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nojirimycin (114) 114
chemistry, organic (68) 68
glycosidase inhibitors (30) 30
biochemistry & molecular biology (25) 25
derivatives (22) 22
index medicus (21) 21
1-deoxynojirimycin (20) 20
iminosugars (18) 18
chemistry, medicinal (16) 16
1-deoxynojirimycin - analogs & derivatives (13) 13
analogs (13) 13
animals (13) 13
glycoside hydrolases - antagonists & inhibitors (13) 13
enzyme inhibitors - pharmacology (12) 12
inhibitors (12) 12
molecular structure (12) 12
-nojirimycin (11) 11
azasugars (11) 11
chemistry (11) 11
chemistry, multidisciplinary (11) 11
enzyme inhibitors - chemistry (11) 11
humans (11) 11
inhibition (11) 11
asymmetric-synthesis (10) 10
glycosidases (10) 10
plant sciences (10) 10
biosynthesis (9) 9
castanospermine (9) 9
chemistry, applied (9) 9
glucosidase (9) 9
pharmacology & pharmacy (9) 9
-1-deoxynojirimycin (8) 8
agents (8) 8
biological evaluation (8) 8
deoxynojirimycin (8) 8
glucosamine - analogs & derivatives (8) 8
rats (8) 8
1-deoxynojirimycin - chemical synthesis (7) 7
alcohols (7) 7
beta-glucosidase (7) 7
d-glucose (7) 7
enzyme inhibitors - chemical synthesis (7) 7
enzymes (7) 7
glycosylation (7) 7
imino sugars (7) 7
piperidine (7) 7
stereoselective-synthesis (7) 7
sugars (7) 7
1-deoxynojirimycin - chemistry (6) 6
1-deoxynojirimycin - pharmacology (6) 6
acid (6) 6
amination (6) 6
amino-sugars (6) 6
magnetic resonance spectroscopy (6) 6
organic-synthesis (6) 6
practical synthesis (6) 6
stereoisomerism (6) 6
1-deoxymannojirimycin (5) 5
alpha-glucosidase (5) 5
biological-activity (5) 5
deoxymannojirimycin (5) 5
enzyme inhibitors - isolation & purification (5) 5
glycosidase inhibitor (5) 5
glycoside hydrolase inhibitors (5) 5
iminosugar (5) 5
mice (5) 5
ring (5) 5
swainsonine (5) 5
alpha-l-fucosidase (4) 4
beta-glucosidase - antagonists & inhibitors (4) 4
c-glycosides (4) 4
carbohydrates - chemistry (4) 4
chemistry, inorganic & nuclear (4) 4
drug design (4) 4
germination (4) 4
glucosamine - chemistry (4) 4
glucosamine - pharmacology (4) 4
glucosidase inhibitors (4) 4
imino sugars - chemistry (4) 4
indicators and reagents (4) 4
inhibitor (4) 4
inhibitory concentration 50 (4) 4
mannojirimycin (4) 4
models, molecular (4) 4
molecular conformation (4) 4
nojirimycins (4) 4
oxidation-reduction (4) 4
piperidines - chemical synthesis (4) 4
potent (4) 4
potent inhibitor (4) 4
stereoselective synthesis (4) 4
structure-activity relationship (4) 4
synthesis (4) 4
α-glucosidase (4) 4
β-glucosidase (4) 4
acarbose (3) 3
acids (3) 3
aldol condensation (3) 3
alkaloids (3) 3
alpha-glucosidase inhibitor (3) 3
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Carbohydrate Research, ISSN 0008-6215, 06/2016, Volume 429, pp. 113 - 122
The synthesis of a complete series of cyclic carbamate-type sp -iminosugar N-, S-, O- and C-octyl pseudoglycosides related to nojirimycin, mannojirimycin and... 
Glycosides | Glycosidase inhibitor | Antitumor activity | sp2-Iminosugar | Nojirimycin | Iminosugar
Journal Article
Synthetic Communications, ISSN 0039-7911, 02/2019, Volume 49, Issue 3, pp. 404 - 409
2,5-Diketopiperazines were prepared and characterized where one of the amino acids is (2S,3R,4R,5S)-3,4,5-trihydroxypipecolic acid. The protected pipecolic... 
2,5-diketopiperazines | nojirimycin | trihydroxypipecolic acid | MEDICINAL CHEMISTRY | PEPTIDES | ACID | CHEMISTRY, ORGANIC
Journal Article
Organic & Biomolecular Chemistry, ISSN 1477-0520, 01/2018, Volume 16, Issue 25, pp. 4688 - 4700
We report herein the development of a stereodivergent route towards polyhydroxylated bicyclic azetidine scaffolds, namely 6-azabicyclo[3.2.0]heptane... 
Amides | Heptanes | Substrates | Desaturation
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 9/2014, Volume 12, Issue 39, pp. 7786 - 7791
The natural product, cyclophellitol and its aziridine analogue are potent mechanism-based retaining β-glucosidase inhibitors. In this paper we explore the... 
(+)-CYCLOPHELLITOL | BIOCHEMISTRY | NOJIRIMYCIN | CHEMISTRY, ORGANIC | GLYCOSIDASE INHIBITORS | IN-SITU | ACTIVITY-BASED PROBES | GLYCOBIOLOGY
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2018, Volume 16, Issue 25, pp. 4688 - 4700
We report herein the development of a stereodivergent route towards polyhydroxylated bicyclic azetidine scaffolds, namely 6-azabicyclo[3.2.0]heptane... 
ALCOHOLS | AMINATION | LIGANDS | CONFIGURATION | NOJIRIMYCIN | CHEMISTRY | CHEMISTRY, ORGANIC | AGENTS | OPPORTUNITIES | SCAFFOLDS | GLYCOSIDASE INHIBITORS
Journal Article
Journal of Pesticide Science, ISSN 1348-589X, 2017
根寄生植物は重要農作物に寄生し収量を低下させるため,世界の食糧生産に深刻な被害を及ぼしている.近年,我々は放線菌Streptomyces ficellusの生産するノジリマイシン(NJ)が根寄生植物種子の発芽を阻害することを見出した.本研究ではS.... 
Streptomyces ficellus | parasitic weeds | marine broth | Pharmamedia | nojirimycin
Journal Article
Current Chemical Biology, ISSN 2212-7968, 01/2014, Volume 8, Issue 1, pp. 10 - 16
Journal Article
SYNTHESIS-STUTTGART, ISSN 0039-7881, 10/2017, Volume 49, Issue 20, pp. 4606 - 4612
Iminosugars are good starting points for the development of different kinds of drugs. Many are polyhydroxylated piperidines that behave as biomimetics of their... 
ylides | REAGENTS | piperidines | NOJIRIMYCIN | CHEMISTRY, ORGANIC | DEOXYMANNOJIRIMYCIN | GLYCOSIDASE INHIBITORS | CLEAVAGE | bicyclic compounds | iminosugars | cyclopropanation | PIPERIDINE | ALCOHOL | stereoselective synthesis | PERSPECTIVES | BIOLOGICAL EVALUATION | STEREOSELECTIVE-SYNTHESIS
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 02/2011, Volume 9, Issue 4, pp. 1231 - 1236
Herein a practical and scalable route to 1-deoxyaltronojirimycin is presented. The target is achieved in 9 steps and 43% yield featuring only two... 
ALCOHOLS | BIOSYNTHESIS | BIOLOGICAL EVALUATION | NOJIRIMYCIN | CHEMISTRY, ORGANIC | AGENTS | INHIBITORS | N-BUTYLDEOXYNOJIRIMYCIN
Journal Article
Journal of Molecular Catalysis. B, Enzymatic, ISSN 1381-1177, 02/2015, Volume 112, pp. 54 - 58
An easy and convenient chemo-enzymatic method for preparation of 1-deoxygalactonojirimycin and 1-deoxynojirimycin hydrochlorides has been demonstrated. All the... 
Aminosugars | Gluoconobacter oxydans | 1-Deoxygalactonojirimycin | 1-Deoxynojirimycin | Amino sorbitol | NOJIRIMYCIN | CHEMISTRY, PHYSICAL | OXYDANS | Enzymes
Journal Article
Organic & biomolecular chemistry, ISSN 1477-0520, 2014, Volume 12, Issue 39, pp. 7786 - 7791
The natural product, cyclophellitol and its aziridine analogue are potent mechanism-based retaining β-glucosidase inhibitors. In this paper we explore the... 
beta-Glucosidase - antagonists & inhibitors | Cyclohexanols - pharmacology | Cyclohexanols - chemistry | Enzyme Inhibitors - chemistry | Humans | Enzyme Inhibitors - pharmacology
Journal Article
Current Organic Synthesis, ISSN 1570-1794, 2018, Volume 15, Issue 6, pp. 853 - 862
Aim and Objective: The efficient synthesis of disaccharide containing iminosugar moiety has a considerable interest in the field of glycoscience. In the... 
Glycosylation | Iminosugars | Iminosugars pseudodisaccharide | Iminosugar glycoside | Iminocyclitols | Stereoselective | GLYCOSIDES | THIOGLYCOSIDES | ROUTE | PROMOTED REACTIONS | NOJIRIMYCIN | CHEMISTRY, ORGANIC | glycosylation | PYRIDINES | stereoselective | CASTANOSPERMINE | iminosugars pseudodisaccharide | iminosugar glycoside | iminosugars | AMINO-SUGARS | INHIBITORS | DERIVATIVES
Journal Article
Journal Article
Organic & Biomolecular Chemistry, ISSN 1477-0520, 2017, Volume 15, Issue 18, pp. 3884 - 3891
We synthesized and evaluated new zwitterionic inhibitors against glycoside hydrolase-like phosphorylase Streptomyces coelicolor (Sco) GlgEI-V279S which plays a... 
Journal Article
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