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Medicinal Research Reviews, ISSN 0198-6325, 07/2012, Volume 32, Issue 4, pp. 687 - 726
Journal Article
Molecular Cell, ISSN 1097-2765, 07/2013, Volume 51, Issue 2, pp. 236 - 248
The tricarboxylic acid cycle enzyme fumarate hydratase (FH) has been identified as a tumor suppressor in a subset of human renal cell carcinomas. Human... 
ACTIVATION | METABOLISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | HYDRATASE | CHEMICAL-MODIFICATION | MUTATIONS | HYPOXIA | CANCER | RENAL-CELL CARCINOMA | CELL BIOLOGY | Antioxidants | Enzymes | Medical colleges | Thiols | Metabolites | Histones | Citric acid | Glutamine
Journal Article
Nature Genetics, ISSN 1061-4036, 12/2015, Volume 47, Issue 12, pp. 1475 - 1481
Tumors have high energetic and anabolic needs for rapid cell growth and proliferation(1), and the serine biosynthetic pathway was recently identified as an... 
PATHWAYS | ACTIVATION | GLUTAMINE | ADENOCARCINOMA | GENETICS & HEREDITY | GENE-EXPRESSION | SENSITIVITY | TUMOR-GROWTH | TUMORIGENESIS | CARCINOMA | KEAP1 MUTATIONS | RNA, Small Interfering - genetics | NF-E2-Related Factor 2 - antagonists & inhibitors | Cell Proliferation | Lung Neoplasms - mortality | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Serine - biosynthesis | Immunoenzyme Techniques | Adenocarcinoma - metabolism | Carcinoma, Non-Small-Cell Lung - secondary | Biomarkers, Tumor - metabolism | NF-E2-Related Factor 2 - genetics | Adenocarcinoma - genetics | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | RNA, Messenger - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Carcinoma, Non-Small-Cell Lung - mortality | Adenocarcinoma - secondary | Blotting, Western | Xenograft Model Antitumor Assays | Animals | NF-E2-Related Factor 2 - metabolism | Biomarkers, Tumor - genetics | Mice | Adenocarcinoma - mortality | Apoptosis | Transcription factors | Cell metabolism | Development and progression | Genetic aspects | Genetic transcription | Lung cancer, Non-small cell | Properties | Health aspects | Medical research | Enzymes | Lung cancer | Biosynthesis | RNA polymerase | Metabolism | Gene expression | Experiments | Metabolites | Scientific imaging | Tumorigenesis | Labeling | Bioinformatics | Mass spectrometry
Journal Article
Journal Article
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2015, Volume 125, Issue 7, pp. 2592 - 2608
The integrated stress response (ISR) is a critical mediator of cancer cell survival, and targeting the ISR inhibits tumor progression. Here, we have shown that... 
EPITHELIAL-MESENCHYMAL TRANSITION | MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | UNFOLDED PROTEIN RESPONSE | ER-STRESS | CANCER-CELL LINES | KINASE PERK | ACTIVATING TRANSCRIPTION FACTOR-4 | ENDOPLASMIC-RETICULUM STRESS | INTEGRATED STRESS-RESPONSE | TUMOR-GROWTH | Glioblastoma - enzymology | NF-E2-Related Factor 2 - antagonists & inhibitors | Reactive Oxygen Species - metabolism | Adenocarcinoma of Lung | Oxidative Stress | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Gene Knockdown Techniques | Heme Oxygenase-1 - genetics | Heterografts | Glioblastoma - genetics | Lung Neoplasms - secondary | Female | NF-E2-Related Factor 2 - genetics | Adenocarcinoma - genetics | Anoikis - physiology | Lung Neoplasms - genetics | Activating Transcription Factor 4 - antagonists & inhibitors | Heme Oxygenase-1 - biosynthesis | Lung Neoplasms - enzymology | Anoikis - genetics | Membrane Proteins - genetics | Neoplasm Invasiveness | Adenocarcinoma - enzymology | Activating Transcription Factor 4 - genetics | Enzyme Induction | Unfolded Protein Response | Gene Expression Regulation, Enzymologic | Neoplasm Metastasis - genetics | Membrane Proteins - biosynthesis | Animals | Activating Transcription Factor 4 - metabolism | Mice, Nude | Neoplasm Metastasis - pathology | NF-E2-Related Factor 2 - metabolism | Neoplasm Metastasis - physiopathology | Cell Line, Tumor | Mice | Cell Movement | Phosphorylation | Transcription factors | Lungs | Rodents | Colleges & universities | Hypoxia | Metastasis | Kinases | Stress response | Tumors | Cancer
Journal Article