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1. Full Text Membrane organization and tumorigenesis - The NF2 tumor suppressor, Merlin
by McClatchey, Andrea I and Giovannini, Marco
Genes & development, ISSN 0890-9369, 10/2005, Volume 19, Issue 19, pp. 2265 - 2277
Meninges | Ependyma | ERM proteins | Merlin/NF2 | Membrane organization | Schwann cells | Genetics & Heredity | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Cell Biology | Neoplasms - metabolism | Mammals - metabolism | Tumor Suppressor Proteins - metabolism | Humans | Actins - metabolism | Neoplasms - ultrastructure | Animals | Cell Adhesion - physiology | Neurofibromin 2 - deficiency | Cytoskeleton - metabolism | Signal Transduction - physiology | Cell Membrane - metabolism | Neurofibromin 2 - metabolism | Index Medicus
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2. Full Text Molecular insights into NF2/Merlin tumor suppressor function
by Cooper, Jonathan and Giancotti, Filippo G
FEBS letters, ISSN 0014-5793, 08/2014, Volume 588, Issue 16, pp. 2743 - 2752
Contact inhibition | DDB1 and Cul4-Associated Factor 1 | Hippo signaling pathway | Neurofibromatosis Type 2 | Merlin | CRL4 E3 ubiquitin ligase | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasms - metabolism | Animals | Humans | Protein Processing, Post-Translational | Neoplasms - pathology | Neurofibromin 2 - metabolism | Neurofibromin 2 - chemistry | Protein Transport | Ubiquitin | Gene expression | Tumors | Index Medicus | DCAF1 | NF2
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3. Full Text Loss of tumor suppressor Merlin results in aberrant activation of Wnt/β-catenin signaling in cancer
by Morrow, K. Adam and Das, Shamik and Meng, Erhong and Menezes, Mitchell E and Bailey, Sarah K and Metge, Brandon J and Buchsbaum, Donald J and Samant, Rajeev S and Shevde, Lalita A
Oncotarget, ISSN 1949-2553, 2016, Volume 7, Issue 14, pp. 17991 - 18005
Breast cancer | NF2 | Wnt | β -catenin | Merlin | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Up-Regulation | Cell Proliferation - genetics | Neurofibromin 2 - genetics | Pancreatic Neoplasms - metabolism | Humans | Pancreatic Neoplasms - pathology | Transcriptional Activation | Pancreatic Neoplasms - genetics | beta Catenin - metabolism | Breast Neoplasms - metabolism | Breast Neoplasms - genetics | Transfection | MCF-7 Cells | Wnt Signaling Pathway - genetics | Breast Neoplasms - pathology | Neurofibromin 2 - deficiency | Cell Line, Tumor | Neurofibromin 2 - metabolism | Index Medicus
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4. Full Text Cluster of differentiation 44 promotes osteosarcoma progression in mice lacking the tumor suppressor Merlin
by Ma, Junzhi and Klemm, Janina and Gerardo‐Ramírez, Monserrat and Frappart, Lucien and Castven, Darko and Becker, Diana and Zoch, Ansgar and Parent, Romain and Bartosch, Birke and Minnich, Kerstin and Giovannini, Marco and Danckwardt, Sven and Hartmann, Nils and Morrison, Helen and Herrlich, Peter and Marquardt, Jens U and Hartmann, Monika
International journal of cancer, ISSN 0020-7136, 11/2020, Volume 147, Issue 9, pp. 2564 - 2577
NF2 | metastasis | CD44 | Merlin | osteosarcoma | Life Sciences & Biomedicine | Oncology | Science & Technology | Antigens | Metastasis | Osteosarcoma | Endothelium | Integrins | Phenotypes | Intravenous administration | Neurofibromin 2 | Osteosarcoma cells | Endothelial cells | Metastases | Mutants | Bone cancer | CD44 antigen | Tumor suppressor genes | Cell migration | Index Medicus
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5. Full Text Merlin sumoylation is required for its tumor suppressor activity
by Qi, Q and Liu, X and Brat, D J and Ye, K
Oncogene, ISSN 0950-9232, 10/2014, Volume 33, Issue 41, pp. 4893 - 4903
tumor suppressor | merlin | sumoylation | Akt | NF2 | Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Line | NIH 3T3 Cells | Neurofibromin 2 - genetics | Phosphorylation | Humans | Cytoplasm - metabolism | p21-Activated Kinases - metabolism | Protein Transport | Animals | MCF-7 Cells | Sumoylation | Lysine - metabolism | Mice | HeLa Cells | Protein Stability | Proto-Oncogene Proteins c-akt - metabolism | Binding Sites | Genes, Tumor Suppressor | Neurofibromin 2 - metabolism | Arginine - metabolism | Amino Acid Substitution | Oncology, Experimental | Neoplastic processes | Genetic research | Cytoskeletal proteins | Genetic aspects | Genetic engineering | Research | Properties | Cancer | Signal transduction | Protein expression | Membranes | Index Medicus
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6. Full Text Tumor suppressor NF2/merlin is a microtubule stabilizer
by Smole, Zlatko and Thoma, Claudio R and Applegate, Kathryn T and Duda, Maria and Gutbrodt, Katrin L and Danuser, Gaudenz and Krek, Wilhelm
Cancer research (Chicago, Ill.), ISSN 0008-5472, 01/2014, Volume 74, Issue 1, pp. 353 - 362
Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Tumors | Neoplasms - metabolism | Microtubules - metabolism | Neurofibromin 2 - genetics | Neoplasms - genetics | Signal Transduction | Microtubules - genetics | Humans | Microtubules - physiology | Neurofibromin 2 - physiology | Genes, Tumor Suppressor | Neurofibromin 2 - metabolism | Index Medicus | siRNA screening | tumor suppressor genes | NF2 | life-cell imaging | microtubule dynamics
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7. Full Text Re-expression of the tumor suppressor NF2 merlin inhibits invasiveness in mesothelioma cells and negatively regulates FAK
by Poulikakos, P.I and Xiao, G.-H and Gallagher, R and Jablonski, S and Jhanwar, S.C and Testa, J.R
Oncogene, ISSN 0950-9232, 09/2006, Volume 25, Issue 44, pp. 5960 - 5968
FAK | Mesothelioma | NF2 | Invasion | Merlin | Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes | Neurofibromin 2 - genetics | Mesothelioma - pathology | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Humans | Neoplasm Invasiveness - prevention & control | Cells, Cultured | Neurofibromin 2 - biosynthesis | Signal Transduction - genetics | Neurofibromin 2 - physiology | Cell Migration Inhibition | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Down-Regulation - genetics | Mesothelioma - prevention & control | Focal Adhesion Protein-Tyrosine Kinases - physiology | Animals | Mesothelioma - enzymology | Cell Line, Tumor | Mice | Inhibitor drugs | Gene expression | Kinases | Tumors | Index Medicus
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8. Full Text Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors
by McClatchey, Andrea I and Saotome, Ichiko and Mercer, Kim and Crowley, Denise and Gusella, James F and Bronson, Roderick T and Jacks, Tyler
Genes & development, ISSN 0890-9369, 04/1998, Volume 12, Issue 8, pp. 1121 - 1133
Cytoskeleton | Metastasis | NF2 | Osteosarcoma | Tumor suppressor | Merlin | Genetics & Heredity | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Cell Biology | Membrane Proteins - genetics | Neoplasms, Experimental - secondary | Humans | Mice, Inbred C57BL | Neoplasm Proteins - physiology | Neurofibromin 2 | Male | Genes, Neurofibromatosis 2 | Genes, p53 | Animals | Mutagenesis | Membrane Proteins - physiology | Neoplasms, Experimental - genetics | Female | Heterozygote | Mice | Tumor Cells, Cultured | Neoplasm Proteins - genetics | Neoplasms, Experimental - physiopathology | Neurofibromatosis | Tumor suppressor genes | Cell membranes | Genetic aspects | Research | Index Medicus | cytoskeleton | metastasis | tumor suppressor | Research Paper | osteosarcoma
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