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Nature, ISSN 0028-0836, 08/2014, Volume 512, Issue 7513, pp. 166 - 170
The gamma-secretase complex, comprising presenilin 1 (PS1), PEN-2, APH-1 and nicastrin, is a membrane-embedded protease that controls a number of important... 
PRESENILIN | COMPLEX | PARTICLE ELECTRON CRYOMICROSCOPY | TRANSMEMBRANE DOMAIN-4 | MEMBRANE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | NICASTRIN | CRYO-EM | FAMILY INTRAMEMBRANE PROTEASE | BINDING | Cryoelectron Microscopy | Protein Structure, Tertiary | Models, Molecular | Crystallography, X-Ray | Amyloid Precursor Protein Secretases - chemistry | Humans | Index Medicus
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 01/2019, Volume 139, Issue 1, pp. 124 - 134
Nicastrin ( ) mutations are associated with familial acne inversa (AI), and emerging evidence suggests that microRNAs (miRNAs) are involved in various skin... 
GROWTH-FACTOR RECEPTOR | NCSTN | HOMEOSTASIS | INFLAMMATION | NOTCH | PROLIFERATION | GAMMA-SECRETASE | HIDRADENITIS SUPPURATIVA | EXPRESSION | NICASTRIN MUTATIONS | DERMATOLOGY
Journal Article
Journal of neurochemistry, ISSN 0022-3042, 3/2016, Volume 136, Issue 6, pp. 1246 - 1258
The γ-secretase complex is composed of at least four components: presenilin (PS1 or PS2), nicastrin (NCT), anterior pharynx-defective 1 (Aph-1), and presenilin... 
nicastrin | APP | Alzheimer’s disease | Aph-1 | gamma-secretase
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 02/2014, Volume 5
A body of evidence suggests that aberrant metabolism of amyloid-beta peptide (A beta) underlies the aetiology of Alzheimer disease (AD). Recently, a... 
PRESENILIN | APP | TRANSPORT | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | TRAFFICKING | NICASTRIN | AMYLOID PRECURSOR PROTEIN | INHIBITOR | CLEAVAGE | PLASMA-MEMBRANE
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 04/2003, Volume 23, Issue 8, pp. 3272 - 3277
Journal Article
British Journal of Dermatology, ISSN 0007-0963, 10/2017, Volume 177, Issue 4, pp. 895 - 896
Linked Article: Frew et al. Br J Dermatol 2017; 177:987–998 . 
GENE-MUTATIONS | PRESENILIN/GAMMA-SECRETASE | NICASTRIN | ASSOCIATION | ACNE INVERSA | DERMATOLOGY | Hidradenitis Suppurativa | Humans | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 04/2006, Volume 440, Issue 7088, pp. 1208 - 1212
The presenilin proteins (PS1 and PS2)(1,2) and their interacting partners nicastrin(3), aph-1 (refs 4, 5) and pen-2 (ref. 5) forma series of... 
CAENORHABDITIS-ELEGANS | MEMBRANE | MULTIDISCIPLINARY SCIENCES | BETA-APP | NOTCH | NICASTRIN | FAMILIAL ALZHEIMERS-DISEASE | AMYLOID PRECURSOR PROTEIN | CLEAVAGE | P24 PROTEINS | MISSENSE MUTATIONS
Journal Article
Nature Cell Biology, ISSN 1465-7392, 08/2006, Volume 8, Issue 8, pp. 894 - 896
γ-secretase and signal peptide peptidase (SPP) are unusual GxGD aspartyl proteases, which mediate intramembrane proteolysis. In addition to SPP, a family of... 
ENZYME | SIGNAL PEPTIDE PEPTIDASE | SUBSTRATE | NICASTRIN | NOTCH-1 | PROTEOLYSIS | IDENTIFICATION | CELL BIOLOGY
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 04/2019, Volume 28, Issue 7, pp. 1173 - 1182
Abstract Hidradenitis suppurativa (HS), or acne inversa, is a chronic inflammatory skin disorder characterized clinically with acne-like lesions in apocrine... 
PSENEN | ADALIMUMAB | ALZHEIMERS-DISEASE | FAMILIES | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | DOUBLE-BLIND | NOTCH | NCSTN GENE | ACNE INVERSA | NICASTRIN MUTATIONS | PRESENILIN GENE | Index Medicus
Journal Article
Chemical Science, ISSN 2041-6520, 2017, Volume 8, Issue 8, pp. 5576 - 5584
gamma-Secretase is an intramembrane-cleaving aspartyl protease that plays an essential role in the processing of a variety of integral membrane proteins. Its... 
PRESENILIN | MARTINI FORCE-FIELD | COMPLEX | ACTIVE-SITE | ALZHEIMERS-DISEASE | AMYLOID-BETA | NICASTRIN FUNCTIONS | TRANSMEMBRANE DOMAIN | ASPARTIC PROTEASES | SIMULATIONS | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2004, Volume 279, Issue 47, pp. 49523 - 49532
The deposition of the amyloid beta (Abeta) peptide in neuritic plaques plays a critical role in the pathogenesis of Alzheimer's disease (AD). Abeta is... 
SIGNAL-TRANSDUCTION | PRESENILIN | COMPLEX | DOMAIN | ALZHEIMERS-DISEASE | DIFFERENTIAL ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-TERMINAL KINASE | BETA-APP | NICASTRIN | RECEPTOR
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1472 - 1472
Endoplasmic-reticulum-associated degradation (ERAD) is an important protein quality control system which maintains protein homeostasis. Constituents of the... 
SYNAPTIC DYSFUNCTION | RETICULUM-ASSOCIATED DEGRADATION | MULTIDISCIPLINARY SCIENCES | UBIQUITIN PROTEASOME SYSTEM | PRESENILIN/GAMMA-SECRETASE | NICASTRIN | ENDOPLASMIC-RETICULUM | BETA-PEPTIDE PRODUCTION | NEURODEGENERATIVE DISEASES | COGNITIVE DEFICITS | LIGASE | Index Medicus
Journal Article
by Ba, F and Zhou, YX and Zhou, J and Chen, XY
MOLECULAR AND CELLULAR BIOCHEMISTRY, ISSN 0300-8177, 08/2019, Volume 458, Issue 1-2, pp. 71 - 78
Repetitive transcranial magnetic stimulation (rTMS) is a technique protecting neurons against diverse neurodegenerative disorders by delivering magnetic... 
PRESENILIN | APP | BETA-SECRETASE ACTIVITY | Parkinson's disease | SIGNS | TRANSCRIPTION | NICASTRIN | A beta(1-42) | Repetitive transcranial magnetic stimulation | MKK7 | CELL BIOLOGY | BACE1 | CEREBROSPINAL-FLUID BIOMARKERS | MOTOR CORTEX | GAMMA-SECRETASE
Journal Article