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index medicus (603) 603
nima-interacting peptidylprolyl isomerase (536) 536
humans (471) 471
peptidylprolyl isomerase - metabolism (379) 379
biochemistry & molecular biology (336) 336
phosphorylation (278) 278
animals (265) 265
peptidylprolyl isomerase - genetics (236) 236
pin1 (207) 207
peptidylprolyl isomerase - chemistry (192) 192
mice (167) 167
cell biology (166) 166
protein binding (155) 155
amino acid sequence (122) 122
proteins (119) 119
prolyl isomerase pin1 (118) 118
protein structure, tertiary (116) 116
cancer (107) 107
isomerization (104) 104
molecular sequence data (104) 104
protein (97) 97
cell line, tumor (96) 96
models, molecular (92) 92
research (84) 84
article (83) 83
protein conformation (83) 83
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signal transduction (82) 82
breast-cancer (78) 78
female (75) 75
biophysics (72) 72
mitosis (69) 69
cell-cycle (66) 66
peptidylprolyl isomerase - antagonists & inhibitors (66) 66
mutation (65) 65
saccharomyces-cerevisiae (64) 64
cell cycle (63) 63
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expression (61) 61
binding (59) 59
hela cells (59) 59
analysis (57) 57
nima-interacting peptidylprolyl isomerase - metabolism (57) 57
apoptosis (56) 56
peptidylprolyl isomerase - physiology (56) 56
alzheimers-disease (55) 55
mice, knockout (52) 52
activation (51) 51
protein folding (51) 51
kinetics (50) 50
pin1 protein (50) 50
enzyme inhibitors - pharmacology (49) 49
molecular biology (49) 49
peptidylprolyl isomerase (49) 49
catalytic domain (45) 45
gene expression (45) 45
cells, cultured (44) 44
oncology (44) 44
protein stability (44) 44
substrate recognition (44) 44
alzheimer's disease (43) 43
physiological aspects (43) 43
prolyl isomerase (43) 43
male (42) 42
substrate specificity (42) 42
genetic aspects (41) 41
cell proliferation (40) 40
cells (40) 40
enzymes (40) 40
recognition (39) 39
thermodynamics (39) 39
multidisciplinary sciences (38) 38
nima-interacting peptidylprolyl isomerase - genetics (38) 38
peptidyl-prolyl isomerase (38) 38
hek293 cells (37) 37
isomerases (37) 37
prolyl-isomerase pin1 (37) 37
transcriptional activity (37) 37
ww domain (36) 36
amino acid motifs (35) 35
gene (35) 35
protein structure, secondary (35) 35
kinases (34) 34
proline (34) 34
biochemistry (33) 33
cyclin d1 (33) 33
nuclear magnetic resonance, biomolecular (33) 33
sequence homology, amino acid (33) 33
biology (32) 32
cell nucleus - metabolism (32) 32
transcription (32) 32
transcription factors - metabolism (32) 32
catalysis (31) 31
dependent proline isomerization (31) 31
p53 (31) 31
beta-catenin (30) 30
domain (30) 30
gene expression regulation, neoplastic (30) 30
mechanism (30) 30
regulatory mechanism (30) 30
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Nature Communications, ISSN 2041-1723, 06/2017, Volume 8, Issue 1, pp. 15772 - 15772
The prolyl isomerase PIN1, a critical modifier of multiple signalling pathways, is overexpressed in the majority of cancers and its activity strongly... 
PROLYL-ISOMERASE PIN1 | BREAST-CANCER | ACCURATE DOCKING | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | GLIDE | MOLECULAR SWITCH | CROSSTALK | TRAITS | ACTS | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2017, Volume 292, Issue 28, pp. 11886 - 11895
The prolyl isomerase Pin1 binds to the phosphorylated Ser/Thr-Pro motif of target proteins and enhances their cis-trans conversion. This report is the first to... 
PATHOGENESIS | TRANSCRIPTIONAL ACTIVITY | OBESITY | PROTEIN | ISLET HYPERPLASIA | CYCLIN D1 | COMPENSATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | RESISTANCE | NONALCOHOLIC STEATOHEPATITIS | NIMA-Interacting Peptidylprolyl Isomerase - metabolism | Cell Proliferation | Humans | Diet, High-Fat - adverse effects | NIMA-Interacting Peptidylprolyl Isomerase - antagonists & inhibitors | Recombinant Fusion Proteins - metabolism | Insulin-Secreting Cells - metabolism | NIMA-Interacting Peptidylprolyl Isomerase - chemistry | RNA Interference | Mice, Mutant Strains | Obesity - etiology | Insulin-Secreting Cells - cytology | Binding Sites | Insulin Secretion | Calcium Signaling | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Protein-Serine-Threonine Kinases - genetics | Enzyme Induction | Mice, Transgenic | NIMA-Interacting Peptidylprolyl Isomerase - genetics | Recombinant Fusion Proteins - chemistry | Mice, Knockout | Obesity - metabolism | Obesity - pathology | Insulin - metabolism | Animals | Recombinant Fusion Proteins - genetics | Diet, Carbohydrate Loading - adverse effects | Protein-Serine-Threonine Kinases - chemistry | Mutation | Amino Acid Substitution | Insulin-Secreting Cells - enzymology | Index Medicus | pancreatic islet | salt inducible kinase | cell proliferation | prolyl isomerase | insulin secretion | Metabolism | diabetes
Journal Article
Structure, ISSN 0969-2126, 12/2015, Volume 23, Issue 12, pp. 2267 - 2279
Journal Article
Journal Article
Journal Article