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Nature, ISSN 0028-0836, 04/2018, Volume 556, Issue 7699, pp. 113 - 117
Journal Article
Kidney International, ISSN 0085-2538, 06/2013, Volume 83, Issue 6, pp. 1029 - 1041
Oxidative stress and inflammation are mediators in the development and progression of chronic kidney disease (CKD) and its complications, and they are... 
ESRD | cardiovascular disease | CKD progression | inflammation | antioxidant therapy | oxidative stress | Oxidative stress | Cardiovascular disease | Antioxidant therapy | Inflammation | CYTOPROTECTIVE GENES | GLUTATHIONE SYNTHESIS | CARBON-MONOXIDE | AORTIC COARCTATION | REVERSE CHOLESTEROL TRANSPORT | BARDOXOLONE METHYL | CYCLOPENTENONE PROSTAGLANDINS | DENSITY-LIPOPROTEIN | UROLOGY & NEPHROLOGY | HEME OXYGENASE-1 | RENAL INJURY | Humans | Oleanolic Acid - analogs & derivatives | Kidney - immunology | NF-E2-Related Factor 2 - agonists | Renal Insufficiency, Chronic - drug therapy | Renal Insufficiency, Chronic - metabolism | Inflammation - metabolism | Kidney - metabolism | Time Factors | Inflammation - drug therapy | Renal Insufficiency, Chronic - diagnosis | Acute Kidney Injury - immunology | Inflammation - diagnosis | Oleanolic Acid - therapeutic use | Kidney Failure, Chronic - immunology | Kidney - drug effects | Renal Insufficiency, Chronic - immunology | Acute Kidney Injury - drug therapy | Kidney Failure, Chronic - drug therapy | Anti-Infective Agents - therapeutic use | Treatment Outcome | Inflammation - immunology | Disease Progression | Kidney Failure, Chronic - metabolism | Antioxidants - therapeutic use | Animals | NF-E2-Related Factor 2 - metabolism | Oxidative Stress - drug effects | Acute Kidney Injury - metabolism | bardoxolone methyl
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2015, Volume 290, Issue 29, pp. 17784 - 17795
Journal Article
Diabetes, ISSN 0012-1797, 11/2011, Volume 60, Issue 11, pp. 3055 - 3066
OBJECTIVE-To determine whether dietary compounds targeting NFE2-related factor 2 (Nrf2) activation can be used to attenuate renal damage and preserve renal... 
PERFORMANCE LIQUID-CHROMATOGRAPHY | GROWTH-FACTOR-BETA | OXIDATIVE STRESS | TGF-BETA | GLOMERULAR HYPERTROPHY | CELLS IN-VITRO | BARDOXOLONE METHYL | KIDNEY-FUNCTION | ENDOCRINOLOGY & METABOLISM | SULFORAPHANE PROTECTS | HIGH-DOSE THIAMINE | Acrolein - analogs & derivatives | Reactive Oxygen Species - metabolism | Kidney - pathology | Humans | Transforming Growth Factor beta1 - metabolism | NF-E2-Related Factor 2 - agonists | Mesangial Cells - drug effects | Dose-Response Relationship, Drug | Diabetic Nephropathies - physiopathology | RNA Interference | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Thiocyanates - pharmacology | NF-E2-Related Factor 2 - genetics | Thiocyanates - administration & dosage | Diabetic Nephropathies - prevention & control | Isothiocyanates | Extracellular Matrix Proteins - metabolism | Kidney - physiopathology | Acrolein - pharmacology | Thiocyanates - therapeutic use | Diabetic Nephropathies - pathology | Kidney - drug effects | Acrolein - administration & dosage | Diabetic Nephropathies - metabolism | Mice, Inbred C57BL | Cells, Cultured | Mesangial Cells - metabolism | Random Allocation | Mice, Knockout | Animals | NF-E2-Related Factor 2 - metabolism | Mesangial Cells - pathology | Acrolein - therapeutic use | Cell Proliferation - drug effects | Mice | RNA, Small Interfering | Oxidative Stress - drug effects | Care and treatment | Streptozocin | Diabetic nephropathies | Weight loss | Development and progression | Research | Health aspects | Risk factors | Pharmacology and Therapeutics
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2016, Volume 59, Issue 21, pp. 9967 - 9973
Journal Article
British Journal of Nutrition, ISSN 0007-1145, 01/2013, Volume 109, Issue 2, pp. 223 - 235
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 07/2016, Volume 25, Issue 2, pp. 61 - 77
Aims: This preclinical study was aimed at determining whether pharmacological targeting of transcription factor NRF2, a master controller of many homeostatic... 
Original Research Communications | OXIDATIVE STRESS | IN-VITRO | TRANSCRIPTION FACTOR NRF2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | MPTP MOUSE MODEL | ALPHA-SYNUCLEIN | HEME OXYGENASE-1 | AUTOPHAGY | NF-KAPPA-B | EXPRESSION | NEUROPROTECTION | Immunohistochemistry | NF-E2-Related Factor 2 - agonists | Parkinson Disease - drug therapy | RNA, Messenger - metabolism | Autophagy | Brain - metabolism | Gliosis - pathology | Neuroprotective Agents - pharmacology | Dimethyl Fumarate - pharmacology | NF-E2-Related Factor 2 - genetics | Parkinson Disease - metabolism | Neuroprotective Agents - administration & dosage | Disease Models, Animal | Gene Expression | Gliosis - genetics | Parkinson Disease - pathology | Synucleins - genetics | Gliosis - metabolism | RNA, Messenger - genetics | Drug Repositioning | Synucleins - metabolism | Mice, Knockout | Phenotype | Animals | Mice | Dimethyl Fumarate - administration & dosage | Care and treatment | Parkinson's disease | Research | Gene expression | Dimethyl | Neuroprotection | Brain | Therapy | Oxidative stress | Basal ganglia | Multiple sclerosis | Mesencephalon | Toxicity | Substantia nigra | Parkinsons disease | Innovations | Synuclein | Proteins | Neurotoxicity | Autopsy | Movement disorders | Dopamine receptors | Recombinant | Phenotypes | Dopamine | Wound healing | Neurodegenerative diseases | Pharmacology | Inflammation | Disease control | Ganglia | Lewy bodies | Gliosis | Cell death | Phagocytosis | Index Medicus
Journal Article
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 02/2014, Volume 67, pp. 387 - 395
Glycogen synthase kinase (GSK)-3β is a multifunctional protein that has been implicated in the pathological characteristics of Alzheimer’s disease (AD),... 
Oxidative stress | Antisense | Alzheimer’s disease (AD) | Nuclear factor-E2-related factor 2 (Nrf2) | Glycogen synthase kinase-3β (GSK-3β) | SAMP8 mice | Alzheimer's disease (AD) | NEUROFIBRILLARY TANGLES | PHOSPHORYLATION | SENESCENCE-ACCELERATED MOUSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLYCOGEN-SYNTHASE KINASE-3 | AMYLOID-BETA PROTEIN | KEAP1 | TAU-HYPERPHOSPHORYLATION | Glycogen synthase kinase-3 beta (GSK-3 beta) | ENDOCRINOLOGY & METABOLISM | A-BETA | NEURONS | EXPRESSION | Protein Carbonylation | Phosphorylation | Reactive Oxygen Species - metabolism | Oxidative Stress | Humans | Cerebral Cortex - pathology | Oligonucleotides, Antisense - metabolism | tau Proteins - metabolism | Glycogen Synthase Kinase 3 beta | Male | NF-E2-Related Factor 2 - agonists | Pattern Recognition, Visual - physiology | Glutathione Transferase - genetics | tau Proteins - genetics | NF-E2-Related Factor 2 - genetics | tau Proteins - antagonists & inhibitors | Disease Models, Animal | Alzheimer Disease - physiopathology | Cerebral Cortex - enzymology | Maze Learning - physiology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Alzheimer Disease - therapy | Gene Expression Regulation | Glutathione Transferase - metabolism | Alzheimer Disease - enzymology | Glycogen Synthase Kinase 3 - metabolism | Animals | Oligonucleotides, Antisense - genetics | Glycogen Synthase Kinase 3 - genetics | NF-E2-Related Factor 2 - metabolism | Mice | Alzheimer Disease - genetics | Blood-Brain Barrier | Genetic Therapy - methods | Memory - physiology | glycogen synthase kinase-3β (GSK-3β) | nuclear factor-E2-related factor 2 (Nrf2) | oxidative stress | antisense