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Proceedings of the National Academy of Sciences, ISSN 0027-8424, 01/2013, Volume 110, Issue 5, pp. 1851 - 1856
A flagellin-independent caspase-1 activation pathway that does not require NAIP5 or NRLC4 is induced by the intracellular pathogen Legionella pneumophila .... 
Cell death | Innate immunity | Inflammasome | PATTERN-RECOGNITION | innate immunity | cell death | inflammasome | MULTIDISCIPLINARY SCIENCES | NLRP3 INFLAMMASOME ACTIVATION | INFECTION | RECEPTORS | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Adaptor Proteins, Vesicular Transport - genetics | Caspase 1 - metabolism | Immunoblotting | Legionella pneumophila - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Necrosis | Caspases - metabolism | Flagellin - genetics | Flagellin - metabolism | Apoptosis Regulatory Proteins - genetics | Cytoskeletal Proteins - metabolism | Receptor, Interferon alpha-beta - genetics | Macrophages - microbiology | Receptor, Interferon alpha-beta - metabolism | Calcium-Binding Proteins - metabolism | Cytokines - metabolism | Caspases - genetics | Mice, Inbred C57BL | Cells, Cultured | Myeloid Differentiation Factor 88 - genetics | Macrophages - cytology | Legionella pneumophila - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Host-Pathogen Interactions | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Bone Marrow Cells - microbiology | Legionella pneumophila - physiology | Mice | Enzyme Activation | Mutation | Myeloid Differentiation Factor 88 - metabolism | Bone Marrow Cells - metabolism | Apoptosis | Calcium-Binding Proteins - genetics | Legionella pneumophila | Genetic aspects | Research | Macrophages | Properties | Immunological research | Biological Sciences
Journal Article
Nature Immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1247 - 1255
The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we found that signaling pathways dependent on the kinases... 
LISTERIA-MONOCYTOGENES | AIM2 INFLAMMASOME | PROTEIN | INNATE IMMUNE-RESPONSES | MACROPHAGES | KINASE | HOST-DEFENSE | NLRP3 INFLAMMASOME | IMMUNOLOGY | CASPASE-1 ACTIVATION | VIRAL-INFECTION | Interleukin-18 - immunology | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | JNK Mitogen-Activated Protein Kinases - immunology | Caspase 1 - metabolism | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | RNA Interference | Bone Marrow Cells - immunology | Phosphorylation - immunology | JNK Mitogen-Activated Protein Kinases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | DNA-Binding Proteins | Tyrosine - immunology | Mice, Knockout | Macrophages - metabolism | Tyrosine - metabolism | Lipopolysaccharides - pharmacology | Mice | Interleukin-18 - metabolism | Intracellular Signaling Peptides and Proteins - immunology | JNK Mitogen-Activated Protein Kinases - metabolism | Caspase 1 - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Female | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Inflammasomes - genetics | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Macrophages - drug effects | Nigericin - pharmacology | Bone Marrow Cells - metabolism | Tyrosine - genetics | Cellular signal transduction | Inflammation | Genetic aspects | Research | Properties | Phosphotransferases
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 08/2010, Volume 207, Issue 8, pp. 1745 - 1755
Intracellular pathogens and endogenous danger signals in the cytosol engage NOD-like receptors (NLRs), which assemble inflammasome complexes to activate... 
MEDICINE, RESEARCH & EXPERIMENTAL | ASC | CANDIDA-ALBICANS | PROTEIN | MURAMYL DIPEPTIDE | ENTERICA SEROVAR TYPHIMURIUM | INFECTION | SECRETION | IMMUNOLOGY | CASPASE-1 ACTIVATION | IPAF | CELL-DEATH | Cytoplasmic Structures - genetics | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Salmonella Infections - immunology | Caspase 1 - metabolism | Blood - microbiology | Cytoplasmic Structures - drug effects | Interleukin-1beta - blood | Animal Structures - microbiology | Protein Transport - immunology | Cytoplasmic Structures - immunology | Immunity, Innate - physiology | Interleukin-1beta - metabolism | Flagellin - genetics | Apoptosis Regulatory Proteins - genetics | Cytoskeletal Proteins - metabolism | Macrophages - microbiology | Interleukin-1 - metabolism | Interleukin-18 - blood | Salmonella typhimurium - genetics | Salmonella typhimurium - immunology | Membrane Proteins - genetics | Bacterial Proteins - genetics | Mice, Inbred Strains | Caspase Inhibitors | Protein Transport - genetics | Mice, Knockout | Protein Precursors - metabolism | Carrier Proteins - genetics | Macrophages - metabolism | Models, Immunological | Animals | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Cysteine Proteinase Inhibitors - pharmacology | Salmonella Infections - microbiology | Mice | Interleukin-18 - metabolism | Calcium-Binding Proteins - genetics | Cytoplasmic Structures - metabolism
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2014, Volume 111, Issue 30, pp. 11181 - 11186
Acute glaucoma is a sight-threatening condition characterized by a sudden and substantial rise in intraocular pressure (IOP) and consequent retinal ganglion... 
Glaucoma | Reperfusion | Messenger RNA | Ischemia | Toll like receptors | Central nervous system | Retina | Brain damage | Intraocular pressure | Microglia | Retinal ischemia/reperfusion injury | Cell apoptosis | BRAIN-INJURY | MICROGLIA ACTIVATION | INTERLEUKIN-1-BETA | MULTIDISCIPLINARY SCIENCES | REPERFUSION INJURY | POPULATIONS | retinal ischemia/reperfusion injury | ANGLE-CLOSURE GLAUCOMA | cell apoptosis | TOLL-LIKE RECEPTORS | CENTRAL-NERVOUS-SYSTEM | MICE | CEREBRAL-ISCHEMIA | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Caspase 8 - metabolism | Caspase 1 - metabolism | Interleukin-1beta - genetics | Caspase 8 - genetics | Interleukin-1beta - metabolism | Apoptosis Regulatory Proteins - genetics | Eye Proteins - genetics | Glaucoma - metabolism | Disease Models, Animal | Acute Disease | Rats | Toll-Like Receptor 4 - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Nerve Tissue Proteins - genetics | Rats, Sprague-Dawley | Toll-Like Receptor 4 - metabolism | Inflammasomes - genetics | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Eye Proteins - metabolism | Caspase 1 - genetics | Adaptor Proteins, Signal Transducing - genetics | Mice | Adaptor Proteins, Signal Transducing - metabolism | Enzyme Activation - genetics | Glaucoma - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Biological Sciences | reperfusion injury | retinal ischemia
Journal Article
Nature Communications, ISSN 2041-1723, 2016, Volume 7, Issue 1, p. 10791
Dysregulated inflammasome activation contributes to respiratory infections and pathologic airway inflammation. Through basic and translational approaches... 
AIRWAY EPITHELIAL-CELLS | ASPERGILLUS-FUMIGATUS | III SECRETION APPARATUS | CHRONIC GRANULOMATOUS-DISEASE | ENVIRONMENT INTERACTIONS | MULTIDISCIPLINARY SCIENCES | NLRC4 INFLAMMASOME | HOST-DEFENSE | NLRP3 INFLAMMASOME | LUNG INFECTION | IMMUNE RECOGNITION | Immunohistochemistry | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Middle Aged | Child, Preschool | Male | Cystic Fibrosis - immunology | Young Adult | Calcium-Binding Proteins - immunology | Autophagy - genetics | Interleukin 1 Receptor Antagonist Protein - pharmacology | Child | Cytokines - genetics | Carrier Proteins - immunology | Disease Models, Animal | Apoptosis Regulatory Proteins - immunology | Interleukin 1 Receptor Antagonist Protein - immunology | Respiratory Mucosa - cytology | Cystic Fibrosis - microbiology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Cystic Fibrosis - genetics | Adolescent | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Mice | Aspergillus fumigatus | Calcium-Binding Proteins - genetics | Infant | Interleukin 1 Receptor Antagonist Protein - genetics | CARD Signaling Adaptor Proteins - genetics | Autophagy - immunology | Apoptosis Regulatory Proteins - genetics | Adult | Female | Pseudomonas aeruginosa | Lung - metabolism | Macrophages - immunology | Cytokines - immunology | In Situ Nick-End Labeling | CARD Signaling Adaptor Proteins - immunology | Cell Line | Enzyme-Linked Immunosorbent Assay | Mice, Inbred C57BL | Inflammation | Inflammasomes - genetics | Pseudomonas Infections - immunology | Carrier Proteins - genetics | Animals | Epithelial Cells - immunology | Inflammasomes - immunology | Fluorescent Antibody Technique | Polymorphism, Single Nucleotide | Aspergillosis - immunology
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2015, Volume 125, Issue 2, pp. 665 - 680
Cellular lipid metabolism has been linked to immune responses; however, the precise mechanisms by which de novo fatty acid synthesis can regulate inflammatory... 
MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | GLUCOSE-METABOLISM | ATP-CITRATE LYASE | UCP2 | SEPTIC SHOCK | CELL-GROWTH | CRITICALLY-ILL PATIENTS | INTENSIVE INSULIN THERAPY | CANCER | MITOCHONDRIAL UNCOUPLING PROTEINS | Fatty Acid Synthase, Type I - genetics | Fatty Acid Synthase, Type I - biosynthesis | Lipids - genetics | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Ion Channels - genetics | Caspase 1 - metabolism | Mitochondrial Proteins - genetics | Interleukin-1beta - genetics | Lipids - biosynthesis | Sepsis - pathology | Interleukin-1beta - metabolism | Mitochondrial Proteins - metabolism | Sepsis - metabolism | Macrophages - pathology | Down-Regulation - genetics | Inflammasomes - genetics | Sepsis - genetics | Mice, Knockout | Carrier Proteins - genetics | Enzyme Induction - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Sepsis - chemically induced | Ion Channels - metabolism | Caspase 1 - genetics | Sepsis - therapy | Mice | Uncoupling Protein 2 | Interleukin-18 - genetics | Interleukin-18 - metabolism | Cellular proteins | Immune response | Synthesis | Sepsis | Development and progression | Lipids | Genetic aspects | Properties | Enzymes | Cytokines | Pathogenesis | Mortality | Glucose | Metabolism | Gene expression | Fatty acids | Proteins | Studies | Metabolites | Consent | Rodents
Journal Article
Nature, ISSN 0028-0836, 02/2016, Volume 530, Issue 7590, pp. 354 - 357
Journal Article
Nature Immunology, ISSN 1529-2908, 2014, Volume 15, Issue 8, pp. 738 - 748
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2014, Volume 211, Issue 7, pp. 1333 - 1347
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2013, Volume 123, Issue 1, pp. 236 - 246
Nephrocalcinosis, acute calcium oxalate (CaOx) nephropathy, and renal stone disease can lead to inflammation and subsequent renal failure, but the underlying... 
KIDNEY-DISEASE | NEPHROLITHIASIS | MEDICINE, RESEARCH & EXPERIMENTAL | DANGER | ACTIVATION | DENDRITIC CELLS | NLRP3 INFLAMMASOME | STONE FORMATION | FAILURE | NEPHROPATHY | NALP3 INFLAMMASOME | Interleukin-18 - immunology | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Dendritic Cells - immunology | Nephrocalcinosis - immunology | Receptors, Interleukin-1 - genetics | Interleukin-1beta - genetics | Inflammation - metabolism | Nephrocalcinosis - metabolism | Myeloid Differentiation Factor 88 - immunology | Cytoskeletal Proteins - metabolism | Kidney Tubules - pathology | Immunologic Deficiency Syndromes - immunology | Kidney Tubules - metabolism | Carrier Proteins - immunology | Dendritic Cells - metabolism | Interleukin-1beta - secretion | Kidney Tubules - immunology | Calcium Oxalate - immunology | Receptors, Interleukin-1 - immunology | Myeloid Differentiation Factor 88 - genetics | Interleukin-1beta - immunology | Inflammation - immunology | Calcium Oxalate - metabolism | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Carrier Proteins - genetics | Nephrocalcinosis - pathology | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | Nephrocalcinosis - genetics | CARD Signaling Adaptor Proteins | Immunologic Deficiency Syndromes - genetics | Immunologic Deficiency Syndromes - metabolism | Inflammation - genetics | Mice | Interleukin-18 - genetics | Myeloid Differentiation Factor 88 - metabolism | Interleukin-18 - metabolism | Phagocytosis
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2009, Volume 284, Issue 36, pp. 24035 - 24048
The role of endogenous inducers of inflammation is poorly understood. To produce the proinflammatory master cytokine interleukin (IL)-1β, macrophages need... 
GENE | LEUCINE-RICH PROTEOGLYCANS | CASPASE-1 | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE IMMUNE-RESPONSE | HYALURONAN | IL-1-BETA | SECRETION | ATP | NALP3 INFLAMMASOME | Toll-Like Receptor 2 - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Immunity, Innate - genetics | Extracellular Matrix - metabolism | Caspase 1 - metabolism | Male | Ureteral Obstruction - metabolism | Interleukin-1beta - genetics | Inflammation - metabolism | Kidney - metabolism | Carrier Proteins - immunology | Signal Transduction | Proteoglycans - immunology | Extracellular Matrix Proteins - genetics | Proteoglycans - metabolism | Toll-Like Receptor 4 - genetics | Biglycan | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Ureteral Obstruction - immunology | Macrophages - metabolism | Receptors, Purinergic P2 - metabolism | Toll-Like Receptor 2 - immunology | Mice | Proteoglycans - genetics | Extracellular Matrix - immunology | Kidney - immunology | Caspase 1 - immunology | Extracellular Matrix - genetics | Receptors, Purinergic P2 - genetics | Ureteral Obstruction - genetics | Interleukin-1beta - biosynthesis | Lung - metabolism | Receptors, Purinergic P2 - immunology | Extracellular Matrix Proteins - metabolism | Macrophages - immunology | Carrier Proteins - biosynthesis | Interleukin-1beta - immunology | Inflammation - immunology | Protein Structure, Tertiary - genetics | Receptors, Purinergic P2X7 | Carrier Proteins - genetics | Immunity, Innate - immunology | Animals | Caspase 1 - genetics | Extracellular Matrix Proteins - immunology | Receptors, Purinergic P2X4 | Inflammation - genetics | Lung - immunology | Animal models | Reactive oxygen species | Oligomerization | Proteoglycans | Transcription | Lung | Inflammation | Macrophages | Kidney | Stress | Caspase-1 | Purine P2X receptors | Signal transduction | Cell activation | TLR2 protein | Interleukin 1 | Toll-like receptors | Extracellular matrix | Sepsis | Cooperativity | Injuries | Glycobiology and Extracellular Matrices
Journal Article
Nature Communications, ISSN 2041-1723, 08/2014, Volume 5, Issue 1, p. 4713
Journal Article