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Stroke (1970), ISSN 0039-2499, 12/2017, Volume 49, Issue 1, pp. 184 - 192
Neuroprotection | Brain edema | Inflammation | Cell death | Clinical Neurology | Peripheral Vascular Disease | Neurosciences & Neurology | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cerebral Hemorrhage - metabolism | Cerebral Hemorrhage - drug therapy | Brain Injuries - drug therapy | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Male | Brain Injuries - metabolism | Animals | Interleukin-1beta - metabolism | Female | Mice | Brain Injuries - etiology | Brain Injuries - pathology | Cerebral Hemorrhage - complications | Cerebral Hemorrhage - pathology | Index Medicus | brain edema | 10177 | cell death | inflammation | Original Contributions | neuroprotection
Journal Article
Nature (London), ISSN 0028-0836, 11/2019, Volume 575, Issue 7784, pp. 669 - 673
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Phosphorylation | Inflammasomes - metabolism | Gene Expression Regulation - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Humans | Mice, Inbred C57BL | tau Proteins - metabolism | Inflammasomes - genetics | Cyclin-Dependent Kinase 5 - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Animals | tau Proteins - genetics | Microglia - pathology | Mice | Protein Aggregation, Pathological - physiopathology | Diagnosis | NLRP proteins | Analysis | Tau proteins | Dementia | Neurodegenerative diseases | Pathogenesis | Interleukin | Cognitive ability | Activation | Agglomeration | Inflammation | Kinases | Gene expression | Caspase-1 | Microglia | Pathology | Neurofibrillary tangles | Tau protein | Neurodegeneration | Transgenic animals | Morphology | Alzheimers disease | Alzheimer's disease | Plaques | Index Medicus | Life Sciences | Neuroscience | Cognitive science | Neurons and Cognition
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 02/2015, Volume 125, Issue 2, pp. 665 - 680
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Fatty Acid Synthase, Type I - genetics | Fatty Acid Synthase, Type I - biosynthesis | Lipids - genetics | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Ion Channels - genetics | Caspase 1 - metabolism | Mitochondrial Proteins - genetics | Interleukin-1beta - genetics | Lipids - biosynthesis | Sepsis - pathology | Interleukin-1beta - metabolism | Mitochondrial Proteins - metabolism | Sepsis - metabolism | Macrophages - pathology | Down-Regulation - genetics | Inflammasomes - genetics | Sepsis - genetics | Mice, Knockout | Carrier Proteins - genetics | Enzyme Induction - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Sepsis - chemically induced | Ion Channels - metabolism | Caspase 1 - genetics | Sepsis - therapy | Mice | Uncoupling Protein 2 | Interleukin-18 - genetics | Interleukin-18 - metabolism | Cellular proteins | Immune response | Synthesis | Sepsis | Development and progression | Lipids | Genetic aspects | Properties | Enzymes | Cytokines | Pathogenesis | Mortality | Glucose | Metabolism | Gene expression | Fatty acids | Proteins | Studies | Metabolites | Consent | Rodents | Index Medicus | Abridged Index Medicus
Journal Article
Nature (London), ISSN 0028-0836, 2014, Volume 512, Issue 1, pp. 69 - 73
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Caspase 1 - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Intracellular Signaling Peptides and Proteins - deficiency | Arthritis, Rheumatoid - metabolism | Arthritis, Rheumatoid - prevention & control | Cysteine Endopeptidases - metabolism | Receptors, Interleukin-1 - deficiency | Cysteine Endopeptidases - deficiency | Female | Tumor Necrosis Factor alpha-Induced Protein 3 | DNA-Binding Proteins | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Interleukin-1 - metabolism | Signal Transduction | Nuclear Proteins - metabolism | Apoptosis Regulatory Proteins - metabolism | Arthritis, Rheumatoid - pathology | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Macrophages - metabolism | Phenotype | Animals | Carrier Proteins - metabolism | Caspase 1 - deficiency | Mice | Arthritis, Rheumatoid - immunology | Prevention | Rheumatoid arthritis | Physiological aspects | NLRP3 | Properties | Macrophages | Risk factors | Proteins | Pathology | Dehydrogenases | Histopathology | Pathogenesis | Rodents | Protein expression | Index Medicus | Nlrp3 | IL1R1 | caspase-1 | inflammasome | A20
Journal Article
Hepatology (Baltimore, Md.), ISSN 0270-9139, 02/2019, Volume 69, Issue 2, pp. 845 - 859
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Biomarkers - metabolism | Liver Cirrhosis - etiology | Liver - pathology | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | Hepatic Stellate Cells - metabolism | Male | Mice, Transgenic | Lipopolysaccharides | Myofibroblasts - metabolism | Animals | Liver Cirrhosis - metabolism | Liver Cirrhosis - pathology | Female | Immunohistochemistry | Flow cytometry | Reactive oxygen species | Lecithin | Liver | Smooth muscle | Western blotting | Proteins | Vitamin A | Actin | Rodents | Cathepsin B | Stellate cells | Phenotypes | Transgenic mice | Inflammation | Acyltransferase | Tamoxifen | Gene expression | Desmin | Pyrin protein | Hepatocytes | Collagen | Fibrosis | Immunofluorescence | ATP | Index Medicus
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 04/2017, Volume 37, Issue 4, pp. 694 - 706
Caspase 1 | Glyburide | Inflammasomes | Contractile proteins | Proteolysis | Aortic aneurysm | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Abdominal - prevention & control | Inflammasomes - metabolism | Humans | Middle Aged | Caspase 1 - metabolism | Male | Mice, 129 Strain | Aorta, Abdominal - drug effects | Aneurysm, Dissecting - physiopathology | Glyburide - pharmacology | Inflammasomes - antagonists & inhibitors | Myocytes, Smooth Muscle - drug effects | Aneurysm, Dissecting - prevention & control | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Myocytes, Smooth Muscle - enzymology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Vasoconstriction - drug effects | Aortic Aneurysm, Thoracic - physiopathology | Mice, Knockout | Aorta, Thoracic - enzymology | Biomechanical Phenomena | Phenotype | Aortic Aneurysm, Abdominal - enzymology | Aortic Aneurysm, Abdominal - physiopathology | Caspase 1 - deficiency | Muscle, Smooth, Vascular - enzymology | Aortic Aneurysm, Thoracic - genetics | Aortic Aneurysm, Thoracic - prevention & control | Myocytes, Smooth Muscle - pathology | Muscle, Smooth, Vascular - physiopathology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aneurysm, Dissecting - enzymology | Muscle Proteins - metabolism | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Angiotensin II | Aorta, Abdominal - physiopathology | Aorta, Thoracic - pathology | Aortic Aneurysm, Thoracic - enzymology | Mice, Inbred C57BL | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Aorta, Thoracic - physiopathology | Aorta, Abdominal - enzymology | Inflammasomes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - deficiency | Muscle, Smooth, Vascular - pathology | Animals | Caspase 1 - genetics | Aged | Index Medicus | aneurysm | cardiovascular diseases | contractility | vessels
Journal Article
Nature immunology, ISSN 1529-2908, 02/2016, Volume 17, Issue 3, pp. 250 - 258
Life Sciences & Biomedicine | Immunology | Science & Technology | Cytoskeletal Proteins | Dendritic Cells | Immunoprecipitation | Reactive Oxygen Species | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Male | Flow Cytometry | HEK293 Cells | Female | Caspase 1 | Colony-Forming Units Assay | Carrier Proteins - immunology | Macrophages - immunology | Cytokines | Mice, Inbred C57BL | Mitosis - immunology | Protein-Serine-Threonine Kinases - genetics | Macrophages, Peritoneal - immunology | Mitochondria - metabolism | Inflammasomes - genetics | Mice, Knockout | Spinal Cord - immunology | Carrier Proteins - genetics | Monocytes | Animals | Apoptosis Regulatory Proteins | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Protein-Serine-Threonine Kinases - immunology | Mice | Chromatography, Gel | In Vitro Techniques | Apoptosis | NIMA-Related Kinases | Cell receptors | Immune response | Mitosis | Genetic aspects | Regulation | Properties | Health aspects | Phosphotransferases | Index Medicus
Journal Article
Antioxidants & redox signaling, ISSN 1523-0864, 02/2019, Volume 30, Issue 4, pp. 52 - 541
Original Research Communications | autophagy | angiotensin II | mitochondria | P62/SQSTM1 | NADPH oxidase 4 | NLRP3 inflammasome | lung fibrosis | nuclear erythroid 2-related factor 2 | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Angiotensin II - pharmacology | Inflammasomes - metabolism | Rats, Wistar | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Humans | Mice, Inbred C57BL | Cells, Cultured | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Rats | Male | Pulmonary Fibrosis - pathology | Autophagy - drug effects | Animals | Inflammasomes - antagonists & inhibitors | Oxidation-Reduction - drug effects | Pulmonary Fibrosis - chemically induced | Mice | Pulmonary Fibrosis - metabolism | Index Medicus
Journal Article
The international journal of biochemistry & cell biology, ISSN 1357-2725, 03/2017, Volume 84, pp. 22 - 34
TXNIP | Senescence | IL-1β | NLRP3 inflammasome | ROS | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Human Umbilical Vein Endothelial Cells | RNA, Small Interfering - genetics | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Cytoskeletal Proteins - antagonists & inhibitors | Cytoskeletal Proteins - genetics | Humans | Cellular Senescence - drug effects | Male | Aorta - metabolism | RNA, Messenger - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aging - genetics | Interleukin-1beta - metabolism | Apoptosis Regulatory Proteins - genetics | Cytoskeletal Proteins - metabolism | Thioredoxins - metabolism | Bleomycin - toxicity | Endothelial Cells - metabolism | Models, Cardiovascular | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Carrier Proteins - antagonists & inhibitors | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Cellular Senescence - physiology | Aging - pathology | Apoptosis Regulatory Proteins - metabolism | Aorta - pathology | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Endothelial Cells - cytology | CARD Signaling Adaptor Proteins | Apoptosis Regulatory Proteins - antagonists & inhibitors | Mice | Aging - metabolism | Endothelial Cells - drug effects | Index Medicus
Journal Article
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Full Text
An NLRP3 inflammasome-triggered Th2-biased adaptive immune response promotes leishmaniasis
The Journal of clinical investigation, ISSN 0021-9738, 03/2015, Volume 125, Issue 3, pp. 1329 - 1338
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Adaptive Immunity | Carrier Proteins - physiology | Interleukin-1beta - secretion | Leishmania major - immunology | NLR Family, Pyrin Domain-Containing 3 Protein | Cells, Cultured | Caspase 1 - metabolism | Th2 Cells - immunology | Leishmaniasis, Cutaneous - immunology | Mice, Knockout | Macrophages - parasitology | Inflammasomes - physiology | Macrophages - secretion | Animals | Interleukin-18 - secretion | Mice, Inbred BALB C | NOD-like receptors | Development and progression | Genetic aspects | Immune response | Leishmaniasis | Health aspects | Flow cytometry | Para