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Acta Cirurgica Brasileira, ISSN 0102-8650, 07/2018, Volume 33, Issue 7, pp. 556 - 564
Journal Article
Current Biology, ISSN 0960-9822, 06/2000, Volume 10, Issue 11, pp. 640 - 648
Background: Activation of Fas (CD95) by its ligand (FasL) rapidly induces cell death through recruitment and activation of caspase-8 via the adaptor protein... 
FADD protein | caspase-8 | FasL protein | FLIP protein | CD3 antigen | Erk protein | NF-^KB protein
Journal Article
PLoS Pathogens, ISSN 1553-7366, 08/2017, Volume 13, Issue 8
Poxviruses have evolved unique proteins and mechanisms to counteract the nuclear factor KB (NF-KB) signaling pathway, which is an essential regulatory pathway... 
Translocation | NF-κB protein | Veterinary colleges | Phosphorylation | Immune response | Virulence | Viruses | Infections | Activation | Inflammation | Gene deletion | Kinases | Gene expression | Veterinary medicine | Nuclear transport | IKK protein | Proteins | Signal transduction | Clonal deletion | Tumor necrosis factor | Deletion | Sheep | Tumor necrosis factor-TNF | Inhibition
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/1999, Volume 274, Issue 43, pp. 30858 - 30863
Endotoxin-induced cytokine gene transcription in monocytes and macrophages is regulated in part by NF-kappa B. We have previously shown that the p38... 
RNA-POLYMERASE-II | TUMOR-NECROSIS-FACTOR | IN-VITRO | BASAL TRANSCRIPTION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR-ALPHA GENE | LIPOPOLYSACCHARIDE | INFLAMMATORY CYTOKINES | INTERLEUKIN-6 | TRANSCRIPTION FACTOR-IIB | NF-^KB protein | p38 protein | p65 protein
Journal Article
Genes and Development, ISSN 0890-9369, 1999, Volume 13, Issue 22, pp. 2905 - 2927
The programmed cell death that occurs as part of normal mammalian development was first observed nearly a century ago. It has since been established that... 
SIGNAL-TRANSDUCTION PATHWAYS | PROTEIN-KINASE-B | GLYCOGEN-SYNTHASE KINASE-3 | GLUCOSE-6-PHOSPHATASE GENE-TRANSCRIPTION | DEVELOPMENTAL BIOLOGY | P70 S6 KINASE | NERVE GROWTH-FACTOR | CELL BIOLOGY | ACTIVATED PHOSPHATIDYLINOSITOL 3-KINASE | INSULIN-RESPONSE SEQUENCE | GENETICS & HEREDITY | PLECKSTRIN HOMOLOGY DOMAIN | FACTOR-BINDING PROTEIN-1 | Caspases - physiology | Caspase 9 | Phosphorylation | Humans | Substrate Specificity | Glycogen Synthase Kinase 3 | Proto-Oncogene Proteins - chemistry | Phosphatidylinositols - metabolism | Cell Survival - physiology | Calcium-Calmodulin-Dependent Protein Kinases - physiology | Carrier Proteins - physiology | Transcription Factors - physiology | Protein-Serine-Threonine Kinases - physiology | Rats | Proto-Oncogene Proteins - genetics | I-kappa B Kinase | Protein Isoforms - physiology | Proto-Oncogene Proteins c-akt | Sequence Alignment | Animals | Cell Transformation, Neoplastic | NF-kappa B - physiology | Proto-Oncogene Proteins - physiology | Phosphatidylinositol 3-Kinases - physiology | Signal Transduction - physiology | Mice | Protein Processing, Post-Translational | Apoptosis - physiology | bcl-Associated Death Protein | Cell death | Neurons | Physiological aspects | Cellular signal transduction | Research | Cytochemistry | Growth factors | neutrophins | nerve growth factor | NF-^KB protein | Akt protein
Journal Article
Trends in Cell Biology, ISSN 0962-8924, 2000, Volume 10, Issue 4, pp. 129 - 133
The NF-κB family of transcription factors plays a crucial role in the immune, inflammatory and apoptotic responses. These proteins are normally found in the... 
NF-κB | Signal transduction | Phosphorylation | Protein degradation | Protein kinase | Inflammation | REL-family | Protein–protein interaction | Apoptosis | Proteasome | TRANSCRIPTION FACTORS | KINASE COMPLEX | LIMB | ALPHA | PROTEINS | FAMILY | BETA | CELL BIOLOGY | NF-^KB protein | I^KB kinase
Journal Article
European Journal of Immunology, ISSN 0014-2980, 08/2001, Volume 31, Issue 8, pp. 2448 - 2457
Taxol can mimic bacterial lipopolysaccharide (LPS) by activating mouse macrophages in a cell cycle‐independent, LPS antagonist‐inhibitable manner. Macrophages... 
Lipopolysaccharide | Taxol | MyD88 | TLR4 | Macrophage | MyD88 protein | lipopolysaccharides | TLR4 protein | NF-^KB protein
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2002, Volume 99, Issue 8, pp. 5567 - 5572
Toll/IL-1 receptor family members are central components of host defense mechanisms in a variety of species. One well conserved element in their signal... 
Proteins | Signal transduction | Molecules | Biological Sciences | Receptors | Phosphorylation | Complementary DNA | Molecular interactions | Cell lines | Amino acids | Family members | CELLS | ACTIVATION | COMPLEX | RECEPTOR-ASSOCIATED KINASE | MULTIDISCIPLINARY SCIENCES | LINKS | IL-1 RECEPTOR | INTERLEUKIN-1 RECEPTOR | KAPPA-B | INDUCTION | EXPRESSION | Protein Kinases - metabolism | Multigene Family | Phosphotransferases (Alcohol Group Acceptor) - chemistry | Humans | Interleukin-1 Receptor-Associated Kinases | Molecular Sequence Data | Immunoblotting | NF-kappa B - metabolism | MAP Kinase Signaling System | Tissue Distribution | Mitogen-Activated Protein Kinase Kinases - metabolism | MAP Kinase Kinase 4 | Time Factors | Cloning, Molecular | Polymerase Chain Reaction | JNK Mitogen-Activated Protein Kinases | Genes, Reporter | Protein-Serine-Threonine Kinases - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Drosophila Proteins | Interleukin-1 - metabolism | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Precipitin Tests | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Receptors, Interleukin-1 - metabolism | Blotting, Northern | TNF Receptor-Associated Factor 6 | Animals | Proteins - metabolism | Protein Kinases - physiology | Protein Binding | Enzyme Activation | DNA, Complementary - metabolism | Drosophila melanogaster | Mitogen-Activated Protein Kinases - metabolism | Physiological aspects | Drosophila | Animal defenses | NF-^KB protein | IRAK-4 protein | interleukin 1 receptors
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/1999, Volume 274, Issue 45, pp. 31868 - 31874
The transcription factor nuclear factor kappa B (NF-kappa B) coordinates the activation of numerous genes in response to pathogens and proinflammatory... 
TUMOR-NECROSIS-FACTOR | GROWTH-FACTOR-BETA | ACTIVATION | CYTOKINE PRODUCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | REGULATORY REGION | ALPHA | INFLAMMATORY BOWEL-DISEASE | HUMAN MONOCYTES | IL-10 | NF-B protein | I^KB protein | lipopolysaccharides | NF-^KB protein | IKK protein
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2000, Volume 275, Issue 15, pp. 11058 - 11063
A missense mutation in the cytoplasmic domain of the Toll-like receptor-4 (TLR-4) has been identified as the defect responsible for lipopolysaccharide (LPS)... 
RESPONSIVENESS | GENE | RECOGNITION | DROSOPHILA TOLL | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTOXIN | MICE | MUTATIONS | LIPOPROTEINS | INNATE IMMUNITY | CUTTING EDGE | TLR-4 protein | lipopolysaccharides | NF-^KB protein | Toll-like receptor 4
Journal Article