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index medicus (84) 84
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genetic aspects (11) 11
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breast neoplasms - pathology (10) 10
cell membrane - metabolism (10) 10
exchanger regulatory factor (10) 10
pdz domain (10) 10
prognosis (10) 10
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beta catenin - metabolism (9) 9
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overexpression (9) 9
rats (9) 9
transmembrane conductance regulator (9) 9
breast neoplasms - genetics (8) 8
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development and progression (8) 8
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moesin-binding phosphoprotein-50 (8) 8
phosphoproteins - physiology (8) 8
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proto-oncogene proteins c-akt - metabolism (8) 8
sodium-hydrogen exchangers - physiology (8) 8
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1. Full Text Independent Negative Prognostic Role of TCF1 Expression within the Wnt/beta-Catenin Signaling Pathway in Primary Breast Cancer Patients
by Saponaro, C and Scarpi, E and Zito, FA and Giotta, F and Silvestris, N and Mangia, A
CANCERS, ISSN 2072-6694, 06/2019, Volume 11, Issue 7, p. 1035
The Wnt pathway is involved in the progression of breast cancer (BC). We aimed to evaluate the expression of some components of the Wnt pathway (beta-catenin,... 
NHERF1 EXPRESSION | ACTIVATION | NHERF1 | Wnt pathway | MARKER | BETA-CATENIN | Breast Cancer | FAMILY | NUCLEAR NHERF1 | OVEREXPRESSION | RECEPTOR 2 | ONCOLOGY | COLORECTAL-CANCER | TCF1
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2. Full Text High density of tryptase‐positive mast cells in human colorectal cancer: a poor prognostic factor related to protease‐activated receptor 2 expression
by Malfettone, Andrea and Silvestris, Nicola and Saponaro, Concetta and Ranieri, Girolamo and Russo, Antonio and Caruso, Stefano and Popescu, Ondina and Simone, Giovanni and Paradiso, Angelo and Mangia, Anita
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 08/2013, Volume 17, Issue 8, pp. 1025 - 1037
Tryptase(+) mast cells (MCs), abundant in the invasive front of tumours, contribute to tissue remodelling. Indeed, protease‐activated receptor‐2 (PAR‐2)... 
invasiveness | NHERF1 | prognostic factor | aggressiveness | Colorectal cancer | mast cell | PAR‐2 | tryptase | PAR-2 | Invasiveness | Tryptase | Prognostic factor | Mast cell | Aggressiveness | MEDICINE, RESEARCH & EXPERIMENTAL | EXCHANGER REGULATORY FACTOR-1 | TRYPSIN | PROLIFERATION | INFILTRATION | CELL BIOLOGY | BREAST-CANCER | COLON-CANCER | NUCLEAR NHERF1 | MATRIX METALLOPROTEINASES | CARCINOMA | TUMOR MICROENVIRONMENT | Tryptases - metabolism | Colorectal Neoplasms - enzymology | Intestinal Mucosa - metabolism | Prognosis | Cell Count | Humans | Middle Aged | Receptor, PAR-2 - metabolism | Cytoplasm - metabolism | Male | Mast Cells - enzymology | Phosphoproteins - metabolism | Cytoplasm - pathology | Sodium-Hydrogen Exchangers - metabolism | Models, Biological | Mast Cells - pathology | Aged, 80 and over | Adult | Female | Aged | Colorectal Neoplasms - pathology | Colorectal Neoplasms - metabolism | Intestinal Mucosa - pathology | Proteases | Correlation | Mucosa | Cloning | Colorectal carcinoma | Proteinase | Metastasis | Parameter identification | Density | Patients | Metastases | Studies | Pathology | Protease | Medical prognosis | Biomarkers | Hypoxia | Mast cells | Immunoreactivity | Adapter proteins | Tumors | Cancer | Original
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3. Full Text NHERF1 together with PARP1 and BRCA1 expression as a new potential biomarker to stratify breast cancer patients
by Mangia, Anita and Scarpi, Emanuela and Partipilo, Giulia and Schirosi, Laura and Opinto, Giuseppina and Giotta, Francesco and Simone, Giovanni
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 39, pp. 65730 - 65742
It has been recognized that Na+/H+ Exchanger Regulatory Factor 1 (NHERF1) in breast cancer (BC) acts as a tumor suppressor or as an oncogenic protein,... 
Immunohistochemistry | exchanger regulatory factor 1 (NHERF1) | Breast cancer | BRCA1 | PARP1 | CELLS | PHOSPHOPROTEIN-50 | DNA-DAMAGE RESPONSE | Na plus /H plus exchanger regulatory factor 1 (NHERF1) | PTEN | breast cancer | CELL BIOLOGY | NUCLEAR NHERF1 | OVEREXPRESSION | REPAIR | COLORECTAL-CANCER | PROTEIN EXPRESSION | immunohistochemistry | PROGNOSTIC-SIGNIFICANCE
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4. Full Text In MMTV-Her-2/neu transgenic mammary tumors the absence of caveolin-1—/—alters PTEN and NHERF1 but not β-catenin expression
by F. Darío Cuello-Carrión and Niubys Cayado-Gutiérrez and Anthony L. Natoli and Christina Restall and Robin L. Anderson and Silvina Nadin and Daiana Alvarez-Olmedo and Gisela N. Castro and Francisco E. Gago and Mariel A. Fanelli and Daniel R. Ciocca
Cell Stress & Chaperones, ISSN 1355-8145, 9/2013, Volume 18, Issue 5, pp. 559 - 567
In a recent study, we have shown that in mammary tumors from mice lacking the Cav-1 gene, there are alterations in specific heat shock proteins as well as in... 
Epithelial cells | Transgenic animals | Cell nucleus | Stromal cells | Antibodies | Breast cancer | Cell membranes | Mice | Gene expression regulation | Tumors | Biochemistry, general | Caveolin-1 | Neurosciences | NHERF1 | Oncogene | PTEN | Biomedicine general | Cell Biology | Biomedicine | Immunology | Her-2/neu | Cancer Research | β-Catenin | LOCALIZATION | PROGESTERONE-RECEPTORS | PHOSPHATASE | REGULATORY FACTOR-1 NHERF1 | CELL BIOLOGY | NUCLEAR PTEN | CARCINOGENESIS | PROTEIN EXPRESSION | beta-Catenin | BREAST-CANCER PATIENTS | MICE | Immunohistochemistry | Receptor, ErbB-2 - genetics | Humans | Receptor, ErbB-2 - metabolism | Caveolin 1 - genetics | PTEN Phosphohydrolase - metabolism | Mice, Transgenic | Phosphoproteins - metabolism | beta Catenin - metabolism | beta Catenin - genetics | Mice, Knockout | Sodium-Hydrogen Exchangers - metabolism | Caveolin 1 - metabolism | Mammary Neoplasms, Animal - pathology | Animals | MCF-7 Cells | Mammary Neoplasms, Animal - metabolism | Female | Mammary Tumor Virus, Mouse - genetics | Proto-Oncogene Proteins c-akt - metabolism | Original Paper | Her-2 | neu
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5. Full Text Loss of PDZK1 expression activates PI3K/AKT signaling via PTEN phosphorylation in gastric cancer
by Zhao, Dong and Zhao, Chunjuan and Tao, Tao and Yang, Xiaomei and Yang, Longyan and Qin, Qiong and Wang, Ying and Wang, Songlin and Wang, Qiqi and Liu, Hua and Song, Ran and Gu, Siyu and Xiong, Ying and Feng, Duiping and Jiang, Wen G and Zhang, Jun and He, Junqi
Cancer Letters, ISSN 0304-3835, 07/2019, Volume 453, pp. 107 - 121
Phosphorylation of PTEN plays an important role in carcinogenesis and progression of gastric cancer. However, the underlying mechanism of PTEN phosphorylation... 
PTEN | Phosphorylation | NHERF3 | Gastric cancer | Carcinogenesis | PDZ | MUTATION ANALYSIS | DOMAIN | NHERF1 | PHOSPHATASE | TENSIN-HOMOLOG PTEN | NUCLEAR PTEN | ONCOLOGY | GENES | TUMOR-SUPPRESSOR | BINDING | ALPHA-ACTININ-4 | Medical colleges | Development and progression | Stomach cancer | Cancer | Protein binding | Cell proliferation | Cell culture | Prognosis | AKT protein | Activation | Kinases | Inactivation | Phosphatase | Proteins | Carcinogens | Cell activation | Cell growth | Cell cycle | Clusters | Conflicts of interest | Inhibition | Deactivation | Patients | 1-Phosphatidylinositol 3-kinase | Domains | Signaling | Plasmids | Medical prognosis | Mutation | PTEN protein
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6. Full Text Na+/H+ exchange regulatory factor 1 is required for ROMK1 K+ channel expression in the surface membrane of cultured M-1 cortical collecting duct cells
by Suzuki, Takashi and Nakamura, Kazuyoshi and Mayanagi, Taira and Sobue, Kenji and Kubokawa, Manabu
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 07/2017, Volume 489, Issue 2, pp. 116 - 122
The ROMK1 K channel, a member of the ROMK channel family, is the major candidate for the K secretion pathway in the renal cortical collecting duct (CCD). ROMK1... 
K+ channel | Cortical collecting duct | NHERF1 | M-1 cell | ROMK1 | channel | PROTEIN | RADIXIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | TRAFFICKING | KNOCKOUT MICE | M-1 cell | BIOPHYSICS | EZRIN | CLONING | ALDOSTERONE | ABSORPTION | POTASSIUM CHANNEL | Animals | Cells, Cultured | Potassium Channels, Inwardly Rectifying - genetics | Cell Membrane - metabolism | Mice | Kidney Tubules, Collecting - cytology | Phosphoproteins - metabolism | Potassium Channels, Inwardly Rectifying - metabolism | Sodium-Hydrogen Exchangers - metabolism
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7. Full Text Nuclear NHERF1 expression as a prognostic marker in breast cancer
by Paradiso, A and Scarpi, E and Malfettone, A and Addati, T and Giotta, F and Simone, G and Amadori, D and Mangia, A
Cell Death and Disease, ISSN 2041-4889, 11/2013, Volume 4, Issue 11, pp. e904 - e904
Our purpose was to investigate whether Na+/H+ exchanger regulatory factor 1 (NHERF1) expression could be linked to prognosis in invasive breast carcinomas.... 
Breast cancer | NHERF1 expression | Prognosis | EBP50 | MERLIN | DOMAIN | EXCHANGER REGULATORY FACTOR-1 | PROTEIN | breast cancer | CELL-PROLIFERATION | prognosis | CELL BIOLOGY | OVEREXPRESSION | INVASION | COLORECTAL-CANCER | BINDING | Immunohistochemistry | Humans | Middle Aged | Male | Phosphoproteins - genetics | Phosphoproteins - metabolism | Breast Neoplasms - metabolism | Sodium-Hydrogen Exchangers - metabolism | Breast Neoplasms - genetics | Cell Nucleus - metabolism | Breast Neoplasms - pathology | Adult | Female | Sodium-Hydrogen Exchangers - genetics | Aged | In Vitro Techniques | Original
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8. Full Text Biological role of NHERF1 protein expression in breast cancer
by Mangia, Anita and Chiriatti, Annalisa and Bellizzi, Antonia and Malfettone, Andrea and Stea, Baldassarre and Zito, Francesso Alfredo and Reshkin, Stephen Joel and Simone, Giovanni and Paradiso, Angelo
Histopathology, ISSN 0309-0167, 11/2009, Volume 55, Issue 5, pp. 600 - 608
Aims:  To determine the role of Na+/H+ exchanger regulatory factor (NHERF1) in breast cancerogenesis and progression. Methods and results:  NHERF1 expression... 
breast cancer | NHERF1 | HER2/neu | immunohistochemistry | immunofluorescence | Immunohistochemistry | Breast cancer | HER2neu | Immunofluorescence | CELLS | METASTASIS | EXCHANGER REGULATORY FACTOR | PROLIFERATION | PATHOLOGY | MOESIN-BINDING PHOSPHOPROTEIN-50 | CELL BIOLOGY | OVEREXPRESSION | RECEPTOR TYROSINE KINASES | EPITHELIA | HER2 | NA+/H+ EXCHANGER | ASSOCIATION | neu | Receptor, ErbB-2 - biosynthesis | Phosphoproteins - biosynthesis | Biomarkers, Tumor - analysis | Carcinoma in Situ - pathology | Humans | In Situ Hybridization, Fluorescence | Breast Neoplasms - metabolism | Breast Neoplasms - pathology | Fluorescent Antibody Technique | Carcinoma, Ductal, Breast - pathology | Female | Sodium-Hydrogen Exchangers - biosynthesis | Carcinoma in Situ - metabolism | Neoplasm Staging | Carcinoma, Ductal, Breast - metabolism | Metastasis
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9. Full Text Gene expression profiling of luminal B breast cancers reveals NHERF1 as a new marker of endocrine resistance
by Karn, Thomas and Ruckhäberle, Eugen and Hanker, Lars and Müller, Volkmar and Schmidt, Marcus and Solbach, Christine and Gätje, Regine and Gehrmann, Mathias and Holtrich, Uwe and Kaufmann, Manfred and Rody, Achim
Breast Cancer Research and Treatment, ISSN 0167-6806, 11/2011, Volume 130, Issue 2, pp. 409 - 420
The luminal B subtype represents a group of high proliferating estrogen receptor positive breast cancers which are associated with a poor prognosis. Genes... 
SLC9A3R1 | NHERF1 | Prognosis | Medicine & Public Health | EBP50 | Luminal B type breast cancer | Oncology | Microarray analysis | CELLS | DOMAIN | PROTEIN | EXCHANGER REGULATORY FACTOR | IDENTIFICATION | RECEPTOR TYROSINE KINASES | MOLECULAR PORTRAITS | HISTOLOGIC GRADE | ONCOLOGY | PI3K PATHWAY | Carcinoma, Ductal, Breast - genetics | Multivariate Analysis | Multigene Family | Receptors, Estrogen - metabolism | Oligonucleotide Array Sequence Analysis | Humans | Middle Aged | Drug Resistance, Neoplasm | Gene Expression Profiling | Phosphoproteins - metabolism | Sodium-Hydrogen Exchangers - metabolism | Biomarkers, Tumor - metabolism | Carcinoma, Ductal, Breast - pathology | Female | Sodium-Hydrogen Exchangers - genetics | Gene Expression | Receptors, Estrogen - genetics | Antineoplastic Agents, Hormonal - pharmacology | Genetic Association Studies | Proportional Hazards Models | Phosphoproteins - genetics | Carcinoma, Ductal, Breast - diagnosis | Disease-Free Survival | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Biomarkers, Tumor - genetics | Breast Neoplasms - diagnosis | DNA microarrays | Analysis | Genes | Estrogen | Breast cancer | Genetic aspects | Gene expression | Cancer | Estrogen receptors | AKT protein | Data processing | Multivariate analysis | ErbB-2 protein | Survival | 1-Phosphatidylinositol 3-kinase | Signal transduction | scaffolds | Tumors
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10. Full Text Pseudomonas aeruginosa reduces the expression of CFTR via post-translational modification of NHERF1
by Rubino, Rosa and Bezzerri, Valentino and Favia, Maria and Facchini, Marcella and Tebon, Maela and Singh, Anurag Kumar and Riederer, Brigitte and Seidler, Ursula and Iannucci, Antonio and Bragonzi, Alessandra and Cabrini, Giulio and Reshkin, Stephan J and Tamanini, Anna
Pflügers Archiv - European Journal of Physiology, ISSN 0031-6768, 12/2014, Volume 466, Issue 12, pp. 2269 - 2278
Pseudomonas aeruginosa infections of the airway cells decrease apical expression of both wild-type (wt) and F508del CFTR through the inhibition of apical... 
Phosphorylation | Biomedicine | NHERF1 | Human Physiology | Ubquitination | Lung infection | CFTR | FLAGELLIN | PHYSIOLOGY | BRONCHIAL EPITHELIAL-CELLS | KINASE | FACTOR-I | BACTERIAL PATHOGENS | TRANSMEMBRANE-CONDUCTANCE-REGULATOR | FUNCTIONAL EXPRESSION | INFLAMMATION | CYSTIC-FIBROSIS | Bronchi - microbiology | Cell Line | Lung - microbiology | Humans | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Phosphoproteins - genetics | Lung - cytology | Phosphoproteins - metabolism | Sodium-Hydrogen Exchangers - metabolism | Respiratory Mucosa - microbiology | Pseudomonas Infections - metabolism | Ubiquitination | Animals | Bronchi - metabolism | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Pseudomonas aeruginosa | Sodium-Hydrogen Exchangers - genetics | Lung - metabolism | Mice | Protein Processing, Post-Translational | Mutation | Respiratory Mucosa - metabolism | Bronchi - cytology | Proteins | Post-translational modification | Cystic fibrosis
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11. Full Text Fine Needle Aspiration Cytology: A Tool to Study NHERF1 Expression as a Potential Marker of Aggressiveness in Lung Cancer
by Mangia, Anita and Partipilo, Giulia and Schirosi, Laura and Saponaro, Concetta and Galetta, Domenico and Catino, Annamaria and Scattone, Anna and Simone, Giovanni
Molecular Biotechnology, ISSN 1073-6085, 6/2015, Volume 57, Issue 6, pp. 549 - 557
Non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide and cytology is often the only diagnostic approach. Na+/H+ exchanger... 
Biochemistry, general | Protein Science | Human Genetics | Immunohistochemistry | Biotechnology | Chemistry | NHERF1 | EBP50 | Non-small cell lung cancer | Biological Techniques | Fine needle aspiration cytology | Cell Biology | PROTEIN | PROGNOSTIC-FACTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOESIN-BINDING PHOSPHOPROTEIN-50 | NUCLEAR NHERF1 | BREAST-CANCER | OVEREXPRESSION | SPECIMENS | EPITHELIA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MUTATIONS | ASSOCIATION | Carcinoma, Non-Small-Cell Lung - pathology | Humans | Lung Neoplasms - metabolism | Middle Aged | Carcinoma, Non-Small-Cell Lung - metabolism | Lung Neoplasms - pathology | Male | Phosphoproteins - metabolism | Sodium-Hydrogen Exchangers - metabolism | Paraffin Embedding | Biopsy, Fine-Needle | Aged, 80 and over | Biomarkers, Tumor - metabolism | Adult | Female | Aged | Research | Lung cancer, Non-small cell | Oncology, Experimental | Cancer | Biomarkers | Gene expression | Lung cancer
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12. Full Text Peritumoral vascular invasion and NHERF1 expression define an immunophenotype of grade 2 invasive breast cancer associated with poor prognosis
by Malfettone, A and Saponaro, C and Paradiso, A and Simone, G and Mangia, A
BMC CANCER, ISSN 1471-2407, 03/2012, Volume 12, Issue 1, pp. 106 - 106
Background: Traditional determinants proven to be of prognostic importance in breast cancer include the TNM staging, histological grade, proliferative... 
NHERF1 | VEGFR1 | SIGNATURES | EXCHANGER REGULATORY FACTOR | Breast cancer | CHEMOTHERAPY | Peritumoral Vascular Invasion | HISTOLOGIC GRADE | Histological grade | ONCOLOGY | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | TUMOR-METASTASIS | TERM-FOLLOW-UP | INDEX | NA+/H+ EXCHANGER | Nottingham Prognostic Index | MOLECULAR-BASIS | Immunohistochemistry | Multivariate Analysis | Prognosis | Neoplasm Invasiveness | Humans | Middle Aged | Male | Phosphoproteins - metabolism | Breast Neoplasms - metabolism | Sodium-Hydrogen Exchangers - metabolism | Young Adult | Breast Neoplasms - pathology | Fluorescent Antibody Technique | Aged, 80 and over | Biomarkers, Tumor - metabolism | Adult | Female | Aged | Neoplasm Staging | Cohort Studies | Nottingham prognostic index | Peritumoral vascular invasion
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13. Full Text The potential predictive role of nuclear NHERF1 expression in advanced gastric cancer patients treated with epirubicin/oxaliplatin/capecitabine first line chemotherapy
by Mangia, Anita and Caldarola, Lucia and Dell'Endice, Stefania and Scarpi, Emanuela and Saragoni, Luca and Monti, Manlio and Santini, Daniele and Brunetti, Oronzo and Simone, Giovanni and Silvestris, Nicola
Cancer Biology & Therapy, ISSN 1538-4047, 08/2015, Volume 16, Issue 8, pp. 1140 - 1147
Cellular resistance in advanced gastric cancer (GC) might be related to function of multidrug resistance (MDR) proteins. The adaptor protein NHERF1 (Na + /H +... 
multi-drug resistance | immunohistochemistry | gastric cancer | chemotherapy | NHERF1/EBP50 | predictive factor | Immunohistochemistry | Chemotherapy | Multi-drug resistance | Predictive factor | Gastric cancer | PROTEIN | ADVANCED ESOPHAGOGASTRIC CANCER | DRUG-RESISTANCE | FOLINIC ACID | P-GLYCOPROTEIN | BREAST-CANCER | ONCOLOGY | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | COLORECTAL-CANCER | MULTIDRUG-RESISTANCE | UP-REGULATION | Capecitabine - administration & dosage | Humans | Middle Aged | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Stomach Neoplasms - metabolism | Male | Reference Values | Stomach Neoplasms - pathology | Treatment Outcome | Epirubicin - administration & dosage | Stomach Neoplasms - drug therapy | Phosphoproteins - metabolism | Sodium-Hydrogen Exchangers - metabolism | Organoplatinum Compounds - administration & dosage | Cell Nucleus - metabolism | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Adult | Female | Aged | Retrospective Studies | Drug Resistance, Neoplasm - drug effects
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14. Full Text β1, β2, and β3 adrenoceptors and Na+/H + Exchanger Regulatory Factor 1 expression in human bronchi and their modifications in cystic fibrosis
by Bossard, Florian and Silantieff, Émilie and Lavazais-Blancou, Emmanuelle and Robay, Amal and Sagan, Christine and Rozec, Bertrand and Gauthier, Chantal
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 01/2010, Volume 44, Issue 1, pp. 91 - 98
To date, three β-adrenoceptor (β-AR) subtypes have been identified, but only β(1)-ARs and β(2)-ARs have been characterized in human lungs. Moreover, β(2)-ARs... 
Bronchus | Cystic fibrosis | β-adrenergic receptor | NHERF1 | Epithelium | Receptors, Adrenergic, beta-3 - drug effects | Albuterol - pharmacology | Humans | Middle Aged | Male | Receptors, Adrenergic, beta-2 - drug effects | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Case-Control Studies | Sodium-Hydrogen Exchangers - metabolism | Bronchi - drug effects | Young Adult | Cystic Fibrosis Transmembrane Conductance Regulator - drug effects | Prazosin - pharmacology | Receptors, Adrenergic, beta-3 - genetics | Bronchi - metabolism | Adult | Female | Sodium-Hydrogen Exchangers - genetics | Receptors, Adrenergic, beta-1 - drug effects | Thiazolidines - pharmacology | Cell Line | Colforsin - pharmacology | Cystic Fibrosis - metabolism | Receptors, Adrenergic, beta-2 - genetics | Gene Expression Regulation | Adrenergic beta-Agonists - pharmacology | Receptors, Adrenergic, beta-1 - metabolism | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Phosphoproteins - genetics | Receptors, Adrenergic, beta-3 - metabolism | Dobutamine - pharmacology | Receptors, Adrenergic, beta-2 - metabolism | Cystic Fibrosis - genetics | Benzoates - pharmacology | Receptors, Adrenergic, beta-1 - genetics | Aged
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