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Cell, ISSN 0092-8674, 2006, Volume 126, Issue 2, pp. 375 - 387
Antigen stimulation of immune cells activates the transcription factor NFAT, a key regulator of T cell activation and anergy. NFAT forms cooperative complexes... 
SCURFIN | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR FOXP3 | GENE-EXPRESSION | CALCINEURIN | MECHANISMS | NUCLEAR FACTOR | KAPPA-B | FORKHEAD-DOMAIN | ANTIGEN | CELL BIOLOGY | Up-Regulation | Luciferases - metabolism | Humans | Molecular Sequence Data | Crystallography, X-Ray | T-Lymphocytes, Regulatory - immunology | Receptors, Interleukin-2 - genetics | Retroviridae - genetics | Forkhead Transcription Factors - metabolism | Forkhead Transcription Factors - chemistry | Binding Sites | Dimerization | Genes, Reporter | Repressor Proteins - metabolism | Biomarkers - metabolism | Interleukin-2 - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Amino Acid Sequence | Jurkat Cells | NFATC Transcription Factors - metabolism | Cells, Cultured | Models, Molecular | Receptors, Interleukin-2 - metabolism | Recombinant Proteins - chemistry | Repressor Proteins - genetics | NFATC Transcription Factors - chemistry | Forkhead Transcription Factors - genetics | Sequence Homology, Amino Acid | Interleukin-2 - genetics | Animals | Protein Binding | Mice, Inbred NOD | Mice | Amino Acid Substitution | NFATC Transcription Factors - genetics | Genetic research | Research | T cells | Genetic regulation | Immunogenetics | Analysis | Crystals | Diabetes | DNA binding proteins | Structure | Index Medicus
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2011, Volume 108, Issue 28, pp. 11381 - 11386
Journal Article
Science, ISSN 0036-8075, 6/2011, Volume 332, Issue 6037, pp. 1565 - 1568
Synthetic biology has advanced the design of genetic devices that can be used to reprogram metabolic activities in mammalian cells. By functionally linking the... 
Cell culture techniques | Diabetes complications | HEK293 cells | Bioreactors | Medical treatment | REPORTS | Cell lines | Mice | Diabetes | Gene expression | Transgenes | RETINAL GANGLION-CELLS | RESPONSES | VISUAL FUNCTION | MELANOPSIN | ROD | MULTIDISCIPLINARY SCIENCES | LIGHT | ECTOPIC EXPRESSION | PHOTOPIGMENT | MAMMALIAN-CELLS | DEGENERATION | Diabetes Mellitus, Type 2 - genetics | Humans | Alkaline Phosphatase - metabolism | Homeostasis | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | Glucagon-Like Peptide 1 - genetics | Rod Opsins - genetics | Light Signal Transduction | Transfection | Isoenzymes - metabolism | Light | Rod Opsins - metabolism | Transcription, Genetic | Genes, Reporter | Genetic Engineering - methods | Cell Line | Alkaline Phosphatase - genetics | Glucagon-Like Peptide 1 - metabolism | Signal Transduction | Isoenzymes - genetics | NFATC Transcription Factors - metabolism | Gene Expression Regulation | GPI-Linked Proteins - metabolism | Animals | Synthetic Biology - methods | Cell Line, Tumor | Optical Fibers | Blood Glucose - metabolism | GPI-Linked Proteins - genetics | NFATC Transcription Factors - genetics | Blood sugar | Physiological aspects | Cellular signal transduction | Genetic aspects | Synthetic biology | Research | Genetic transcription | Glucose | Chemical synthesis | Rodents | Blood | Index Medicus | Optical fibers | Circuit design | Peptides | Cascade control | Illumination | Devices | Fiber optics
Journal Article
Cell Metabolism, ISSN 1550-4131, 12/2015, Volume 22, Issue 6, pp. 1020 - 1032
Chronic kidney disease (CKD) is a worldwide public health threat that increases risk of death due to cardiovascular complications, including left ventricular... 
SIGNAL-TRANSDUCTION | MORTALITY | FACTOR FAMILY | KLOTHO | POINT MUTATION | TYROSINE KINASE | ENDOCRINOLOGY & METABOLISM | CHRONIC KIDNEY-DISEASE | CANCER PROGRESSION | EXPRESSION | FGF RECEPTOR | CELL BIOLOGY | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Humans | Glucuronidase - metabolism | Fibroblast Growth Factors - genetics | Male | Renal Insufficiency, Chronic - metabolism | Fibroblast Growth Factors - metabolism | Hypertrophy, Left Ventricular - pathology | HEK293 Cells | Receptor, Fibroblast Growth Factor, Type 4 - deficiency | Female | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Disease Models, Animal | Phospholipase C gamma - metabolism | Mutagenesis, Site-Directed | Myocytes, Cardiac - cytology | Signal Transduction | Hypertrophy, Left Ventricular - metabolism | Mice, Inbred C57BL | NFATC Transcription Factors - metabolism | Cells, Cultured | Rats | Rats, Sprague-Dawley | Gene Knock-In Techniques | Mice, Knockout | Renal Insufficiency, Chronic - pathology | Animals | Glucuronidase - genetics | Myocytes, Cardiac - metabolism | Mice | Calcineurin - metabolism | Hypertension | Medical colleges | Chronic kidney failure | Heart enlargement | Stem cells | Physiological aspects | Fibroblast growth factors | Phospholipases | Drug discovery | T cells | Health aspects | Heart | Resveratrol | Development and progression | Kidney diseases | Cells | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 06/2010, Volume 465, Issue 7299, pp. 808 - 812
The generation of reprogrammed induced pluripotent stem cells (iPSCs) from patients with defined genetic disorders holds the promise of increased understanding... 
SOMATIC PTPN11 MUTATIONS | SHP2 MUTATIONS | HUMAN ES | HEMATOPOIESIS | MULTIDISCIPLINARY SCIENCES | CARDIAC-HYPERTROPHY | DISEASE | LEUKEMOGENESIS | DIFFERENTIATION | LEUKEMIA | FIBROBLASTS | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Embryonic Stem Cells - metabolism | Humans | Male | Gene Expression Profiling | LEOPARD Syndrome - drug therapy | Octamer Transcription Factor-3 - genetics | Phosphoproteins - analysis | SOXB1 Transcription Factors - genetics | Polymerase Chain Reaction | Adult | Female | Cell Differentiation | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Precision Medicine | Induced Pluripotent Stem Cells - pathology | Cell Line | Induced Pluripotent Stem Cells - enzymology | Nanog Homeobox Protein | LEOPARD Syndrome - metabolism | NFATC Transcription Factors - metabolism | Cells, Cultured | Fibroblasts - pathology | Homeodomain Proteins - genetics | Cell Lineage | Myocytes, Cardiac - pathology | Models, Biological | LEOPARD Syndrome - pathology | Myocytes, Cardiac - metabolism | Enzyme Activation | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Mitogen-Activated Protein Kinases - metabolism | NFATC Transcription Factors - genetics | Proteins | Signal transduction | Insects | Genes | Cardiomyocytes | Mutation | Kinases | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 05/2010, Volume 465, Issue 7296, pp. 368 - 372
Calcineurin inhibitors such as cyclosporin A (CsA) are the mainstay of immunosuppressive treatment for organ transplant recipients. Squamous cell carcinoma... 
STEM-CELLS | INHIBITOR DSCR1 | TUMOR SUPPRESSION | MULTIDISCIPLINARY SCIENCES | GROWTH | TRANSFORMED PHENOTYPE | C-MYC | PROLIFERATION | DIFFERENTIATION | CELLULAR SENESCENCE | CARCINOMA | Neoplasm Transplantation | Cell Proliferation | Cyclosporine - pharmacology | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Carcinoma, Squamous Cell - chemically induced | Gene Expression Regulation, Neoplastic | Gene Knockdown Techniques | Calcineurin Inhibitors | Calcineurin - genetics | Cell Transformation, Neoplastic - genetics | Cellular Senescence | Skin Neoplasms - pathology | Signal Transduction | NFATC Transcription Factors - metabolism | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Skin Neoplasms - chemically induced | Mice, SCID | Activating Transcription Factor 3 - metabolism | Cell Transformation, Neoplastic - metabolism | Skin Neoplasms - metabolism | Keratinocytes - pathology | Animals | Calcineurin - deficiency | Keratinocytes - metabolism | Cell Line, Tumor | Mice, Inbred NOD | Mice | NFATC Transcription Factors - deficiency | NFATC Transcription Factors - antagonists & inhibitors | Calcineurin - metabolism | NFATC Transcription Factors - genetics | Squamous cell carcinoma | Transcription factors | Calcineurin | Physiological aspects | Diagnosis | Research | Risk factors | Mutation | Cysts | Genes | Binding sites | Cancer | Index Medicus
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2015, Volume 125, Issue 8, pp. 2879 - 2994
Journal Article