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Nature, ISSN 0028-0836, 03/2011, Volume 471, Issue 7340, pp. 637 - 641
Journal Article
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 506, Issue 7489, pp. 451 - 455
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2012, Volume 122, Issue 6, pp. 1973 - 1990
EC activation and dysfunction have been linked to a variety of vascular inflammatory disease states. The function of microRNAs (miRNAs) in vascular EC... 
CELL-ADHESION MOLECULE-1 | TRANSCRIPTION FACTORS | MEDICINE, RESEARCH & EXPERIMENTAL | TUMOR-NECROSIS-FACTOR | DEPENDENT INDUCTION | LEUKOCYTE RECRUITMENT | HUMAN-ENDOTHELIAL-CELLS | ACUTE MYELOID-LEUKEMIA | PROGNOSTIC-SIGNIFICANCE | EXPRESSION PROFILES | SIGNAL-TRANSDUCTION PATHWAY | alpha Karyopherins - metabolism | Endotoxemia - therapy | Leukocytes - pathology | Vasculitis - metabolism | Acute Lung Injury - therapy | Endotoxemia - genetics | Humans | NF-kappa B - immunology | Critical Illness | Acute Lung Injury - genetics | MicroRNAs - metabolism | NF-kappa B - metabolism | Endotoxemia - pathology | Vasculitis - immunology | Leukocytes - immunology | Vasculitis - genetics | alpha Karyopherins - immunology | E-Selectin - genetics | Endotoxemia - immunology | Vascular Cell Adhesion Molecule-1 - genetics | Acute Lung Injury - metabolism | Vascular Cell Adhesion Molecule-1 - immunology | Vasculitis - therapy | Lipopolysaccharides - toxicity | Endothelial Cells - metabolism | E-Selectin - metabolism | E-Selectin - immunology | MicroRNAs - immunology | Acute Lung Injury - pathology | Endothelial Cells - immunology | Animals | NF-kappa B - genetics | alpha Karyopherins - genetics | Acute Lung Injury - immunology | Mice | MicroRNAs - genetics | Endothelial Cells - pathology | Endotoxemia - metabolism | Vascular Cell Adhesion Molecule-1 - metabolism | Leukocytes - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Blood, ISSN 0006-4971, 06/2011, Volume 117, Issue 23, pp. 6287 - 6296
B-cell receptor (BCR) signaling is aberrantly activated in chronic lymphocytic leukemia (CLL). Bruton tyrosine kinase (BTK) is essential to BCR signaling and... 
B-CELLS | CLL | FLUDARABINE PLUS CYCLOPHOSPHAMIDE | APOPTOTIC CELL-DEATH | RITUXIMAB | SURVIVAL SIGNALS | LYMPHOMA | DRUG-RESISTANCE | INHIBITOR | HEMATOLOGY | EXPRESSION | T-Lymphocytes - enzymology | Apoptosis - drug effects | Humans | Tumor Necrosis Factor-alpha - genetics | Cell Survival - genetics | Apoptosis - genetics | Male | NF-kappa B - metabolism | Neoplasm Proteins - antagonists & inhibitors | Receptors, Antigen, B-Cell - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Neoplasm Proteins - genetics | Interleukin-6 - metabolism | Cell Survival - drug effects | Drug Screening Assays, Antitumor - methods | Interleukin-6 - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Gene Expression Regulation, Leukemic - drug effects | Pyrimidines - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | B-Cell Activating Factor - metabolism | CD40 Ligand - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Gene Expression Regulation, Enzymologic - genetics | Cell Line, Tumor | Receptors, Antigen, B-Cell - genetics | Mice | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Mitogen-Activated Protein Kinase 1 - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Tumor Necrosis Factor-alpha - metabolism | Gene Expression Regulation, Enzymologic - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Gene Expression Regulation, Leukemic - genetics | Protein-Tyrosine Kinases - genetics | CD40 Ligand - metabolism | MAP Kinase Signaling System - genetics | Female | Interleukin-4 - genetics | Protein-Tyrosine Kinases - biosynthesis | Pyrazoles - pharmacology | B-Lymphocytes - enzymology | Neoplasm Proteins - biosynthesis | Interleukin-4 - metabolism | Phosphatidylinositol 3-Kinases - genetics | Animals | MAP Kinase Signaling System - drug effects | NF-kappa B - genetics | B-Cell Activating Factor - genetics | Cell Proliferation - drug effects | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia
Journal Article
Journal Article
Nature, ISSN 0028-0836, 04/2011, Volume 472, Issue 7343, pp. 361 - 365
TRIM5 is a RING domain-E3 ubiquitin ligase that restricts infection by human immunodeficiency virus (HIV)-1 and other retroviruses immediately following virus... 
HIV-1 | CYCLOPHILIN-A | UNANCHORED POLYUBIQUITIN CHAINS | TRIM5-ALPHA PROTEIN | RECOGNITION | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | RESISTANCE | INFECTION | RESTRICTION | Capsid - chemistry | Receptors, Pattern Recognition - immunology | Humans | Ubiquitin - metabolism | NF-kappa B - metabolism | Lipopolysaccharides - immunology | Transcription Factor AP-1 - metabolism | Receptors, Pattern Recognition - metabolism | Signal Transduction - immunology | Ubiquitin-Protein Ligases - immunology | HIV-1 - chemistry | HEK293 Cells | Carrier Proteins - immunology | Cell Line | Retroviridae - chemistry | Ubiquitin-Protein Ligases - metabolism | Retroviridae - immunology | MAP Kinase Kinase Kinases - metabolism | Transcription Factors - metabolism | Capsid - immunology | Carrier Proteins - genetics | Immunity, Innate - immunology | HIV-1 - immunology | Carrier Proteins - metabolism | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Lipopolysaccharides - pharmacology | Protein Binding | Enzyme Activation | Ubiquitin-Protein Ligases - genetics | Signal transduction | Efficiency | RNA polymerase | Pattern recognition | Kinases | Evacuations & rescues | Immune system | Index Medicus | HIV-1/immunology | Capsid/immunology | Life Sciences | MAP Kinase Kinase Kinases/metabolism | Carrier Proteins/immunology | Immunology | Transcription Factors/metabolism | Capsid/chemistry | HIV-1/chemistry | Ubiquitin/metabolism | Receptors, Pattern Recognition/immunology | Retroviridae/chemistry | Ubiquitin-Protein Ligases/immunology | Ubiquitin-Conjugating Enzymes/metabolism | HumansImmunity, Innate/immunology | Lipopolysaccharides/pharmacology | Signal Transduction/drug effects | Retroviridae/immunology | Transcription Factor AP-1/metabolism | Lipopolysaccharides/immunology | Ubiquitin-Protein Ligases/metabolism | Carrier Proteins/genetics | Signal Transduction/immunology | NF-kappa B/metabolism | Ubiquitin-Protein Ligases/genetics | Carrier Proteins/metabolism | Receptors, Pattern Recognition/metabolism
Journal Article
Molecular Cell, ISSN 1097-2765, 12/2012, Volume 48, Issue 5, pp. 771 - 784
Many types of human tumor cells have overexpressed pyruvate kinase M2 (PKM2). However, the mechanism underlying this increased PKM2 expression remains to be... 
GROWTH-FACTOR RECEPTOR | PROTEIN-KINASE-C | PYRUVATE-KINASE | UBIQUITIN LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA | BETA-CATENIN | TUMOR-GROWTH | TRANSCRIPTIONAL REGULATION | CANCER | CELL BIOLOGY | Receptor, Epidermal Growth Factor - genetics | Up-Regulation | Glioblastoma - enzymology | Humans | NF-kappa B - metabolism | Ubiquitination | Glioblastoma - genetics | RNA Interference | Cell Transformation, Neoplastic - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Signal Transduction | Membrane Proteins - genetics | Lactic Acid - metabolism | Protein Kinase C-epsilon - genetics | Brain Neoplasms - genetics | Polypyrimidine Tract-Binding Protein - metabolism | Mice, Nude | Glioblastoma - pathology | Protein Kinase C-epsilon - metabolism | Cell Line, Tumor | Glucose - metabolism | Mice | Enzyme Activation | Mutation | Neoplasm Transplantation | Phosphorylation | Prognosis | Serine | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | Receptor, Epidermal Growth Factor - metabolism | Neoplasm Grading | Transfection | I-kappa B Kinase - metabolism | HEK293 Cells | Female | Membrane Proteins - metabolism | Genes, Reporter | Promoter Regions, Genetic | Brain Neoplasms - enzymology | Phospholipase C gamma - metabolism | Mutagenesis, Site-Directed | Heterogeneous-Nuclear Ribonucleoproteins - metabolism | Epidermal Growth Factor - metabolism | Thyroid Hormones - genetics | Cell Transformation, Neoplastic - metabolism | Gene Expression Regulation, Enzymologic | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | NF-kappa B - genetics | Transcription Factor RelA - metabolism | Thyroid Hormones - metabolism | Glycolysis | Cell Transformation, Neoplastic - pathology | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 05/2012, Volume 36, Issue 5, pp. 742 - 754
In vitro data suggest that a subgroup of NLR proteins, including NLRP12, inhibits the transcription factor NF-κB, although physiologic and disease-relevant... 
MULTIPLE-MYELOMA | CELLS | ACTIVATION | PROTEIN | ANGIOGENESIS | PATHWAY | INNATE | IKK-ALPHA | IMMUNOLOGY | TUMOR-GROWTH | CUTTING EDGE | Colonic Neoplasms - genetics | Colitis - genetics | Colitis - pathology | Male | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Colonic Neoplasms - metabolism | Proto-Oncogene Proteins c-akt - genetics | Chemokine CXCL12 - genetics | Cell Transformation, Neoplastic - genetics | TNF Receptor-Associated Factor 3 - genetics | Proto-Oncogene Proteins c-akt - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Chemokine CXCL13 - genetics | Signal Transduction | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | TNF Receptor-Associated Factor 3 - metabolism | Cell Transformation, Neoplastic - metabolism | Disease Progression | Animals | Chemokine CXCL12 - metabolism | NF-kappa B - genetics | Chemokine CXCL13 - metabolism | Colonic Neoplasms - pathology | Colitis - metabolism | Mice | Cell Transformation, Neoplastic - pathology | Index Medicus | CXCL12 protein | Transcription factors | CXCL13 protein | Extracellular signal-regulated kinase | AKT protein | Data processing | Nlr protein | Inflammation | Signal transduction | NF- Kappa B protein |