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International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 03/2017, Volume 84, pp. 22 - 34
Endothelial dysfunction caused by endothelial cells senescence and chronic inflammation is tightly linked to the development of cardiovascular diseases. NLRP3... 
TXNIP | Senescence | IL-1β | NLRP3 inflammasome | ROS | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATHEROSCLEROSIS | PHENOTYPE | IL-1 beta | MECHANISMS | CELLULAR SENESCENCE | CELL BIOLOGY | PREMATURE SENESCENCE | IN-VIVO | PERSPECTIVES | CARDIOVASCULAR-DISEASE | SECRETION | Human Umbilical Vein Endothelial Cells | RNA, Small Interfering - genetics | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Cytoskeletal Proteins - antagonists & inhibitors | Cytoskeletal Proteins - genetics | Humans | Cellular Senescence - drug effects | Male | Aorta - metabolism | RNA, Messenger - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aging - genetics | Interleukin-1beta - metabolism | Apoptosis Regulatory Proteins - genetics | Cytoskeletal Proteins - metabolism | Thioredoxins - metabolism | Bleomycin - toxicity | Endothelial Cells - metabolism | Models, Cardiovascular | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Carrier Proteins - antagonists & inhibitors | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Cellular Senescence - physiology | Aging - pathology | Apoptosis Regulatory Proteins - metabolism | Aorta - pathology | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Endothelial Cells - cytology | CARD Signaling Adaptor Proteins | Apoptosis Regulatory Proteins - antagonists & inhibitors | Mice | Aging - metabolism | Endothelial Cells - drug effects
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 11/2017, Volume 214, Issue 11, pp. 3219 - 3238
The NLRP3 inflammasome has been implicated in the pathogenesis of a wide variety of human diseases. A few compounds have been developed to inhibit NLRP3... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | BAY 11-7082 | MECHANISM | GOUT | NEK7 | BLOCKING INTERLEUKIN-1 | KAPPA-B | INFLAMMASOMES | IMMUNOLOGY | ATP-BINDING | BETA | Small Molecule Libraries - pharmacology | Inflammasomes - metabolism | Diabetes Mellitus, Type 2 - genetics | Humans | Immunoblotting | Diabetes Mellitus, Type 2 - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Inflammation - metabolism | Inflammasomes - drug effects | Inflammation - drug therapy | HEK293 Cells | Adult | Molecular Structure | Thiazolidines - pharmacology | Thiazolidines - chemistry | Disease Models, Animal | Cryopyrin-Associated Periodic Syndromes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | Thiones - chemistry | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Mice, Transgenic | Cryopyrin-Associated Periodic Syndromes - drug therapy | Inflammasomes - genetics | Mice, Knockout | Microscopy, Confocal | Small Molecule Libraries - chemistry | Animals | Cell Line, Tumor | Inflammation - genetics | Thiones - pharmacology | Diabetes Mellitus, Type 2 - drug therapy | Cryopyrin-Associated Periodic Syndromes - metabolism | Synovial fluid | Monocytes | Animal models | Inhibitors | Cryopyrin | Pathogenesis | Diabetes mellitus | Gout | Activation | Adenosine triphosphatase | Diseases | 311
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 11/2016, Volume 7, Issue 1, p. 13344
Diabetes mellitus (DM) encompasses a multitude of secondary disorders, including heart disease. One of the most frequent and potentially life threatening... 
ACTIVATION | MYOCARDIAL-INFARCTION | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | TOLL-LIKE RECEPTORS | NLRP3 INFLAMMASOME | SARCOPLASMIC-RETICULUM | HUMAN MONOCYTES | VENTRICULAR REPOLARIZATION | NALP3 INFLAMMASOME | CONVERTING-ENZYME | Potassium - metabolism | Toll-Like Receptor 2 - genetics | Calcium - metabolism | Myocytes, Cardiac - immunology | Receptors, Interleukin-1 - genetics | Caspase 1 - metabolism | Interleukin-1beta - genetics | Action Potentials | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Inflammasomes - antagonists & inhibitors | Interleukin-1beta - metabolism | Arrhythmias, Cardiac - immunology | Tachycardia, Ventricular - metabolism | Diabetes Mellitus, Experimental - complications | Antirheumatic Agents - pharmacology | Interleukin 1 Receptor Antagonist Protein - pharmacology | Diabetes Mellitus, Experimental - metabolism | Macrophages - immunology | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Arrhythmias, Cardiac - metabolism | Myocardial Contraction | Receptors, Interleukin-1 - immunology | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Tachycardia, Ventricular - etiology | Interleukin-1beta - immunology | Mice, Transgenic | Arrhythmias, Cardiac - etiology | Diabetes Mellitus, Experimental - immunology | Animals | NLR Family, Pyrin Domain-Containing 3 Protein - immunology | Myocytes, Cardiac - metabolism | Toll-Like Receptor 2 - immunology | Mice | Receptors, Interleukin-1 - antagonists & inhibitors | Tachycardia, Ventricular - immunology
Journal Article
Kidney International, ISSN 0085-2538, 03/2018, Volume 93, Issue 3, pp. 656 - 669
Primary/secondary hyperoxalurias involve nephrocalcinosis-related chronic kidney disease (CKD) leading to end-stage kidney disease. Mechanistically, intrarenal... 
beta-hydroxybutyrate | necroinflammation | fibrosis | crystal nephropathy | NALP3 | OXALATE | REPAIR | DENDRITIC CELLS | RENAL INFLAMMATION | UROLOGY & NEPHROLOGY | MICROENVIRONMENTS | PROGRESSION | Cell Plasticity - drug effects | Inflammasomes - metabolism | Kidney - pathology | Nephrocalcinosis - immunology | Kidney - immunology | Hyperoxaluria - metabolism | Male | CARD Signaling Adaptor Proteins - genetics | Hyperoxaluria - drug therapy | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Renal Insufficiency, Chronic - metabolism | CARD Signaling Adaptor Proteins - metabolism | Kidney - metabolism | Nephrocalcinosis - metabolism | Butylene Glycols - pharmacology | Inflammasomes - drug effects | Interleukin-1 - immunology | Nephrocalcinosis - prevention & control | Female | Macrophages - immunology | Disease Models, Animal | Fibroblasts - metabolism | Interleukin-1 - metabolism | Renal Insufficiency, Chronic - immunology | Macrophages - pathology | Signal Transduction | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | Cells, Cultured | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Fibroblasts - pathology | Inflammasomes - genetics | Hyperoxaluria - pathology | Mice, Knockout | Renal Insufficiency, Chronic - pathology | Renal Insufficiency, Chronic - prevention & control | Macrophages - metabolism | Nephrocalcinosis - pathology | Phenotype | Animals | NLR Family, Pyrin Domain-Containing 3 Protein - immunology | Receptors, Transforming Growth Factor beta - metabolism | Inflammasomes - immunology | Fibroblasts - immunology | Macrophages - drug effects | Hyperoxaluria - immunology | End-stage renal disease | Phenotypes | CD11b antigen | Kidneys | Interleukin 1 receptor antagonist | Therapeutic applications | CX3CR1 protein | Inflammation | Macrophages | CD45 antigen | Atrophy | Signal transduction | Calcium oxalate | Oxalic acid | Calcinosis | Interleukin 1 | Fibrosis | Fibroblasts | Hyperoxaluria | Kidney diseases
Journal Article
Journal Article
Kidney International, ISSN 0085-2538, 09/2016, Volume 90, Issue 3, pp. 525 - 539
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 08/2017, Volume 37, Issue 8, pp. 1457 - 1461
Objective-Inflammasomes are multiprotein complexes, and their activation has been associated with cardiovascular disease. Inflammasome activation leads to... 
atherosclerosis | macrophages | inflammasomes | interleukin-1beta | CELLS | PROTEIN | INTERLEUKIN-1 RECEPTOR ANTAGONIST | CANAKINUMAB | CRYSTALS | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | EXPRESSION | Carotid Arteries - drug effects | Carotid Arteries - metabolism | Carotid Artery Diseases - prevention & control | Inflammasomes - metabolism | Apolipoproteins E - deficiency | Atherosclerosis - genetics | RNA, Messenger - metabolism | Sulfones - pharmacology | Heterocyclic Compounds, 4 or More Rings - pharmacology | Necrosis | Inflammasomes - antagonists & inhibitors | Time Factors | Carotid Artery Diseases - pathology | Interleukin-1beta - metabolism | Dendritic Cells - drug effects | Female | Vascular Cell Adhesion Molecule-1 - genetics | Carotid Artery Diseases - metabolism | Diet, Western | Dendritic Cells - metabolism | Disease Models, Animal | Atherosclerosis - pathology | Genetic Predisposition to Disease | Anti-Inflammatory Agents - pharmacology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Cells, Cultured | Crystallization | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Plaque, Atherosclerotic | Atherosclerosis - metabolism | Mice, Knockout | Intercellular Adhesion Molecule-1 - metabolism | Macrophages - metabolism | Phenotype | Animals | Signal Transduction - drug effects | Apolipoproteins E - genetics | Intercellular Adhesion Molecule-1 - genetics | Carotid Artery Diseases - genetics | Lipopolysaccharides - pharmacology | Cholesterol - pharmacology | Macrophages - drug effects | Carotid Arteries - pathology | Vascular Cell Adhesion Molecule-1 - metabolism | Atherosclerosis - prevention & control
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2550 - 12
Oridonin (Ori) is the major active ingredient of the traditional Chinese medicinal herb Rabdosia rubescens and has anti-inflammatory activity, but the target... 
ACTIVATION | CYTOKINES | ACID | MECHANISM | ANTIBACTERIAL ACTIVITY | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | DISEASE | NEK7 | BINDING | NALP3 INFLAMMASOME | Plant Extracts - chemistry | Diterpenes, Kaurane - isolation & purification | Diabetes Mellitus, Type 2 - genetics | Humans | Arthritis, Gouty - genetics | NIMA-Related Kinases - immunology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Arthritis, Gouty - immunology | Peritonitis - pathology | Inflammasomes - drug effects | NIMA-Related Kinases - antagonists & inhibitors | Peritonitis - genetics | Diabetes Mellitus, Type 2 - immunology | Anti-Inflammatory Agents - isolation & purification | Disease Models, Animal | Diterpenes, Kaurane - pharmacology | Isodon - chemistry | Signal Transduction | Anti-Inflammatory Agents - pharmacology | Inflammasomes - chemistry | Mice, Inbred C57BL | Gene Expression Regulation | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Inflammation | Peritonitis - immunology | Mice, Knockout | Arthritis, Gouty - drug therapy | Animals | NLR Family, Pyrin Domain-Containing 3 Protein - immunology | Inflammasomes - immunology | Arthritis, Gouty - pathology | NIMA-Related Kinases - genetics | Protein Binding | Mice | Diabetes Mellitus, Type 2 - pathology | Peritonitis - drug therapy | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Medicinal plants | Animal models | Antiinflammatory agents | Diabetes mellitus | Activation | Arthritis | Herbal medicine | Covalence | Inhibitors | Inhibition | Diabetes mellitus (non-insulin dependent) | Peritonitis
Journal Article