X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (899) 899
nfat (827) 827
animals (570) 570
humans (542) 542
nfatc transcription factors - metabolism (366) 366
mice (347) 347
biochemistry & molecular biology (335) 335
calcineurin (332) 332
cell biology (306) 306
signal transduction (217) 217
expression (205) 205
t cells (201) 201
activation (194) 194
transcription factors (189) 189
gene-expression (175) 175
gene expression (174) 174
calcineurin - metabolism (173) 173
immunology (169) 169
nfatc transcription factors - genetics (164) 164
nuclear factor (164) 164
cells, cultured (157) 157
calcium (155) 155
cyclosporine-a (153) 153
article (152) 152
proteins (146) 146
male (142) 142
nfatc transcription factors (136) 136
transcription factors - metabolism (127) 127
rats (121) 121
transcription (114) 114
dna-binding proteins - metabolism (110) 110
cells (108) 108
gene expression regulation (106) 106
cell line (103) 103
activated t-cells (101) 101
analysis (101) 101
phosphorylation (101) 101
calcium - metabolism (100) 100
jurkat cells (100) 100
transcription factor (99) 99
lymphocytes (96) 96
nuclear proteins (95) 95
apoptosis (93) 93
differentiation (92) 92
nf-at protein (91) 91
female (88) 88
mice, inbred c57bl (84) 84
pharmacology & pharmacy (82) 82
signal transduction - drug effects (82) 82
cyclosporine - pharmacology (79) 79
inhibition (75) 75
biophysics (74) 74
inflammation (74) 74
t-lymphocytes - immunology (73) 73
t-lymphocytes - metabolism (72) 72
cancer (71) 71
calcineurin inhibitors (70) 70
cell nucleus - metabolism (68) 68
genes (68) 68
mice, knockout (68) 68
protein binding (68) 68
research (68) 68
transcription factors - genetics (68) 68
in-vivo (67) 67
medicine, research & experimental (67) 67
molecular sequence data (67) 67
nf-kappa-b (67) 67
transcription factor nfat (67) 67
promoter regions, genetic (66) 66
transcription, genetic (64) 64
oncology (63) 63
base sequence (62) 62
binding (60) 60
binding sites (60) 60
growth (60) 60
signal transduction - physiology (60) 60
t-cells (60) 60
lymphocyte activation (59) 59
physiological aspects (59) 59
protein (59) 59
gene (57) 57
genetic aspects (55) 55
nuclear factor of activated t cells (55) 55
hypertrophy (54) 54
cytokines (53) 53
calcium signaling (51) 51
cell line, tumor (51) 51
kinases (51) 51
proliferation (51) 51
gene expression regulation - drug effects (50) 50
immunosuppressive agents - pharmacology (50) 50
dna-binding proteins - genetics (49) 49
nf-kappa b - metabolism (49) 49
biology (48) 48
calcineurin - genetics (48) 48
cardiac-hypertrophy (48) 48
physiology (48) 48
transfection (48) 48
cell proliferation (46) 46
family (46) 46
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Chemical & Pharmaceutical Bulletin, ISSN 0009-2363, 2005, Volume 53, Issue 1, pp. 114 - 117
Two new compounds were isolated from the stem and twigs of Ribes fasciculatum var. chinense and their structures were identified to be... 
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2011, Volume 108, Issue 4, pp. 1573 - 1578
Acute activation of cells by tumor necrosis factor (TNF) has been well characterized, but little is known about later phases of TNF responses that are relevant... 
T lymphocytes | Myeloid cells | Monocytes | Receptors | Osteoclasts | Bones | Gene expression regulation | Inflammation | Macrophages | Cell fusion | Calcium signaling | Polykaryon | TRANSCRIPTION FACTORS | RHEUMATOID-ARTHRITIS | RANKL | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | calcium signaling | BONE HOMEOSTASIS | polykaryon | TUMOR-NECROSIS-FACTOR | NFAT ACTIVATION | CALCINEURIN | OSTEOCLAST DIFFERENTIATION | EXPRESSION | Gene Expression - drug effects | Calcium - metabolism | Monocytes - cytology | Humans | Immunoblotting | Monocytes - metabolism | NF-kappa B - metabolism | Osteoclasts - cytology | Transcription Factor AP-1 - metabolism | RANK Ligand - pharmacology | Time Factors | Tumor Necrosis Factors - pharmacology | Intracellular Space - drug effects | NFATC Transcription Factors - metabolism | Cells, Cultured | Macrophages - cytology | Reverse Transcriptase Polymerase Chain Reaction | Osteoclasts - metabolism | Monocytes - drug effects | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Intracellular Space - metabolism | Macrophages - drug effects | Microscopy, Fluorescence | Osteoclasts - drug effects | NFATC Transcription Factors - genetics | Proteins | Calcium, Dietary | Tumor necrosis factor | Research | T cells | Gene expression | Properties | Calcium | TNF inhibitors | T cell receptors | Arthritis | Physiology | Inflammatory diseases | Index Medicus | Transcription factors | c-Jun protein | Lymphocytes T | NF-AT protein | Bone resorption | Calcium signalling | Osteoclastogenesis | Signal transduction | Cell activation | NF- Kappa B protein | Transcription activation | TRANCE protein | Biological Sciences
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2011, Volume 286, Issue 2, pp. 1025 - 1036
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 03/2001, Volume 193, Issue 5, pp. 607 - 620
Cyclosporin A (CsA) is an immunosuppressive drug that inhibits the activity of transcription factors of the nuclear factor of activated T cells (NFAT) family,... 
Angiogenesis | Cyclooxygenase | Cyclosporin A | VEGF | NFAT | DIABETIC-RETINOPATHY | MEDICINE, RESEARCH & EXPERIMENTAL | angiogenesis | SYNTHASE GENE | cyclosporin A | cyclooxygenase | KAPPA-B | IMMUNOLOGY | RESPONSE ELEMENT | COLON-CANCER | NF-ATC | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | GENE-EXPRESSION | TRANSCRIPTION FACTOR | UP-REGULATION | Endothelium, Vascular - cytology | Neovascularization, Physiologic - drug effects | Vascular Endothelial Growth Factor A | Endothelial Growth Factors - metabolism | Cyclosporine - pharmacology | Vascular Endothelial Growth Factors | Cyclooxygenase 2 | Humans | Endothelium, Vascular - drug effects | Endothelial Growth Factors - pharmacology | Nitrobenzenes - pharmacology | Cell Migration Inhibition | DNA-Binding Proteins - metabolism | Cornea - blood supply | Cornea - drug effects | Transfection | Isoenzymes - metabolism | Lymphokines - antagonists & inhibitors | Lymphokines - metabolism | Lymphokines - pharmacology | Genes, Reporter | Prostaglandin-Endoperoxide Synthases - genetics | Dinoprostone - pharmacology | Promoter Regions, Genetic | Mutagenesis, Site-Directed | Isoenzymes - genetics | Mice, Inbred C57BL | Cells, Cultured | Angiogenesis Inhibitors - pharmacology | NFATC Transcription Factors | Sulfonamides - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Nuclear Proteins | Endothelial Growth Factors - antagonists & inhibitors | Gene Expression Regulation - drug effects | Membrane Proteins | Transcription Factors - metabolism | Cell Movement - drug effects | Animals | Cyclooxygenase 2 Inhibitors | Endothelium, Vascular - metabolism | Prostaglandin-Endoperoxide Synthases - metabolism | Mice | Isoenzymes - antagonists & inhibitors | cyclooxygenase 2 | NF-AT protein | vascular endothelial growth factor | Index Medicus | Original
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2014, Volume 289, Issue 39, pp. 26752 - 26761
Th2 memory lymphocytes have imprinted their Il4 genes epigenetically for expression in dependence of T cell receptor restimulation. However, in a given... 
LOCUS-CONTROL REGION | PROBABILISTIC REGULATION | MEMORY | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR NFAT1 | HELPER-CELLS | DEPHOSPHORYLATION | GENE-EXPRESSION | IL-4 EXPRESSION | GATA-3 | LYMPHOCYTES | Cell Nucleus - immunology | GATA3 Transcription Factor - genetics | Phosphorylation - physiology | Active Transport, Cell Nucleus - physiology | E1A-Associated p300 Protein - immunology | GATA3 Transcription Factor - immunology | E1A-Associated p300 Protein - genetics | E1A-Associated p300 Protein - metabolism | STAT6 Transcription Factor - genetics | Th2 Cells - immunology | DNA Helicases - immunology | Transcription Factor RelA - genetics | Interleukin-4 - biosynthesis | Cell Nucleus - metabolism | NFATC Transcription Factors - immunology | Adaptor Proteins, Signal Transducing - immunology | Transcription Factor RelA - immunology | Receptors, Antigen, T-Cell - immunology | Interleukin-4 - genetics | Nuclear Proteins - genetics | Response Elements - physiology | Transcription Factors - immunology | DNA Helicases - genetics | GATA3 Transcription Factor - metabolism | Receptors, Antigen, T-Cell - metabolism | NFATC Transcription Factors - metabolism | Gene Expression Regulation - physiology | Mice, Transgenic | Nuclear Proteins - metabolism | Th2 Cells - cytology | STAT6 Transcription Factor - metabolism | Transcription Factors - genetics | Nuclear Proteins - immunology | STAT6 Transcription Factor - immunology | Th2 Cells - metabolism | Transcription Factors - metabolism | DNA Helicases - metabolism | Interleukin-4 - immunology | Animals | Cell Nucleus - genetics | Transcription Factor RelA - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mice | Mice, Inbred BALB C | Receptors, Antigen, T-Cell - genetics | Adaptor Proteins, Signal Transducing - metabolism | NFATC Transcription Factors - genetics | Index Medicus | NFAT Transcription Factor | Immunology | T-cell | T-cell Receptor (TCR) | Calcineurin | Cytokine
Journal Article
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2011, Volume 286, Issue 13, pp. 11275 - 11282
Minocycline is a tetracycline family antibiotic that has anti-inflammatory and immunomodulatory properties. These properties have shown promise in the... 
RHEUMATOID-ARTHRITIS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | PROTEIN-KINASE-C | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR NFAT1 | GENE-EXPRESSION | DOUBLE-BLIND | PLACEBO-CONTROLLED TRIAL | HUMAN-IMMUNODEFICIENCY-VIRUS | LYMPHOCYTE-ACTIVATION | DISEASE PROGRESSION | Enzyme Activators - pharmacology | Minocycline - pharmacology | Humans | NF-kappa B - metabolism | Transcription Factor AP-1 - metabolism | Arthritis, Rheumatoid - metabolism | Cell Nucleus - metabolism | Protein Isoforms - metabolism | Arthritis, Rheumatoid - drug therapy | Phosphorylation - drug effects | Huntington Disease - drug therapy | Multiple Sclerosis - metabolism | Anti-Inflammatory Agents - pharmacology | CD4-Positive T-Lymphocytes - cytology | NFATC Transcription Factors - metabolism | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Enzyme Activation - drug effects | Glycogen Synthase Kinase 3 - metabolism | Huntington Disease - metabolism | NF-kappa B - genetics | Calcium Signaling - drug effects | Lymphocyte Activation - drug effects | Active Transport, Cell Nucleus - drug effects | Anti-Bacterial Agents - pharmacology | Multiple Sclerosis - drug therapy | Index Medicus | NFAT Transcription Factor | Immunosupressor | Transcription Regulation | Immunology | Signal Transduction | Transcription Factors | Cellular Immune Response | Lymphocyte
Journal Article