERIN | Drugs | Stereoselectivity | Natural products | Glycosides | Glycosylation | Chemical synthesis | Cyclic compounds | Biological activity | Pharmaceuticals
Journal Article
Letters in Organic Chemistry, ISSN 1570-1786, 05/2017, Volume 14, Issue 4, pp. 261 - 266
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 10/2012, Volume 2012, Issue 29, pp. 5789 - 5802
The syntheses of the marine sponge‐derived γ‐amino carboxylic acid dysibetaine CPa and five analogs in their racemic forms were successfully performed by... 
Amino acids | Natural products | Chemoselectivity | Neurological agents | Total synthesis | Diastereoselectivity | DYSIBETAINE | DYSIHERBAINE | ENANTIOSELECTIVE SYNTHESIS | CHEMISTRY, ORGANIC | NEODYSIHERBAINE-A | EXCITATORY AMINO-ACIDS | Accountants | Synthesis | Universities and colleges | Cyclopropane compounds | Organic compounds
Journal Article
Pure and Applied Chemistry, ISSN 0033-4545, 03/2013, Volume 85, Issue 6, pp. 1175 - 1184
Journal Article
Tetrahedron, ISSN 0040-4020, 2007, Volume 63, Issue 38, pp. 9373 - 9381
Access to multifunctional hydrazones of relevance to dysiherbaine synthesis studies is described. Subsequent radical cyclizations of multifunctional hydrazones... 
Radical cyclization | Stereoselectivity | Aminosugars | Dysiherbaine | dysiherbaine | HYDROXYHYDRAZONES | radical cyclization | CHEMISTRY, ORGANIC | aminosugars | MARINE SPONGE | AMINO-ACID | MONOSACCHARIDES | stereoselectivity | SILICON TETHER APPROACH | BIOLOGICAL EVALUATION | CHIRAL HYDRAZONES | NEODYSIHERBAINE-A | (-)-DYSIHERBAINE
Journal Article
Neuropharmacology, ISSN 0028-3908, 03/2010, Volume 58, Issue 3, pp. 640 - 649
Kainate receptor antagonists have potential as therapeutic agents in a number of neuropathologies. Synthetic modification of the convulsant marine toxin... 
Electrophysiology | Synthetic | Glutamate receptor | Marine natural product | Radioligand binding | Ligand-binding domain | LIGAND-BINDING CORE | SPONGE DYSIDEA-HERBACEA | CRYSTAL-STRUCTURES | NEUROSCIENCES | MARINE SPONGE | GENETIC ALGORITHM | N-3-SUBSTITUTED WILLARDIINE DERIVATIVES | AMINO-ACID | ANIMAL-MODELS | PHARMACOLOGY & PHARMACY | PARTICLE-MESH EWALD | NEODYSIHERBAINE-A | Receptors, Kainic Acid - chemistry | Humans | Mutagenesis, Site-Directed - methods | Green Fluorescent Proteins - genetics | Receptors, Kainic Acid - genetics | Structure-Activity Relationship | Receptors, Kainic Acid - agonists | Patch-Clamp Techniques - methods | Dose-Response Relationship, Drug | Alanine - analogs & derivatives | Transfection - methods | Time Factors | Radioligand Assay - methods | Molecular Structure | Alanine - pharmacology | Protein Subunits - genetics | Membrane Potentials - drug effects | Glutamic Acid - pharmacology | Models, Molecular | Excitatory Amino Acid Agonists - pharmacology | Molecular Dynamics Simulation | Binding, Competitive - drug effects | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacokinetics | Receptors, Kainic Acid - metabolism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Kainic Acid - pharmacokinetics | Ligands | Cell Line, Transformed | Tritium - pharmacokinetics | Index Medicus | synthetic | radioligand binding | electrophysiology | marine natural product | glutamate receptor | ligand-binding domain
Journal Article
MOLECULES, ISSN 1420-3049, 07/2020, Volume 25, Issue 13, p. 3049
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 07/2018, Volume 59, Issue 29, pp. 2809 - 2812
[Display omitted] •Versatile 2-(trimethylsilyl)methyl-2-propen-1-ol derivatives prepared.•Method shows broad functional group compatability.•Mild reaction... 
Co catalyst | Trimethylenemethane precursors | Allylsilane | Sp2-sp3 coupling | IMINES | CHEMISTRY, ORGANIC | MEDIATED CYCLOADDITION APPROACH | TRIMETHYLENEMETHANE | CYCLOPENTANOIDS | ALLYLSILANES | CARBOCYCLES | BIOLOGICAL EVALUATION | STEREOSELECTIVE-SYNTHESIS | NEODYSIHERBAINE-A | ACCESS | Chemical tests and reagents | Cobalt | Silane
Journal Article
Yūki gōsei kagaku kyōkaishi, ISSN 0037-9980, 04/2020, Volume 78, Issue 4, pp. 292 - 303
By a hybrid design of naturally derived excitatory amino acids, dysiherbaines and kainic acid, we have successfully developed a series of artificial glutamate... 
ionotropic glutamate receptor | hybrid strategy | DYSIHERBAINE | Prins-Ritter reaction | MARINE TOXIN NEODYSIHERBAINE | sp-rich scaffold | Ugi reaction | ANALOGS | ONE-POT | CHEMISTRY, ORGANIC | DOMINO METATHESIS | AMINO-ACID | metathesis | DIASTEREOSELECTIVE SYNTHESIS | artificial analog | BIOLOGICAL EVALUATION | STEREOSELECTIVE-SYNTHESIS | domino reaction
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 12/2016, Volume 2016, Issue 34, pp. 5624 - 5628
A readily available intermediate obtained from d‐arabinose was identified as a versatile starting material for the stereoselective synthesis of... 
C‐glycosides | Drug design | Glycosylation | Asymmetric synthesis | Epoxides | C-glycosides | ACID | FUNCTIONALIZED DIHYDROPYRANS | ENANTIOMERS | RING-OPENING REACTIONS | CHEMISTRY, ORGANIC | DIRECTED ENANTIOSELECTIVE SYNTHESIS | NUCLEOPHILES | ACTING DPP-4 INHIBITOR | CONTRACTION | ARYLGLUCOSIDE | NEODYSIHERBAINE-A
Journal Article
RSC Advances, ISSN 2046-2069, 08/2013, Volume 3, Issue 31, pp. 12466 - 12484
Journal Article
Tetrahedron, ISSN 0040-4020, 2008, Volume 64, Issue 12, pp. 2740 - 2749
Journal Article
Chemical Communications, ISSN 1359-7345, 2007, Issue 40, pp. 4158 - 4160
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2007, Volume 48, Issue 32, pp. 5697 - 5700
An efficient synthetic route to dysiherbaine is described. An efficient total synthesis of dysiherbaine, a potent and subtype-selective agonist for ionotropic... 
KAINATE RECEPTORS | RECEPTOR ION CHANNELS | GLUTAMATE RECEPTORS | ANALOGS | SPONGE DYSIDEA-HERBACEA | BIOLOGICAL EVALUATION | CHEMISTRY, ORGANIC | NEODYSIHERBAINE-A | EXCITATORY AMINO-ACIDS | MARINE SPONGE |