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Cancer research, ISSN 0008-5472, 10/2017, Volume 77, Issue 20, pp. 5664 - 5675
Maturation of human natural killer cells (NK cells) as defined by accumulation of cell surface expression of CD57 is associated with increased cytotoxic... 
maturation | GSK3 | NK cell | immunotherapy
Journal Article
Innate Immunity, ISSN 1753-4259, 01/2019, Volume 25, Issue 1, pp. 3 - 12
Pseudomonas aeruginosa-derived pigment pyocyanin (PCN) has been proved to induce cell apoptosis mediated by the generation of reactive oxygen species (ROS),... 
mitochondrial damage | intracellular calcium | Pyocyanin | NK cell
Journal Article
European Journal of Immunology, ISSN 0014-2980, 10/2001, Volume 31, Issue 10, pp. 3121 - 3126
In this study we present new differential characteristics of NK cells expressing CD56 surface antigen in low (CD56dim) or high (CD56bright) density. In... 
KLR | CD56dim | CD56bright | KIR | NK cell | CD56
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 11/2004, Volume 200, Issue 10, pp. 1325 - 1335
Journal Article
The Journal of allergy and clinical immunology, ISSN 0091-6749, 8/2018, Volume 142, Issue 2, pp. 605 - 617.e7
Gain-of-function mutations in PI3K110δ lead to impaired NK cell cytolytic function that can be partially restored with rapamycin treatment. 
APDS | PI3K signaling | NK cell deficiency | cytotoxicity | combined immunodeficiency
Journal Article
Methods in Enzymology, ISSN 0076-6879, 2019
Natural killer (NK) cells constitute the predominant innate lymphocyte subset that mediates the anti-viral and anti-tumor immune responses. NK cells use an... 
Cytotoxicity assay | Flow cytometry | NK-cell mediated cytotoxicity | Degranulation assay
Journal Article
Virus Research, ISSN 0168-1702, 07/2019, Volume 267, pp. 21 - 25
Human noroviruses (HuNoVs) are a leading cause of acute gastroenteritis worldwide. It is unclear which arm of the immune system regulates resistance to HuNoV... 
Pigs | NK Cell | Innate immunity | SCID | Human norovirus
Journal Article
JOURNAL OF INVESTIGATIVE DERMATOLOGY, ISSN 0022-202X, 01/2016, Volume 136, Issue 1, pp. 9 - 11
Inozume et al. describe a novel immunosuppressive mechanism in melanoma that is triggered by the interaction between CD155 (expressed by melanomas) and T-cell... 
NK-CELL CYTOTOXICITY | RESPONSES | REGULATORY T-CELLS | TIGIT | PVR | DERMATOLOGY
Journal Article
Leukemia, ISSN 0887-6924, 2005, Volume 19, Issue 5, pp. 835 - 840
Journal Article
Transplantation, ISSN 0041-1337, 04/2017, Volume 101, Issue 4, pp. 688 - 689
Journal Article
International Journal of Cancer, ISSN 0020-7136, 03/2020, Volume 146, Issue 5, pp. 1409 - 1420
Therapeutic success of targeted therapy with BRAF inhibitors (BRAFi) for melanoma is limited by resistance development. Observations from preclinical mouse... 
targeted therapy | melanoma | BRAF inhibitor resistance | T cell and NK cell immunity
Journal Article
European Journal of Immunology, ISSN 0014-2980, 05/1999, Volume 29, Issue 5, pp. 1656 - 1666
NKp46 is a novel triggering receptor expressed by all human NK cells that is involved in natural cytotoxicity. In this study we show that the surface density... 
Natural cytotoxicity | Activating receptor | NK cell
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 01/2020, Volume 521, Issue 2, pp. 457 - 462
Polymethoxylated flavones (PMFs) are naturally occurring compounds that have biological effects on many cell types. We previously demonstrated that PMFs such... 
NF-κB | exportin | Granzyme B | Nobiletin | NK cell | p53
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 03/2004, Volume 199, Issue 6, pp. 879 - 884
Few studies have demonstrated that innate lymphocytes play a major role in preventing spontaneous tumor formation. We evaluated the development of spontaneous... 
Immunosurveillance | Tumor | Perforin | Effector | NK cell | perforin | effector | Brief Definitive Report | immunosurveillance | tumor
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 2/2014, Volume 192, Issue 4, pp. 1661 - 1670
The cytokine IL-10 has an important role in limiting inflammation in many settings, including toxoplasmosis. In these studies, an IL-10 reporter mouse was used... 
IL-10 | NK cell | aryl hydrocarbon receptor
Journal Article
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