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Metabolic Brain Disease, ISSN 0885-7490, 3/2014, Volume 29, Issue 1, pp. 47 - 58
Here, we have investigated the effect of metformin pretreatment in the rat models of global cerebral ischemia. Cerebral ischemia which leads to brain... 
Biochemistry, general | Neurology | Neurosciences | Compound c | Biomedicine | Metabolic Diseases | Oncology | AMPK | Metformin | Global cerebral ischemia | Mitochondrial biogenesis proteins | Apoptosis | SURVIVAL | OXIDATIVE STRESS | MITOCHONDRIAL BIOGENESIS | APOPTOTIC CELL-DEATH | DOWN-REGULATION | MUSCLE | NEUROSCIENCES | NEUROPROTECTION | DAMAGE | DELAYED NEURONAL DEATH | HEART | ENDOCRINOLOGY & METABOLISM | Neuroprotective Agents - therapeutic use | Metformin - therapeutic use | Apoptosis - drug effects | Brain - enzymology | Male | NF-E2-Related Factor 1 - genetics | Hippocampus - drug effects | Dose-Response Relationship, Drug | Neuroprotective Agents - pharmacology | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Hippocampus - enzymology | Adenylate Kinase - physiology | Metformin - administration & dosage | Drug Evaluation, Preclinical | Pyrazoles - pharmacology | Transcription Factors - physiology | Metformin - pharmacology | Rats | Transcription Factors - biosynthesis | Brain Ischemia - prevention & control | Hippocampus - pathology | Pyrimidines - pharmacology | Transcription Factors - genetics | Enzyme Activation - drug effects | NF-E2-Related Factor 1 - biosynthesis | Brain - drug effects | Mitochondrial Turnover - drug effects | Animals | Reperfusion Injury - prevention & control | Signal Transduction - drug effects | Brain Ischemia - pathology | Brain - pathology | Adenylate Kinase - antagonists & inhibitors | Premedication | AMP
Journal Article
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 04/2016, Volume 93, pp. 23 - 31
Journal Article
Toxicology, ISSN 0300-483X, 2009, Volume 264, Issue 1, pp. 10 - 15
Abstract Perfluorooctanoic acid (PFOA), used in the production of non-stick surface compounds, exhibits a worldwide distribution in the serum of humans and... 
Emergency | Mitochondria | PGC-1α | Mitochondrial biogenesis | PPAR | PFOA | Perfluorinated chemicals | PGC-1 alpha | PHOSPHORYLATION | NUCLEAR RECEPTORS | PGC-1-ALPHA | TOXICITY | SKELETAL-MUSCLE | ACTIVATED-RECEPTOR-ALPHA | FLUORINATED HYDROCARBONS | PEROXISOME PROLIFERATION | CHEMICALS | COACTIVATOR PGC-1 | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Prostaglandin-Endoperoxide Synthases - biosynthesis | Transcription, Genetic - drug effects | Electron Transport - drug effects | Mitochondria, Liver - metabolism | Male | Fluorocarbons - pharmacology | Caprylates - pharmacology | Nuclear Respiratory Factor 1 - genetics | Transcription Factors - drug effects | DNA, Mitochondrial - isolation & purification | RNA - isolation & purification | Cell Nucleus - metabolism | Nuclear Respiratory Factor 1 - biosynthesis | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | NF-E2-Related Factor 2 - genetics | DNA, Mitochondrial - biosynthesis | PPAR gamma - genetics | Prostaglandin-Endoperoxide Synthases - genetics | Transcription Factors - physiology | RNA-Binding Proteins - physiology | Rats | Transcription Factors - biosynthesis | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Blotting, Western | PPAR gamma - biosynthesis | RNA-Binding Proteins - drug effects | Mitochondria, Liver - drug effects | RNA - biosynthesis | Animals | Signal Transduction - drug effects | Cell Nucleus - drug effects | NF-E2-Related Factor 2 - biosynthesis | Proteins | Genetic research | Genetic aspects | Mitochondrial DNA | Biosynthesis | Ammonium perfluorooctanoate
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 07/2011, Volume 301, Issue 1, pp. 119 - 127
Journal Article
Journal Article
Antioxidants and Redox Signaling, ISSN 1523-0864, 07/2009, Volume 11, Issue 7, pp. 1501 - 1517
Journal Article
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2015, Volume 88, Issue Pt B, pp. 179 - 188
Journal Article
Nature Genetics, ISSN 1061-4036, 12/2015, Volume 47, Issue 12, pp. 1475 - 1481
Tumors have high energetic and anabolic needs for rapid cell growth and proliferation(1), and the serine biosynthetic pathway was recently identified as an... 
PATHWAYS | ACTIVATION | GLUTAMINE | ADENOCARCINOMA | GENETICS & HEREDITY | GENE-EXPRESSION | SENSITIVITY | TUMOR-GROWTH | TUMORIGENESIS | CARCINOMA | KEAP1 MUTATIONS | RNA, Small Interfering - genetics | NF-E2-Related Factor 2 - antagonists & inhibitors | Cell Proliferation | Lung Neoplasms - mortality | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Serine - biosynthesis | Immunoenzyme Techniques | Adenocarcinoma - metabolism | Carcinoma, Non-Small-Cell Lung - secondary | Biomarkers, Tumor - metabolism | NF-E2-Related Factor 2 - genetics | Adenocarcinoma - genetics | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | RNA, Messenger - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Carcinoma, Non-Small-Cell Lung - mortality | Adenocarcinoma - secondary | Blotting, Western | Xenograft Model Antitumor Assays | Animals | NF-E2-Related Factor 2 - metabolism | Biomarkers, Tumor - genetics | Mice | Adenocarcinoma - mortality | Apoptosis | Transcription factors | Cell metabolism | Development and progression | Genetic aspects | Genetic transcription | Lung cancer, Non-small cell | Properties | Health aspects | Medical research | Enzymes | Lung cancer | Biosynthesis | RNA polymerase | Metabolism | Gene expression | Experiments | Metabolites | Scientific imaging | Tumorigenesis | Labeling | Bioinformatics | Mass spectrometry
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 04/2010, Volume 333, Issue 1, pp. 140 - 151
The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) induces a battery of cytoprotective genes after oxidative stress. Nrf2 aids in... 
INSULIN | OXIDATIVE STRESS | ENZYME GENE-EXPRESSION | PATHWAY | LIVER | NRF2 TRANSCRIPTION FACTOR | PHARMACOLOGY & PHARMACY | ACETAMINOPHEN HEPATOTOXICITY | KNOCKOUT MICE | IDENTIFICATION | RESPONSIVE ELEMENT | Glucose-6-Phosphatase - genetics | Insulin - analysis | Pyruvate Kinase - biosynthesis | Diabetes Mellitus, Experimental - genetics | Male | Glucose Intolerance - pathology | NAD(P)H Dehydrogenase (Quinone) - genetics | Hyperglycemia - genetics | Phosphoenolpyruvate Carboxykinase (GTP) - genetics | RNA, Messenger - biosynthesis | Liver Glycogen - metabolism | Hyperglycemia - pathology | NF-E2-Related Factor 2 - genetics | Hyperglycemia - physiopathology | Glucose Intolerance - physiopathology | Diabetes Mellitus, Experimental - physiopathology | Glucose Intolerance - genetics | Blood Glucose - analysis | Diabetes Mellitus, Type 1 - physiopathology | Liver - metabolism | Mice, Inbred C57BL | Diabetes Mellitus, Type 1 - pathology | Diabetes Mellitus, Type 1 - genetics | Pancreas - pathology | Pancreas - metabolism | Phosphoenolpyruvate Carboxykinase (GTP) - biosynthesis | Mice, Knockout | Urodynamics | NAD(P)H Dehydrogenase (Quinone) - biosynthesis | Animals | Glucose-6-Phosphatase - biosynthesis | Diabetes Mellitus, Experimental - pathology | Mice | Pyrazines - pharmacology | Pyruvate Kinase - genetics | Index Medicus
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 05/2006, Volume 97, Issue 3, pp. 687 - 696
Astrocytes may modulate the survival of motor neurons in amyotrophic lateral sclerosis (ALS). We have previously shown that fibroblast growth factor‐1 (FGF‐1)... 
motor neurons | astrocytes | nuclear factor erythroid 2‐related factor 2 | p75 neurotrophin receptor | amyotrophic lateral sclerosis | glutathione | Motor neurons | Amyotrophic lateral sclerosis | Astrocytes | Glutathione | Nuclear factor erythroid 2-related factor 2 | Propionates - pharmacology | Embryo, Mammalian | Glutathione - metabolism | Nitrites - metabolism | Methionine - pharmacology | Glial Fibrillary Acidic Protein - metabolism | Hydroquinones - pharmacology | Quinolines - pharmacology | RNA, Messenger - biosynthesis | Glutathione - biosynthesis | Drug Interactions | Transfection - methods | Methionine - analogs & derivatives | Reverse Transcriptase Polymerase Chain Reaction - methods | Urea - analogs & derivatives | Spinal Cord - cytology | Receptor, Nerve Growth Factor - metabolism | Animals, Newborn | Astrocytes - drug effects | Cell Survival - drug effects | Blotting, Western - methods | Motor Neurons - physiology | Animals, Genetically Modified | Cells, Cultured | Nerve Growth Factor - pharmacology | Rats | Antioxidants - pharmacology | Pyrimidines - pharmacology | Coculture Techniques - methods | Enzyme Activation - drug effects | Rats, Sprague-Dawley | Nitrates - metabolism | Animals | Cell Count - methods | NF-E2-Related Factor 2 - metabolism | Fibroblast Growth Factor 1 - pharmacology | Urea - pharmacology | Astrocytes - metabolism | Nitric Oxide Synthase Type II - metabolism | Superoxide Dismutase | Neurosciences | Inhibitor drugs | Gene expression | Neurons | Spine | Motor ability
Journal Article