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Tropical Medicine & International Health, ISSN 1360-2276, 02/2016, Volume 21, Issue 2, pp. 219 - 223
ObjectiveCD4 count decline often triggers antiretroviral regimen switches in resource-limited settings, even when viral load testing is available. We therefore... 
first‐line antiretroviral therapy | détermination de la charge virale du | M184V | prueba de carga viral | adherence | M184V, Major | drug resistance mutations | NNRTI | adherencia | 1 drug resistance | resistencia a medicamentos | fallo inmunológico | immunologic failure criteria | mutations | HIV | VIH | terapia antirretroviral de primera línea | compliance | critères d’échec immunologique | traitement antirétroviral de première ligne | 1 viral load testing | mutaciones de resistencia a medicamentos | de résistance majeure aux médicaments | résistance aux médicaments du | first-line antiretroviral therapy | M184V, Major NNRTI drug resistance mutations | HIV-1 drug resistance | HIV-1 viral load testing | résistance aux médicaments du VIH-1 | mutaciones de resistencia a medicamentos NNRTI | resistencia a medicamentos VIH-1 | mutations NNRTI de résistance majeure aux médicaments | prueba de carga viral VIH-1 | détermination de la charge virale du VIH-1 | SOUTH-AFRICA | COST-EFFECTIVENESS | HIV DRUG-RESISTANCE | SUBTYPE C | ANTIRETROVIRAL TREATMENT FAILURE | TROPICAL MEDICINE | Major NNRTI drug resistance mutations | WESTERN CAPE | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | RESOURCE-LIMITED SETTINGS | IMMUNOLOGICAL CRITERIA | THERAPY | VIROLOGICAL FAILURE | Decision Making | HIV Infections - blood | HIV-1 | HIV Infections - virology | Humans | Middle Aged | Drug Resistance, Viral | Male | CD4 Lymphocyte Count | Viremia - drug therapy | Viral Load | Antiretroviral Therapy, Highly Active | Treatment Failure | Adult | Anti-HIV Agents - therapeutic use | Female | HIV Infections - drug therapy | South Africa | Retrospective Studies | Drug Monitoring | Highly active antiretroviral therapy | Antiviral agents | AIDS treatment | Analysis | HIV testing | Drug resistance | Anti-HIV agents | Antiretroviral drugs | Mutation | Human immunodeficiency virus--HIV | First-line antiretroviral therapy
Journal Article
03/2008
AIDS is responsible for more than 3 million deaths annually worldwide and the HIV is the etiologic agent of the disease. At the moment, there isn’t an... 
INNRT | SIDA | INRT | NNRTI | AIDS | NRTI
Web Resource
by Liu, XY and Chen, PP and Li, XY and Ba, MY and Jiao, XZ and Guo, Y and Xie, P
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 06/2018, Volume 28, Issue 10, pp. 1699 - 1703
SG-1 was previously identified as a potent Non-nucleoside reverse transcriptase inhibitors (NNRTI) which works through inhibition of reverse transcriptase (RT)... 
CHEMISTRY, MEDICINAL | NNRTI-resistant | HIV | Structure-activity relationship | NNRTIs | REVERSE-TRANSCRIPTASE | CHEMISTRY, ORGANIC | INHIBITORS | MUTATIONS | SG-1
Journal Article
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, ISSN 0066-4804, 08/2019, Volume 63, Issue 8
Substitutions at residue Y181 in HIV-1 reverse transcriptase (RT), in particular, Y181C, Y181I, and Y181V, are associated with nonnucleoside RT inhibitor... 
mechanisms of resistance | HIV | MECHANISM | reverse transcriptase | VIROLOGICAL FAILURE | NNRTI | MICROBIOLOGY | PHARMACOLOGY & PHARMACY
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 04/2018, Volume 9, Issue 4, pp. 334 - 338
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 03/2019, Volume 68, Issue 6, pp. 1044 - 1047
Abstract Concentrations of antiretrovirals in hair are associated with virologic outcomes in cohorts of human immunodeficiency virus (HIV)-positive individuals... 
HIV | hair concentrations | non-NNRTI regimens | AIDS Clinical Trials Group (ACTG) | A5257 study | INFECTIOUS DISEASES | MICROBIOLOGY | ATAZANAVIR | OUTCOMES | IMMUNOLOGY | PREEXPOSURE PROPHYLAXIS | ADHERENCE | Brief Reports
Journal Article
Journal Article
Klinicka Farmakologie a Farmacie, ISSN 1212-7973, 2014, Volume 28, Issue 2, pp. 68 - 71
Journal Article
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, ISSN 0066-4804, 05/2019, Volume 63, Issue 5
Doravirine is a non-nucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. Due to the high... 
REVERSE-TRANSCRIPTASE INHIBITOR | drug-drug interactions | SINGLE | HIV | HEPATITIS-C VIRUS | SAFETY | COINFECTION | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | nonnucleoside reverse transcriptase inhibitor (NNRTI) | doravirine
Journal Article
Synthesis, ISSN 0039-7881, 08/2018, Volume 50, Issue 16, pp. 3177 - 3186
Abstract A C(sp 2 )–C(sp 3 ) decarboxylative cross-coupling reaction utilizing dual nickel and photoredox catalysis for rapid parallel synthesis of diverse... 
special topic | decarboxylative coupling | NNRTI | photoredox catalysis | visible light | HIV | ORGANIC-SYNTHESIS | CATALYSIS | CHEMISTRY, ORGANIC | ALPHA-AMINO-ACIDS | INFECTION
Journal Article
Phytochemistry, ISSN 0031-9422, 04/2017, Volume 136, pp. 94 - 100
In a search for new anti-HIV active leads from over several thousands of plant extracts, we have identified a potent plant lead. The active plant is determined... 
Acanthaceae | Anti-HIV | Antiviral activity | NRTI- and NNRTI-resistant HIV-1 variants | Justicia gendarussa | Justiprocumins | Plant natural products | Arylnaphthalide lignans glycosides | NONNUCLEOSIDE INHIBITORS | COMPLETE ASSIGNMENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INHIBITORY NATURAL-PRODUCTS | REVERSE-TRANSCRIPTASE | HUMAN-IMMUNODEFICIENCY-VIRUS | and NNRTI-resistant HIV-1 variants | C-13 NMR DATA | PLANT SCIENCES | AGENTS | ARYLNAPHTHALENE LIGNAN | TYPE-1 | NRTI | LITSEA-VERTICILLATA | Anti-HIV Agents - pharmacology | Justicia - chemistry | HIV-1 - drug effects | Lignans - chemistry | Drugs, Chinese Herbal - pharmacology | Glycosides - pharmacology | Lignans - pharmacology | Lignans - isolation & purification | Anti-HIV Agents - chemistry | Drugs, Chinese Herbal - chemistry | Glycosides - isolation & purification | Inhibitory Concentration 50 | Nuclear Magnetic Resonance, Biomolecular | Benzodioxoles - chemistry | Molecular Structure | Anti-HIV Agents - isolation & purification | Benzodioxoles - isolation & purification | Drugs, Chinese Herbal - isolation & purification | Glycosides - chemistry | Benzodioxoles - pharmacology | Medicinal plants | Medical colleges | Biological products | Medicine, Botanic | Nucleosides | DNA polymerases | Arthritis | Medicine, Herbal | HIV (Viruses) | Antiviral agents | Analysis | Index Medicus
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 02/2019, Volume 10, Issue 2, pp. 196 - 202
Since the discovery of HIV as the etiological agent of AIDS, the virus has infected millions of people each year. Fortunately, with the use of HAART, viremia... 
NNRTI | indole | benzimidazolone | HIV | reverse transcriptase | WILD-TYPE | DESIGN | CHEMISTRY, MEDICINAL | MECHANISM | SUSCEPTIBILITY | DISCOVERY
Journal Article
Journal Article