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Publication DateStroke, ISSN 0039-2499, 12/2017, Volume 49, Issue 1, pp. 184 - 192
BACKGROUND AND PURPOSE—Intracerebral hemorrhage (ICH) is a devastating disease without effective treatment. As a key component of the innate immune system, the...
Neuroprotection | Brain edema | Inflammation | Cell death | brain edema | ACTIVATION | cell death | RAT | DEPLETION | MECHANISMS | MODEL | TRANSLATION | CLINICAL NEUROLOGY | STROKE | inflammation | neuroprotection | PERIPHERAL VASCULAR DISEASE | MICE | CELL | Cerebral Hemorrhage - metabolism | Cerebral Hemorrhage - drug therapy | Brain Injuries - drug therapy | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Male | Brain Injuries - metabolism | Animals | Interleukin-1beta - metabolism | Female | Mice | Brain Injuries - etiology | Brain Injuries - pathology | Cerebral Hemorrhage - complications | Cerebral Hemorrhage - pathology | 10177 | Original Contributions
Neuroprotection | Brain edema | Inflammation | Cell death | brain edema | ACTIVATION | cell death | RAT | DEPLETION | MECHANISMS | MODEL | TRANSLATION | CLINICAL NEUROLOGY | STROKE | inflammation | neuroprotection | PERIPHERAL VASCULAR DISEASE | MICE | CELL | Cerebral Hemorrhage - metabolism | Cerebral Hemorrhage - drug therapy | Brain Injuries - drug therapy | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Male | Brain Injuries - metabolism | Animals | Interleukin-1beta - metabolism | Female | Mice | Brain Injuries - etiology | Brain Injuries - pathology | Cerebral Hemorrhage - complications | Cerebral Hemorrhage - pathology | 10177 | Original Contributions
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Loading RightsArteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2017, Volume 37, Issue 4, pp. 694 - 706
OBJECTIVE—Increasing evidence suggests that contractile dysfunction in smooth muscle cells (SMCs) plays a critical role in aortic biomechanical dysfunction and...
Caspase 1 | Glyburide | Inflammasomes | Contractile proteins | Proteolysis | Aortic aneurysm | OXIDATIVE STRESS | ACTIVATION | glyburide | inflammasomes | FOCUS | INJURY | caspase 1 | DELETION | aortic aneurysm | PERIPHERAL VASCULAR DISEASE | MICE | MUTATIONS | ISCHEMIA-REPERFUSION | HEMATOLOGY | proteolysis | contractile proteins | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Abdominal - prevention & control | Inflammasomes - metabolism | Humans | Middle Aged | Caspase 1 - metabolism | Male | Mice, 129 Strain | Aorta, Abdominal - drug effects | Aneurysm, Dissecting - physiopathology | Glyburide - pharmacology | Inflammasomes - antagonists & inhibitors | Myocytes, Smooth Muscle - drug effects | Aneurysm, Dissecting - prevention & control | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Myocytes, Smooth Muscle - enzymology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Vasoconstriction - drug effects | Aortic Aneurysm, Thoracic - physiopathology | Mice, Knockout | Aorta, Thoracic - enzymology | Biomechanical Phenomena | Phenotype | Aortic Aneurysm, Abdominal - enzymology | Aortic Aneurysm, Abdominal - physiopathology | Caspase 1 - deficiency | Muscle, Smooth, Vascular - enzymology | Aortic Aneurysm, Thoracic - genetics | Aortic Aneurysm, Thoracic - prevention & control | Myocytes, Smooth Muscle - pathology | Muscle, Smooth, Vascular - physiopathology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aneurysm, Dissecting - enzymology | Muscle Proteins - metabolism | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Angiotensin II | Aorta, Abdominal - physiopathology | Aorta, Thoracic - pathology | Aortic Aneurysm, Thoracic - enzymology | Mice, Inbred C57BL | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Aorta, Thoracic - physiopathology | Aorta, Abdominal - enzymology | Inflammasomes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - deficiency | Muscle, Smooth, Vascular - pathology | Animals | Caspase 1 - genetics | Aged | aneurysm | cardiovascular diseases | contractility | vessels
Caspase 1 | Glyburide | Inflammasomes | Contractile proteins | Proteolysis | Aortic aneurysm | OXIDATIVE STRESS | ACTIVATION | glyburide | inflammasomes | FOCUS | INJURY | caspase 1 | DELETION | aortic aneurysm | PERIPHERAL VASCULAR DISEASE | MICE | MUTATIONS | ISCHEMIA-REPERFUSION | HEMATOLOGY | proteolysis | contractile proteins | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Abdominal - prevention & control | Inflammasomes - metabolism | Humans | Middle Aged | Caspase 1 - metabolism | Male | Mice, 129 Strain | Aorta, Abdominal - drug effects | Aneurysm, Dissecting - physiopathology | Glyburide - pharmacology | Inflammasomes - antagonists & inhibitors | Myocytes, Smooth Muscle - drug effects | Aneurysm, Dissecting - prevention & control | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Myocytes, Smooth Muscle - enzymology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Vasoconstriction - drug effects | Aortic Aneurysm, Thoracic - physiopathology | Mice, Knockout | Aorta, Thoracic - enzymology | Biomechanical Phenomena | Phenotype | Aortic Aneurysm, Abdominal - enzymology | Aortic Aneurysm, Abdominal - physiopathology | Caspase 1 - deficiency | Muscle, Smooth, Vascular - enzymology | Aortic Aneurysm, Thoracic - genetics | Aortic Aneurysm, Thoracic - prevention & control | Myocytes, Smooth Muscle - pathology | Muscle, Smooth, Vascular - physiopathology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aneurysm, Dissecting - enzymology | Muscle Proteins - metabolism | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Angiotensin II | Aorta, Abdominal - physiopathology | Aorta, Thoracic - pathology | Aortic Aneurysm, Thoracic - enzymology | Mice, Inbred C57BL | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Aorta, Thoracic - physiopathology | Aorta, Abdominal - enzymology | Inflammasomes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - deficiency | Muscle, Smooth, Vascular - pathology | Animals | Caspase 1 - genetics | Aged | aneurysm | cardiovascular diseases | contractility | vessels
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Loading RightsJournal of Experimental Medicine, ISSN 0022-1007, 06/2017, Volume 214, Issue 6, pp. 1725 - 1736
NLRP3 is a cytosolic pattern recognition receptor that senses microbes and endogenous danger signals. Upon activation, NLRP3 forms an inflammasome with the...
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | INHIBITION | MACROPHAGES | DISEASE | RIG-I | IMMUNOLOGY | OLIGOMERIZATION | NF-KAPPA-B | RECOGNIZES | ADAPTER ASC | DEUBIQUITINATION | Amino Acid Sequence | Phosphorylation | Inflammasomes - metabolism | Pyrin - chemistry | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Humans | Models, Molecular | Structure-Activity Relationship | Phosphoserine - metabolism | Animals | Models, Biological | HEK293 Cells | Protein Phosphatase 2 - metabolism | Protein Binding | Protein Domains | Mice | NLR Family, Pyrin Domain-Containing 3 Protein - chemistry | Immune response | Cytokines | Adapters | Caspase | Activation | Hazards | Inflammation | Pattern recognition | Dephosphorylation | Kinases | Caspase-1 | Cell activation | Pyrin protein | Cell death | Transcription activation | Aberration | Assembly | 311
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | INHIBITION | MACROPHAGES | DISEASE | RIG-I | IMMUNOLOGY | OLIGOMERIZATION | NF-KAPPA-B | RECOGNIZES | ADAPTER ASC | DEUBIQUITINATION | Amino Acid Sequence | Phosphorylation | Inflammasomes - metabolism | Pyrin - chemistry | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Humans | Models, Molecular | Structure-Activity Relationship | Phosphoserine - metabolism | Animals | Models, Biological | HEK293 Cells | Protein Phosphatase 2 - metabolism | Protein Binding | Protein Domains | Mice | NLR Family, Pyrin Domain-Containing 3 Protein - chemistry | Immune response | Cytokines | Adapters | Caspase | Activation | Hazards | Inflammation | Pattern recognition | Dephosphorylation | Kinases | Caspase-1 | Cell activation | Pyrin protein | Cell death | Transcription activation | Aberration | Assembly | 311
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Loading RightsInternational Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 03/2017, Volume 84, pp. 22 - 34
Endothelial dysfunction caused by endothelial cells senescence and chronic inflammation is tightly linked to the development of cardiovascular diseases. NLRP3...
TXNIP | Senescence | IL-1β | NLRP3 inflammasome | ROS | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATHEROSCLEROSIS | PHENOTYPE | IL-1 beta | MECHANISMS | CELLULAR SENESCENCE | CELL BIOLOGY | PREMATURE SENESCENCE | IN-VIVO | PERSPECTIVES | CARDIOVASCULAR-DISEASE | SECRETION | Human Umbilical Vein Endothelial Cells | RNA, Small Interfering - genetics | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Cytoskeletal Proteins - antagonists & inhibitors | Cytoskeletal Proteins - genetics | Humans | Cellular Senescence - drug effects | Male | Aorta - metabolism | RNA, Messenger - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aging - genetics | Interleukin-1beta - metabolism | Apoptosis Regulatory Proteins - genetics | Cytoskeletal Proteins - metabolism | Thioredoxins - metabolism | Bleomycin - toxicity | Endothelial Cells - metabolism | Models, Cardiovascular | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Carrier Proteins - antagonists & inhibitors | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Cellular Senescence - physiology | Aging - pathology | Apoptosis Regulatory Proteins - metabolism | Aorta - pathology | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Endothelial Cells - cytology | CARD Signaling Adaptor Proteins | Apoptosis Regulatory Proteins - antagonists & inhibitors | Mice | Aging - metabolism | Endothelial Cells - drug effects
TXNIP | Senescence | IL-1β | NLRP3 inflammasome | ROS | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATHEROSCLEROSIS | PHENOTYPE | IL-1 beta | MECHANISMS | CELLULAR SENESCENCE | CELL BIOLOGY | PREMATURE SENESCENCE | IN-VIVO | PERSPECTIVES | CARDIOVASCULAR-DISEASE | SECRETION | Human Umbilical Vein Endothelial Cells | RNA, Small Interfering - genetics | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Cytoskeletal Proteins - antagonists & inhibitors | Cytoskeletal Proteins - genetics | Humans | Cellular Senescence - drug effects | Male | Aorta - metabolism | RNA, Messenger - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aging - genetics | Interleukin-1beta - metabolism | Apoptosis Regulatory Proteins - genetics | Cytoskeletal Proteins - metabolism | Thioredoxins - metabolism | Bleomycin - toxicity | Endothelial Cells - metabolism | Models, Cardiovascular | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Carrier Proteins - antagonists & inhibitors | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Cellular Senescence - physiology | Aging - pathology | Apoptosis Regulatory Proteins - metabolism | Aorta - pathology | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Endothelial Cells - cytology | CARD Signaling Adaptor Proteins | Apoptosis Regulatory Proteins - antagonists & inhibitors | Mice | Aging - metabolism | Endothelial Cells - drug effects
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Loading RightsArteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 12/2018, Volume 38, Issue 12, pp. 2765 - 2779
Inflammation is an important innate immune response to infection or tissue damage. Inflammasomes are involved in the onset and development of inflammation. The...
atherosclerosis | myocardial ischemia | cardiovascular diseases | inflammation | interleukins | C-REACTIVE PROTEIN | TISSUE-SPECIFIC EXPRESSION | THIOREDOXIN-INTERACTING PROTEIN | GENE 2 NDRG2 | ACUTE MYOCARDIAL-INFARCTION | TOLL-LIKE RECEPTORS | PERIPHERAL VASCULAR DISEASE | ISCHEMIA-REPERFUSION | HEMATOLOGY | NF-KAPPA-B | CORONARY-ARTERY-DISEASE | GENOME-WIDE ASSOCIATION | Cardiovascular Diseases - physiopathology | Inflammasomes - metabolism | Cardiovascular Diseases - metabolism | Immunity, Innate - drug effects | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Cardiovascular Diseases - drug therapy | Humans | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Molecular Targeted Therapy | Cardiovascular Agents - therapeutic use | Cardiovascular Diseases - immunology | Animals | NLR Family, Pyrin Domain-Containing 3 Protein - immunology | Inflammasomes - antagonists & inhibitors | Signal Transduction - drug effects | Inflammasomes - immunology | Anti-Inflammatory Agents - therapeutic use
atherosclerosis | myocardial ischemia | cardiovascular diseases | inflammation | interleukins | C-REACTIVE PROTEIN | TISSUE-SPECIFIC EXPRESSION | THIOREDOXIN-INTERACTING PROTEIN | GENE 2 NDRG2 | ACUTE MYOCARDIAL-INFARCTION | TOLL-LIKE RECEPTORS | PERIPHERAL VASCULAR DISEASE | ISCHEMIA-REPERFUSION | HEMATOLOGY | NF-KAPPA-B | CORONARY-ARTERY-DISEASE | GENOME-WIDE ASSOCIATION | Cardiovascular Diseases - physiopathology | Inflammasomes - metabolism | Cardiovascular Diseases - metabolism | Immunity, Innate - drug effects | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Cardiovascular Diseases - drug therapy | Humans | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Molecular Targeted Therapy | Cardiovascular Agents - therapeutic use | Cardiovascular Diseases - immunology | Animals | NLR Family, Pyrin Domain-Containing 3 Protein - immunology | Inflammasomes - antagonists & inhibitors | Signal Transduction - drug effects | Inflammasomes - immunology | Anti-Inflammatory Agents - therapeutic use
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Loading RightsAmerican Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 08/2017, Volume 196, Issue 3, pp. 283 - 297
Rationale: Severe, steroid-resistant asthma is the major unmet need in asthma therapy. Disease heterogeneity and poor understanding of pathogenic mechanisms...
Pyrin domain-containing 3 | MCC950 | IL-1β | Nucleotide-binding oligomerization domain-like receptor family | Steroidresistant asthma | ALLERGIC AIRWAYS DISEASE | IL-1 beta | PHENOTYPES | steroid-resistant asthma | HYPERRESPONSIVENESS | FEATURES | RESPIRATORY-INFECTION | NEUTROPHILIC ASTHMA | EPITHELIAL-CELLS | INDUCED SPUTUM | RESPIRATORY SYSTEM | REGULATORY T-CELLS | nucleotide-binding oligomerization domain-like receptor family, pyrin domain-containing 3 | PARTICULATE MATTER | CRITICAL CARE MEDICINE | Severity of Illness Index | Asthma - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Interleukin-1beta - immunology | Treatment Outcome | Interleukin-1beta - genetics | Asthma - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Animals | NLR Family, Pyrin Domain-Containing 3 Protein - immunology | Interleukin-1beta - metabolism | Asthma - immunology | Mice | Mice, Inbred BALB C | Drug Resistance | Disease Models, Animal | Disease | Cytokines | Pathogenesis | Neutrophils | Infections | Inflammation | Roles | Gene expression | Asthma | Studies | Chlamydia | Rodents | Chronic obstructive pulmonary disease
Pyrin domain-containing 3 | MCC950 | IL-1β | Nucleotide-binding oligomerization domain-like receptor family | Steroidresistant asthma | ALLERGIC AIRWAYS DISEASE | IL-1 beta | PHENOTYPES | steroid-resistant asthma | HYPERRESPONSIVENESS | FEATURES | RESPIRATORY-INFECTION | NEUTROPHILIC ASTHMA | EPITHELIAL-CELLS | INDUCED SPUTUM | RESPIRATORY SYSTEM | REGULATORY T-CELLS | nucleotide-binding oligomerization domain-like receptor family, pyrin domain-containing 3 | PARTICULATE MATTER | CRITICAL CARE MEDICINE | Severity of Illness Index | Asthma - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Interleukin-1beta - immunology | Treatment Outcome | Interleukin-1beta - genetics | Asthma - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Animals | NLR Family, Pyrin Domain-Containing 3 Protein - immunology | Interleukin-1beta - metabolism | Asthma - immunology | Mice | Mice, Inbred BALB C | Drug Resistance | Disease Models, Animal | Disease | Cytokines | Pathogenesis | Neutrophils | Infections | Inflammation | Roles | Gene expression | Asthma | Studies | Chlamydia | Rodents | Chronic obstructive pulmonary disease
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Loading RightsAMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, ISSN 1044-1549, 12/2016, Volume 55, Issue 6, pp. 815 - 824
The number of individuals in the population exposed to biomass fuel smoke (BS) is far greater than the number of cigarette smokers. About 20% of cigarette...
APOPTOSIS | IMMUNITY | OXIDATIVE STRESS | ACTIVATION | bronchial epithelial cells | BIOCHEMISTRY & MOLECULAR BIOLOGY | alveolar macrophages | INNATE | NLRP3 INFLAMMASOME | INDOOR AIR-POLLUTION | CELL BIOLOGY | nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 | OBSTRUCTIVE PULMONARY-DISEASE | biomass fuel smoke | RESPIRATORY SYSTEM | PARTICULATE MATTER | COPD | Immunohistochemistry | Smoking - adverse effects | Inflammation - pathology | Up-Regulation | Cell Proliferation | Demography | Epithelial Cells - metabolism | Inflammasomes - metabolism | Oxidative Stress | Humans | Middle Aged | Male | Biomass | Pulmonary Disease, Chronic Obstructive - pathology | Inflammation Mediators - metabolism | Female | Bronchi - pathology | Cytokines - metabolism | Cell Survival | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Smoke - adverse effects | Epithelial Cells - pathology | Aged | Apoptosis | Cell Movement
APOPTOSIS | IMMUNITY | OXIDATIVE STRESS | ACTIVATION | bronchial epithelial cells | BIOCHEMISTRY & MOLECULAR BIOLOGY | alveolar macrophages | INNATE | NLRP3 INFLAMMASOME | INDOOR AIR-POLLUTION | CELL BIOLOGY | nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 | OBSTRUCTIVE PULMONARY-DISEASE | biomass fuel smoke | RESPIRATORY SYSTEM | PARTICULATE MATTER | COPD | Immunohistochemistry | Smoking - adverse effects | Inflammation - pathology | Up-Regulation | Cell Proliferation | Demography | Epithelial Cells - metabolism | Inflammasomes - metabolism | Oxidative Stress | Humans | Middle Aged | Male | Biomass | Pulmonary Disease, Chronic Obstructive - pathology | Inflammation Mediators - metabolism | Female | Bronchi - pathology | Cytokines - metabolism | Cell Survival | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Smoke - adverse effects | Epithelial Cells - pathology | Aged | Apoptosis | Cell Movement
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Loading RightsOncology Reports, ISSN 1021-335X, 04/2016, Volume 35, Issue 4, pp. 2053 - 2064
Lung cancer is the leading cause of cancer death, and it is widely accepted that chronic inflammation is an important risk for the development of lung cancer....
lung cancer | migration | proliferation | NLRP3 inflammasome | Proliferation | Lung cancer | Migration | METASTASIS | E-CADHERIN EXPRESSION | MESENCHYMAL TRANSITION | HUMAN GASTRIC-CANCER | ADHESION MOLECULE-1 | INTERLEUKIN-18 | ONCOLOGY | PATHWAY | GENE-EXPRESSION | IL-1-BETA | TUMOR-GROWTH | Lung Neoplasms - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Adenosine Triphosphate - pharmacology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Cell Movement - drug effects | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Cell Proliferation - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Adenocarcinoma | Cell receptors | Development and progression | Genetic aspects | Models | Properties | Cell migration | Cell culture | Metastasis | Kinases | Cancer therapies | Cell adhesion & migration | Skin cancer | Studies | Proteins | Signal transduction | Liver cancer | Cell growth | Medical prognosis | Apoptosis
lung cancer | migration | proliferation | NLRP3 inflammasome | Proliferation | Lung cancer | Migration | METASTASIS | E-CADHERIN EXPRESSION | MESENCHYMAL TRANSITION | HUMAN GASTRIC-CANCER | ADHESION MOLECULE-1 | INTERLEUKIN-18 | ONCOLOGY | PATHWAY | GENE-EXPRESSION | IL-1-BETA | TUMOR-GROWTH | Lung Neoplasms - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Adenosine Triphosphate - pharmacology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Cell Movement - drug effects | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Cell Proliferation - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Adenocarcinoma | Cell receptors | Development and progression | Genetic aspects | Models | Properties | Cell migration | Cell culture | Metastasis | Kinases | Cancer therapies | Cell adhesion & migration | Skin cancer | Studies | Proteins | Signal transduction | Liver cancer | Cell growth | Medical prognosis | Apoptosis
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Loading RightsScience, ISSN 0036-8075, 05/2017, Volume 356, Issue 6337, pp. 513 - 519
Interleukin 10 (IL-10) is an anti-inflammatory cytokine that plays a critical role in the control of immune responses. However, its mechanisms of action remain...
GROWTH-CONTROL | MTORC1 | ACTIVATION | DENDRITIC CELLS | PROTEIN-KINASE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | DISEASE | MICE | AUTOPHAGY | MECHANISTIC TARGET | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Signal Transduction | TOR Serine-Threonine Kinases - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Humans | Inflammatory Bowel Diseases - immunology | Mitochondria - immunology | Mitochondria - metabolism | Intestines - immunology | TOR Serine-Threonine Kinases - antagonists & inhibitors | Transcription Factors - metabolism | Receptors, Interleukin-10 - metabolism | Macrophages - metabolism | Animals | Interleukin-1beta - metabolism | Mice, Mutant Strains | Inflammasomes - immunology | Interleukin-10 - genetics | Interleukin-10 - metabolism | Mice | Colitis - immunology | Disease Models, Animal | Phosphorylation | Immune response | Cytokines | Interleukin | Inflammation | Rapamycin | Glucose | Metabolism | Macrophages | IL-1β | Inflammatory bowel disease | Mitochondria | Crohn's Disease | Immunology | Inhibitors | Rodents | Glycolysis | Damage accumulation | Patients | Diseases
GROWTH-CONTROL | MTORC1 | ACTIVATION | DENDRITIC CELLS | PROTEIN-KINASE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | DISEASE | MICE | AUTOPHAGY | MECHANISTIC TARGET | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Signal Transduction | TOR Serine-Threonine Kinases - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Humans | Inflammatory Bowel Diseases - immunology | Mitochondria - immunology | Mitochondria - metabolism | Intestines - immunology | TOR Serine-Threonine Kinases - antagonists & inhibitors | Transcription Factors - metabolism | Receptors, Interleukin-10 - metabolism | Macrophages - metabolism | Animals | Interleukin-1beta - metabolism | Mice, Mutant Strains | Inflammasomes - immunology | Interleukin-10 - genetics | Interleukin-10 - metabolism | Mice | Colitis - immunology | Disease Models, Animal | Phosphorylation | Immune response | Cytokines | Interleukin | Inflammation | Rapamycin | Glucose | Metabolism | Macrophages | IL-1β | Inflammatory bowel disease | Mitochondria | Crohn's Disease | Immunology | Inhibitors | Rodents | Glycolysis | Damage accumulation | Patients | Diseases
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Loading RightsNature Immunology, ISSN 1529-2908, 09/2016, Volume 17, Issue 10, pp. 1176 - 1186
Inflammasomes are positioned to rapidly escalate the intensity of inflammation by activating interleukin (IL)-1β, IL-18 and cell death by pyroptosis. However,...
Cryopyrin-Associated Periodic Syndromes - immunology | Cyclic AMP-Dependent Protein Kinases - metabolism | Cell Line | Inflammasomes - metabolism | Cryopyrin-Associated Periodic Syndromes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Humans | Mice, Inbred C57BL | Adenosine Triphosphatases - metabolism | Serine - genetics | Male | Signal Transduction - genetics | Mutation - genetics | Dinoprostone - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Phenotype | Phosphorylation - genetics | Animals | Mice | Mice, Inbred BALB C | Monocytes - physiology | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Cellular signal transduction | Genetic aspects | Disease susceptibility | Gene mutations | Health aspects
Cryopyrin-Associated Periodic Syndromes - immunology | Cyclic AMP-Dependent Protein Kinases - metabolism | Cell Line | Inflammasomes - metabolism | Cryopyrin-Associated Periodic Syndromes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Humans | Mice, Inbred C57BL | Adenosine Triphosphatases - metabolism | Serine - genetics | Male | Signal Transduction - genetics | Mutation - genetics | Dinoprostone - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Phenotype | Phosphorylation - genetics | Animals | Mice | Mice, Inbred BALB C | Monocytes - physiology | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Cellular signal transduction | Genetic aspects | Disease susceptibility | Gene mutations | Health aspects
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Loading RightsProceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2017, Volume 114, Issue 6, pp. E961 - E969
Necroptosis is a physiological cell suicide mechanism initiated by receptor-interacting protein kinase-3 (RIPK3) phosphorylation of mixed-lineage kinase...
NLRP3 | Gasdermin D | MLKL | Necroptosis | Interleukin-1β | ACTIVATION | BRAIN-INJURY | MULTIDISCIPLINARY SCIENCES | DOMAIN-LIKE PROTEIN | MIXED LINEAGE KINASE | PROGRAMMED NECROSIS | K+ EFFLUX | interleukin-1 beta | RIP3 KINASE | MULTIPLE-SCLEROSIS | MEMBRANE PORES | necroptosis | Protein Kinases - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Protein Kinases - genetics | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Humans | Protein Kinases - chemistry | Caspase 1 - metabolism | Mice, Knockout | Necrosis | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Macrophages - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Caspase 1 - genetics | Interleukin-1beta - metabolism | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Bone Marrow Cells - drug effects | Macrophages - drug effects | Mice | Bone Marrow Cells - metabolism | Protein Multimerization - drug effects | Apoptosis | Physiological aspects | Observations | Protein kinases | Protein-protein interactions | Proteins | Signal transduction | Membranes | Kinases | Biological Sciences | PNAS Plus | interleukin-1β
NLRP3 | Gasdermin D | MLKL | Necroptosis | Interleukin-1β | ACTIVATION | BRAIN-INJURY | MULTIDISCIPLINARY SCIENCES | DOMAIN-LIKE PROTEIN | MIXED LINEAGE KINASE | PROGRAMMED NECROSIS | K+ EFFLUX | interleukin-1 beta | RIP3 KINASE | MULTIPLE-SCLEROSIS | MEMBRANE PORES | necroptosis | Protein Kinases - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Protein Kinases - genetics | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Humans | Protein Kinases - chemistry | Caspase 1 - metabolism | Mice, Knockout | Necrosis | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Macrophages - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Caspase 1 - genetics | Interleukin-1beta - metabolism | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Bone Marrow Cells - drug effects | Macrophages - drug effects | Mice | Bone Marrow Cells - metabolism | Protein Multimerization - drug effects | Apoptosis | Physiological aspects | Observations | Protein kinases | Protein-protein interactions | Proteins | Signal transduction | Membranes | Kinases | Biological Sciences | PNAS Plus | interleukin-1β
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Loading Rights中国免疫学杂志：英文版, ISSN 1672-7681, 2016, Volume 13, Issue 2, pp. 148 - 159
Inflammasomes are multi-protein signaling complexes that trigger the activation of inflammatory caspases and the maturation of interleukin-1β. Among various...
蛋白复合物 | 激活 | 化调 | 分子机制 | 自身免疫性疾病 | 半胱天冬酶 | 白细胞介素-1β | 炎症反应 | interaction | NLRP3 | mechanism | inflammation | inflammasome | OXIDATIVE STRESS | XANTHINE OXIDOREDUCTASE | DENDRITIC CELLS | CHRONIC GRANULOMATOUS-DISEASE | IMMUNOLOGY | NALP3 INFLAMMASOME | INTERLEUKIN-1-BETA IL-1-BETA | IL-1-BETA PRODUCTION | INSULIN-RESISTANCE | BACTERIAL-INFECTION | ANTIVIRAL IMMUNITY | Inflammation - pathology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Cytosol - immunology | Humans | Autoimmune Diseases - immunology | Interleukin-1beta - immunology | Inflammation - immunology | Signal Transduction - immunology | Animals | NLR Family, Pyrin Domain-Containing 3 Protein - immunology | Inflammasomes - immunology | Cytosol - pathology | Autoimmune Diseases - pathology | Review
蛋白复合物 | 激活 | 化调 | 分子机制 | 自身免疫性疾病 | 半胱天冬酶 | 白细胞介素-1β | 炎症反应 | interaction | NLRP3 | mechanism | inflammation | inflammasome | OXIDATIVE STRESS | XANTHINE OXIDOREDUCTASE | DENDRITIC CELLS | CHRONIC GRANULOMATOUS-DISEASE | IMMUNOLOGY | NALP3 INFLAMMASOME | INTERLEUKIN-1-BETA IL-1-BETA | IL-1-BETA PRODUCTION | INSULIN-RESISTANCE | BACTERIAL-INFECTION | ANTIVIRAL IMMUNITY | Inflammation - pathology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Cytosol - immunology | Humans | Autoimmune Diseases - immunology | Interleukin-1beta - immunology | Inflammation - immunology | Signal Transduction - immunology | Animals | NLR Family, Pyrin Domain-Containing 3 Protein - immunology | Inflammasomes - immunology | Cytosol - pathology | Autoimmune Diseases - pathology | Review
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