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1. Full Text Selective NLRP3 (Pyrin Domain–Containing Protein 3) Inflammasome Inhibitor Reduces Brain Injury After Intracerebral Hemorrhage
by Ren, Honglei and Kong, Ying and Liu, Zhijia and Zang, Dongyun and Yang, Xiaoxia and Wood, Kristofer and Li, Minshu and Liu, Qiang
Stroke (1970), ISSN 0039-2499, 12/2017, Volume 49, Issue 1, pp. 184 - 192
Neuroprotection | Brain edema | Inflammation | Cell death | Clinical Neurology | Peripheral Vascular Disease | Neurosciences & Neurology | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cerebral Hemorrhage - metabolism | Cerebral Hemorrhage - drug therapy | Brain Injuries - drug therapy | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Male | Brain Injuries - metabolism | Animals | Interleukin-1beta - metabolism | Female | Mice | Brain Injuries - etiology | Brain Injuries - pathology | Cerebral Hemorrhage - complications | Cerebral Hemorrhage - pathology | Index Medicus | brain edema | 10177 | cell death | inflammation | Original Contributions | neuroprotection
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2. Full Text NLRP3 inflammasome activation drives tau pathology
by Ising, Christina and Venegas, Carmen and Zhang, Shuangshuang and Scheiblich, Hannah and Schmidt, Susanne V and Vieira-Saecker, Ana and Schwartz, Stephanie and Albasset, Shadi and McManus, Roisin M and Tejera, Dario and Griep, Angelika and Santarelli, Francesco and Brosseron, Frederic and Opitz, Sabine and Stunden, James and Merten, Maximilian and Kayed, Rakez and Golenbock, Douglas T and Blum, David and Latz, Eicke and Buee, Luc and Heneka, Michael T
Nature (London), ISSN 0028-0836, 11/2019, Volume 575, Issue 7784, pp. 669 - 673
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Phosphorylation | Inflammasomes - metabolism | Gene Expression Regulation - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Humans | Mice, Inbred C57BL | tau Proteins - metabolism | Inflammasomes - genetics | Cyclin-Dependent Kinase 5 - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Animals | tau Proteins - genetics | Microglia - pathology | Mice | Protein Aggregation, Pathological - physiopathology | Diagnosis | NLRP proteins | Analysis | Tau proteins | Dementia | Neurodegenerative diseases | Pathogenesis | Interleukin | Cognitive ability | Activation | Agglomeration | Inflammation | Kinases | Gene expression | Caspase-1 | Microglia | Pathology | Neurofibrillary tangles | Tau protein | Neurodegeneration | Transgenic animals | Morphology | Alzheimers disease | Alzheimer's disease | Plaques | Index Medicus | Life Sciences | Neuroscience | Cognitive science | Neurons and Cognition
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3. Full Text UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis
by Moon, Jong-Seok and Lee, Seonmin and Park, Mi-Ae and Siempos, Ilias I and Haslip, Maria and Lee, Patty J and Yun, Mijin and Kim, Chun K and Howrylak, Judie and Ryter, Stefan W and Nakahira, Kiichi and Choi, Augustine M. K
The Journal of clinical investigation, ISSN 0021-9738, 02/2015, Volume 125, Issue 2, pp. 665 - 680
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Fatty Acid Synthase, Type I - genetics | Fatty Acid Synthase, Type I - biosynthesis | Lipids - genetics | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Ion Channels - genetics | Caspase 1 - metabolism | Mitochondrial Proteins - genetics | Interleukin-1beta - genetics | Lipids - biosynthesis | Sepsis - pathology | Interleukin-1beta - metabolism | Mitochondrial Proteins - metabolism | Sepsis - metabolism | Macrophages - pathology | Down-Regulation - genetics | Inflammasomes - genetics | Sepsis - genetics | Mice, Knockout | Carrier Proteins - genetics | Enzyme Induction - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Sepsis - chemically induced | Ion Channels - metabolism | Caspase 1 - genetics | Sepsis - therapy | Mice | Uncoupling Protein 2 | Interleukin-18 - genetics | Interleukin-18 - metabolism | Cellular proteins | Immune response | Synthesis | Sepsis | Development and progression | Lipids | Genetic aspects | Properties | Enzymes | Cytokines | Pathogenesis | Mortality | Glucose | Metabolism | Gene expression | Fatty acids | Proteins | Studies | Metabolites | Consent | Rodents | Index Medicus | Abridged Index Medicus
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4. Full Text Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis
by Walle, Lieselotte Vande and Van Opdenbosch, Nina and Jacques, Peggy and Fossoul, Amelie and Verheugen, Eveline and Vogel, Peter and Beyaert, Rudi and Elewaut, Dirk and Kanneganti, Thirumala-Devi and Van Loo, Geert and Lamkanfi, Mohamed
Nature (London), ISSN 0028-0836, 2014, Volume 512, Issue 1, pp. 69 - 73
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Caspase 1 - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Intracellular Signaling Peptides and Proteins - deficiency | Arthritis, Rheumatoid - metabolism | Arthritis, Rheumatoid - prevention & control | Cysteine Endopeptidases - metabolism | Receptors, Interleukin-1 - deficiency | Cysteine Endopeptidases - deficiency | Female | Tumor Necrosis Factor alpha-Induced Protein 3 | DNA-Binding Proteins | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Interleukin-1 - metabolism | Signal Transduction | Nuclear Proteins - metabolism | Apoptosis Regulatory Proteins - metabolism | Arthritis, Rheumatoid - pathology | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Macrophages - metabolism | Phenotype | Animals | Carrier Proteins - metabolism | Caspase 1 - deficiency | Mice | Arthritis, Rheumatoid - immunology | Prevention | Rheumatoid arthritis | Physiological aspects | NLRP3 | Properties | Macrophages | Risk factors | Proteins | Pathology | Dehydrogenases | Histopathology | Pathogenesis | Rodents | Protein expression | Index Medicus | Nlrp3 | IL1R1 | caspase-1 | inflammasome | A20
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5. Full Text NLR Family Pyrin Domain‐Containing 3 Inflammasome Activation in Hepatic Stellate Cells Induces Liver Fibrosis in Mice
by Inzaugarat, Maria Eugenia and Johnson, Casey D and Holtmann, Theresa Maria and McGeough, Matthew D and Trautwein, Christian and Papouchado, Bettina G and Schwabe, Robert and Hoffman, Hal M and Wree, Alexander and Feldstein, Ariel E
Hepatology (Baltimore, Md.), ISSN 0270-9139, 02/2019, Volume 69, Issue 2, pp. 845 - 859
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Biomarkers - metabolism | Liver Cirrhosis - etiology | Liver - pathology | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | Hepatic Stellate Cells - metabolism | Male | Mice, Transgenic | Lipopolysaccharides | Myofibroblasts - metabolism | Animals | Liver Cirrhosis - metabolism | Liver Cirrhosis - pathology | Female | Immunohistochemistry | Flow cytometry | Reactive oxygen species | Lecithin | Liver | Smooth muscle | Western blotting | Proteins | Vitamin A | Actin | Rodents | Cathepsin B | Stellate cells | Phenotypes | Transgenic mice | Inflammation | Acyltransferase | Tamoxifen | Gene expression | Desmin | Pyrin protein | Hepatocytes | Collagen | Fibrosis | Immunofluorescence | ATP | Index Medicus
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6. Full Text NLRP3 (Nucleotide Oligomerization Domain–Like Receptor Family, Pyrin Domain Containing 3)–Caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation
by Wu, Darrell and Ren, Pingping and Zheng, Yanqiu and Zhang, Lin and Xu, Gaiping and Xie, Wanmu and Lloyd, Eric E and Zhang, Sui and Zhang, Qianzi and Curci, John A and Coselli, Joseph S and Milewicz, Dianna M and Shen, Ying H and LeMaire, Scott A
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 04/2017, Volume 37, Issue 4, pp. 694 - 706
Caspase 1 | Glyburide | Inflammasomes | Contractile proteins | Proteolysis | Aortic aneurysm | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Abdominal - prevention & control | Inflammasomes - metabolism | Humans | Middle Aged | Caspase 1 - metabolism | Male | Mice, 129 Strain | Aorta, Abdominal - drug effects | Aneurysm, Dissecting - physiopathology | Glyburide - pharmacology | Inflammasomes - antagonists & inhibitors | Myocytes, Smooth Muscle - drug effects | Aneurysm, Dissecting - prevention & control | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Myocytes, Smooth Muscle - enzymology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Vasoconstriction - drug effects | Aortic Aneurysm, Thoracic - physiopathology | Mice, Knockout | Aorta, Thoracic - enzymology | Biomechanical Phenomena | Phenotype | Aortic Aneurysm, Abdominal - enzymology | Aortic Aneurysm, Abdominal - physiopathology | Caspase 1 - deficiency | Muscle, Smooth, Vascular - enzymology | Aortic Aneurysm, Thoracic - genetics | Aortic Aneurysm, Thoracic - prevention & control | Myocytes, Smooth Muscle - pathology | Muscle, Smooth, Vascular - physiopathology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aneurysm, Dissecting - enzymology | Muscle Proteins - metabolism | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Angiotensin II | Aorta, Abdominal - physiopathology | Aorta, Thoracic - pathology | Aortic Aneurysm, Thoracic - enzymology | Mice, Inbred C57BL | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Aorta, Thoracic - physiopathology | Aorta, Abdominal - enzymology | Inflammasomes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - deficiency | Muscle, Smooth, Vascular - pathology | Animals | Caspase 1 - genetics | Aged | Index Medicus | aneurysm | cardiovascular diseases | contractility | vessels
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7. Full Text NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component
by Shi, Hexin and Wang, Ying and Li, Xiaohong and Zhan, Xiaoming and Tang, Miao and Fina, Maggy and Su, Lijing and Pratt, David and Hui Bu, Chun and Hildebrand, Sara and Lyon, Stephen and Scott, Lindsay and Quan, Jiexia and Sun, Qihua and Russell, Jamie and Arnett, Stephanie and Jurek, Peter and Chen, Ding and Kravchenko, Vladimir V and Mathison, John C and Moresco, Eva Marie Y and Monson, Nancy L and Ulevitch, Richard J and Beutler, Bruce
Nature immunology, ISSN 1529-2908, 02/2016, Volume 17, Issue 3, pp. 250 - 258
Life Sciences & Biomedicine | Immunology | Science & Technology | Cytoskeletal Proteins | Dendritic Cells | Immunoprecipitation | Reactive Oxygen Species | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Male | Flow Cytometry | HEK293 Cells | Female | Caspase 1 | Colony-Forming Units Assay | Carrier Proteins - immunology | Macrophages - immunology | Cytokines | Mice, Inbred C57BL | Mitosis - immunology | Protein-Serine-Threonine Kinases - genetics | Macrophages, Peritoneal - immunology | Mitochondria - metabolism | Inflammasomes - genetics | Mice, Knockout | Spinal Cord - immunology | Carrier Proteins - genetics | Monocytes | Animals | Apoptosis Regulatory Proteins | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Protein-Serine-Threonine Kinases - immunology | Mice | Chromatography, Gel | In Vitro Techniques | Apoptosis | NIMA-Related Kinases | Cell receptors | Immune response | Mitosis | Genetic aspects | Regulation | Properties | Health aspects | Phosphotransferases | Index Medicus
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8. Full Text Autophagy Attenuates Angiotensin II-Induced Pulmonary Fibrosis by Inhibiting Redox Imbalance-Mediated NOD-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation
by Meng, Ying and Pan, Miaoxia and Zheng, Bojun and Chen, Yan and Li, Wei and Yang, Qianjie and Zheng, Zemao and Sun, Nana and Zhang, Yue and Li, Xu
Antioxidants & redox signaling, ISSN 1523-0864, 02/2019, Volume 30, Issue 4, pp. 52 - 541
Original Research Communications | autophagy | angiotensin II | mitochondria | P62/SQSTM1 | NADPH oxidase 4 | NLRP3 inflammasome | lung fibrosis | nuclear erythroid 2-related factor 2 | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Angiotensin II - pharmacology | Inflammasomes - metabolism | Rats, Wistar | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Humans | Mice, Inbred C57BL | Cells, Cultured | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Rats | Male | Pulmonary Fibrosis - pathology | Autophagy - drug effects | Animals | Inflammasomes - antagonists & inhibitors | Oxidation-Reduction - drug effects | Pulmonary Fibrosis - chemically induced | Mice | Pulmonary Fibrosis - metabolism | Index Medicus
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9. Full Text Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway
by Yin, Yanlin and Zhou, Zhihui and Liu, Weiwei and Chang, Qun and Sun, Guanqun and Dai, Yalei
The international journal of biochemistry & cell biology, ISSN 1357-2725, 03/2017, Volume 84, pp. 22 - 34
TXNIP | Senescence | IL-1β | NLRP3 inflammasome | ROS | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Human Umbilical Vein Endothelial Cells | RNA, Small Interfering - genetics | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Cytoskeletal Proteins - antagonists & inhibitors | Cytoskeletal Proteins - genetics | Humans | Cellular Senescence - drug effects | Male | Aorta - metabolism | RNA, Messenger - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aging - genetics | Interleukin-1beta - metabolism | Apoptosis Regulatory Proteins - genetics | Cytoskeletal Proteins - metabolism | Thioredoxins - metabolism | Bleomycin - toxicity | Endothelial Cells - metabolism | Models, Cardiovascular | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Carrier Proteins - antagonists & inhibitors | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Cellular Senescence - physiology | Aging - pathology | Apoptosis Regulatory Proteins - metabolism | Aorta - pathology | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Endothelial Cells - cytology | CARD Signaling Adaptor Proteins | Apoptosis Regulatory Proteins - antagonists & inhibitors | Mice | Aging - metabolism | Endothelial Cells - drug effects | Index Medicus
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10. Full Text An NLRP3 inflammasome-triggered Th2-biased adaptive immune response promotes leishmaniasis
by Gurung, Prajwal and Karki, Rajendra and Vogel, Peter and Watanabe, Makiko and Bix, Mark and Lamkanfi, Mohamed and Kanneganti, Thirumala-Devi
The Journal of clinical investigation, ISSN 0021-9738, 03/2015, Volume 125, Issue 3, pp. 1329 - 1338
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Adaptive Immunity | Carrier Proteins - physiology | Interleukin-1beta - secretion | Leishmania major - immunology | NLR Family, Pyrin Domain-Containing 3 Protein | Cells, Cultured | Caspase 1 - metabolism | Th2 Cells - immunology | Leishmaniasis, Cutaneous - immunology | Mice, Knockout | Macrophages - parasitology | Inflammasomes - physiology | Macrophages - secretion | Animals | Interleukin-18 - secretion | Mice, Inbred BALB C | NOD-like receptors | Development and progression | Genetic aspects | Immune response | Leishmaniasis | Health aspects | Flow cytometry | Para