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Blood, ISSN 0006-4971, 12/2012, Volume 120, Issue 24, pp. 4751 - 4760
Natural killer (NK) cells are lymphocytes that play an important role in the immune response to infection and malignancy. Recent studies in mice have shown... 
INNATE | NATURAL-KILLER-CELLS | INFECTION | HEMATOLOGY | EXPANSION | Receptors, Interleukin-12 - immunology | Antigens, CD - immunology | Interleukin-18 - immunology | Humans | Lectins, C-Type - immunology | Interferon-gamma - metabolism | Interleukin-15 - immunology | Antigens, CD - metabolism | NK Cell Lectin-Like Receptor Subfamily D - immunology | Lectins, C-Type - metabolism | NK Cell Lectin-Like Receptor Subfamily C - immunology | Lymphocyte Activation - immunology | Flow Cytometry | Time Factors | Killer Cells, Natural - immunology | Receptors, Interleukin-12 - genetics | Interferon-gamma - genetics | CD56 Antigen - immunology | Immunologic Memory - immunology | Cytokines - immunology | Interleukin-12 - pharmacology | Receptors, Interleukin-18 - metabolism | CD56 Antigen - metabolism | NK Cell Lectin-Like Receptor Subfamily C - metabolism | Antigens, Differentiation, T-Lymphocyte - immunology | Antigens, Differentiation, T-Lymphocyte - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Interleukin-15 - pharmacology | Receptors, Interleukin-12 - metabolism | Lymphocyte Activation - drug effects | Interferon-gamma - immunology | Interleukin-12 - immunology | K562 Cells | Receptors, Interleukin-18 - genetics | Receptors, Interleukin-18 - immunology | Cell Proliferation - drug effects | Interleukin-18 - pharmacology | Killer Cells, Natural - drug effects | Killer Cells, Natural - metabolism | NK Cell Lectin-Like Receptor Subfamily D - metabolism | Cytokines - pharmacology | Index Medicus | Abridged Index Medicus | Immunobiology
Journal Article
PLoS Pathogens, ISSN 1553-7366, 04/2013, Volume 9, Issue 4, pp. e1003257 - e1003257
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 114, Issue 13, pp. 2657 - 2666
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2012, Volume 287, Issue 19, pp. 15874 - 15885
Failure of immune surveillance related to inadequate host antitumor immune responses has been suggested as a possible cause of the high incidence of recurrence... 
IMMUNE-RESPONSE | MECHANISM | K562 CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHASE-II | STRESS | RECEPTORS | TUMOR-DERIVED EXOSOMES | GRANZYME-B | CHEMOTHERAPY | IMPAIRMENT | Exosomes - drug effects | Exosomes - metabolism | Coculture Techniques | Granzymes - metabolism | Humans | Chaperonin 60 - immunology | Dose-Response Relationship, Drug | NK Cell Lectin-Like Receptor Subfamily D - immunology | HSP90 Heat-Shock Proteins - immunology | Exosomes - immunology | Killer Cells, Natural - immunology | Liver Neoplasms - pathology | Antineoplastic Agents - pharmacology | Carcinoma, Hepatocellular - immunology | Chaperonin 60 - metabolism | Granzymes - immunology | Cell Survival - drug effects | HSP70 Heat-Shock Proteins - immunology | Heat-Shock Proteins - metabolism | Cells, Cultured | Liver Neoplasms - immunology | Hot Temperature | Cell Survival - immunology | Blotting, Western | Heat-Shock Proteins - immunology | HSP70 Heat-Shock Proteins - metabolism | Hep G2 Cells | Carcinoma, Hepatocellular - pathology | K562 Cells | Liver Neoplasms - metabolism | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Killer Cells, Natural - metabolism | Cytotoxicity, Immunologic - immunology | NK Cell Lectin-Like Receptor Subfamily D - metabolism | Carcinoma, Hepatocellular - metabolism | Index Medicus | Immunology | Natural Killer (NK) Cell | HCC | Exosomes | Anticancer Drug | Heat Shock Protein (HSP) | Hepatocellular Carcinoma
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e76781 - e76781
Natural killer (NK) cells are important mediators of anti-tumor immunity and are active against several hematologic malignancies, including multiple myeloma... 
EX-VIVO EXPANSION | MULTIPLE-MYELOMA | NK CELLS | UNRELATED DONOR | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | AUTOLOGOUS TRANSPLANTATION | TERM-FOLLOW-UP | IMMUNOLOGICAL SYNAPSE FORMATION | ANTITUMOR-ACTIVITY | T-LYMPHOCYTES | Cell Proliferation | Coculture Techniques | Humans | Multiple Myeloma - immunology | Interleukin Receptor Common gamma Subunit - immunology | NK Cell Lectin-Like Receptor Subfamily D - immunology | NK Cell Lectin-Like Receptor Subfamily C - immunology | Multiple Myeloma - therapy | Interleukin-2 - immunology | Killer Cells, Natural - immunology | Cell Culture Techniques | CD56 Antigen - immunology | Cytotoxicity, Immunologic - drug effects | CD56 Antigen - metabolism | Fetal Blood - immunology | NK Cell Lectin-Like Receptor Subfamily C - metabolism | Cells, Cultured | Fetal Blood - cytology | Fetal Blood - metabolism | Mice, SCID | Xenograft Model Antitumor Assays - methods | Antigen-Presenting Cells - immunology | CD3 Complex - metabolism | Interleukin Receptor Common gamma Subunit - genetics | Mice, Knockout | Interleukin Receptor Common gamma Subunit - deficiency | Microscopy, Confocal | Multiple Myeloma - pathology | Animals | CD3 Complex - immunology | K562 Cells | Cell Line, Tumor | Interleukin-2 - pharmacology | Mice, Inbred NOD | Mice | Killer Cells, Natural - metabolism | Cytotoxicity, Immunologic - immunology | NK Cell Lectin-Like Receptor Subfamily D - metabolism | Antigens | Killer cells | Cell culture | Pediatrics | Transcription factors | Transplants & implants | Toxicity | Leukemia | Multiple myeloma | Cytotoxicity | Immunological synapses | Immunity | Blood | NKG2 antigen | Receptors | Interleukin 2 | Cord blood | Cryopreservation | Immunotherapy | Bone marrow | Biocompatibility | Natural killer cells | CD56 antigen | Expansion | Immunoglobulins | Cytokines | CD3 antigen | Permeability | Medicine | Studies | Stem cells | Ligands | Umbilical cord | Gene therapy | Synapses | Cancer | Index Medicus
Journal Article
Journal Article
Blood, ISSN 0006-4971, 07/2012, Volume 120, Issue 3, pp. 592 - 602
Journal Article
Journal of Immunology, ISSN 0022-1767, 03/2015, Volume 194, Issue 6, pp. 2847 - 2854
NK cells are an important component of host immune defense against malignancy and infection. NK cells are educated by MHC class I ligands to ensure... 
ADAPTIVE IMMUNITY | REPERTOIRE | NATURAL-KILLER-CELLS | ACTIVATION | RESPONSIVENESS | INHIBITORY RECEPTORS | DIFFERENTIATION | IMMUNOLOGY | EXPRESSION | SELF-TOLERANCE | CUTTING EDGE | Self Tolerance - immunology | Inositol Polyphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - deficiency | NK Cell Lectin-Like Receptor Subfamily K - immunology | Interferon-gamma - metabolism | Mice, 129 Strain | Bone Marrow Transplantation - methods | Haptens - immunology | NK Cell Lectin-Like Receptor Subfamily D - immunology | Dermatitis, Contact - immunology | Flow Cytometry | Phosphoric Monoester Hydrolases - immunology | NK Cell Lectin-Like Receptor Subfamily K - metabolism | Natural Cytotoxicity Triggering Receptor 1 - genetics | Self Tolerance - genetics | Killer Cells, Natural - immunology | Natural Cytotoxicity Triggering Receptor 1 - immunology | Cytokines - immunology | Dermatitis, Contact - genetics | NK Cell Lectin-Like Receptor Subfamily A - metabolism | Phosphoric Monoester Hydrolases - genetics | Cytokines - metabolism | Mice, Inbred C57BL | Histocompatibility Antigens Class I - immunology | Homeostasis - immunology | Mice, Transgenic | NK Cell Lectin-Like Receptor Subfamily A - immunology | Histocompatibility - immunology | Mice, Knockout | Animals | Interferon-gamma - immunology | Natural Cytotoxicity Triggering Receptor 1 - metabolism | Graft Rejection - immunology | Killer Cells, Natural - metabolism | Graft Rejection - genetics | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | NK Cell Lectin-Like Receptor Subfamily D - metabolism | Homeostasis - genetics | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 03/2008, Volume 205, Issue 3, pp. 725 - 735
The recognition of human leukocyte antigen (HLA)-E by the heterodimeric CD94-NKG2 natural killer (NK) receptor family is a central innate mechanism by which NK... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATING IMMUNORECEPTOR NKG2D | NATURAL-KILLER-CELLS | NK CELLS | CRYSTAL-STRUCTURE | HUMAN CYTOMEGALOVIRUS | T-CELL-RECEPTOR | INHIBITORY RECEPTOR | MEDIATED LYSIS | IMMUNOLOGY | E-RESTRICTED RECOGNITION | CUTTING EDGE | Protein Subunits | Receptors, Immunologic - chemistry | Humans | Multiprotein Complexes | Crystallography, X-Ray | HLA Antigens - genetics | Histocompatibility Antigens Class I - metabolism | Receptors, Natural Killer Cell | NK Cell Lectin-Like Receptor Subfamily D - genetics | Binding Sites | Recombinant Proteins - metabolism | Amino Acid Sequence | NK Cell Lectin-Like Receptor Subfamily K | Models, Molecular | Recombinant Proteins - chemistry | Histocompatibility Antigens Class I - genetics | Recombinant Proteins - genetics | HLA-G Antigens | HLA Antigens - chemistry | HLA Antigens - metabolism | Histocompatibility Antigens Class I - chemistry | Static Electricity | Protein Sorting Signals - genetics | NK Cell Lectin-Like Receptor Subfamily D - chemistry | Protein Binding | NK Cell Lectin-Like Receptor Subfamily C | In Vitro Techniques | Receptors, Immunologic - genetics | NK Cell Lectin-Like Receptor Subfamily D - metabolism | Receptors, Immunologic - metabolism | Index Medicus | MUTAGENESIS | LEUKOCYTES | PEPTIDES | MONITORS | CRYSTAL STRUCTURE | national synchrotron light source | ANTIGENS | MATERIALS SCIENCE | CONFORMATIONAL CHANGES
Journal Article
Immunity, ISSN 1074-7613, 2007, Volume 26, Issue 5, pp. 593 - 604
The ability of natural-killer cells to regulate adaptive immunity is not well understood. Here we define an interaction between the class Ib major... 
HUMDISEASE | CELLIMMUNO | NATURAL-KILLER-CELLS | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | RECEPTOR CD94/NKG2A | MULTIPLE-SCLEROSIS | DENDRITIC CELLS | IFN-GAMMA | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | IN-VIVO | IMMUNOLOGY | CLASS IB MOLECULES | SELF-TOLERANCE | Bone Marrow - immunology | Cell Proliferation | Encephalomyelitis, Autoimmune, Experimental - metabolism | Encephalomyelitis, Autoimmune, Experimental - immunology | DNA-Binding Proteins - deficiency | CD4-Positive T-Lymphocytes - immunology | DNA-Binding Proteins - metabolism | Histocompatibility Antigens Class I - metabolism | Signal Transduction - immunology | Lymphocyte Activation - immunology | Bone Marrow - metabolism | Receptors, Natural Killer Cell | NK Cell Lectin-Like Receptor Subfamily D - genetics | Killer Cells, Natural - immunology | Lentivirus - genetics | Encephalomyelitis, Autoimmune, Experimental - genetics | Chimerin Proteins - immunology | Immunologic Memory - immunology | Genetic Predisposition to Disease | Encephalomyelitis, Autoimmune, Experimental - pathology | Gene Expression Regulation - immunology | CD4-Positive T-Lymphocytes - cytology | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Histocompatibility Antigens Class I - genetics | DNA-Binding Proteins - genetics | Mice, Knockout | Killer Cells, Natural - cytology | Phenotype | Animals | Chimerin Proteins - metabolism | Mice | NK Cell Lectin-Like Receptor Subfamily C | Killer Cells, Natural - metabolism | Receptors, Immunologic - genetics | NK Cell Lectin-Like Receptor Subfamily D - metabolism | Interferon-gamma - biosynthesis | Receptors, Immunologic - metabolism | Chimerin Proteins - genetics | Hypotheses | Peptides | Lymphocytes | Rodents | Ligands | T cell receptors | Immune system | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 04/2012, Volume 36, Issue 4, pp. 600 - 611
Natural killer (NK) cell inhibitory receptors recruit tyrosine phosphatases to prevent activation, induce phosphorylation and dissociation of the small adaptor... 
MHC CLASS-I | IMMUNE SYNAPSES | TYROSINE PHOSPHORYLATION | COMPLEX CLASS-I | REORGANIZATION | ACTIN CYTOSKELETON | IMMUNOLOGY | CHRONIC VIRAL-INFECTION | RECEPTORS | T-CELLS | LIVING CELLS | NK Cell Lectin-Like Receptor Subfamily C - metabolism | Phosphorylation | Lymphocyte Activation | Humans | Actins - metabolism | Cells, Cultured | Histocompatibility Antigens Class I - immunology | NK Cell Lectin-Like Receptor Subfamily C - genetics | Receptors, IgG - immunology | Proto-Oncogene Proteins c-crk - genetics | Receptors, IgG - metabolism | Histocompatibility Antigens Class I - metabolism | NK Cell Lectin-Like Receptor Subfamily D - immunology | NK Cell Lectin-Like Receptor Subfamily C - immunology | Immunoglobulin Fc Fragments - immunology | Lipid Bilayers | RNA Interference | Immunoglobulin G - immunology | Receptors, Natural Killer Cell | Killer Cells, Natural - immunology | Proto-Oncogene Proteins c-crk - metabolism | RNA, Small Interfering | Killer Cells, Natural - metabolism | NK Cell Lectin-Like Receptor Subfamily D - metabolism | Tyrosine | Fc receptors | Security software | Killer cells | Immunogenetics | Histocompatibility antigens | Phosphatases | Analysis | Immunoglobulin G | HLA histocompatibility antigens | Cells | Medical research | Microscopy | Research & development--R&D | Ligands | Infections | Kinases | Blood banks | Immune system | Index Medicus
Journal Article