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Journal of Clinical Investigation, ISSN 0021-9738, 02/2013, Volume 123, Issue 2, pp. 700 - 711
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2010, Volume 107, Issue 33, pp. 14739 - 14744
Mutations in the NOD2 gene are strong genetic risk factors for ileal Crohn's disease. However, the mechanism by which these mutations predispose to intestinal... 
T lymphocytes | Crohn disease | Peyers patches | Epithelial cells | Crypts | Inflammation | Bone marrow cells | Ileum | Genetic mutation | Lymph nodes | Helicobacter hepaticus | Granuloma | Innate immunity | Crohn's disease | Paneth cells | IMMUNITY | PEYERS-PATCHES | MULTIDISCIPLINARY SCIENCES | INNATE | ILEAL CROHNS-DISEASE | BOWEL-DISEASE | innate immunity | EPITHELIAL-CELLS | granuloma | FRAMESHIFT MUTATION | NOD2 MUTATION | DEFENSIN EXPRESSION | Crohn Disease - genetics | Nod2 Signaling Adaptor Protein - deficiency | Peyer's Patches - metabolism | Humans | Crohn Disease - metabolism | Ileum - metabolism | Male | Nod2 Signaling Adaptor Protein - genetics | Interleukin-1beta - genetics | Ileum - immunology | Th1 Cells - immunology | Host-Pathogen Interactions - immunology | Th1 Cells - metabolism | Flow Cytometry | Peyer's Patches - microbiology | Female | Interferon-gamma - genetics | Interleukin-6 - genetics | Helicobacter hepaticus - immunology | Mice, Inbred C57BL | Helicobacter hepaticus - physiology | Interleukin-1beta - immunology | Nod2 Signaling Adaptor Protein - immunology | Helicobacter Infections - immunology | Reverse Transcriptase Polymerase Chain Reaction | Crohn Disease - immunology | Mice, Knockout | Animals | Interferon-gamma - immunology | Interleukin-6 - immunology | Mice | Peyer's Patches - immunology | Ileum - microbiology | Helicobacter Infections - microbiology | Gene mutations | Genetic aspects | Research | Health aspects | Risk factors | Cytokines | Rodents | Bone marrow | Mutation | Gram-negative bacteria | Gene expression | Small intestine | Crohns disease | Index Medicus | Peyer's patches | Animal models | Inflammatory bowel diseases | CD8 antigen | Helper cells | Transgenic mice | Antimicrobial agents | Lymphocytes T | CD4 antigen | Intestine | gamma -Interferon | NOD2 protein | Biological Sciences | Crohn’s disease
Journal Article
Gastroenterology, ISSN 0016-5085, 2014, Volume 147, Issue 4, pp. 835 - 846
Background & Aims Continuous stimulation of pattern recognition receptors (PRRs), including nucleotide-binding oligomerization domain-2 (NOD2) (variants in... 
Gastroenterology and Hepatology | Inflammatory Bowel Disease | Signal Transduction | Intestinal Inflammation | Innate Immunity | Disease | Bowel | Inflammation | Immunity | Intestinal | Signal | Inflammatory | Innate | Transduction | CYTOKINE SECRETION | STIMULATION | PROTEIN | TOLERANCE | INNATE | NOD2 | SUPPLEMENTATION | ATG16L1 | GASTROENTEROLOGY & HEPATOLOGY | Intestines - drug effects | Metallothionein - metabolism | Nod2 Signaling Adaptor Protein - deficiency | Zinc - metabolism | Humans | Caspase 1 - metabolism | NF-kappa B - metabolism | Nod2 Signaling Adaptor Protein - genetics | Intestines - metabolism | Autophagy - drug effects | DNA-Binding Proteins - metabolism | Transfection | RNA Interference | Time Factors | Nod2 Signaling Adaptor Protein - agonists | Toll-Like Receptors - metabolism | Macrophages - microbiology | Intestines - pathology | Macrophages - pathology | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mice, Knockout | Transcription Factors - metabolism | Macrophages - metabolism | Animals | Intestines - microbiology | Metallothionein - genetics | Nod2 Signaling Adaptor Protein - metabolism | Macrophages - drug effects | Anti-Bacterial Agents - pharmacology | Mice | Oligomers | Macrophages | Index Medicus | Abridged Index Medicus
Journal Article
by Rivas, Manuel A and Beaudoin, Mélissa and Gardet, Agnes and Stevens, Christine and Sharma, Yashoda and Zhang, Clarence K and Boucher, Gabrielle and Ripke, Stephan and Ellinghaus, David and Burtt, Noel and Fennell, Tim and Kirby, Anew and Latiano, Anna and Goyette, Philippe and Green, Todd and Halfvarson, Jonas and Haritunians, Talin and Korn, Joshua M and Kuruvilla, Finny and Lagacé, Caroline and Neale, Benjamin and Lo, Ken Sin and Schumm, Phil and Törkvist, Leif and Dubinsky, Marla C and Brant, Steven R and Silverberg, Mark S and Duerr, Richard H and Altshuler, David and Gabriel, Stacey and Lettre, Guillaume and Franke, Ane and D'Amato, Mauro and McGovern, Dermot P. B and Cho, Judy H and Rioux, John D and Xavier, Ramnik J and Daly, Mark J and Parkes, Miles and Lee, James and Zhang, Hu and Bredin, Francesca and Ahmad, Tariq and Satsangi, Jack and Nimmo, Elaine and mmond, Hazel and Lees, Charlie and Mansfield, John and Mathew, Christopher G and Prescott, Natalie and Harrison, Kristina and Sanderson, Jeremy and Newman, William and Phillips, Anne and Mowat, Craig and Edwards, Cathryn and Wilson, David C and Barrett, Jeffrey and Anderson, Carl and Gray, Emma and Edkins, Sarah and Russell, Richard K and Henderson, Paul and Anderson, Carl A and Annese, Vito and Baldassano, Robert N and Balschun, Tobias and Barclay, Murray and Barrett, Jeffrey C and Bayless, Theodore M and Bis, Joshua C and Brand, Stephan and Bumpstead, Suzanne and Buning, Carsten and Cohen, Albert and Colombel, Jean-Frederick and Cottone, Mario and D'Inca, Renata and Denson, Ted and Dubinsky, Marla and Florin, Tim and Franchimont, Denis and Gearry, Richard and Georges, Michel and Glas, Jurgen and van Gossum, Ane and Griffiths, Anne M and Guthery, Stephen L and Hakonarson, Hakon and Hugot, Jean-Pierre and de Jong, Dirk J and Jostins, Luke and Kugathasan, Subra and Kullack-Ublick, Gerd and Laukens, Debby and Lawrance, Ian and Lees, Charlie W and Lemann, Marc and Levine, Arie and Libioulle, Cecile and ... and United Kingdom Inflammatory Bowel and Natl Inst Diabet Digestive Kidney and Int Inflammatory Bowel Dis and United Kingdom Inflammatory Bowel Disease Genetics Consortium and National Institute of Diabetes and Digestive Kidney Diseases Inflammatory Bowel Disease Genetics Consortium (NIDDK IBDGC) and International Inflammatory Bowel Disease Genetics Consortium and Hälsoakademin and Örebro universitet
Nature genetics, ISSN 1061-4036, 2011, Volume 43, Issue 11, pp. 1066 - 1073
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 08/2009, Volume 206, Issue 8, pp. 1709 - 1716
Journal Article
Gastroenterology, ISSN 0016-5085, 2010, Volume 139, Issue 3, pp. 904 - 917.e6
Background & Aims Factors that regulate enterocyte apoptosis in necrotizing enterocolitis (NEC) remain incompletely understood, although Toll-like receptor-4... 
Gastroenterology and Hepatology | TLR4 | NEC | NOD2 | TRANSLOCATION | ACTIVATION | NECROTIZING ENTEROCOLITIS | ENTEROCYTE MIGRATION | PATHOGENESIS | NOD-LIKE RECEPTORS | HOST-DEFENSE | RESTITUTION | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Intestinal Mucosa - metabolism | Nod2 Signaling Adaptor Protein - deficiency | Age Factors | Endotoxemia - genetics | Enterocytes - metabolism | Enterocolitis, Necrotizing - genetics | Enterocolitis, Necrotizing - metabolism | Humans | NF-kappa B - metabolism | Nod2 Signaling Adaptor Protein - genetics | Endotoxemia - pathology | Intestinal Mucosa - drug effects | Mitochondrial Proteins - metabolism | Nod2 Signaling Adaptor Protein - agonists | Enterocolitis, Necrotizing - pathology | Disease Models, Animal | Animals, Newborn | Severity of Illness Index | Cell Line | Transduction, Genetic | Enterocolitis, Necrotizing - prevention & control | Mice, Inbred C57BL | Rats | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Animals | Carrier Proteins - metabolism | Nod2 Signaling Adaptor Protein - metabolism | Signal Transduction - drug effects | Protein Array Analysis | Mice | Endotoxemia - metabolism | Apoptosis | Cell Movement | Intestinal Mucosa - pathology | Oligomers | Fluorescence | Mitogens | Nitric oxide | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2018, Volume 13, Issue 10, pp. e0206244 - e0206244
RIP2, one of the RIP kinases, interacts with p75 neurotrophin receptor, regulating the neuron survival, and with NOD1 and NOD2 proteins, causing the innate... 
MULTIDISCIPLINARY SCIENCES | DISEASE | N-15 | RELAXATION | COUPLINGS | NOD2 | CELL-DEATH | Amino Acid Sequence | Nod1 Signaling Adaptor Protein - chemistry | Magnetic Resonance Spectroscopy - methods | Nod2 Signaling Adaptor Protein - chemistry | Protein Multimerization | Protein Refolding | Models, Molecular | Nod2 Signaling Adaptor Protein - genetics | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Static Electricity | Nod1 Signaling Adaptor Protein - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Sequence Homology, Amino Acid | Nod2 Signaling Adaptor Protein - metabolism | Solutions | Receptor-Interacting Protein Serine-Threonine Kinase 2 - chemistry | Protein Binding | Caspase Activation and Recruitment Domain | Hydrogen-Ion Concentration | Nod1 Signaling Adaptor Protein - genetics | Physiological aspects | Genetic aspects | Research | Properties | Structure | Protein kinases | Protein-protein interactions | Gram-positive bacteria | Homology | Drug development | Kinases | pH effects | Neurogenesis | Inflammatory diseases | Magnetic resonance spectroscopy | Proteins | Oligomers | Protein folding | Neurodegeneration | pH | Nod1 protein | NOD2 protein | Cell survival | Oligomerization | Immune response | Caspase | Electrostatic properties | Physics | Domains | Immune systems | Chemistry | Protein expression | Protein interaction | NMR spectroscopy | Protein structure | Index Medicus
Journal Article
Journal Article
Journal Article
Journal of Digestive Diseases, ISSN 1751-2972, 11/2017, Volume 18, Issue 11, pp. 625 - 633
Journal Article
Journal Article