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Science Translational Medicine, ISSN 1946-6234, 10/2015, Volume 7, Issue 309, pp. 309ra162 - 309ra162
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2016, Volume 113, Issue 10, pp. 2702 - 2707
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 6, pp. 1957 - 1965.e3
Journal Article
Oncogene, ISSN 0950-9232, 02/2012, Volume 31, Issue 6, pp. 787 - 798
Several lines of evidence suggest that aberrant Notch signaling contributes to the development of several types of cancer. Activation of Notch receptor is... 
membrane protein | g-secretase | functional antibody | intramembrane cleavage | Notch | PRESENILIN | CELLS | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | gamma-secretase | AMYLOID PRECURSOR PROTEIN | CELL BIOLOGY | INHIBITION | ONCOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | GENETICS & HEREDITY | BUDDED BACULOVIRUS | BETA-APP | MEMBRANE-PROTEINS | Neoplasms - metabolism | Amyloid Precursor Protein Secretases - genetics | Amyloid Precursor Protein Secretases - immunology | Membrane Glycoproteins - metabolism | Humans | Antibodies, Neutralizing - metabolism | Immunoblotting | Male | Neoplasms - prevention & control | Neutralization Tests | Dose-Response Relationship, Drug | Antibodies, Neutralizing - immunology | Antibody Specificity - immunology | Biocatalysis - drug effects | Protein Binding - drug effects | HEK293 Cells | Membrane Glycoproteins - immunology | Antibodies, Monoclonal - immunology | Antibodies, Monoclonal - pharmacology | Antibodies, Neutralizing - pharmacology | Mice, SCID | Membrane Glycoproteins - genetics | Mice, Knockout | Xenograft Model Antitumor Assays | Amyloid Precursor Protein Secretases - metabolism | Animals | Tumor Burden - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Antibodies, Monoclonal - metabolism | HeLa Cells | Neoplasms - pathology | nicastrin | PEN-2 protein | Proteolysis | Proteinase | Xenografts | Monoclonal antibodies | Presenilin | Data processing | Notch protein | Cell surface | Secretase | Cancer | γ-secretase
Journal Article
Nature Biotechnology, ISSN 1087-0156, 11/2013, Volume 31, Issue 11, pp. 1047 - 1052
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2018, Volume 24, Issue 11, pp. 1701 - 1707
Journal Article