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Circulation, ISSN 0009-7322, 02/2017, Volume 135, Issue 9, pp. 881 - 897
BACKGROUND:Chronic heart failure (HF) is associated with altered signal transduction via β-adrenoceptors and G proteins and with reduced cAMP formation.... 
heart failure | receptors, adrenergic, beta | myocardial contraction | signal transduction | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | receptors | HETEROTRIMERIC G-PROTEINS | PHOSPHORYLATION | CARDIAC MYOCYTES | BETA-ADRENERGIC-STIMULATION | CYCLIC-AMP | adrenergic | RECOMBINANT ADENOVIRUSES | PERIPHERAL VASCULAR DISEASE | NDPK-B | ENERGY PHOSPHATE TRANSFER | beta | GAMMA DIMERS | Rats, Wistar | Humans | Embryo, Nonmammalian - metabolism | Male | NM23 Nucleoside Diphosphate Kinases - genetics | NM23 Nucleoside Diphosphate Kinases - metabolism | GTP-Binding Protein alpha Subunits, G12-G13 - metabolism | NM23 Nucleoside Diphosphate Kinases - analysis | Protein Isoforms - metabolism | RNA Interference | Protein Isoforms - chemistry | Cell Membrane - metabolism | Cyclic AMP - metabolism | Disease Models, Animal | Cyclic AMP - analysis | Cell Line | Myocytes, Cardiac - cytology | Mice, Inbred C57BL | NM23 Nucleoside Diphosphate Kinases - antagonists & inhibitors | Rats | Heart Failure - metabolism | Heart Failure - pathology | Zebrafish - growth & development | Mice, Knockout | Animals | Myocytes, Cardiac - drug effects | Isoproterenol - pharmacology | Myocytes, Cardiac - metabolism | Protein Binding | Mice | Protein Isoforms - genetics | RNA, Small Interfering - metabolism | Heart failure | Polymerase chain reaction | Care and treatment | Usage | Cellular signal transduction | Research | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 37, pp. 15205 - 15215
Transcriptional activation of the human telomerase reverse transcriptase (hTERT) gene, which remains repressed in adult somatic cells, is critical during... 
CELLS | ACTIVATION | NM23-H2 | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | TRANSCRIPTION | GENE-EXPRESSION | HUMAN CANCERS | PROMOTER | GENOME | Epigenetic Repression | Humans | Protein Multimerization | Neoplasm Proteins - antagonists & inhibitors | Fibrosarcoma - metabolism | Neoplasm Proteins - metabolism | NM23 Nucleoside Diphosphate Kinases - genetics | NM23 Nucleoside Diphosphate Kinases - metabolism | Repressor Proteins - antagonists & inhibitors | Fibrosarcoma - pathology | Telomerase - genetics | Chromatin Immunoprecipitation | RNA Interference | Carcinoma - enzymology | G-Quadruplexes | Telomerase - metabolism | Carcinoma - pathology | Neoplasm Proteins - genetics | Genes, Reporter | Repressor Proteins - metabolism | Recombinant Proteins - metabolism | NM23 Nucleoside Diphosphate Kinases - chemistry | Promoter Regions, Genetic | Repressor Proteins - chemistry | Mutagenesis, Site-Directed | Histone Demethylases - chemistry | NM23 Nucleoside Diphosphate Kinases - antagonists & inhibitors | Cells, Cultured | Recombinant Proteins - chemistry | Repressor Proteins - genetics | Neoplasm Proteins - chemistry | Histone Demethylases - metabolism | Point Mutation | Cell Line, Tumor | Carcinoma - metabolism | Telomerase - antagonists & inhibitors | Fibrosarcoma - enzymology | Amino Acid Substitution | Index Medicus | Gene Regulation | transcription regulation | chromatin modification | G-quadruplex | telomerase reverse transcriptase (TERT) | NME2 | REST repressor complex | epigenetics
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2017, Volume 60, Issue 16, pp. 6924 - 6941
c-MYC is one of the important human proto-oncogenes, and transcriptional factor NM23-H2 can activate c-MYC transcription by recognizing the G-quadruplex in the... 
SUPPRESSOR | HEPATOCELLULAR-CARCINOMA | ACTIVATION | CHEMISTRY, MEDICINAL | MECHANISM | GENE-EXPRESSION | NUCLEOSIDE DIPHOSPHATE KINASE | ISAINDIGOTONE DERIVATIVES | TUMOR-CELLS | G-QUADRUPLEX DNA | CHRONIC MYELOID-LEUKEMIA | Quinazolines - chemical synthesis | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Quinazolinones - administration & dosage | Structure-Activity Relationship | Antineoplastic Agents - administration & dosage | NM23 Nucleoside Diphosphate Kinases - genetics | Pyrroles - administration & dosage | Drug Design | G-Quadruplexes | Quinazolines - administration & dosage | Transcription, Genetic | Antineoplastic Agents - pharmacology | Quinazolines - chemistry | Quinazolinones - pharmacology | NM23 Nucleoside Diphosphate Kinases - chemistry | Promoter Regions, Genetic | Down-Regulation | NM23 Nucleoside Diphosphate Kinases - antagonists & inhibitors | Antineoplastic Agents - chemistry | Quinazolinones - chemical synthesis | Xenograft Model Antitumor Assays | Pyrroles - pharmacology | Animals | Pyrroles - chemical synthesis | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Cell Line, Tumor | Pyrroles - chemistry | Ligands | Cell Proliferation - drug effects | Mice, Inbred BALB C | Molecular Docking Simulation | Proto-Oncogene Proteins c-myc - genetics | Quinazolinones - chemistry | G1 Phase Cell Cycle Checkpoints - drug effects | Quinazolines - pharmacology | Doxorubicin - pharmacology | Index Medicus
Journal Article
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 10/2013, Volume 73, Issue 19, pp. 5949 - 5962
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2017, Volume 60, Issue 4, pp. 1292 - 1308
Journal Article
Journal of Computer-Aided Molecular Design, ISSN 0920-654X, 06/2017, Volume 31, Issue 6, pp. 547 - 562
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2012, Volume 287, Issue 24, pp. 20443 - 20455
The luteinizing hormone chorionic gonadotropin receptor (LHCGR) is a G(s)-coupled GPCR that is essential for the maturation and function of the ovary and... 
CELLS | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-COUPLED RECEPTORS | STIMULATED TRANSLOCATION | BREFELDIN-A | BETA-GAMMA-SUBUNITS | ENDOCYTOSIS | PLASMA-MEMBRANE | PHOSPHOINOSITIDE 3-KINASE | RIBOSYLATION FACTOR 6 | Dynamins - metabolism | Gelsolin - metabolism | Humans | Receptors, LH - metabolism | Phosphatidylinositol 3-Kinases - metabolism | GTPase-Activating Proteins - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | NM23 Nucleoside Diphosphate Kinases - genetics | NM23 Nucleoside Diphosphate Kinases - metabolism | Receptors, LH - genetics | Cyclic AMP - genetics | ADP-Ribosylation Factors - metabolism | ADP-Ribosylation Factors - genetics | Cyclic AMP - metabolism | Peptide Fragments - genetics | Chorionic Gonadotropin - genetics | Peptide Fragments - metabolism | Dynamins - antagonists & inhibitors | NM23 Nucleoside Diphosphate Kinases - antagonists & inhibitors | Dynamins - genetics | Clathrin - genetics | Chorionic Gonadotropin - metabolism | Clathrin - metabolism | Phosphatidylinositol 3-Kinases - genetics | Signal Transduction - drug effects | Signal Transduction - physiology | Gelsolin - genetics | Protein Kinase Inhibitors - pharmacology | GTPase-Activating Proteins - genetics | Index Medicus | Receptor Regulation | G Protein-coupled Receptors (GPCR) | LHCGR | SecinH3 | Signal Transduction | Guanine Nucleotide Exchange Factor (GEF) | Internalization | Cytohesin | PI 3-Kinase (PI3K) | ARF6
Journal Article
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 08/2010, Volume 5, Issue 8, pp. 1143 - 1151
Pemetrexed disodium (Alimta®), LY231514, is an antifolate that is able to simultaneously inhibit the synthesis of purines and pyrimidines. Pemetrexed has been... 
nm23-H1 | Biomarker | Lipocalin-2 | Lung cancer | PREDICTOR | GELATINASE-ASSOCIATED LIPOCALIN | BREAST-CANCER | METASTASIS SUPPRESSOR | PHASE-II TRIAL | ONCOLOGY | RESPIRATORY SYSTEM | INCREASED SENSITIVITY | RESISTANCE | SYNTHETASE | INFECTION | EXPRESSION | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | Oligonucleotide Array Sequence Analysis | Guanine - analogs & derivatives | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Lung Neoplasms - pathology | Gene Expression Profiling | Acute-Phase Proteins - genetics | Acute-Phase Proteins - antagonists & inhibitors | NM23 Nucleoside Diphosphate Kinases - genetics | NM23 Nucleoside Diphosphate Kinases - metabolism | Lipocalins - antagonists & inhibitors | Lipocalins - genetics | Guanine - pharmacology | Biomarkers, Tumor - metabolism | Adenocarcinoma - genetics | Antineoplastic Agents - pharmacology | Lung - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Lipocalins - metabolism | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Lung - pathology | Acute-Phase Proteins - metabolism | Carcinoma, Non-Small-Cell Lung - genetics | NM23 Nucleoside Diphosphate Kinases - antagonists & inhibitors | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Cells, Cultured | Proto-Oncogene Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Adenocarcinoma - drug therapy | Pemetrexed | Blotting, Western | Carcinoma, Squamous Cell - drug therapy | Lung - drug effects | Glutamates - pharmacology | Biomarkers, Tumor - genetics | Cell Proliferation - drug effects | Carcinoma, Non-Small-Cell Lung - drug therapy | Cell Cycle - drug effects | Index Medicus
Journal Article