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PLoS ONE, ISSN 1932-6203, 05/2016, Volume 11, Issue 5, p. e0155456
Background We previously developed and validated a strategy for stimulating heart regeneration by administration of recombinant neuregulin (rNRG1), a growth... 
RECOMBINANT HUMAN NEUREGULIN-1 | MULTICENTER | ACTIVATION | INHIBITION | MULTIDISCIPLINARY SCIENCES | HEART-FAILURE | ERBB2 | CYNOPS-PYRRHOGASTER | PROLIFERATION | FACTOR-I | MODEL | Animals, Newborn | ErbB Receptors - metabolism | Kidney - drug effects | Ribosomal Protein S6 Kinases - metabolism | Heart - physiology | Humans | Kidney - enzymology | ErbB Receptors - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | Neuregulin-1 - pharmacology | Recombinant Proteins - pharmacology | Neuregulin-1 - genetics | Gene Expression Regulation - drug effects | Organ Size - drug effects | Regeneration - drug effects | Animals | Aging - physiology | Heart - drug effects | Morphogenesis - drug effects | Neuregulin-1 - blood | Mice | Neuregulin-1 - administration & dosage | Phosphorylation - drug effects | Neoplasms - pathology | Heart failure | Antimitotic agents | Care and treatment | Dosage and administration | Research | Antineoplastic agents | Health aspects | Enzyme-linked immunosorbent assay | Heart | Cell proliferation | Neonates | Brain | Pediatrics | Spinal cord | Neuregulin 1 | Syngeneic grafts | Liver | Body weight | Clinical trials | Amino acids | Cardiovascular disease | Biology | Kinases | Human populations | Receptors | Epidermal growth factor | Tibia | Rodents | Cell cycle | Neuregulin | Cardiology | Heart diseases | Recombinant | Spleen | Weighing | Kidneys | Cardiac muscle | ErbB protein | Muscles | Extracellular signal-regulated kinase | Inspection | Cardiomyocytes | ErbB-3 protein | ErbB-2 protein | Medicine | Studies | Polymerase chain reaction | Regeneration | Hospitals | Magnetic resonance imaging | Lungs | Kidney transplantation | Cancer
Journal Article
Science, ISSN 0036-8075, 10/2006, Volume 314, Issue 5799, pp. 664 - 666
Journal Article
Glia, ISSN 0894-1491, 07/2017, Volume 65, Issue 7, pp. 1152 - 1175
Spinal cord injury (SCI) results in glial activation and neuroinflammation, which play pivotal roles in the secondary injury mechanisms with both pro‐ and... 
spinal cord injury | IL‐10 | neuregulin‐1 | functional recovery | glial scar | neuroinflammation | neuregulin-1 | IL-10 | PRO-INFLAMMATORY CYTOKINES | CHONDROITIN SULFATE PROTEOGLYCANS | MICROGLIAL CELLS | NEUROSCIENCES | OLIGODENDROCYTE DIFFERENTIATION | TOLL-LIKE RECEPTORS | NITRIC-OXIDE | CENTRAL-NERVOUS-SYSTEM | ACTIVATED MACROPHAGES | NEURAL PRECURSOR CELLS | Recovery of Function - drug effects | Spinal Cord Injuries - complications | Arginase - metabolism | Culture Media, Conditioned - pharmacology | Neuregulin-1 - therapeutic use | Glial Fibrillary Acidic Protein - metabolism | Neuroglia - drug effects | Spinal Cord Injuries - pathology | Time Factors | Interleukin-10 - metabolism | Recovery of Function - physiology | Female | Disease Models, Animal | Locomotion - drug effects | Animals, Newborn | Lipopolysaccharides - toxicity | Mice, Inbred C57BL | Cells, Cultured | Nervous System Diseases - drug therapy | Neuroglia - physiology | Gene Expression Regulation - physiology | Rats | Neuregulin-1 - pharmacology | Gene Expression Regulation - drug effects | Animals | Signal Transduction - drug effects | Neuregulin-1 - metabolism | Nervous System Diseases - etiology | Mice | Tyrosine | Disabled persons | Interleukins | Analysis | Nitric oxide | Spinal cord injuries | Sulfates | Neuroprotection | Phosphorylation | Spinal cord | Matrix metalloproteinases | Neuregulin 1 | Downstream effects | Interleukin | Recovery of function | Arginase | Spinal cord injury | Dosage | Neuronal-glial interactions | Proteins | Recovering | Receptors | Rodents | Interleukin 1 | Toll-like receptors | Neuregulin | Immune system | Proteoglycans | Preservation | Immunomodulation | Stat3 protein | Extracellular signal-regulated kinase | Inflammation | ErbB-2 protein | Gelatinase A | Injury prevention | Gliosis | Molecular modelling | Interleukin 10 | MyD88 protein | Chondroitin sulfate | Sulfate | In vitro methods and tests
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2010, Volume 55, Issue 18, pp. 1907 - 1914
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, p. e55741
Aims: Recombinant Neuregulin (NRG)-1 beta has multiple beneficial effects on cardiac myocytes in culture, and has potential as a clinical therapy for heart... 
SURVIVAL | RECOMBINANT HUMAN NEUREGULIN-1 | CHRONIC HEART-FAILURE | INHIBITION | MULTIDISCIPLINARY SCIENCES | CARDIAC MYOCYTES | ERBB2 | CARDIOMYOPATHY | MITOCHONDRIAL DYSFUNCTION | DIFFERENCE GEL-ELECTROPHORESIS | STANDARD | Myocardial Infarction - genetics | Injections, Intravenous | Humans | Male | Myocardial Infarction - diagnostic imaging | Neuregulin-1 - therapeutic use | Positron-Emission Tomography | Tissue Survival - drug effects | Protein Isoforms - metabolism | Diet, High-Fat | Myocardium - metabolism | Ultrasonography | Electrocardiography | Myocardial Infarction - physiopathology | Neuregulin-1 - administration & dosage | Real-Time Polymerase Chain Reaction | Heart Ventricles - pathology | Ventricular Function, Left - drug effects | Rats | Myocardium - pathology | Neuregulin-1 - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Rats, Sprague-Dawley | Gene Expression Regulation - drug effects | Organ Size - drug effects | Animals | Myocardial Infarction - drug therapy | Heart Ventricles - physiopathology | Neuregulin-1 - metabolism | Fibrosis | Glucose - metabolism | Oxidative Stress - drug effects | Proteome - metabolism | Heart Ventricles - drug effects | Myocardial infarction | Heart | Intravenous administration | Heart attacks | Neuregulin 1 | Cardiomyopathy | Genomics | Medical services | mRNA | Myocytes | Kinases | Neuronal-glial interactions | High fat diet | Proteins | Rodents | Neuregulin | Heart diseases | Growth factors | Informatics | Recombinant | Heart failure | Echocardiography | ErbB protein | Cardiomyocytes | Gene expression | Medicine | DNA microarrays | Medical prognosis | Proteomics | Myocardium | Infarction | Ventricle | Laboratory animals | Cancer
Journal Article
FASEB Journal, ISSN 0892-6638, 2014, Volume 28, Issue 8, pp. 3618 - 3632
C boutons are large, cholinergic, synaptic terminals that arise from local interneurons and specifically contact spinal alpha-motoneurons (MNs). C boutons... 
Amyotrophic lateral sclerosis | Interneurons | Spinal cord ventral horn | erbB receptors | Spinal muscular atrophy | GENE-RELATED PEPTIDE | SOD1(G93A) MOUSE MODEL | DIFFERENTIAL EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | spinal cord ventral horn | AMYOTROPHIC-LATERAL-SCLEROSIS | amyotrophic lateral sclerosis | CELL BIOLOGY | PERIPHERAL-NERVE INJURY | CHOLINERGIC SYNAPSES | LUMBAR MOTONEURONS | SPINAL MUSCULAR-ATROPHY | BIOLOGY | spinal muscular atrophy | SIGMA-1 RECEPTOR | NEUROMUSCULAR-JUNCTIONS | interneurons | Organelles - chemistry | Sciatic Nerve - injuries | Spinal Cord - growth & development | Humans | Male | Post-Synaptic Density - chemistry | Sciatic Nerve - ultrastructure | Neuregulin-1 - biosynthesis | Presynaptic Terminals - ultrastructure | Motor Neurons - pathology | Neuregulin-1 - genetics | Female | Neuregulin-1 - analysis | Spinal Cord - cytology | Muscular Atrophy, Spinal - metabolism | Presynaptic Terminals - chemistry | Mice, Inbred C57BL | Avian Proteins - analysis | Neuregulin-1 - physiology | Mice, Transgenic | Post-Synaptic Density - ultrastructure | Receptor, Epidermal Growth Factor - analysis | Chick Embryo | Muscular Atrophy, Spinal - pathology | Motor Neurons - metabolism | Avian Proteins - physiology | Spinal Cord - embryology | Amyotrophic Lateral Sclerosis - pathology | Animals | Chickens | Amyotrophic Lateral Sclerosis - metabolism | Mice | Receptor, ErbB-2 - analysis | Receptor, ErbB-4
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e34129
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2010, Volume 107, Issue 12, pp. 5622 - 5627
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 12/2015, Volume 220, Issue Pt A, pp. 388 - 396
Journal Article