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Human Vaccines & Immunotherapeutics, ISSN 2164-5515, 11/2014, Volume 10, Issue 11, pp. 3270 - 3285
Research on innate immune signaling and regulation has recently focused on pathogen recognition receptors (PRRs) and their signaling pathways. Members of PRRs... 
IFI16, interferon, gamma-inducible protein 16 | IRF, interferon regulatory factor | CDNs, cyclic dinucleotides | AIM2, absent in melanoma 2 | LT, lethal toxin | MIB, mind bomb | ALRs, AIM2-like receptors | MDP, muramyl dipeptide | LUBAC, linear ubiquitin assembly complex | innate immunity | TRIF, TIR domain-containing adaptor inducing IFN-b | DDX41, DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | IKK, IkB kinase | MyD88, myeloid differentiation factor 88 | TRAILR, tumor-necrosis factor-related apoptosis-inducing ligand receptor | AMPK, AMP activated protein kinase | LBP, LPS-binding protein | NEMO, NF-kB essential modulator | TRIMs, tripartite motif containing proteins | IKKi, inducible IkB kinase | PKC-d, protein kinase C delta | LRR, leucine-rich repeat | TAK1, TGF-b-activating kinase 1 | RIP, receptor-interacting protein | TBK1, TANK binding kinase 1 | TRIP, TRAF-interacting protein | TLRs, Toll-like receptors | LGP 2, laboratory of genetics and physiology 2 | PKR, dsRNA-dependent protein kinase | PRRs, pathogen recognition receptors | STING, stimulator of interferon gene | GBP5, guanylate-binding protein 5 | RLRs, RIG-I-like receptors | ULK1, autophagy related serine threonine UNC-51- like kinase | TIR, Toll IL-1 receptor | LPS, lipopolysaccharide | TRAF, TNFR-associated factor | Atg16L, autophagy related 16-like | cDC, conventional dendritic cell | MDA5, melanoma differentiation-associated protein 5 | DCs, dendritic cells | CARD, caspase recruitment domain | PRRs | KSHV, Kaposi's sarcoma-associated herpesvirus | RAUL, RTA-associated E3 ligase | CLRs, C-type lectin receptors | pDC, plasmacytoid dendritic cell | MAVS, mitochondrial antiviral signaling protein | inflammation | NAIPs, neuronal apoptosis inhibitory proteins | CYLD, the familial cylindromatosis tumor suppressor gene | SIGIRR, single Ig IL-1-related receptor | ROS, reactive oxygen species | RIG-I, retinoic acid-inducible gene 1 | TANK, TRAF family-member-associated NF-kB activator | ASC, apoptosis-associated speck-like protein containing a CARD | DAMPs, danger-associated molecular patterns | IFN, interferon | TRAM, TRIF-related adaptor molecule | TIRAP, TIR domain-containing adapter protein | iE-DAP, g-D-glutamyl-meso-diaminopimelic acid | PAMPs, pathogen-associated molecular patterns | cGAS, cyclic GMP-AMP synthase | cIAP, cellular inhibitor of apoptosis protein | GSK3β, Glycogen synthase kinase 3β | NOD, nucleotide-binding oligomerization domain | IRAK, interleukin-1 receptor-associated kinase | BMM, bone marrow-derived macrophage | type I interferon | RACK1, receptor for activated C kinase 1 | SARM, sterile a- and armadillo motif-containing protein | SOCS, suppressor of cytokine signaling | CMV, cytomegalovirus | cancer | NLRs, Nod- like receptors | Nrdp1, neuregulin receptor degradation protein 1 | HCC, hepatocellular carcinoma | ER, endoplasmic reticulum | Innate immunity | Inflammation | Type I interferon | Cancer | linear ubiquitin assembly complex | C-type lectin receptors | IKKi | TRIP | TRAF | apoptosis-associated speck-like protein containing a CARD | neuregulin receptor degradation protein 1 | RIG-I | TRAM | CARD | TRIF-related adaptor molecule | dendritic cells | TBK1 | cytomegalovirus | cyclic dinucleotides | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | cellular inhibitor of apoptosis protein | GSK3 | PAMPs | retinoic acid-inducible gene 1 | CDNs | hepatocellular carcinoma | TANK binding kinase 1 | RAUL | GBP5 | Toll IL-1 receptor | cDC | MIB | protein kinase C delta | iE-DAP | CMV | SARM | SIGIRR | IRAK | sterile a- and armadillo motif-containing protein | cyclic GMP-AMP synthase | TNFR-associated factor | autophagy related serine threonine UNC-51-like kinase | AMPK | ULK1 | lipopolysaccharide | TRIF | IRF | RLRs | Nrdp1 | receptor-interacting protein | LPS-binding protein | plasmacytoid dendritic cell | tripartite motif containing proteins | LPS | DAMPs | melanoma differentiation-associated protein 5 | ASC | TAK1 | KSHV | LGP 2 | neuronal apoptosis inhibitory proteins | TRIMs | danger-associated molecular patterns | cGAS | T-CELL DEVELOPMENT | RIG-I-like receptors | lethal toxin | BMM | muramyl dipeptide | interleukin-1 receptor-associated kinase | IKK | AMP activated protein kinase | absent in melanoma 2 | IkB kinase | CYLD | dsRNA-dependent protein kinase | MAVS | Kaposi's sarcoma-associated herpesvirus | TIR domain-containing adaptor inducing IFN-b | STING | TIR | AIM2-like receptors | laboratory of genetics and physiology 2 | DDX41 | IMMUNOLOGY | LRR | MyD88 | nucleotide-binding oligomerization domain | CLRs | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | myeloid differentiation factor 88 | MDP | RACK1 | LBP | TRAF-interacting protein | bone marrow-derived macrophage | NF-KAPPA-B | NOD-LIKE RECEPTOR | NOD | conventional dendritic cell | IFN-BETA PRODUCTION | HCC | TGF-b-activating kinase 1 | inducible IkB kinase | TUMOR-SUPPRESSOR CYLD | TIRAP | Atg16L | mind bomb | pathogen-associated molecular patterns | AIM2 | PKR | SINGLE-STRANDED RNA | TRAF family-member-associated NF-kB activator | ROS | interferon regulatory factor | g-D-glutamyl-meso-diaminopimelic acid | pathogen recognition receptors | NLRs | UBIQUITIN-DEPENDENT KINASE | NEMO | stimulator of interferon gene | RTA-associated E3 ligase | Nod- like receptors | CYTOSOLIC DNA SENSOR | the familial cylindromatosis tumor suppressor gene | tumor-necrosis factor-related apoptosis-inducing ligand receptor | TANK | MDA5 | IFN | mitochondrial antiviral signaling protein | ALRs | IFI16 | DCs | TRAILR | reactive oxygen species | Toll-like receptors | cIAP | TIR domain-containing adapter protein | PATTERN-RECOGNITION RECEPTORS | single Ig IL-1-related receptor | guanylate-binding protein 5 | suppressor of cytokine signaling | autophagy related 16-like | leucine-rich repeat | NF-kB essential modulator | Glycogen synthase kinase 3 | SOCS | interferon | LUBAC | caspase recruitment domain | pDC | NAIPs | receptor for activated C kinase 1 | PKC-d | RIP | gamma-inducible protein 16 | TLRs | endoplasmic reticulum | Immunity, Innate - immunology | Signal Transduction - immunology | Neoplasms - immunology | Humans | Inflammasomes - immunology | RNA Viruses - immunology | Toll-Like Receptors - immunology | Interferon Type I - immunology | DNA Viruses - immunology
Journal Article
Glia, ISSN 0894-1491, 01/2018, Volume 66, Issue 1, pp. 94 - 107
Radial glial cells play an essential role through their function as guides for neuronal migration during development. Disruption of metabotropic glutamate... 
migration | neurogenesis | GPCR | calcium | time lapse | transient receptor potential | NEURONAL MIGRATION | NERVOUS-SYSTEM | SIGNALING PATHWAYS | STEM-CELLS | 2-AMINOETHOXYDIPHENYL BORATE | FACTOR RECEPTOR TRANSACTIVATION | NEUROSCIENCES | PROGENITOR | SUSCEPTIBILITY GENE | EGF RECEPTOR | ERBB RECEPTORS | Receptor, ErbB-4 - metabolism | Glutamic Acid - pharmacology | Calcium - metabolism | Embryo, Mammalian | Mice, Inbred C57BL | Cells, Cultured | Ependymoglial Cells - metabolism | Gene Expression Regulation, Developmental - drug effects | Lateral Ventricles - cytology | Ependymoglial Cells - drug effects | RNA, Messenger - metabolism | Receptor, Metabotropic Glutamate 5 - metabolism | Receptor, Metabotropic Glutamate 5 - genetics | Animals | Signal Transduction - drug effects | TRPC Cation Channels - metabolism | Signal Transduction - physiology | Mice | Receptor, ErbB-4 - genetics | Neuregulins - genetics | TRPC Cation Channels - genetics | Neuregulins - metabolism | Gene Expression Regulation, Developmental - physiology | Glutamate | Neurons | Growth | Proteases | ErbB-1 protein | Leukocyte migration | Acetylcholine receptors (muscarinic) | Radial glial cells | Activation | Glutamic acid receptors | ErbB-3 protein | Glial cells | ErbB-2 protein | Neuronal-glial interactions | Transient receptor potential proteins | Signaling | Receptors | Neurotransmitters | Proteolysis | Neuregulin | Cooperativity | Glutamic acid receptors (metabotropic) | Cell migration | Elongation
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 10/2013, Volume 73, Issue 19, pp. 6024 - 6035
HER2/HER3 dimerization resulting from overexpression of HER2 or neuregulin (NRG1) in cancer leads to HER3-mediated oncogenic activation of phosphoinositide... 
BREAST-CANCER | EXTRACELLULAR REGION | COMPLEX | DOMAIN | ACTIVATION | ERBB3 | ONCOLOGY | AFFINITY | CRYSTAL-STRUCTURE | FACTOR RECEPTOR | TRASTUZUMAB RESISTANCE | Receptor, ErbB-3 - metabolism | Immunoprecipitation | Humans | Protein Conformation - drug effects | Receptor, ErbB-2 - metabolism | Immunoblotting | Receptor, ErbB-3 - chemistry | Breast Neoplasms - metabolism | Receptor, Epidermal Growth Factor - metabolism | Receptor, ErbB-3 - immunology | Antibodies, Monoclonal, Humanized - pharmacology | Female | Receptor, ErbB-2 - antagonists & inhibitors | Receptor, ErbB-2 - immunology | Phosphorylation - drug effects | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Signal Transduction | Receptor, ErbB-3 - antagonists & inhibitors | Survival Rate | Mice, SCID | Xenograft Model Antitumor Assays | Animals | Breast Neoplasms - pathology | Mice, Nude | Neuregulin-1 - metabolism | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Breast Neoplasms - mortality | Mice, Inbred NOD | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Protein Multimerization - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | BASIC BIOLOGICAL SCIENCES | 60 APPLIED LIFE SCIENCES | PI-3 kinase | NRG | ligand-independent | Antibody | neuregulin | SCCHN | EGFR | resistance | feedback | HER | PIK3CA | cancer | HER2 | HER3 | ligand-dependent
Journal Article
Molecular Cell, ISSN 1097-2765, 02/2003, Volume 11, Issue 2, pp. 495 - 505
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 02/2009, Volume 29, Issue 8, pp. 2404 - 2413
Neuregulin-1s (NRG-1s) are a family of growth and differentiation factors with multiple roles in the development and function in different organs including the... 
Cerebellum | Development | Granule cell | Neuregulin | Synapse formation | NMDA receptor | PURKINJE-CELLS | development | DENDRITIC GROWTH | SYNAPSE ELIMINATION | neuregulin | RECEPTOR SUBUNIT EXPRESSION | NEUROSCIENCES | synapse formation | cerebellum | granule cell | MESSENGER-RNAS | POSTNATAL-DEVELOPMENT | RAT-BRAIN | DIFFERENTIATION | GRANULE CELLS | CLIMBING-FIBER | Electric Stimulation | Receptors, N-Methyl-D-Aspartate - metabolism | Gene Expression Regulation, Developmental - genetics | Male | Receptors, N-Methyl-D-Aspartate - genetics | Excitatory Postsynaptic Potentials - physiology | Neurons - physiology | Female | Tetrodotoxin - pharmacology | ErbB Receptors - deficiency | Organ Culture Techniques | Gene Expression Regulation, Developmental - physiology | Animals, Newborn | Receptors, GABA - genetics | Cerebellum - metabolism | Valine - analogs & derivatives | Enzyme Inhibitors - pharmacology | Neuregulins - physiology | Sodium Channel Blockers - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Mice, Knockout | Patch-Clamp Techniques | Animals | Cerebellum - cytology | Receptors, GABA - metabolism | Cerebellum - growth & development | Signal Transduction - physiology | Mice | Valine - pharmacology | Receptor, ErbB-4 | Receptor, ErbB-2 - deficiency | Index Medicus | Tetrodotoxin | Enzyme Inhibitors | Neurons and Cognition | Life Sciences | Neuregulins | Receptors, GABA | Excitatory Postsynaptic Potentials | Gene Expression Regulation, Developmental | Signal Transduction | Neurons | Receptors, N-Methyl-D-Aspartate | Receptor, erbB-2 | Valine | Sodium Channel Blockers | Excitatory Amino Acid Antagonists | Receptor, Epidermal Growth Factor
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 04/2007, Volume 27, Issue 17, pp. 4519 - 4529
Journal Article
Scientific reports, ISSN 2045-2322, 08/2017, Volume 7, Issue 1, pp. 9758 - 1
A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. 
Schizophrenia | Neuregulin | Receptor mechanisms | Neuregulin 1 | Mental disorders | ErbB protein
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2010, Volume 107, Issue 38, pp. 16703 - 16708
Both treatment of disease and basic studies of complex tissues can benefit from directing viral vector infection to specific cell types. We have used a unique... 
Brain | Receptors | Interneurons | Genetic vectors | Neurons | Viruses | Infections | Viral morphology | Rabies virus | Cells | Avian virus receptor for subgroup B | Neuregulin | EnvB | Lentivirus | rabies virus | PARVALBUMIN | VIRUS | MULTIDISCIPLINARY SCIENCES | neuregulin | NEUREGULIN-1 | NEURAL DEVELOPMENT | GREEN FLUORESCENT PROTEIN | CORTEX | TARGETING LENTIVIRAL VECTORS | SOMATOSTATIN | avian virus receptor for subgroup B | NEURONS | BRAIN | lentivirus | Receptor, Epidermal Growth Factor - genetics | Receptors, Virus - metabolism | DNA Primers - genetics | Green Fluorescent Proteins - genetics | Receptors, Virus - genetics | Cerebral Cortex - cytology | Recombinant Fusion Proteins - metabolism | Cerebral Cortex - metabolism | Receptor, Epidermal Growth Factor - metabolism | Base Sequence | Neuregulins - metabolism | Green Fluorescent Proteins - metabolism | Avian Proteins - metabolism | Transduction, Genetic | Rats | Mice, Transgenic | Mice, Inbred ICR | Mice, Knockout | Rabies virus - genetics | Animals | Interneurons - metabolism | Recombinant Fusion Proteins - genetics | Ligands | Mice | Neuregulins - genetics | Genetic Vectors | Receptor, ErbB-4 | Avian Proteins - genetics | Physiological aspects | Transduction | Properties | Gene expression | Ligands (Biochemistry) | Infection | Mental disorders | Circuits | ErbB protein | Cortex | Schizophrenia | ErbB-2 protein | Expression vectors | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e46682
Human luteinizing hormone (hLH) and chorionic gonadotropin (hCG) act on the same receptor (LHCGR) but it is not known whether they elicit the same cellular and... 
HUMAN GRANULOSA-CELLS | STEROID-PRODUCTION | OOCYTE MATURATION | HUMAN LUTEINIZING-HORMONE | OVARIAN-FOLLICLES | MULTIDISCIPLINARY SCIENCES | GROWTH-FACTORS | GENE-EXPRESSION | FOLLICLE-STIMULATING-HORMONE | HUMAN CHORIONIC-GONADOTROPIN | LUTROPIN RECEPTOR | Chorionic Gonadotropin - physiology | Humans | Middle Aged | Receptors, LH - metabolism | Transcriptome | Cercopithecus aethiops | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | Granulosa Cells - metabolism | Chorionic Gonadotropin - pharmacology | Dose-Response Relationship, Drug | Cell Shape | Adult | Female | Luteinizing Hormone - pharmacology | Progesterone - biosynthesis | Proto-Oncogene Proteins c-akt - metabolism | Cyclic AMP - metabolism | Receptors, LH - physiology | Signal Transduction | 1-Methyl-3-isobutylxanthine - pharmacology | Animals | Luteinizing Hormone - physiology | Protein Kinase Inhibitors - pharmacology | Kinetics | Primary Cell Culture | Receptors, LH - agonists | COS Cells | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Chorionic gonadotropin | Luteinizing hormone | Cyclic adenylic acid | Glycoproteins | Progesterone | Hormones | Gene expression | Dehydrogenases | Neuregulin 1 | Genes | Intracellular signalling | AKT protein | Activation | Kinases | Proteins | Signal transduction | Cell activation | Epidermal growth factor | Pathways | Rodents | Aromatase | Transcription activation | Cell cycle | Granulosa cells | Neuregulin | Physiology | Inhibition | Recombinant | Secretion | Gynecology | Extracellular signal-regulated kinase | Cyclic AMP | Pituitary (anterior) | Gonadotropins | Metabolism | Obstetrics | Studies | Intracellular | Apoptosis
Journal Article