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-monocalcium bis{ (3) 3
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Journal of Atherosclerosis and Thrombosis, ISSN 1340-3478, 2015
Aim: The purpose of this study was to evaluate the efficacy and safety of LIVALO® tablets (pitavastatin) in Japanese male children with heterozygous familial... 
Pitavastatin | Livalo | NK-104 | Male | Efficacy | Familial hypercholesterolemia | Safety | Child
Journal Article
Atherosclerosis, ISSN 0021-9150, 2015, Volume 241, Issue 2, pp. 409 - 418
Journal Article
by Chung, JY and Cho, JY and Yu, KS and Kim, JR and Oh, DS and Jung, HR and Lim, KS and Moon, KH and Shin, SG and Jang, IJ
CLINICAL PHARMACOLOGY & THERAPEUTICS, ISSN 0009-9236, 10/2005, Volume 78, Issue 4, pp. 342 - 350
Background. Pitavastatin is a potent, newly developed 3-hydroxy-3-methylglutaryl- coenzyme A reductase inhibitor for the treatment of hyperlipidemia. We... 
COA REDUCTASE INHIBITOR | ANION TRANSPORTING POLYPEPTIDE | NK-104 | HUMANS | PHARMACOLOGY & PHARMACY | METABOLIC-FATE | C SLC21A6 | PRAVASTATIN | IDENTIFICATION | OATP1B1 | SINGLE NUCLEOTIDE POLYMORPHISMS
Journal Article
Synthesis, ISSN 0039-7881, 12/2016, Volume 48, Issue 23, pp. 4167 - 4174
Abstract A novel asymmetric synthesis of a (3 R ,5 S )-dihydroxyhexanoic ester is described. The ester, which serves as the precursor for generating the side... 
paper | d -glucose | diastereoselective reduction | Wittig olefination | sugar chemistry | lactone reduction | rosuvastatin calcium | total synthesis | COA REDUCTASE INHIBITOR | ROUTE | MOIETY | ACID | CROSS-COUPLING REACTION | ENANTIOSELECTIVE SYNTHESIS | CHEMISTRY, ORGANIC | D-glucose | STATINS | NK-104 | INTERMEDIATE | STEREOSELECTIVE-SYNTHESIS
Journal Article
Organic Letters, ISSN 1523-7060, 10/2014, Volume 16, Issue 20, pp. 5486 - 5489
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 10/2008, Volume 130, Issue 39, pp. 12975 - 12985
Journal Article
Journal of Organometallic Chemistry, ISSN 0022-328X, 2002, Volume 653, Issue 1, pp. 58 - 61
Journal Article
Organic Letters, ISSN 1523-7060, 04/2001, Volume 3, Issue 7, pp. 1073 - 1076
[GRAPHICS] The formal addition of an aryl-H or alkenyl-H bond across a terminal alkyne has been accomplished by the combination of platinum-catalyzed... 
HALIDES | HYDROBORATION | REDUCTASE INHIBITOR NK-104 | SEQUENCE | FLUORIDE-ION | CHEMISTRY, ORGANIC | ARYL | DERIVATIVES | BROMIDES | ALKENYLSILACYCLOBUTANES | UNSYMMETRICAL BIARYLS
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 08/2015, Volume 13, Issue 38, pp. 9813 - 9819
An efficient and concise asymmetric synthesis of pitavastatin calcium (1) starting from commercially available (S)-epichlorohydrin is described. A convergent... 
REDUCTASE INHIBITOR NK-104 | ENANTIOMERS | SIDE-CHAIN PRECURSOR | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | STATINS | ZINC | Bismuth - chemistry | Temperature | Models, Chemical | Stereoisomerism | Quinolines - chemistry | Ketones - chemistry | Molecular Structure | Catalysis | Acetals - chemistry | Calcium - chemistry | Index Medicus
Journal Article
Synthesis, ISSN 0039-7881, 09/2014, Volume 46, Issue 17, pp. 2333 - 2346
Abstract An expedient and simple synthetic approach to pitava­statin and rosuvastatin final intermediates is described. The presented approach consists of... 
paper | aldehydes | lactones | sulfones | drugs | heterocycles | stereoselective synthesis | olefination | HMG-COA-REDUCTASE | CROSS-COUPLING REACTION | COENZYME-A REDUCTASE | COMPETITIVE INHIBITOR | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | HYPERCHOLESTEROLEMIA | AGENT | INHIBITOR NK-104 | CONFORMATIONAL-ANALYSIS
Journal Article
Journal of Heterocyclic Chemistry, ISSN 0022-152X, 01/2013, Volume 50, Issue 1, pp. 1 - 16
The use of palladium complexes in catalyzing the cross‐coupling of halogenated quinolines with various organometalic reagents has led to the development of... 
ORGANOZINC REAGENTS | ELECTROGENERATED CHEMILUMINESCENCE | REDUCTASE INHIBITOR NK-104 | SUCCESSIVE SUBSTITUTION | BIOLOGICAL EVALUATION | CHEMISTRY, ORGANIC | HETEROARYL HALIDES | CONTAINING HETEROCYCLES | DERIVATIVES | ARYLBORONIC ACIDS | WATER | Quinoline | Palladium
Journal Article
Synthesis, ISSN 0039-7881, 06/2012, Volume 44, Issue 11, pp. 1700 - 1710
Abstract A concise and simple synthetic route to pitavastatin is described. The approach involves a highly stereoselective Wittig olefination reaction between... 
paper | lactones | Wittig reactions | drugs | heterocycles | quinolines | HMG-COA-REDUCTASE | ACID | CROSS-COUPLING REACTION | ENANTIOMERS | CHEMISTRY, ORGANIC | HYPERCHOLESTEROLEMIA | PYRIMIDINE | INHIBITOR NK-104 | A REDUCTASE | INTERMEDIATE | ROSUVASTATIN
Journal Article
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, ISSN 1368-5031, 02/2005, Volume 59, Issue 2, pp. 239 - 252
The growing number of trials that have highlighted the benefit of intensive lowering of total- and low density lipoprotein (LDL)-cholesterol levels especially... 
myotoxicity | drug interactions | HMG-CoA reductase inhibitors | APOLIPOPROTEIN B-100 | HMG-COA REDUCTASE | LOW-DENSITY-LIPOPROTEIN | cytochrome P450 | pleiotropy | CLINICAL PHARMACOKINETICS | STATINS | MEDICINE, GENERAL & INTERNAL | NK-104 | DOUBLE-BLIND | METABOLIC-FATE | CORONARY-HEART-DISEASE | INHIBITOR | dyslipidaemia
Journal Article
Helvetica Chimica Acta, ISSN 0018-019X, 2007, Volume 90, Issue 6, pp. 1069 - 1081
A new synthetic method for the preparation of pitavastatin is described. The approach circumvents various synthetic problems associated with the buildup of the... 
AGENT | ASYMMETRIC-SYNTHESIS | COENZYME-A REDUCTASE | COMPACTIN | NK-104 | MEVINOLIN | ANALOGS | ENANTIOMERS | ML-236A | SYNTHON | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Journal Article
Journal of Fluorine Chemistry, ISSN 0022-1139, 2012, Volume 133, pp. 178 - 183
Journal Article
Journal Article
Analytical Letters, ISSN 0003-2719, 10/2007, Volume 40, Issue 14, pp. 2625 - 2632
A simple, sensitive, reliable, and rapid HPTLC method has been developed for the determination of pitavastatin calcium in tablet dosage form. Identification... 
pharmaceutical dosage form | pitavastatin calcium | validation | HPTLC | Validation | Pharmaceutical dosage form | Pitavastatin calcium | CHEMISTRY, ANALYTICAL | NK-104 | SAMPLES | CHROMATOGRAPHY
Journal Article
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