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Nature, ISSN 0028-0836, 07/2011, Volume 475, Issue 7354, pp. 106 - 110
Reactive oxygen species (ROS) are mutagenic and may thereby promote cancer(1). Normally, ROS levels are tightly controlled by an inducible antioxidant program... 
TRANSFORMATION | OXIDATIVE STRESS | ACTIVATION | INHIBITION | K-RAS | PATHWAY | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | HEME OXYGENASE-1 | MUTATIONS | EXPRESSION | NIH 3T3 Cells | Cell Proliferation | Pancreatic Neoplasms - metabolism | Reactive Oxygen Species - metabolism | Cytoskeletal Proteins - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Antioxidants - metabolism | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | MAP Kinase Signaling System | Mitogen-Activated Protein Kinase Kinases - metabolism | Cell Transformation, Neoplastic - genetics | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Intracellular Signaling Peptides and Proteins - genetics | Kelch-Like ECH-Associated Protein 1 | Proto-Oncogene Proteins B-raf - metabolism | Fibroblasts - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Oncogenes - genetics | Oxidation-Reduction | Pancreatic Neoplasms - pathology | Cells, Cultured | Pancreatic Neoplasms - genetics | NF-E2-Related Factor 2 - deficiency | Cell Transformation, Neoplastic - metabolism | Animals | Proto-Oncogene Proteins B-raf - genetics | Genes, myc - genetics | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Alleles | Cell Line, Tumor | Mice | Adaptor Proteins, Signal Transducing - metabolism | Cell Transformation, Neoplastic - pathology | Polymerase chain reaction | Usage | Reactive oxygen species | Physiological aspects | Research | Gene expression | Oncogenes | Studies | Mass spectrometry | Rodents | Evacuations & rescues | Cancer | Index Medicus
Journal Article
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 07/2010, Volume 299, Issue 1, pp. H18 - H24
Ungvari Z, Bagi Z, Feher A, Recchia FA, Sonntag WE, Pearson K, de Cabo R, Csiszar A. Resveratrol confers endothelial protection via activation of the... 
Nuclear factor-E | Endothelial cell | Gracilis | related factor-2 | Resveratrol | MITOCHONDRIAL SUPEROXIDE-PRODUCTION | KAPPA-B ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | VASCULAR OXIDATIVE STRESS | endothelial cell | NITRIC-OXIDE SYNTHASE | NECROSIS-FACTOR-ALPHA | nuclear factor-E-2-related factor-2 | CORONARY-ARTERIES | gracilis | CALORIC RESTRICTION | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | TNF-ALPHA | resveratrol | SMALL-MOLECULE ACTIVATORS | Heme Oxygenase-1 - metabolism | Apoptosis - drug effects | Cardiovascular Diseases - prevention & control | Humans | Transcriptional Activation - drug effects | Male | Intracellular Signaling Peptides and Proteins - metabolism | Stilbenes - pharmacology | Cardiovascular Diseases - pathology | Coronary Vessels - metabolism | Dose-Response Relationship, Drug | Transfection | RNA Interference | NF-E2-Related Factor 2 - genetics | Glutathione Synthase - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Kelch-Like ECH-Associated Protein 1 | Genes, Reporter | Cytoprotection | Disease Models, Animal | Cardiovascular Diseases - etiology | Cardiovascular Diseases - physiopathology | Coronary Vessels - drug effects | Dietary Fats - adverse effects | Cardiovascular Diseases - metabolism | Endothelial Cells - metabolism | Cells, Cultured | Antioxidants - pharmacology | Femoral Artery - drug effects | NF-E2-Related Factor 2 - deficiency | Mice, Inbred ICR | Mice, Knockout | Response Elements - drug effects | Animals | NF-E2-Related Factor 2 - metabolism | Femoral Artery - metabolism | Glucose - metabolism | NAD(P)H Dehydrogenase (Quinone) - metabolism | Mice | Oxidative Stress - drug effects | Vasodilation - drug effects | Endothelial Cells - pathology | Endothelial Cells - drug effects | Physiological aspects | Care and treatment | Health aspects | Endothelium | Antioxidants | Diet | Cardiovascular disease | Effects | Diabetes | Ribonucleic acid--RNA | Epidemiology | Cells | Index Medicus | nuclear factor-E2-related factor-2
Journal Article
Molecular Cell, ISSN 1097-2765, 07/2013, Volume 51, Issue 2, pp. 236 - 248
Journal Article
Cancer Cell, ISSN 1535-6108, 10/2011, Volume 20, Issue 4, pp. 511 - 523
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2010, Volume 12, Issue 3, pp. 213 - 223
Impaired selective turnover of p62 by autophagy causes severe liver injury accompanied by the formation of p62-positive inclusions and upregulation of... 
OXIDATIVE STRESS | PROTEIN | MECHANISM | CUL3-BASED E3 LIGASE | STRUCTURAL BASIS | DLG MOTIFS | DEGRADATION | MICE | BETA-CELL MASS | INDUCTION | CELL BIOLOGY | Adaptor Proteins, Signal Transducing - chemistry | Liver - pathology | Microtubule-Associated Proteins - genetics | Cytoskeletal Proteins - genetics | Gene Expression - genetics | Protein Interaction Domains and Motifs - physiology | Sequestosome-1 Protein | Humans | Oxidative Stress - physiology | Crystallography, X-Ray | Hepatocytes - pathology | Autophagy - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Hepatocytes - metabolism | Liver - physiopathology | Heat-Shock Proteins - genetics | Mutation - physiology | Transfection | Organ Size - genetics | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Inclusion Bodies - metabolism | Kelch-Like ECH-Associated Protein 1 | Cell Line | Binding, Competitive - physiology | Heat-Shock Proteins - metabolism | Liver - metabolism | Models, Molecular | Mice, Transgenic | Cytoskeletal Proteins - chemistry | Mice, Knockout | Protein Interaction Mapping | Autophagy-Related Protein 7 | Animals | Models, Biological | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Calorimetry | Signal Transduction - physiology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Heat-Shock Proteins - chemistry | Protein Binding - physiology | Autophagy (Cytology) | Care and treatment | Transcription factors | Liver diseases | Physiological aspects | Genetic aspects | Research | Index Medicus
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 10/2011, Volume 20, Issue 4, pp. 524 - 537
Journal Article
Brain, ISSN 0006-8950, 2011, Volume 134, Issue 3, pp. 678 - 692
Inflammation and oxidative stress are thought to promote tissue damage in multiple sclerosis. Thus, novel therapeutics enhancing cellular resistance to free... 
oral therapy | transcription factor | autoimmune demyelination | multiple sclerosis | neuroprotection | astrocyte | oxidative stress | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | ENZYME INDUCERS | DIMETHYLFUMARATE | SPINAL-CORD | NEUROSCIENCES | HUMAN ENDOTHELIAL-CELLS | CLINICAL NEUROLOGY | RESPONSE ELEMENT | TRANSCRIPTION FACTOR NRF2 | MULTIPLE-SCLEROSIS | IN-VIVO | Embryo, Mammalian | Antioxidants - metabolism | Humans | Green Fluorescent Proteins - genetics | Neuroprotective Agents - pharmacology | Time Factors | Statistics, Nonparametric | Aldehyde Reductase - metabolism | Nogo Proteins | Sleep - physiology | Tandem Mass Spectrometry - methods | Disease Models, Animal | Fumarates - therapeutic use | Myelin-Oligodendrocyte Glycoprotein | Glycoproteins - adverse effects | CD3 Complex - metabolism | Motor Neurons - metabolism | Signal Transduction - drug effects | Axons - pathology | Fumarates - pharmacology | NF-E2-Related Factor 2 - metabolism | Encephalomyelitis, Autoimmune, Experimental - prevention & control | Mice | Peptide Fragments - adverse effects | Oxidative Stress - drug effects | Myelin Proteins - metabolism | Neuroprotective Agents - therapeutic use | Chromatography, High Pressure Liquid - methods | Encephalomyelitis, Autoimmune, Experimental - etiology | Transfection | Astrocytes - immunology | Mass Spectrometry | Motor Neurons - cytology | Antigens, Differentiation - metabolism | Female | Spinal Cord - cytology | Motor Neurons - drug effects | Multiple Sclerosis - metabolism | Astrocytes - drug effects | Cytokines - metabolism | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | Cells, Cultured | Hydrogen Peroxide - pharmacology | Axons - metabolism | 2',3'-Cyclic-Nucleotide Phosphodiesterases - metabolism | Gene Expression Regulation - drug effects | Animals | Multiple Sclerosis - pathology | NAD(P)H Dehydrogenase (Quinone) - metabolism | Cell Proliferation - drug effects | Index Medicus | Abridged Index Medicus
Journal Article