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1.
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NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer
The Journal of clinical investigation, ISSN 0021-9738, 02/2013, Volume 123, Issue 2, pp. 700 - 711
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Nod2 Signaling Adaptor Protein - deficiency | Humans | Colitis - pathology | Male | Nod2 Signaling Adaptor Protein - genetics | Colorectal Neoplasms - etiology | Female | Colorectal Neoplasms - metabolism | Disease Models, Animal | Digestive System - metabolism | Risk Factors | Colorectal Neoplasms - microbiology | Mice, Knockout | Digestive System - pathology | Pregnancy | Colitis - etiology | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Colitis - microbiology | Colitis - metabolism | Mice | Receptor-Interacting Protein Serine-Threonine Kinases - deficiency | Colorectal Neoplasms - pathology | Metagenome | Digestive System - microbiology | Care and treatment | Microbiota (Symbiotic organisms) | Colorectal cancer | Physiological aspects | Genetic aspects | Research | Colitis | Risk factors | Index Medicus | Abridged Index Medicus | Receptor-Interacting Protein Serine-Threonine Kinases | Nod2 Signaling Adaptor Protein | Life Sciences | Immunology | Digestive System | Colorectal Neoplasms
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 09/2019, Volume 20, Issue 17, p. 4265
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Nod2 Signaling Adaptor Protein - metabolism | Cell Survival | Humans | Nod1 Signaling Adaptor Protein - agonists | Inflammation Mediators - metabolism | Nod2 Signaling Adaptor Protein - antagonists & inhibitors | THP-1 Cells | Nod2 Signaling Adaptor Protein - agonists | Nod1 Signaling Adaptor Protein - antagonists & inhibitors | Nod1 Signaling Adaptor Protein - metabolism | Toll-Like Receptor 4 - metabolism | Cytokines - biosynthesis | NF-κB protein | Cytokines | Downstream effects | Interleukin | Cytotoxicity | Leukocytes (mononuclear) | Antagonists | Assaying | Kinases | Blood | Cell density | Monocytes | Cell activation | Reporter gene | Peripheral blood mononuclear cells | Ligands | Nod1 protein | Autoimmune diseases | Interleukin 8 | NOD2 protein | Index Medicus | THP-1 | immunomodulation | NOD1 antagonist | TNF-α | cytokines | NOD2 antagonist | IL-8 | functional characterization
Journal Article
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Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2
Nature (London), ISSN 0028-0836, 04/2019, Volume 568, Issue 7752, pp. 405 - 409
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Inflammation - pathology | T-Lymphocytes, Regulatory - metabolism | Nod2 Signaling Adaptor Protein - deficiency | T-Lymphocytes, Regulatory - classification | Humans | Crohn Disease - metabolism | Male | Nod2 Signaling Adaptor Protein - genetics | Intestines - immunology | T-Lymphocytes, Regulatory - immunology | Antigens - administration & dosage | Interleukin-2 - immunology | Interleukin-1beta - metabolism | Female | Intestine, Small - immunology | Macrophages - immunology | Interleukin-2 - metabolism | Myeloid Differentiation Factor 88 - genetics | Homeostasis - immunology | Interleukin-1beta - immunology | Inflammation - immunology | Crohn Disease - immunology | Immunity, Innate - immunology | Macrophages - metabolism | Animals | Myeloid Differentiation Factor 88 - deficiency | Intestine, Small - cytology | Nod2 Signaling Adaptor Protein - metabolism | Crohn Disease - pathology | Interleukin-2 - deficiency | Antigens - immunology | Mice | Gastrointestinal Microbiome - immunology | Myeloid Differentiation Factor 88 - metabolism | Intestines - cytology | Care and treatment | Crohn's disease | Interleukin-2 | Diagnosis | Research | Genetic regulation | Flow cytometry | Inflammatory bowel diseases | Interleukin | Science | Homeostasis | Lymphocytes T | Macrophages | Small intestine | Cell adhesion & migration | Microbiota | Cell activation | Cell growth | Immunology | Clonal deletion | Interleukin 2 | Lymphocytes | Population | NOD2 protein | Cellular manufacture | Antigens | Lymphatic system | Lymphoid cells | Cytokines | Dendritic cells | Immunoregulation | Gastrointestinal tract | IL-1β | Disease control | Immunological tolerance | Diet | Antibiotics | Large intestine | Gastrointestinal system | MyD88 protein | Index Medicus
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 05/2019, Volume 294, Issue 22, pp. 9007 - 9015
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Nod2 Signaling Adaptor Protein - deficiency | Cytokines - metabolism | Endoplasmic Reticulum Stress - drug effects | Calcium - metabolism | HCT116 Cells | Humans | Nod1 Signaling Adaptor Protein - deficiency | Nod2 Signaling Adaptor Protein - genetics | Calcimycin - chemistry | Gene Knockout Techniques | Calcimycin - pharmacology | Calcium - chemistry | Nod1 Signaling Adaptor Protein - metabolism | Peptidoglycan - blood | Nod2 Signaling Adaptor Protein - metabolism | Signal Transduction - drug effects | Thapsigargin - pharmacology | Interleukin-8 - metabolism | Chemokine CXCL1 - metabolism | Nod1 Signaling Adaptor Protein - genetics | Index Medicus | Immunology | cell biology | innate immunity | Nod-like receptor (NLR) | cell signaling | calcium intracellular release | endoplasmic reticulum stress (ER stress) | NOD1 | NOD2
Journal Article
Immunological reviews, ISSN 0105-2896, 07/2014, Volume 260, Issue 1, pp. 249 - 260
defensins | Crohn's disease | colitis | NOD2 | microbiome | IRFā4 | Colitis | Defensins | IRF-4 | Microbiome | Life Sciences & Biomedicine | Immunology | Science & Technology | Crohn Disease - genetics | Intestinal Mucosa - metabolism | Nod2 Signaling Adaptor Protein - deficiency | Defensins - biosynthesis | Humans | Inflammatory Bowel Diseases - immunology | Crohn Disease - metabolism | Nod2 Signaling Adaptor Protein - genetics | Intestines - metabolism | Inflammatory Bowel Diseases - metabolism | Intestines - immunology | Microbiota | Intestinal Mucosa - immunology | Inflammatory Bowel Diseases - genetics | Crohn Disease - microbiology | Paneth Cells - metabolism | Genetic Predisposition to Disease | Genetic Association Studies | Immunomodulation | Intestinal Mucosa - microbiology | Immunity, Innate | Crohn Disease - immunology | Polymorphism, Genetic | Animals | Intestines - microbiology | Nod2 Signaling Adaptor Protein - metabolism | Inflammatory Bowel Diseases - microbiology | Microbiota (Symbiotic organisms) | Genetic aspects | Index Medicus
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2010, Volume 139, Issue 3, pp. 904 - 917.e6
Gastroenterology and Hepatology | TLR4 | NEC | NOD2 | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Intestinal Mucosa - metabolism | Nod2 Signaling Adaptor Protein - deficiency | Age Factors | Endotoxemia - genetics | Enterocytes - metabolism | Enterocolitis, Necrotizing - genetics | Enterocolitis, Necrotizing - metabolism | Humans | NF-kappa B - metabolism | Nod2 Signaling Adaptor Protein - genetics | Endotoxemia - pathology | Intestinal Mucosa - drug effects | Mitochondrial Proteins - metabolism | Nod2 Signaling Adaptor Protein - agonists | Enterocolitis, Necrotizing - pathology | Disease Models, Animal | Animals, Newborn | Severity of Illness Index | Cell Line | Transduction, Genetic | Enterocolitis, Necrotizing - prevention & control | Mice, Inbred C57BL | Rats | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Animals | Carrier Proteins - metabolism | Nod2 Signaling Adaptor Protein - metabolism | Signal Transduction - drug effects | Protein Array Analysis | Mice | Endotoxemia - metabolism | Apoptosis | Cell Movement | Intestinal Mucosa - pathology | Oligomers | Fluorescence | Mitogens | Nitric oxide | Index Medicus | Abridged Index Medicus
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Crohnās Disease Variants of Nod2 Are Stabilized by the Critical Contact Region of Hsp70
Biochemistry (Easton), ISSN 0006-2960, 08/2017, Volume 56, Issue 34, pp. 4445 - 4448
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Crohn Disease - genetics | HSP70 Heat-Shock Proteins - immunology | Humans | Nod2 Signaling Adaptor Protein - chemistry | Crohn Disease - metabolism | Nod2 Signaling Adaptor Protein - immunology | HSP70 Heat-Shock Proteins - genetics | Nod2 Signaling Adaptor Protein - genetics | Mutation, Missense | Crohn Disease - immunology | HSP70 Heat-Shock Proteins - metabolism | Nod2 Signaling Adaptor Protein - metabolism | Protein Domains | HSP70 Heat-Shock Proteins - chemistry | Protein Stability | Amino Acid Substitution | Index Medicus | Hsp70 | nucleotide cofactors | chaperone | innate immunity | muramyl dipeptide | Nod2 | protein-protein interaction | protein stability
Journal Article
Nature communications, ISSN 2041-1723, 2018, Volume 9, Issue 1, pp. 2636 - 15
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Lung - pathology | Nod2 Signaling Adaptor Protein - deficiency | Disease Resistance | Cytokines - metabolism | Humans | Lectins, C-Type | Mice, Inbred C57BL | Risk Factors | Aspergillosis - genetics | Male | Nod2 Signaling Adaptor Protein - genetics | Microbial Viability | Aspergillus | Animals | Aspergillosis - etiology | Aspergillosis - microbiology | Hematopoietic Stem Cell Transplantation - adverse effects | Polymorphism, Single Nucleotide - genetics | Female | Lung - metabolism | Paranasal Sinuses - pathology | Phagocytosis | Fungicides | Stem cell transplantation | Infections | Transplantation | Genetic diversity | Macrophages | Gene polymorphism | Hemopoiesis | Monocytes | Cell activation | Aspergillosis | Immunocompromised hosts | Polymorphism | NOD2 protein | Index Medicus
Journal Article
FEMS microbiology letters, ISSN 0378-1097, 09/2016, Volume 363, Issue 17, p. fnw170
peptidoglycan | NOD1 | NOD2 | inflammation | chlamydia | host defense | Life Sciences & Biomedicine | Microbiology | Science & Technology | Nod1 Signaling Adaptor Protein - chemistry | Cytokines - metabolism | Signal Transduction | Humans | Nod2 Signaling Adaptor Protein - chemistry | Peptidoglycan - chemistry | Nod2 Signaling Adaptor Protein - genetics | Inflammation | Chlamydia - immunology | Immunity, Innate | Nod1 Signaling Adaptor Protein - metabolism | Toll-Like Receptors | Chlamydia Infections - immunology | Animals | Chlamydia Infections - microbiology | Nod2 Signaling Adaptor Protein - metabolism | Chlamydia - pathogenicity | Mice | Nod1 Signaling Adaptor Protein - genetics | Oligomerization | Cytokines | Cell walls | Peptidoglycans | Infections | Parasites | Nucleotides | Pattern recognition | Proteins | Signal transduction | Receptors | Toll-like receptors | Intracellular | Nod1 protein | NOD2 protein | Index Medicus
Journal Article
Inflammatory bowel diseases, ISSN 1078-0998, 01/2011, Volume 17, Issue 1, pp. 179 - 184
microbiota | NOD2 | inflammatory bowel diseases | ATG16L1 | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Crohn Disease - genetics | Autophagy-Related Proteins | Intestines - pathology | Prognosis | Humans | Colitis, Ulcerative - genetics | Genotype | Nod2 Signaling Adaptor Protein - genetics | Colitis, Ulcerative - pathology | RNA, Ribosomal - genetics | Case-Control Studies | Carrier Proteins - genetics | Metagenome - genetics | Phenotype | Intestines - microbiology | Colitis, Ulcerative - microbiology | Crohn Disease - pathology | Polymorphism, Single Nucleotide - genetics | Crohn Disease - microbiology | Inflammatory bowel diseases | Statistical analysis | rRNA 16S | Data processing | Crohn's disease | Multivariate analysis | Intestine | Surgery | Mathematical models | Models | Age | Genotypes | NOD2 protein | Ulcerative colitis | Index Medicus
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