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PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 2, p. e87897
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 12, p. e52782
Journal Article
European journal of nutrition, ISSN 1436-6215, 2015, Volume 56, Issue 2, pp. 705 - 713
Obesity is usually associated with low-grade inflammation, which impairs insulin action. The amino acid, taurine (TAU), regulates glucose homeostasis and lipid... 
Taurine supplementation | Obesity | Chemistry | Nutrition | Cytokines | Monosodium glutamate | INDUCED-INHIBITION | INDUCED INFLAMMATION | NECROSIS-FACTOR-ALPHA | HYPOTHALAMIC OBESITY | NEONATAL-RATS | NUTRITION & DIETETICS | CYTOKINE PRODUCTION | INSULIN-RESISTANCE | GENE-EXPRESSION | MICE | Obesity - diet therapy | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Rats, Wistar | I-kappa B Proteins - agonists | Obesity - immunology | Tumor Necrosis Factor-alpha - blood | Male | NF-KappaB Inhibitor alpha - agonists | NF-KappaB Inhibitor alpha - genetics | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Anti-Obesity Agents - therapeutic use | Adiposity | Hyperinsulinism - etiology | Injections, Subcutaneous | Sodium Glutamate - adverse effects | Obesity - etiology | Taurine - therapeutic use | Hyperinsulinism - diet therapy | Biomarkers - metabolism | Hyperinsulinism - metabolism | Intra-Abdominal Fat - immunology | Interleukin-4 - antagonists & inhibitors | Interleukin-4 - metabolism | Gene Expression Regulation | Biomarkers - blood | Intra-Abdominal Fat - metabolism | Obesity - metabolism | Interleukin-4 - blood | Animals | Hyperinsulinism - immunology | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | NF-KappaB Inhibitor alpha - metabolism | Protein Processing, Post-Translational | Dietary Supplements | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Sodium Glutamate - administration & dosage
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2010, Volume 285, Issue 21, pp. 16096 - 16104
... (also called Bortezomib or Velcade) is the first proteasome inhibitor approved for newly diagnosed and relapsed multiple myeloma and is currently being tested in many clinical trials against other types of cancers... 
LUNG-CARCINOMA CELLS | CANCER-CELLS | TARGET | APOPTOSIS | ACTIVATION | THERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYNTHETIC RETINOID CD437 | DEATH | PROTEOLYSIS | CALPASTATIN | Signal Transduction | Proteosomes | Calpain | NF-kappaB | PS-341 | Protein | Gene Regulation | Degradation | IkappaBalpha | Protease | Proteases | Apoptosis | Cancer
Journal Article
Bioscience, Biotechnology, and Biochemistry, ISSN 0916-8451, 07/2017, Volume 81, Issue 7, pp. 1305 - 1313
We investigated the anti-inflammatory effects of 3α-hydroxy-lup-20(29)-en-23, 28-dioic acid (HLEDA)-a lupane-type triterpene isolated from leaves of... 
anti-inflammatory | HMGB1 | TNF-α | IL-1β | 3α-hydroxy-lup-20-en-23,28-dioic acid | Anti-inflammatory | CELLS | TNF-alpha | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOOD SCIENCE & TECHNOLOGY | 3 alpha-hydroxy-lup-20-en-23 | IL-1 beta | TRITERPENE | TUMOR-NECROSIS-FACTOR | IN-VITRO | INFLAMMATORY-BOWEL-DISEASE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | LATE MEDIATOR | NITRIC-OXIDE | 28-dioic acid | ACANTHOPANAX-GRACILISTYLUS | CHEMISTRY, APPLIED | NF-KAPPA-B | Tumor Necrosis Factor-alpha - metabolism | Triterpenes - pharmacology | Tumor Necrosis Factor-alpha - genetics | NF-KappaB Inhibitor alpha - genetics | Interleukin-1beta - genetics | Lipopolysaccharides - antagonists & inhibitors | HMGB1 Protein - genetics | HMGB1 Protein - secretion | Dose-Response Relationship, Drug | NF-KappaB Inhibitor alpha - antagonists & inhibitors | Interleukin-1beta - metabolism | Anti-Inflammatory Agents - isolation & purification | Phosphorylation - drug effects | HMGB1 Protein - antagonists & inhibitors | Interleukin-1beta - antagonists & inhibitors | Cell Line | Nitric Oxide - biosynthesis | Gene Expression | Anti-Inflammatory Agents - pharmacology | Nitric Oxide - antagonists & inhibitors | Inflammation | Macrophages - cytology | Macrophages - metabolism | Animals | Drugs, Chinese Herbal - chemistry | NF-KappaB Inhibitor alpha - metabolism | Lipopolysaccharides - pharmacology | Triterpenes - isolation & purification | Macrophages - drug effects | Mice | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
Oncotarget, ISSN 1949-2553, 2016, Volume 7, Issue 48, pp. 78883 - 78895
.... Selinexor, a first-in-class Selective Inhibitor of Nuclear Export (SINE) compound, binds covalently to XPO1 and blocks its function... 
NF-κB | XPO1 | SINE | Proteasome inhibitors | Selinexor | SIGNAL | ACTIVATION | PHOSPHORYLATION | proteasome inhibitors | NECROSIS-FACTOR-ALPHA | CRM1 | CANCER | CELL BIOLOGY | NF-kappa B | selinexor | SERUM-LEVELS | PROTEINS | CORRELATE | KINASES | Osteosarcoma - drug therapy | Phosphorylation | Humans | Drug Resistance, Neoplasm | NF-KappaB Inhibitor alpha - genetics | NF-kappa B - metabolism | Bortezomib - pharmacology | Bone Neoplasms - pathology | Transcription Factor RelA - genetics | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Cell Nucleus - metabolism | Fibrosarcoma - pathology | Transfection | RNA Interference | Time Factors | Cell Nucleus - pathology | Proteolysis | Female | Bone Neoplasms - drug therapy | Cell Death - drug effects | Hydrazines - pharmacology | Bone Neoplasms - enzymology | Osteosarcoma - enzymology | Proteasome Inhibitors - pharmacology | Mice, SCID | Mice, Inbred ICR | Drug Synergism | Triazoles - pharmacology | Fibrosarcoma - genetics | Animals | Karyopherins - metabolism | NF-kappa B - genetics | Signal Transduction - drug effects | Transcription Factor RelA - metabolism | Active Transport, Cell Nucleus - drug effects | NF-KappaB Inhibitor alpha - metabolism | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Cell Line, Tumor | Proteasome Endopeptidase Complex - metabolism | Cell Nucleus - drug effects | Fibrosarcoma - enzymology | Karyopherins - antagonists & inhibitors | Fibrosarcoma - drug therapy | Osteosarcoma - pathology | Receptors, Cytoplasmic and Nuclear - metabolism
Journal Article
Journal of Antibiotics, ISSN 0021-8820, 08/2017, Volume 70, Issue 9, pp. 929 - 936
Allantopyrone A is a fungal metabolite that uniquely possesses two alpha,beta-unsaturated carbonyl moieties... 
DEATH DOMAIN | APOPTOSIS | ACTIVATION | PYRONE METABOLITE | SUPERFAMILIES | MICROBIOLOGY | IMMUNOLOGY | CELL-DEATH | ENDOPHYTIC FUNGUS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | INFLAMMATION | BIOLOGY | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Tumor Necrosis Factor-alpha - metabolism | Molecular Weight | Antibiotics, Antineoplastic - pharmacology | Transcription Factor RelA - antagonists & inhibitors | Humans | Tumor Necrosis Factor-alpha - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - chemistry | Receptors, Tumor Necrosis Factor, Type I - metabolism | Pyrones - pharmacology | Recombinant Fusion Proteins - metabolism | NF-KappaB Inhibitor alpha - antagonists & inhibitors | Protein Processing, Post-Translational - drug effects | Receptors, Tumor Necrosis Factor, Type I - chemistry | HEK293 Cells | TNF Receptor-Associated Factor 2 - chemistry | HSP90 Heat-Shock Proteins - chemistry | Cysteine - metabolism | HSP90 Heat-Shock Proteins - genetics | Protein Interaction Domains and Motifs | Peptide Fragments - genetics | NF-KappaB Inhibitor alpha - chemistry | A549 Cells | Peptide Fragments - metabolism | TNF Receptor-Associated Factor 2 - metabolism | Cysteine - chemistry | Recombinant Fusion Proteins - chemistry | Receptors, Tumor Necrosis Factor, Type I - antagonists & inhibitors | Receptors, Tumor Necrosis Factor, Type I - genetics | TNF Receptor-Associated Factor 2 - antagonists & inhibitors | Peptide Fragments - chemistry | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Tumor Necrosis Factor-alpha - chemistry | Signal Transduction - drug effects | Transcription Factor RelA - metabolism | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Peptide Fragments - antagonists & inhibitors | NF-KappaB Inhibitor alpha - metabolism | Transcription Factor RelA - chemistry | HSP90 Heat-Shock Proteins - metabolism | Genes, Reporter - drug effects | Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors | Protein Multimerization - drug effects | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
Cellular physiology and biochemistry, ISSN 1421-9778, 2018, Volume 48, Issue 5, pp. 2035 - 2045
.... However, the mechanism is still unclear. Methods: We generated stable cell lines expressing the super-repressor form of the NF-kappa B inhibitor I kappa B alpha and cell lines with lentivirus vector-mediated silencing of the HIF-1 alpha gene... 
Dihydroartemisinin | HIF-1a | NF-?B | Photodynamic therapy | VEGF | Esophageal cancer | APOPTOSIS | ACTIVATION | RESPONSIVENESS | PHYSIOLOGY | HIF-1 alpha | ANGIOGENESIS | CYCLE ARREST | FACTOR-KAPPA-B | DETERMINES | NF-kappa B | INHIBITION | ANTIANGIOGENIC TREATMENT | EXPRESSION | Photosensitizing Agents - therapeutic use | Humans | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | NF-KappaB Inhibitor alpha - genetics | NF-kappa B - metabolism | Photochemotherapy | Esophageal Neoplasms - pathology | NF-KappaB Inhibitor alpha - antagonists & inhibitors | Artemisinins - pharmacology | RNA Interference | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Esophageal Neoplasms - metabolism | Female | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Aminolevulinic Acid - therapeutic use | Animals | Artemisinins - therapeutic use | Signal Transduction - drug effects | Mice, Nude | NF-KappaB Inhibitor alpha - metabolism | Cell Line, Tumor | Vascular Endothelial Growth Factors - genetics | Vascular Endothelial Growth Factors - metabolism | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Esophageal Neoplasms - drug therapy | RNA, Small Interfering - metabolism | Medical research | Cancer therapies | Stomach cancer | Angiogenesis | Chemotherapy | Pancreatic cancer | Cell cycle | Hypoxia | Laboratory animals | Vascular endothelial growth factor | Tumors | Apoptosis | NF-κB | HIF-1α
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 538, Issue 7623, pp. 114 - 117
The common participation of oncogenic KRAS proteins in many of the most lethal human cancers, together with the ease of detecting somatic KRAS mutant alleles... 
TARGET | CRM1/XPO1 | ACTIVATION | MODELS | MULTIDISCIPLINARY SCIENCES | KINASE | YAP | MUTATIONS | INHIBITORS | IDENTIFICATION | Lung Neoplasms - drug therapy | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Lung Neoplasms - metabolism | Cell Survival - genetics | Lung Neoplasms - pathology | NF-kappa B - metabolism | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | RNA Interference | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Female | Verteporfin | Protein-Serine-Threonine Kinases - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Follistatin-Related Proteins - genetics | Lung Neoplasms - genetics | Cell Survival - drug effects | NF-kappa B - antagonists & inhibitors | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Porphyrins - pharmacology | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Animals | Karyopherins - metabolism | Active Transport, Cell Nucleus - drug effects | Genes, Lethal - genetics | NF-KappaB Inhibitor alpha - metabolism | Nuclear Proteins - antagonists & inhibitors | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | RNA, Small Interfering | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Cell Nucleus - drug effects | Karyopherins - antagonists & inhibitors | Receptors, Cytoplasmic and Nuclear - metabolism | Care and treatment | Genetic aspects | Gene mutations | Health aspects | Guanosine triphosphatase | Lung cancer | Genomics | Genomes | Kinases | Drug resistance | Gene expression | Drug dosages
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 1995, Volume 92, Issue 23, pp. 10599 - 10603
The nuclear translocation of NF-κ B follows the degradation of its inhibitor, Iκ Bα, an event coupled with stimulation-dependent inhibitor phosphorylation... 
T lymphocytes | Enzymes | Phosphorylation | Ubiquitins | Cell lines | Reagents | HeLa cells | Reticulocytes | Molecular weight | Cells | CELLS | ACTIVATION | COMPLEX | PHASE | PROTEIN | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION FACTOR | CYCLIN | Biodegradation | Research | Observations
Journal Article