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Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2015, Volume 125, Issue 2, pp. 665 - 680
... studies suggest that altered plasma metabolic profiles may reflect disease severity and predict mortality in critical illnesses such as sepsis (3, 4). Furthermore... 
MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | GLUCOSE-METABOLISM | ATP-CITRATE LYASE | UCP2 | SEPTIC SHOCK | CELL-GROWTH | CRITICALLY-ILL PATIENTS | INTENSIVE INSULIN THERAPY | CANCER | MITOCHONDRIAL UNCOUPLING PROTEINS | Fatty Acid Synthase, Type I - genetics | Fatty Acid Synthase, Type I - biosynthesis | Lipids - genetics | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Ion Channels - genetics | Caspase 1 - metabolism | Mitochondrial Proteins - genetics | Interleukin-1beta - genetics | Lipids - biosynthesis | Sepsis - pathology | Interleukin-1beta - metabolism | Mitochondrial Proteins - metabolism | Sepsis - metabolism | Macrophages - pathology | Down-Regulation - genetics | Inflammasomes - genetics | Sepsis - genetics | Mice, Knockout | Carrier Proteins - genetics | Enzyme Induction - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Sepsis - chemically induced | Ion Channels - metabolism | Caspase 1 - genetics | Sepsis - therapy | Mice | Uncoupling Protein 2 | Interleukin-18 - genetics | Interleukin-18 - metabolism | Cellular proteins | Immune response | Synthesis | Sepsis | Development and progression | Lipids | Genetic aspects | Properties | Enzymes | Cytokines | Pathogenesis | Mortality | Glucose | Metabolism | Gene expression | Fatty acids | Proteins | Studies | Metabolites | Consent | Rodents
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2017, Volume 37, Issue 4, pp. 694 - 706
.... In this study, we examined the role of the NLRP3 (nucleotide oligomerization domain–like receptor family, pyrin domain containing 3... 
Caspase 1 | Glyburide | Inflammasomes | Contractile proteins | Proteolysis | Aortic aneurysm | OXIDATIVE STRESS | ACTIVATION | glyburide | inflammasomes | FOCUS | INJURY | caspase 1 | DELETION | aortic aneurysm | PERIPHERAL VASCULAR DISEASE | MICE | MUTATIONS | ISCHEMIA-REPERFUSION | HEMATOLOGY | proteolysis | contractile proteins | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Abdominal - prevention & control | Inflammasomes - metabolism | Humans | Middle Aged | Caspase 1 - metabolism | Male | Mice, 129 Strain | Aorta, Abdominal - drug effects | Aneurysm, Dissecting - physiopathology | Glyburide - pharmacology | Inflammasomes - antagonists & inhibitors | Myocytes, Smooth Muscle - drug effects | Aneurysm, Dissecting - prevention & control | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Myocytes, Smooth Muscle - enzymology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Vasoconstriction - drug effects | Aortic Aneurysm, Thoracic - physiopathology | Mice, Knockout | Aorta, Thoracic - enzymology | Biomechanical Phenomena | Phenotype | Aortic Aneurysm, Abdominal - enzymology | Aortic Aneurysm, Abdominal - physiopathology | Caspase 1 - deficiency | Muscle, Smooth, Vascular - enzymology | Aortic Aneurysm, Thoracic - genetics | Aortic Aneurysm, Thoracic - prevention & control | Myocytes, Smooth Muscle - pathology | Muscle, Smooth, Vascular - physiopathology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aneurysm, Dissecting - enzymology | Muscle Proteins - metabolism | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Angiotensin II | Aorta, Abdominal - physiopathology | Aorta, Thoracic - pathology | Aortic Aneurysm, Thoracic - enzymology | Mice, Inbred C57BL | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Aorta, Thoracic - physiopathology | Aorta, Abdominal - enzymology | Inflammasomes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - deficiency | Muscle, Smooth, Vascular - pathology | Animals | Caspase 1 - genetics | Aged | aneurysm | cardiovascular diseases | contractility | vessels
Journal Article
Nature immunology, ISSN 1529-2916, 2015, Volume 17, Issue 3, pp. 250 - 258
Journal Article
Nature (London), ISSN 1476-4687, 2014, Volume 512, Issue 7512, pp. 69 - 73
....sub.myel-KO] macrophages failed to induce A20 messenger RNA (mRNA) and protein expression in response to the Toll-like receptor-4 (TLR4) ligand lipopolysaccharide (LPS... 
RHEUMATOID-ARTHRITIS | ACTIVATION | VARIANTS | CASPASE-1 | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | RECEPTOR | TNFAIP3 | INHIBITOR | NF-KAPPA-B | ASSOCIATION | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Caspase 1 - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Intracellular Signaling Peptides and Proteins - deficiency | Arthritis, Rheumatoid - metabolism | Arthritis, Rheumatoid - prevention & control | Cysteine Endopeptidases - metabolism | Receptors, Interleukin-1 - deficiency | Cysteine Endopeptidases - deficiency | Female | Tumor Necrosis Factor alpha-Induced Protein 3 | DNA-Binding Proteins | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Interleukin-1 - metabolism | Signal Transduction | Nuclear Proteins - metabolism | Apoptosis Regulatory Proteins - metabolism | Arthritis, Rheumatoid - pathology | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Macrophages - metabolism | Phenotype | Animals | Carrier Proteins - metabolism | Caspase 1 - deficiency | Mice | Arthritis, Rheumatoid - immunology | Prevention | Rheumatoid arthritis | Physiological aspects | NLRP3 | Properties | Macrophages | Risk factors | Proteins | Pathology | Dehydrogenases | Histopathology | Pathogenesis | Rodents | Protein expression | Nlrp3 | IL1R1 | caspase-1 | inflammasome | A20
Journal Article
American journal of physiology. Renal physiology, ISSN 1522-1466, 2015, Volume 308, Issue 9, pp. F993 - F1003
IL-1β-secreting nucleotide-binding oligomerization domain protein 3 (NLRP3) inflammasomes play a pivotal role in triggering innate immune responses in metabolic disease... 
Diabetic nephropathy | Uric acid | NLRP3 inflammasome | Macrophage | PHYSIOLOGY | INJURY | macrophage | CELL-PROLIFERATION | MECHANISMS | ALLOPURINOL | PATHOGENESIS | KIDNEY-FUNCTION | INFLAMMASOME | DISEASE | UROLOGY & NEPHROLOGY | uric acid | NF-KAPPA-B | diabetic nephropathy | URIC-ACID | Inflammasomes - metabolism | Diabetic Nephropathies - etiology | NLR Family, Pyrin Domain-Containing 3 Protein | Coculture Techniques | Diabetes Mellitus, Type 2 - genetics | Humans | Male | NF-kappa B - metabolism | Hyperuricemia - metabolism | Diabetes Mellitus, Type 2 - metabolism | Diabetic Nephropathies - immunology | Hyperuricemia - immunology | Inflammation - metabolism | Transfection | RNA Interference | Time Factors | Interleukin-1beta - metabolism | Diabetes Mellitus, Type 2 - immunology | HMGB1 Protein - metabolism | Inflammation Mediators - metabolism | Diabetic Nephropathies - prevention & control | Hyperuricemia - complications | Diabetes Mellitus, Type 2 - complications | Macrophages - immunology | Disease Models, Animal | Cell Line | Kidney Tubules, Proximal - immunology | Uric Acid - metabolism | Signal Transduction | Diabetic Nephropathies - metabolism | Diabetic Nephropathies - genetics | Inflammation - immunology | Inflammation - etiology | Disease Progression | Inflammasomes - genetics | Hyperuricemia - drug therapy | Carrier Proteins - genetics | Rats, Inbred OLETF | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Chemokine CXCL12 - metabolism | Kidney Tubules, Proximal - metabolism | Gout Suppressants - pharmacology | Macrophages - drug effects | Kidney Tubules, Proximal - drug effects | Receptors, Cytoplasmic and Nuclear - metabolism | Type 2 diabetes | Cellular proteins | Kidneys | Immune response | Physiological aspects | Genetic aspects | Properties | Injuries
Journal Article
Frontiers in immunology, ISSN 1664-3224, 2018, Volume 9, Issue MAY, p. 1054
Journal Article
Gut, ISSN 0017-5749, 07/2017, Volume 66, Issue 7, pp. 1216 - 1224
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2017, Volume 140, Issue 4, pp. 1054 - 1067.e10
Background The Nod-like receptor NACHT, LRR, and PYD domain–containing protein 3 (NLRP3... 
Allergy and Immunology | ibrutinib | Bruton tyrosine kinase | IL-1 | inflammation | inflammasome | NLRP3 | macrophage | X-linked agammaglobulinemia | Muckle-Wells syndrome | Staphylococcus aureus | IMMUNITY | ACTIVATION | IMMUNOLOGY | MASS-SPECTROMETRY | NALP3 INFLAMMASOME | B-CELL | ALLERGY | IN-VIVO | BTK | CHRONIC LYMPHOCYTIC-LEUKEMIA | EXPRESSION | Inflammasomes - metabolism | Agammaglobulinemia - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Leukocidins - immunology | Molecular Targeted Therapy | Protein-Tyrosine Kinases - genetics | Genetic Diseases, X-Linked - genetics | Bacterial Proteins - immunology | Adaptive Immunity | Cryopyrin-Associated Periodic Syndromes - genetics | Nigericin - immunology | Staphylococcal Infections - immunology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | Cells, Cultured | Immunity, Innate | Mice, Knockout | Adaptor Proteins, Signal Transducing | Animals | Apoptosis Regulatory Proteins | Pyrin Domain - genetics | Agammaglobulinaemia Tyrosine Kinase | Proteomics | Staphylococcus aureus - immunology | Mice | Receptors, Cytoplasmic and Nuclear - metabolism | Proteins | Tyrosine | Phenols | Cells | Immunodeficiency | Regulators | Identification methods | Activation | Arthritis | Kinases | Immunity | Caspase-1 | Genotype & phenotype | Bacteria | Protein-tyrosine kinase | Immune system | Cytokines | Agammaglobulinemia | Neutrophils | Caspase | Pharmacology | Adaptive immunity | FDA approval | IL-1β | Patients | Ablation | Bruton's tyrosine kinase | Human subjects | Nigericin | Speck | Mutation | Proteomes | Leukocidin | Cancer | Apoptosis
Journal Article