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Nature (London), ISSN 1476-4687, 2013, Volume 506, Issue 7488, pp. 371 - 375
Cervical cancer is responsible for 10-15% of cancer-related deaths in women worldwide(1,2). The aetiological role of infection with high-risk human papilloma... 
DOMAIN | CATALOG | FUSION | MULTIDISCIPLINARY SCIENCES | FRAMEWORK | HUMAN-PAPILLOMAVIRUS | SENSITIVE DETECTION | CANCER | EXPRESSION | SOMATIC MUTATIONS | DISCOVERY | F-Box-WD Repeat-Containing Protein 7 | Receptor, ErbB-2 - genetics | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - virology | Genomics | Humans | E1A-Associated p300 Protein - genetics | Core Binding Factor beta Subunit - genetics | Case-Control Studies | Papillomaviridae - genetics | Tumor Suppressor Protein p53 - genetics | DNA Mutational Analysis | Mitogen-Activated Protein Kinase 1 - genetics | Cell Cycle Proteins - genetics | Female | NF-E2-Related Factor 2 - genetics | Adenocarcinoma - genetics | Papillomaviridae - physiology | HLA-B Antigens - genetics | Gene Expression Regulation, Neoplastic - genetics | Proto-Oncogene Proteins c-ets | Virus Integration - genetics | Proto-Oncogene Proteins - genetics | DNA Copy Number Variations - genetics | Transcriptome - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Uterine Cervical Neoplasms - genetics | Adenocarcinoma - virology | Genome, Human - genetics | Papillomavirus Infections - genetics | Exome - genetics | Uterine Cervical Neoplasms - virology | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Prevention | Gene mutations | Oncology, Experimental | Exome sequencing | Genetic aspects | Research | Cervical cancer | Cancer | Human papillomavirus | Mutation
Journal Article
Journal Article
Nature genetics, ISSN 1546-1718, 2015, Volume 47, Issue 12, pp. 1475 - 1481
.... Here we show that the activity of this pathway is highly heterogeneous and is regulated by NRF2, a transcription factor frequently deregulated in NSCLC... 
ACTIVATION | PROTEIN | GLUTAMINE | PATHWAY | GLUCOSE | GROWTH | GENETICS & HEREDITY | GENE-EXPRESSION | IMPAIR | CARCINOMA | KEAP1 MUTATIONS | RNA, Small Interfering - genetics | NF-E2-Related Factor 2 - antagonists & inhibitors | Cell Proliferation | Lung Neoplasms - mortality | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Serine - biosynthesis | Immunoenzyme Techniques | Adenocarcinoma - metabolism | Carcinoma, Non-Small-Cell Lung - secondary | Biomarkers, Tumor - metabolism | NF-E2-Related Factor 2 - genetics | Adenocarcinoma - genetics | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | RNA, Messenger - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Carcinoma, Non-Small-Cell Lung - mortality | Adenocarcinoma - secondary | Blotting, Western | Xenograft Model Antitumor Assays | Animals | NF-E2-Related Factor 2 - metabolism | Biomarkers, Tumor - genetics | Mice | Adenocarcinoma - mortality | Apoptosis | Transcription factors | Cell metabolism | Development and progression | Genetic aspects | Genetic transcription | Lung cancer, Non-small cell | Properties | Health aspects | Medical research | Enzymes | Lung cancer | Biosynthesis | RNA polymerase | Metabolism | Gene expression | Experiments | Metabolites | Scientific imaging | Tumorigenesis | Labeling | Bioinformatics | Mass spectrometry
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2015, Volume 125, Issue 4, pp. 1433 - 1445
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 07/2012, Volume 342, Issue 1, pp. 81 - 90
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an antioxidant-activated transcription factor that recently emerged as a critical regulator of cellular defense against oxidative and inflammatory lesions. Resveratrol (Res... 
TRANSCRIPTION FACTOR NRF2 | CARCINOGENESIS | PROTECTION | PHENOLIC ANTIOXIDANTS | INDUCED LUNG INJURY | RATS | PHARMACOLOGY & PHARMACY | EXPRESSION | PULMONARY-FIBROSIS | MICE LACKING | MOLECULAR-MECHANISMS | Tumor Necrosis Factor-alpha - metabolism | NF-E2-Related Factor 2 - antagonists & inhibitors | Epithelial Cells - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Antioxidants - metabolism | Epithelial Cells - drug effects | Humans | Transforming Growth Factor beta1 - metabolism | Tumor Necrosis Factor-alpha - genetics | Apoptosis - genetics | Stilbenes - pharmacology | Paraquat - antagonists & inhibitors | Myofibroblasts - metabolism | Inflammation - metabolism | Cell Death - genetics | Mitochondria - genetics | Inflammation - drug therapy | Cytoprotection - drug effects | NF-E2-Related Factor 2 - genetics | Response Elements - genetics | Cell Death - drug effects | Paraquat - pharmacology | Interleukin-6 - metabolism | Fibroblasts - metabolism | Interleukin-6 - genetics | Cells, Cultured | Oxidative Stress - genetics | Mitochondria - metabolism | Signal Transduction - genetics | Transforming Growth Factor beta1 - genetics | Mitochondria - drug effects | Myofibroblasts - drug effects | Mice, Knockout | Response Elements - drug effects | Animals | Signal Transduction - drug effects | Fibroblasts - drug effects | NF-E2-Related Factor 2 - metabolism | Cytoprotection - genetics | Mice | Oxidative Stress - drug effects | Index Medicus
Journal Article
Genome biology, ISSN 1474-760X, 2015, Volume 16, Issue 1, p. 105
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 02/2014, Volume 67, pp. 91 - 102
...β1/2, and Zeb1/2 signaling. In vivo in streptozotocin-induced diabetic mice, we found that aldose reductase deficiency caused significant elevations... 
Epithelial–mesenchymal transition | Free radicals | Aldose reductase | miR-200a-3p/141-3p | Fibrogenesis | Antioxidant defense | Epithelial-mesenchymal transition | Aldehyde Reductase - genetics | Cytoskeletal Proteins - genetics | Kidney Cortex - metabolism | Transforming Growth Factor beta2 - metabolism | Homeodomain Proteins - metabolism | Transforming Growth Factor beta1 - metabolism | Diabetes Mellitus, Experimental - genetics | Male | MicroRNAs - metabolism | Zinc Finger E-box Binding Homeobox 2 | Kruppel-Like Transcription Factors - metabolism | Aldehyde Reductase - metabolism | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Diabetes Mellitus, Experimental - metabolism | Kelch-Like ECH-Associated Protein 1 | Repressor Proteins - metabolism | Cell Line | Diabetic Nephropathies - pathology | Diabetic Nephropathies - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Repressor Proteins - genetics | Diabetic Nephropathies - genetics | Kidney Cortex - pathology | Mice, Transgenic | Signal Transduction - genetics | Transforming Growth Factor beta1 - genetics | Mesangial Cells - metabolism | Homeodomain Proteins - genetics | Animals | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mesangial Cells - pathology | Diabetes Mellitus, Experimental - pathology | Mice | MicroRNAs - genetics | Transforming Growth Factor beta2 - genetics | Adaptor Proteins, Signal Transducing - metabolism | Kruppel-Like Transcription Factors - genetics | Zinc Finger E-box-Binding Homeobox 1
Journal Article
Free radical biology & medicine, ISSN 0891-5849, 2012, Volume 52, Issue 2, pp. 462 - 472
Journal Article
The FEBS journal, ISSN 1742-464X, 2012, Volume 279, Issue 22, pp. 4121 - 4130
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2016, Volume 126, Issue 6, pp. 2356 - 2366
Journal Article