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British Journal of Pharmacology, ISSN 0007-1188, 12/2014, Volume 171, Issue 24, pp. 5555 - 5572
Journal Article
Methods in Enzymology, ISSN 0076-6879, 2017, Volume 593, pp. 199 - 215
PIMSR is among the first neutral antagonists for the CB1R and was demonstrated pharmacologically to bind to the CB1R, yet not alter calcium flux. It was... 
Glycemic control | Obesity | Neutral antagonist | Metabolic syndrome effects | Alcoholic steatosis | PIMSR | Modeling | CB1R | ENERGY-BALANCE | OBESITY | CANNABINOID RECEPTOR | INVERSE AGONISM | BINGE DRINKING | BIOCHEMISTRY & MOLECULAR BIOLOGY | PERSPECTIVES | BIOCHEMICAL RESEARCH METHODS | ENDOCANNABINOID SYSTEM
Journal Article
Expert Opinion on Emerging Drugs, ISSN 1472-8214, 03/2009, Volume 14, Issue 1, pp. 43 - 65
Journal Article
European Journal of Heart Failure, ISSN 1388-9842, 07/2014, Volume 16, Issue 7, pp. 817 - 825
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2014, Volume 10, Issue 8, pp. 671 - 676
(+)-7-iso-Jasmonoyl-L-isoleucine (JA-Ile) regulates developmental and stress responses in plants. Its perception involves the formation of a ternary complex... 
SIGNAL-TRANSDUCTION | PLANT STRESS-RESPONSE | DOMAIN PROTEINS INTERACT | PATHOGEN | AUXIN PERCEPTION | BIOSYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | JAZ REPRESSORS | ARABIDOPSIS | BHLH TRANSCRIPTION FACTORS | REGULATED DEFENSE | Indenes - metabolism | Amino Acids - chemistry | Indenes - chemistry | Amino Acids - pharmacology | Pseudomonas syringae - pathogenicity | Arabidopsis Proteins - metabolism | Botrytis - pathogenicity | DNA-Binding Proteins - metabolism | Amino Acids - metabolism | Isoleucine - pharmacology | Plants, Genetically Modified | Drug Design | Gene Expression Regulation, Plant | Plant Roots - growth & development | Repressor Proteins - metabolism | Amino Acids, Neutral - pharmacology | Indenes - pharmacology | Arabidopsis Proteins - genetics | Arabidopsis - drug effects | DNA-Binding Proteins - antagonists & inhibitors | Plant Roots - metabolism | Repressor Proteins - genetics | Transcription Factors - antagonists & inhibitors | Cyclopentanes - pharmacology | Anthocyanins - metabolism | Arabidopsis - metabolism | Isoleucine - metabolism | Transcription Factors - metabolism | Arabidopsis - microbiology | Oxylipins - metabolism | Isoleucine - analogs & derivatives | Oximes - pharmacology | Cyclopentanes - metabolism | Ligands | Arabidopsis Proteins - antagonists & inhibitors | Plant diseases | Plant pathology | Sustainable agriculture | Agricultural biotechnology | Plant resistance | Hormones
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 03/2007, Volume 150, Issue 5, pp. 613 - 623
Background and purpose: A nonpsychoactive constituent of the cannabis plant, cannabidiol has been demonstrated to have low affinity for both cannabinoid CB1... 
cannabidiol | CP55940 | S assay | GTP | O‐2654 | receptor | mouse brain | inverse agonism | neutral antagonism | CB2 receptor | O-2654 | GTP gamma S assay | INHIBITION | LIGANDS | CB1 receptor | SELECTIVE INVERSE AGONIST | MOUSE VAS-DEFERENS | PERIPHERAL CANNABINOID RECEPTOR | PHARMACOLOGY & PHARMACY | BINDING | BRAIN | Cricetulus | Cyclohexanols | Receptor, Cannabinoid, CB2 - agonists | Cannabinoid Receptor Antagonists | Cyclohexanes - pharmacology | Humans | Bornanes - pharmacology | Anti-Inflammatory Agents - metabolism | Brain - metabolism | Dose-Response Relationship, Drug | Receptors, Cannabinoid - metabolism | Receptor, Cannabinoid, CB1 - agonists | Transfection | Piperidines - pharmacology | Morpholines - antagonists & inhibitors | Phenols - antagonists & inhibitors | Cyclohexanes - antagonists & inhibitors | Benzoxazines - antagonists & inhibitors | Cell Membrane - metabolism | Cell Membrane - drug effects | Receptors, Cannabinoid - genetics | CHO Cells | Phenols - pharmacology | Pyrazoles - pharmacology | Cricetinae | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | Morpholines - pharmacology | Cannabidiol - pharmacology | Mice, Knockout | Naphthalenes - pharmacology | Brain - drug effects | Cannabinoid Receptor Agonists | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Animals | Benzoxazines - pharmacology | Protein Binding | Mice | Cannabidiol - metabolism | In Vitro Techniques | Naphthalenes - antagonists & inhibitors | Research Papers | GTPγS assay
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2018, Volume 146, pp. 68 - 78
A series of novel oxazolo[5,4- ]pyrimidines was designed via a scaffold hopping strategy and synthesized through a newly developed approach. All these... 
CB2 receptor | Cannabinoid | Neutral antagonist | oxazolo[5,4-d]pyrimidine | receptor | CANNABINOID RECEPTOR 2 | SR 144528 | CHEMISTRY, MEDICINAL | ENDOCANNABINOID SYSTEM | OSTEOCLAST INHIBITORS | TRANSFECTED CELLS | DISCOVERY | INVERSE AGONISTS | MEDICINAL CHEMISTRY | LIGANDS | BIOLOGICAL EVALUATION
Journal Article
03/2014
Introduction: Tobacco dependence is a chronic disorder that carries the risk of relapse at any time point during abstinence. It is a major health issue in the... 
cannabinoid 1 receptor | nicotine | CB1 receptor neutral antagonist | self administration | tobacco dependence | AM4113
Dissertation
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 02/2008, Volume 8, Issue 3, pp. 205 - 230
During the last decade there has been a growing interest towards the modulation of the cannabinoid CB1 receptor. The identification of CB1 cannabinoid receptor... 
CB1 | Antagonist | Endocannabinoid | Rimonabant | Cannabinoid | endocannabinoid | rimonabant | SELECTIVE ANTAGONIST | CHEMISTRY, MEDICINAL | cannabinoid | RECEPTOR INVERSE AGONISTS | ENDOCANNABINOID SYSTEM | TRICYCLIC PYRAZOLES | CONSTRAINED ANALOGS | antagonist | MOLECULAR MODELING INVESTIGATIONS | IN-VIVO | BIOLOGICAL EVALUATION | NEUTRAL ANTAGONISM | PHARMACOLOGICAL EVALUATION
Journal Article
Pharmacological Reviews, ISSN 0031-6997, 09/2011, Volume 63, Issue 3, pp. 585 - 640
The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene family (also referred to as the neurotransmitter-sodium-symporter family... 
BIOGENIC-AMINE TRANSPORTERS | TRANSMEMBRANE DOMAIN-I | PROTEIN-KINASE-C | CYSTEINE-SCANNING MUTAGENESIS | HUMAN DOPAMINE TRANSPORTER | PHARMACOLOGY & PHARMACY | GAMMA-AMINOBUTYRIC-ACID | MAJOR DEPRESSIVE DISORDER | HUMAN NOREPINEPHRINE TRANSPORTER | GABA UPTAKE INHIBITORS | HUMAN SEROTONIN TRANSPORTER | Amino Acid Transport Systems, Neutral - chemistry | Membrane Microdomains - metabolism | Humans | Plasma Membrane Neurotransmitter Transport Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Nerve Tissue Proteins - chemistry | Protein Isoforms - metabolism | Protein Isoforms - agonists | Protein Isoforms - chemistry | Synaptic Transmission - drug effects | Neurons - metabolism | Neurons - drug effects | Nerve Tissue Proteins - antagonists & inhibitors | Amino Acid Transport Systems, Neutral - agonists | Nerve Tissue Proteins - agonists | Plasma Membrane Neurotransmitter Transport Proteins - agonists | Amino Acid Transport Systems, Neutral - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Organ Specificity | Protein Transport | Nerve Tissue Proteins - metabolism | Animals | Ligands | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | Protein Processing, Post-Translational | Protein Isoforms - antagonists & inhibitors | Amino Acid Transport Systems, Neutral - antagonists & inhibitors
Journal Article