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nima-interacting peptidylprolyl isomerase (556) 556
humans (492) 492
peptidylprolyl isomerase - metabolism (399) 399
index medicus (374) 374
peptidylprolyl isomerase - genetics (355) 355
animals (327) 327
phosphorylation (283) 283
biochemistry & molecular biology (242) 242
pin1 (231) 231
mice (219) 219
cell biology (181) 181
prolyl isomerase pin1 (141) 141
female (121) 121
protein binding (121) 121
peptidylprolyl isomerase - chemistry (113) 113
cancer (112) 112
proteins (111) 111
cell line, tumor (100) 100
isomerization (100) 100
signal transduction (92) 92
breast-cancer (91) 91
amino acid sequence (84) 84
research (82) 82
expression (81) 81
male (81) 81
oncology (78) 78
protein (78) 78
article (76) 76
mice, knockout (75) 75
protein structure, tertiary (75) 75
molecular sequence data (74) 74
mutation (73) 73
peptidylprolyl isomerase - physiology (73) 73
cell line (71) 71
cell-cycle (71) 71
cells, cultured (68) 68
cell cycle (66) 66
gene expression (63) 63
activation (62) 62
apoptosis (61) 61
saccharomyces-cerevisiae (61) 61
pin1 protein (60) 60
peptidylprolyl isomerase - antagonists & inhibitors (59) 59
alzheimers-disease (58) 58
binding (58) 58
hela cells (57) 57
mitosis (57) 57
nima-interacting peptidylprolyl isomerase - genetics (57) 57
models, molecular (56) 56
multidisciplinary sciences (56) 56
nima-interacting peptidylprolyl isomerase - metabolism (56) 56
protein conformation (55) 55
genetic aspects (53) 53
cell proliferation (51) 51
binding sites (49) 49
alzheimer's disease (48) 48
biophysics (48) 48
gene expression regulation, neoplastic (47) 47
peptidylprolyl isomerase (46) 46
physiological aspects (45) 45
protein stability (45) 45
beta-catenin (44) 44
gene (44) 44
hek293 cells (42) 42
biology (41) 41
cells (41) 41
kinases (41) 41
p53 (41) 41
prolyl-isomerase pin1 (41) 41
transcription, genetic (41) 41
analysis (40) 40
health aspects (40) 40
breast neoplasms - metabolism (39) 39
middle aged (39) 39
molecular biology (39) 39
overexpression (39) 39
transcriptional activity (39) 39
transcription (38) 38
aged (37) 37
breast cancer (37) 37
cyclin d1 (36) 36
research article (36) 36
neurosciences (35) 35
rna interference (35) 35
transcription factors - metabolism (35) 35
genetics & heredity (34) 34
isomerases (34) 34
breast neoplasms - genetics (33) 33
regulatory mechanism (33) 33
blotting, western (32) 32
down-regulation (32) 32
enzymes (32) 32
substrate specificity (32) 32
adult (31) 31
amino acid motifs (30) 30
enzyme inhibitors - pharmacology (30) 30
models, biological (30) 30
rna, messenger - metabolism (30) 30
rna-polymerase-ii (30) 30
sequence homology, amino acid (30) 30
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Nature Cell Biology, ISSN 1465-7392, 2012, Volume 14, Issue 12, pp. 1295 - 1304
Journal Article
Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7547, pp. 378 - 382
Infectious agents develop intricate mechanisms to interact with host cell pathways and hijack their genetic and epigenetic machinery to change host cell... 
ARABIDOPSIS-THALIANA | CIS/TRANS ISOMERASE | UBIQUITIN LIGASE | DOCKING | MULTIDISCIPLINARY SCIENCES | IN-VIVO | PIN1 | BUPARVAQUONE | ANNULATA | C-JUN | CANCER | Host-parasite relationships | Isomerases | Theileria | Leukocytes | Health aspects | Identification and classification | Proteins | Leucocytes | Signal transduction | Peptides | Genomics | Parasites | Mutation
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 01/2014, Volume 6, Issue 1, pp. 99 - 119
Mammary epithelial stem cells are fundamental to maintain tissue integrity. Cancer stem cells (CSCs) are implicated in both treatment resistance and disease... 
stem cells | breast cancer | Fbxw7 E3 ubiquitin‐ligase | prolyl‐isomerase Pin1 | Notch | Breast cancer | Prolyl-isomerase Pin1 | Fbxw7 E3 ubiquitin-ligase | Stem cells | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | ACTIVATION | prolyl-isomerase Pin1 | PHOSPHORYLATION | MOLECULAR HETEROGENEITY | P53 | EPITHELIAL-MESENCHYMAL TRANSITION | THERAPEUTIC TARGET | TUMOR-SUPPRESSOR | GROWTH-FACTOR | F-Box-WD Repeat-Containing Protein 7 | Neoplastic Stem Cells - cytology | Receptors, Notch - metabolism | Humans | Peptidylprolyl Isomerase - antagonists & inhibitors | Receptors, Notch - genetics | Transplantation, Heterologous | Antineoplastic Agents - therapeutic use | Stem Cells - cytology | Stem Cells - metabolism | Breast Neoplasms - metabolism | Neoplastic Stem Cells - metabolism | Triple Negative Breast Neoplasms - pathology | Cell Cycle Proteins - genetics | Female | Peptidylprolyl Isomerase - metabolism | Peptidylprolyl Isomerase - genetics | Proto-Oncogene Proteins - metabolism | Mammary Glands, Human - cytology | Signal Transduction | F-Box Proteins - metabolism | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Proto-Oncogene Proteins - genetics | NIMA-Interacting Peptidylprolyl Isomerase | Receptor, Notch1 - metabolism | Mice, SCID | Breast Neoplasms - drug therapy | Mice, Knockout | Animals | Breast Neoplasms - pathology | Triple Negative Breast Neoplasms - metabolism | Cell Line, Tumor | Mice | Receptor, Notch1 - genetics | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Receptor, Notch4 | Ubiquitin | Ligases | Phenotypes | Phosphorylation | Metastasis | Gene expression | Kinases | Pin1 protein | Experiments | Metastases | Signal transduction | Disease resistance | Cell fate | Proteasomes | Breast | Mutation | Ubiquitin-protein ligase | Tumors
Journal Article
Molecular Cell, ISSN 1097-2765, 2011, Volume 42, Issue 2, pp. 147 - 159
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 03/2016, Volume 61, Issue 5, pp. 705 - 719
It is unclear how the Warburg effect that exemplifies enhanced glycolysis in the cytosol is coordinated with suppressed mitochondrial pyruvate metabolism. We... 
hypoxia | K-Ras | PDH | mitochondria | glycolysis | PGK1 | B-Raf | tumorigenesis | PDHK1 | phosphorylation | EGFR | Mitochondria | Phosphorylation | Glycolysis | Hypoxia | Tumorigenesis | PYRUVATE-DEHYDROGENASE KINASE | HISTONE H3 | PKM2 | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-CELLS | HYPOXIA | CANCER | PROMOTES | HUMAN PHOSPHOGLYCERATE KINASE | GENE-TRANSCRIPTION | CELL BIOLOGY | Mitochondria - enzymology | Receptor, Epidermal Growth Factor - genetics | Glioblastoma - enzymology | Cell Proliferation | Prognosis | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Pyruvate Dehydrogenase Complex - genetics | Cell Hypoxia | Receptor, Epidermal Growth Factor - metabolism | Transfection | Glioblastoma - genetics | RNA Interference | Time Factors | Female | Peptidylprolyl Isomerase - metabolism | Peptidylprolyl Isomerase - genetics | Phosphoglycerate Kinase - genetics | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Pyruvate Dehydrogenase Complex - metabolism | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Rats | NIMA-Interacting Peptidylprolyl Isomerase | Mitochondria - pathology | Citric Acid Cycle | Protein Transport | Animals | Mice, Nude | Proto-Oncogene Proteins B-raf - genetics | Glioblastoma - pathology | Cell Line, Tumor | Protein Binding | Enzyme Activation | Mutation | Phosphoglycerate Kinase - metabolism | Lactates | Glucose metabolism | Gliomas | Isomerization | Mitochondrial DNA | Protein kinases | Cells | Medical colleges | Brain tumors
Journal Article