X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (1018) 1018
nlrp3 inflammasome (786) 786
animals (660) 660
humans (607) 607
inflammation (476) 476
immunology (383) 383
inflammasomes - metabolism (380) 380
nlrp3 (370) 370
mice (369) 369
activation (348) 348
inflammasome (316) 316
male (260) 260
cell biology (250) 250
nlr family, pyrin domain-containing 3 protein (250) 250
nalp3 inflammasome (231) 231
biochemistry & molecular biology (227) 227
nf-kappa-b (225) 225
nlr family, pyrin domain-containing 3 protein - metabolism (221) 221
cytokines (212) 212
proteins (210) 210
apoptosis (201) 201
caspase-1 (194) 194
oxidative stress (190) 190
il-1β (189) 189
inflammasomes - immunology (182) 182
carrier proteins - metabolism (181) 181
expression (175) 175
interleukin-1beta - metabolism (169) 169
macrophages (167) 167
signal transduction (165) 165
mice, inbred c57bl (159) 159
female (150) 150
caspase 1 - metabolism (143) 143
article (139) 139
pharmacology & pharmacy (135) 135
innate immunity (134) 134
disease (129) 129
analysis (128) 128
research (123) 123
neurosciences (121) 121
cells (119) 119
nlr family, pyrin domain-containing 3 protein - genetics (112) 112
caspase (111) 111
health aspects (110) 110
interleukins (109) 109
cell death (107) 107
reactive oxygen species - metabolism (106) 106
inflammation - immunology (104) 104
carrier proteins - genetics (103) 103
mice, knockout (101) 101
cells, cultured (100) 100
il-1 beta (100) 100
cell-death (99) 99
nlrp3 inflammasome activation (99) 99
rodents (98) 98
inflammation - metabolism (97) 97
rats (95) 95
review (95) 95
inflammasomes - genetics (94) 94
gene expression (93) 93
disease models, animal (92) 92
immune response (90) 90
immunity, innate (90) 90
immune system (89) 89
medicine, research & experimental (89) 89
cell line (85) 85
integumentary system (85) 85
inhibition (82) 82
toll-like receptors (81) 81
macrophages - metabolism (80) 80
cytokines - metabolism (79) 79
pathogenesis (79) 79
physiological aspects (79) 79
pyrin protein (79) 79
autophagy (78) 78
pathology (75) 75
carrier proteins - immunology (74) 74
secretion (73) 73
inflammasomes (71) 71
interleukin-1beta - genetics (69) 69
dendritic cells (67) 67
inflammasomes - drug effects (66) 66
caspase-1 activation (65) 65
medical research (65) 65
protein (65) 65
development and progression (64) 64
il-1-beta (64) 64
interleukin-1beta - immunology (64) 64
middle aged (64) 64
cancer (63) 63
atherosclerosis (62) 62
insulin-resistance (62) 62
endocrinology & metabolism (61) 61
signal transduction - drug effects (61) 61
nf-kappa b - metabolism (60) 60
pyroptosis (60) 60
inflammation - pathology (59) 59
internal medicine (59) 59
macrophages - immunology (59) 59
kinases (58) 58
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature, ISSN 0028-0836, 2014, Volume 512, Issue 1, pp. 69 - 73
Rheumatoid arthritis is a chronic autoinflammatory disease that affects 1-2% of the world's population and is characterized by widespread joint inflammation.... 
RHEUMATOID-ARTHRITIS | COLLAGEN-INDUCED ARTHRITIS | ACTIVATION | 6Q23 | CASPASE-1 | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | MICE | INHIBITOR | NF-KAPPA-B | ASSOCIATION | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Caspase 1 - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Intracellular Signaling Peptides and Proteins - deficiency | Arthritis, Rheumatoid - metabolism | Arthritis, Rheumatoid - prevention & control | Cysteine Endopeptidases - metabolism | Receptors, Interleukin-1 - deficiency | Cysteine Endopeptidases - deficiency | Female | Tumor Necrosis Factor alpha-Induced Protein 3 | DNA-Binding Proteins | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Interleukin-1 - metabolism | Signal Transduction | Nuclear Proteins - metabolism | Apoptosis Regulatory Proteins - metabolism | Arthritis, Rheumatoid - pathology | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Macrophages - metabolism | Phenotype | Animals | Carrier Proteins - metabolism | Caspase 1 - deficiency | Mice | Arthritis, Rheumatoid - immunology | Prevention | Rheumatoid arthritis | Physiological aspects | NLRP3 | Properties | Macrophages | Risk factors | Proteins | Pathology | Dehydrogenases | Histopathology | Pathogenesis | Rodents | Protein expression | Nlrp3 | IL1R1 | caspase-1 | inflammasome | A20
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 05/2015, Volume 308, Issue 9, pp. F993 - F1003
IL-1 beta-secreting nucleotide-binding oligomerization domain protein 3 (NLRP3) inflammasomes play a pivotal role in triggering innate immune responses in... 
Diabetic nephropathy | Uric acid | NLRP3 inflammasome | Macrophage | PHYSIOLOGY | INJURY | macrophage | CELL-PROLIFERATION | MECHANISMS | ALLOPURINOL | PATHOGENESIS | KIDNEY-FUNCTION | INFLAMMASOME | DISEASE | UROLOGY & NEPHROLOGY | uric acid | NF-KAPPA-B | diabetic nephropathy | URIC-ACID | Inflammasomes - metabolism | Diabetic Nephropathies - etiology | NLR Family, Pyrin Domain-Containing 3 Protein | Coculture Techniques | Diabetes Mellitus, Type 2 - genetics | Humans | Male | NF-kappa B - metabolism | Hyperuricemia - metabolism | Diabetes Mellitus, Type 2 - metabolism | Diabetic Nephropathies - immunology | Hyperuricemia - immunology | Inflammation - metabolism | Transfection | RNA Interference | Time Factors | Interleukin-1beta - metabolism | Diabetes Mellitus, Type 2 - immunology | HMGB1 Protein - metabolism | Inflammation Mediators - metabolism | Diabetic Nephropathies - prevention & control | Hyperuricemia - complications | Diabetes Mellitus, Type 2 - complications | Macrophages - immunology | Disease Models, Animal | Cell Line | Kidney Tubules, Proximal - immunology | Uric Acid - metabolism | Signal Transduction | Diabetic Nephropathies - metabolism | Diabetic Nephropathies - genetics | Inflammation - immunology | Inflammation - etiology | Disease Progression | Inflammasomes - genetics | Hyperuricemia - drug therapy | Carrier Proteins - genetics | Rats, Inbred OLETF | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Chemokine CXCL12 - metabolism | Kidney Tubules, Proximal - metabolism | Gout Suppressants - pharmacology | Macrophages - drug effects | Kidney Tubules, Proximal - drug effects | Receptors, Cytoplasmic and Nuclear - metabolism | Type 2 diabetes | Cellular proteins | Kidneys | Immune response | Physiological aspects | Genetic aspects | Properties | Injuries
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 03/2017, Volume 84, pp. 22 - 34
Endothelial dysfunction caused by endothelial cells senescence and chronic inflammation is tightly linked to the development of cardiovascular diseases. NLRP3... 
TXNIP | Senescence | IL-1β | NLRP3 inflammasome | ROS | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATHEROSCLEROSIS | PHENOTYPE | IL-1 beta | MECHANISMS | CELLULAR SENESCENCE | CELL BIOLOGY | PREMATURE SENESCENCE | IN-VIVO | PERSPECTIVES | CARDIOVASCULAR-DISEASE | SECRETION | Human Umbilical Vein Endothelial Cells | RNA, Small Interfering - genetics | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Cytoskeletal Proteins - antagonists & inhibitors | Cytoskeletal Proteins - genetics | Humans | Cellular Senescence - drug effects | Male | Aorta - metabolism | RNA, Messenger - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aging - genetics | Interleukin-1beta - metabolism | Apoptosis Regulatory Proteins - genetics | Cytoskeletal Proteins - metabolism | Thioredoxins - metabolism | Bleomycin - toxicity | Endothelial Cells - metabolism | Models, Cardiovascular | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Carrier Proteins - antagonists & inhibitors | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Cellular Senescence - physiology | Aging - pathology | Apoptosis Regulatory Proteins - metabolism | Aorta - pathology | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Endothelial Cells - cytology | CARD Signaling Adaptor Proteins | Apoptosis Regulatory Proteins - antagonists & inhibitors | Mice | Aging - metabolism | Endothelial Cells - drug effects
Journal Article
Journal Article
中华医学杂志:英文版, ISSN 0366-6999, 2016, Volume 129, Issue 9, pp. 1047 - 1052
Journal Article
Frontiers in Pharmacology, ISSN 1663-9812, 12/2017, Volume 8, p. 944
Yupingfeng San (YPFS) is a representative Traditional Chinese Medicine (TCM) formula with accepted therapeutic effect on Asthma. However, its action mechanism... 
Yupingfeng San | Inflammation | Network pharmacology | NLRP3 inflammasome | Asthma | network pharmacology | inflammation | DISEASE | AIRWAY INFLAMMATION | PHARMACOLOGY & PHARMACY | asthma | FORMULA | EXPRESSION | Care and treatment | Patient outcomes | Development and progression | Cellular signal transduction | Genetic aspects | Medicine, Chinese | Health aspects | Methods
Journal Article
International Immunopharmacology, ISSN 1567-5769, 11/2013, Volume 17, Issue 3, pp. 638 - 650
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue... 
Signaling | Receptors | Inflammation | Kinases | Neutrophils | ACTIVATED PROTEIN-KINASE | COLONY-STIMULATING FACTOR | LEUKOCYTE ADHESION DEFICIENCY | IMMUNOLOGY | SRC-FAMILY KINASES | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | HIGH-AFFINITY RECEPTOR | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | BETA-GAMMA-SUBUNITS | NF-KAPPA-B | Signal Transduction - immunology | Animals | Receptors, Cell Surface - immunology | Humans | Neutrophils - immunology | Selectins - immunology | Mycoses | Lectins | Fc receptors | Integrins | FcR, Fc-receptor | GPI, glycosylphosphatidylinositol anchor | CLEC, C-type lectin | OSCAR, osteoclast-associated receptor | PKB, protein kinase B | DAG, diacyl-glycerol | Tyk2, tyrosine protein kinase 2 | VCAM-1, vascular cell adhesion molecule 1 | ICAM-1, intercellular adhesion molecule 1 | FADD, Fas-associated protein with death domain | IκB, inhibitor of NF-κB | GM-CSF, granulocyte | MyD88, myeloid differentiation protein 88 | TNF, tumor necrosis factor | LTβ, lymphotoxin β | TRADD, TNFR1-associated death domain protein | Abl, Abelson leukemia proto-oncogene | SLP-76, SH2 domain-containing leukocyte protein of 76 kDa | CALDAG-GEFI, calcium and DAG-regulated guanine nucleotide exchange factor I | IL, interleukin | Src, Rous sarcoma virus proto-oncogene | IRF, IFN regulatory factor | RIG, retinoic acid-inducible gene | PLC, phospholipase C | TCR, T-cell receptor | IKK, IκB kinase | ITAM, immunoreceptor tyrosine-based activation motif | CARD, caspase activation and recruitment domain | IP3, inositol-tris-phosphate | CHO, Chinese hamster ovary cells | MKK, MAP kinase kinase | fMLP, formly-Met-Leu-Phe | TRAF, TNF receptor-associated factor | MIP, macrophage inflammatory protein | Rac, Ras-related C3 botulinum toxin substrate | monocyte colony-stimulating factor | PIP3, phosphatidylinositol-3-phosphate | VLA-4, very late antigen 4 (α4β1 integrin) | PAF, platelet activating factor | STAT, signal transducer and activator of transcription | TAK, TGFβ-activated kinase 1 | Mac-1, macrophage antigen 1 (αMβ2 integrin) | FcRγ, Fc-receptor γ-chain | Asc, apoptosis-associated speck-like protein containing a CARD | cIAP, cellular inhibitor of apoptosis | BCR, B-cell receptor | Fgr, Gardner–Rasheed feline sarcoma proto-oncogene | VASP, vasodilator-stimulated phosphoprotein | Hck, hematopoietic cell kinase | TGFβ, transforming growth factor β | Rap, Ras-related protein | SHP-1, SH2 domain-containing protein tyrosine phosphatase 1 | Syk, spleen tyrosine kinase | GPCR, G protein-coupled receptor | G-CSF, granulocyte colony-stimulating factor | TREM, triggering receptor expressed on myeloid cells | DISC, death-inducing signaling complex | MDL-1, myeloid DAP12-associating lectin 1 | C3G, Crk SH3 domain-binding guanine nucleotide exchange factor (RapGEF1) | NF-κB, nuclear factor κB | ERM, ezrin-radixin-moesin | Epac1, exchange protein activated by cyclic AMP 1 | LTB4, leukotriene B4 | Mcl, macrophage C-type lectin | SAP130, Sin3A-associated protein of 130 kDa | SH2, Src-homology 2 domain | MAP kinase, mitogen-activated protein kinase | PSGL-1, P-selectin glycoprotein ligand | PI3K, phoshoinositide-3-kinase | ADAP, adhesion and degranulation promoting adapter protein (Fyb, SLAP-130) | NLRP3, NOD-like receptor family, pyrin domain containing 3 | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | GRK, GPCR kinase | LAD, leukocyte adhesion deficiency | MAPKAP-kinase, MAP kinase-associated protein kinase | ZAP-70, ζ-chain-associated protein of 70 kDa | TRAIL, TNF-related apoptosis-inducing ligand | JNK, c-Jun N-terminal kinase | LFA-1, lymphocyte function-associated receptor 1 (αLβ2 integrin) | ROS, reactive oxygen species | RIP3, receptor-interacting serine-threonine protein kinase 3 | DAP12, DNAX activating protein 12 | IFN, interferon | PIR, paired immunoglobulin-like receptor | PKC, protein kinase C | PAK, p21-activated kinase | ESL-1, E-selectin ligand 1 | GAP, GTPase activating protein | ERK, extracellular signal-regulated kinase | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | RANK, receptor activator of NF-κB | IRAK, IL-1 receptor-associated kinase | NOD, nucleotide-binding oligomerization domain containing protein | CEACAM3, carcinoembryonic antigen-related cell adhesion molecule 3 (CD66b)
Journal Article