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Nature, ISSN 0028-0836, 2014, Volume 506, Issue 7488, pp. 371 - 375
Cervical cancer is responsible for 10-15% of cancer-related deaths in women worldwide(1,2). The aetiological role of infection with high-risk human papilloma... 
FUSION | MULTIDISCIPLINARY SCIENCES | SQUAMOUS-CELL CARCINOMA | HUMAN-PAPILLOMAVIRUS | SENSITIVE DETECTION | SAMPLES | DNA-SEQUENCING DATA | EXPRESSION | SOMATIC MUTATIONS | HUMAN CANCER | DISCOVERY | F-Box-WD Repeat-Containing Protein 7 | Receptor, ErbB-2 - genetics | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - virology | Genomics | Humans | E1A-Associated p300 Protein - genetics | Core Binding Factor beta Subunit - genetics | Case-Control Studies | Papillomaviridae - genetics | Tumor Suppressor Protein p53 - genetics | DNA Mutational Analysis | Mitogen-Activated Protein Kinase 1 - genetics | Cell Cycle Proteins - genetics | Female | NF-E2-Related Factor 2 - genetics | Adenocarcinoma - genetics | Papillomaviridae - physiology | HLA-B Antigens - genetics | Gene Expression Regulation, Neoplastic - genetics | Proto-Oncogene Proteins c-ets | Virus Integration - genetics | Proto-Oncogene Proteins - genetics | DNA Copy Number Variations - genetics | Transcriptome - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Uterine Cervical Neoplasms - genetics | Adenocarcinoma - virology | Genome, Human - genetics | Papillomavirus Infections - genetics | Exome - genetics | Uterine Cervical Neoplasms - virology | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Prevention | Gene mutations | Oncology, Experimental | Exome sequencing | Genetic aspects | Research | Cervical cancer | Cancer | Human papillomavirus | Mutation | Index Medicus
Journal Article
Genome Biology, ISSN 1474-7596, 05/2015, Volume 16, Issue 1, pp. 105 - 105
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2015, Volume 125, Issue 4, pp. 1433 - 1445
Oxidative stress contributes to the loss of neurons in many disease conditions as well as during normal aging; however, small-molecule agents that reduce... 
RETINAL DEGENERATION | MEDICINE, RESEARCH & EXPERIMENTAL | DIFFUSIBLE FACTOR | OXIDATIVE STRESS | OPTIC-NERVE | PLACEBO-CONTROLLED PHASE-3 | MOUSE MODEL | AXON REGENERATION | PARTIAL RECOVERY | RETINITIS-PIGMENTOSA | CONE CELL-DEATH | NF-E2-Related Factor 2 - physiology | Dependovirus - genetics | Genetic Therapy | Catalase - therapeutic use | NF-E2-Related Factor 2 - therapeutic use | Oxidative Stress - physiology | Genetic Vectors - therapeutic use | Mice, Mutant Strains | Superoxide Dismutase - physiology | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Neurons - physiology | NF-E2-Related Factor 2 - genetics | Optic Nerve Injuries - therapy | Transcription Factors - therapeutic use | Retinal Ganglion Cells - physiology | Transcription Factors - physiology | Catalase - physiology | Mice, Inbred C57BL | Optic Nerve Injuries - physiopathology | Nerve Crush | Retinal Cone Photoreceptor Cells - physiology | Genetic Vectors - genetics | Superoxide Dismutase - therapeutic use | Animals | Retinitis Pigmentosa - therapy | Mice | Nerve Degeneration | Apoptosis | Oxidative stress | Transcription factors | Nervous system | Development and progression | Degeneration | Genetic aspects | Health aspects | Antioxidants | Proteins | Enzymes | Statistical analysis | Optic nerve | Disease | Genes | Lipids | Photoreceptors | Physiology | Index Medicus | Abridged Index Medicus | Genetics | Neuroscience | Ophthalmology | Therapeutics
Journal Article
Nature, ISSN 0028-0836, 07/2011, Volume 475, Issue 7354, pp. 106 - 110
Reactive oxygen species (ROS) are mutagenic and may thereby promote cancer(1). Normally, ROS levels are tightly controlled by an inducible antioxidant program... 
TRANSFORMATION | OXIDATIVE STRESS | ACTIVATION | INHIBITION | K-RAS | PATHWAY | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | HEME OXYGENASE-1 | MUTATIONS | EXPRESSION | NIH 3T3 Cells | Cell Proliferation | Pancreatic Neoplasms - metabolism | Reactive Oxygen Species - metabolism | Cytoskeletal Proteins - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Antioxidants - metabolism | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | MAP Kinase Signaling System | Mitogen-Activated Protein Kinase Kinases - metabolism | Cell Transformation, Neoplastic - genetics | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Intracellular Signaling Peptides and Proteins - genetics | Kelch-Like ECH-Associated Protein 1 | Proto-Oncogene Proteins B-raf - metabolism | Fibroblasts - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Oncogenes - genetics | Oxidation-Reduction | Pancreatic Neoplasms - pathology | Cells, Cultured | Pancreatic Neoplasms - genetics | NF-E2-Related Factor 2 - deficiency | Cell Transformation, Neoplastic - metabolism | Animals | Proto-Oncogene Proteins B-raf - genetics | Genes, myc - genetics | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Alleles | Cell Line, Tumor | Mice | Adaptor Proteins, Signal Transducing - metabolism | Cell Transformation, Neoplastic - pathology | Polymerase chain reaction | Usage | Reactive oxygen species | Physiological aspects | Research | Gene expression | Oncogenes | Studies | Mass spectrometry | Rodents | Evacuations & rescues | Cancer | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2010, Volume 12, Issue 3, pp. 213 - 223
Impaired selective turnover of p62 by autophagy causes severe liver injury accompanied by the formation of p62-positive inclusions and upregulation of... 
OXIDATIVE STRESS | PROTEIN | MECHANISM | CUL3-BASED E3 LIGASE | STRUCTURAL BASIS | DLG MOTIFS | DEGRADATION | MICE | BETA-CELL MASS | INDUCTION | CELL BIOLOGY | Adaptor Proteins, Signal Transducing - chemistry | Liver - pathology | Microtubule-Associated Proteins - genetics | Cytoskeletal Proteins - genetics | Gene Expression - genetics | Protein Interaction Domains and Motifs - physiology | Sequestosome-1 Protein | Humans | Oxidative Stress - physiology | Crystallography, X-Ray | Hepatocytes - pathology | Autophagy - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Hepatocytes - metabolism | Liver - physiopathology | Heat-Shock Proteins - genetics | Mutation - physiology | Transfection | Organ Size - genetics | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Inclusion Bodies - metabolism | Kelch-Like ECH-Associated Protein 1 | Cell Line | Binding, Competitive - physiology | Heat-Shock Proteins - metabolism | Liver - metabolism | Models, Molecular | Mice, Transgenic | Cytoskeletal Proteins - chemistry | Mice, Knockout | Protein Interaction Mapping | Autophagy-Related Protein 7 | Animals | Models, Biological | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Calorimetry | Signal Transduction - physiology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Heat-Shock Proteins - chemistry | Protein Binding - physiology | Autophagy (Cytology) | Care and treatment | Transcription factors | Liver diseases | Physiological aspects | Genetic aspects | Research | Index Medicus
Journal Article
The Journal of Physiology, ISSN 0022-3751, 09/2016, Volume 594, Issue 18, pp. 5195 - 5207
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 07/2012, Volume 342, Issue 1, pp. 81 - 90
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an antioxidant-activated transcription factor that recently emerged as a critical regulator of cellular... 
TRANSCRIPTION FACTOR NRF2 | CARCINOGENESIS | PROTECTION | PHENOLIC ANTIOXIDANTS | INDUCED LUNG INJURY | RATS | PHARMACOLOGY & PHARMACY | EXPRESSION | PULMONARY-FIBROSIS | MICE LACKING | MOLECULAR-MECHANISMS | Tumor Necrosis Factor-alpha - metabolism | NF-E2-Related Factor 2 - antagonists & inhibitors | Epithelial Cells - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Antioxidants - metabolism | Epithelial Cells - drug effects | Humans | Transforming Growth Factor beta1 - metabolism | Tumor Necrosis Factor-alpha - genetics | Apoptosis - genetics | Stilbenes - pharmacology | Paraquat - antagonists & inhibitors | Myofibroblasts - metabolism | Inflammation - metabolism | Cell Death - genetics | Mitochondria - genetics | Inflammation - drug therapy | Cytoprotection - drug effects | NF-E2-Related Factor 2 - genetics | Response Elements - genetics | Cell Death - drug effects | Paraquat - pharmacology | Interleukin-6 - metabolism | Fibroblasts - metabolism | Interleukin-6 - genetics | Cells, Cultured | Oxidative Stress - genetics | Mitochondria - metabolism | Signal Transduction - genetics | Transforming Growth Factor beta1 - genetics | Mitochondria - drug effects | Myofibroblasts - drug effects | Mice, Knockout | Response Elements - drug effects | Animals | Signal Transduction - drug effects | Fibroblasts - drug effects | NF-E2-Related Factor 2 - metabolism | Cytoprotection - genetics | Mice | Oxidative Stress - drug effects | Index Medicus
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 07/2012, Volume 40, Issue 7, pp. 1366 - 1379
The transcription factors aryl hydrocarbon receptor (AhR), constitutive androstane receptor (CAR), pregnane X receptor (PXR), peroxisome proliferator-activated... 
TRANSCRIPTION FACTORS | PRIMARY HUMAN HEPATOCYTES | ANTIOXIDANT RESPONSE ELEMENT | MESSENGER-RNA EXPRESSION | CONSTITUTIVE ANDROSTANE RECEPTOR | BILIARY-EXCRETION | PROLIFERATOR-ACTIVATED RECEPTOR | MOUSE-LIVER | PHARMACOLOGY & PHARMACY | MICROSOMAL-ENZYME INDUCERS | PREGNANE-X-RECEPTOR | Inactivation, Metabolic | Receptors, Steroid - metabolism | Cytochrome P-450 Enzyme System - metabolism | Male | NAD(P)H Dehydrogenase (Quinone) - genetics | Organic Anion Transporters - metabolism | Glucuronosyltransferase - genetics | Organic Anion Transporters - genetics | Glutathione Transferase - genetics | Receptors, Aryl Hydrocarbon - metabolism | Female | NF-E2-Related Factor 2 - genetics | Sulfotransferases - metabolism | Aldehyde Dehydrogenase - metabolism | Sulfotransferases - genetics | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Receptors, Aryl Hydrocarbon - genetics | Glutathione Transferase - metabolism | Aldehyde Dehydrogenase - genetics | PPAR alpha - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | Mice, Knockout | Gene Expression Regulation, Enzymologic | Transcription Factors - metabolism | Animals | Glucuronosyltransferase - metabolism | Receptors, Steroid - genetics | NF-E2-Related Factor 2 - metabolism | Cytochrome P-450 Enzyme System - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Mice | PPAR alpha - metabolism | Multidrug Resistance-Associated Proteins | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 02/2014, Volume 67, pp. 91 - 102
Aberrant regulation in oxidative stress, fibrogenesis, and the epithelial–mesenchymal transition (EMT) in renal cells under hyperglycemic conditions... 
Epithelial–mesenchymal transition | Free radicals | Aldose reductase | miR-200a-3p/141-3p | Fibrogenesis | Antioxidant defense | Epithelial-mesenchymal transition | Aldehyde Reductase - genetics | Cytoskeletal Proteins - genetics | Kidney Cortex - metabolism | Transforming Growth Factor beta2 - metabolism | Homeodomain Proteins - metabolism | Transforming Growth Factor beta1 - metabolism | Diabetes Mellitus, Experimental - genetics | Male | MicroRNAs - metabolism | Zinc Finger E-box Binding Homeobox 2 | Kruppel-Like Transcription Factors - metabolism | Aldehyde Reductase - metabolism | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Diabetes Mellitus, Experimental - metabolism | Kelch-Like ECH-Associated Protein 1 | Repressor Proteins - metabolism | Cell Line | Diabetic Nephropathies - pathology | Diabetic Nephropathies - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Repressor Proteins - genetics | Diabetic Nephropathies - genetics | Kidney Cortex - pathology | Mice, Transgenic | Signal Transduction - genetics | Transforming Growth Factor beta1 - genetics | Mesangial Cells - metabolism | Homeodomain Proteins - genetics | Animals | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mesangial Cells - pathology | Diabetes Mellitus, Experimental - pathology | Mice | MicroRNAs - genetics | Transforming Growth Factor beta2 - genetics | Adaptor Proteins, Signal Transducing - metabolism | Kruppel-Like Transcription Factors - genetics | Zinc Finger E-box-Binding Homeobox 1 | Index Medicus
Journal Article
by Linehan, W. Marston and Spellman, Paul T and Ricketts, Christopher J and Creighton, Chad J and Fei, Suzanne S and Davis, Caleb and Wheeler, David A and Murray, Bradley A and Schmidt, Laura and Vocke, Cathy D and Peto, Myron and Al Mamun, Abu Amar M and Shinbrot, Eve and Sethi, Anurag and Brooks, Samira and Rathmell, W. Kimryn and Brooks, Angela N and Hoadley, Katherine A and Robertson, A. Gordon and Brooks, Denise and Bowlby, Reanne and Sadeghi, Sara and Shen, Hui and Weisenberger, Daniel J and Bootwalla, Moiz and Baylin, Stephen B and Laird, Peter W and Cherniack, Andrew D and Saksena, Gordon and Haake, Scott and Li, Jun and Liang, Han and Lu, Yiling and Mills, Gordon B and Akbani, Rehan and Leiserson, Mark D.M and Raphael, Benjamin J and Anur, Pavana and Bottaro, Donald and Albiges, Laurence and Barnabas, Nandita and Choueiri, Toni K and Czerniak, Bogdan and Godwin, Andrew K and Hakimi, A. Ari and Ho, Thai H and Hsieh, James and Ittmann, Michael and Kim, William Y and Krishnan, Bhavani and Merino, Maria J and Shaw, Kenna R. Mills and Reuter, Victor E and Reznik, Ed and Shelley, Carl S and Shuch, Brian and Signoretti, Sabina and Srinivasan, Ramaprasad and Tamboli, Pheroze and Thomas, George and Tickoo, Satish and Burnett, Kenneth and Crain, Daniel and Gardner, Johanna and Lau, Kevin and Mallery, David and Morris, Scott and Paulauskis, Joseph D and Penny, Robert J and Shelton, Candace and Shelton, W. Troy and Sherman, Mark and Thompson, Eric and Yena, Peggy and Avedon, Melissa T and Bowen, Jay and Gastier-Foster, Julie M and Gerken, Mark and Leraas, Kristen M and Lichtenberg, Tara M and Ramirez, Nilsa C and Santos, Tracie and Wise, Lisa and Zmuda, Erik and Demchok, John A and Felau, Ina and Hutter, Carolyn M and Sheth, Margi and Sofia, Heidi J and Tarnuzzer, Roy and Wang, Zhining and Yang, Liming and Zenklusen, Jean C and Zhang, Jiashan and Ayala, Brenda and Baboud, Julien and Chudamani, Sudha and Liu, Jia and Lolla, Laxmi and Naresh, Rashi and ... and The Cancer Genome Atlas Research Network and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
The New England Journal of Medicine, ISSN 0028-4793, 01/2016, Volume 374, Issue 2, pp. 135 - 145
Papillary renal-cell carcinomas account for 15 to 20% of kidney cancers. Type 1, which is often multifocal and more indolent, was associated with mutations in... 
FUMARATE | MEDICINE, GENERAL & INTERNAL | MET PROTOONCOGENE |