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1. Full Text Long noncoding RNA HOTAIR involvement in cancer
by Wu, Yansheng and Zhang, Li and Wang, Yang and Li, Hui and Ren, Xiubao and Wei, Feng and Yu, Wenwen and Wang, Xudong and Zhang, Lun and Yu, Jinpu and Hao, Xishan
Tumor Biology, ISSN 1010-4283, 10/2014, Volume 35, Issue 10, pp. 9531 - 9538
Evidences have been provided that long noncoding RNAs (lncRNAs) act as key molecules in epigenetic regulation and are involved in the development process of... 
HOTAIR | Noncoding RNA | Biomedicine | Gene regulation | Cancer Research | Metastasis | Cancer | TUMOR INVASION | PRINCIPLES | EPITHELIAL-MESENCHYMAL TRANSITION | CELL LUNG-CANCER | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | POOR-PROGNOSIS | EPIGENETIC REGULATION | UP-REGULATION | PROGRESSION | Neoplasms - metabolism | Animals | Neoplasms - genetics | Humans | RNA, Long Noncoding - genetics | Neoplasms - pathology | RNA, Long Noncoding - metabolism | Gene Expression Regulation, Neoplastic - genetics | Prevention | Epigenetic inheritance | Medical colleges | Development and progression | Antisense RNA | Genetic engineering | Methylation | Health aspects | Ribonucleic acid--RNA
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2. Full Text HOX transcript antisense RNA (HOTAIR) in cancer
by Qu, Xiaohan and Alsager, Simon and Zhuo, Ying and Shan, Bin
Cancer Letters, ISSN 0304-3835, 07/2019, Volume 454, pp. 90 - 97
Long noncoding RNAs (lncRNAs) have emerged as a new family of master regulators of cancer. The lncRNA HOX transcript antisense RNA ( ) is a prime example of an... 
Epigenetics | PRC2 | R-loop | G-quadruplex | CERVICAL-CANCER | LNCRNA HOTAIR | EPITHELIAL-MESENCHYMAL TRANSITION | INTERGENIC RNA | NASOPHARYNGEAL CARCINOMA | LONG NONCODING RNA | ONCOLOGY | SQUAMOUS-CELL CARCINOMA | TUMOR-GROWTH | UP-REGULATION | EXPRESSION | Regulators | Transcription | Genomes | Metastasis | Drug resistance | Stomach cancer | Metastases | Proteins | Cell cycle | DNA methylation | Lymphatic system | Antisense RNA | Breast cancer | RNA polymerase | Gene expression | Ribonucleic acid--RNA | Androgens | Molecular modelling | Medical prognosis | Biomarkers | Diagnostic systems | Prostate cancer | Cancer | Apoptosis | Tumors
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3. Full Text Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer
by Liu, Xiang-hua and Sun, Ming and Nie, Feng-qi and Ge, Ying-bin and Zhang, Er-bao and Yin, Dan-dan and Kong, Rong and Xia, Rui and Lu, Kai-hua and Li, Jin-hai and De, Wei and Wang, Ke-ming and Wang, Zhao-xia
Molecular Cancer, ISSN 1476-4598, 04/2014, Volume 13, Issue 1, pp. 92 - 92
Background: Accumulating evidence indicates that the long non-coding RNA HOTAIR plays a critical role in cancer progression and metastasis. However, the... 
HOTAIR | Proliferation and invasion | HER2 | Gastric cancer | Competing endogenous RNA | CELLS | TRASTUZUMAB | BIOCHEMISTRY & MOLECULAR BIOLOGY | VALIDATION | BREAST-CANCER | OVEREXPRESSION | LONG NONCODING RNA | ONCOLOGY | POOR-PROGNOSIS | GENE AMPLIFICATION | UP-REGULATION | CARCINOMA | Neoplasm Transplantation | Cell Proliferation | Receptor, ErbB-2 - genetics | Humans | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Carcinoma - mortality | Molecular Sequence Data | Stomach Neoplasms - metabolism | Tumor Microenvironment | Male | MicroRNAs - metabolism | Stomach Neoplasms - pathology | Base Sequence | Biomarkers, Tumor - metabolism | Female | Carcinoma - pathology | Stomach Neoplasms - genetics | Signal Transduction | Cell Survival | Lymphatic Metastasis | RNA, Long Noncoding - genetics | Animals | Mice, Nude | Survival Analysis | Carcinoma - genetics | Biomarkers, Tumor - genetics | Mice | MicroRNAs - genetics | Carcinoma - metabolism | RNA, Long Noncoding - metabolism | Stomach Neoplasms - mortality | Development and progression | Metastasis | Research | Oncology, Experimental | Cancer | Statistical analysis | Pathogenesis | Mortality | Breast cancer | Biology | Gene expression | Stomach cancer | Proteins | Liver cancer | Medical prognosis | MicroRNAs | Software | Tumors | Index Medicus
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4. Full Text Binding Interactions between Long Noncoding RNA HOTAIR and PRC2 Proteins
by Wu, Liang and Murat, Pierre and Matak-Vinkovic, Dijana and Murrell, Adele and Balasubramanian, Shankar
Biochemistry, ISSN 0006-2960, 12/2013, Volume 52, Issue 52, pp. 9519 - 9527
Long noncoding RNAs (lncRNAs) play a key role in the epigenetic regulation of cells. Many of these lncRNAs function by interacting with histone repressive... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | QUADRUPLEXES | Polycomb Repressive Complex 2 - genetics | RNA, Long Noncoding - chemistry | Humans | Protein Binding | RNA, Long Noncoding - genetics | Kinetics | Nucleic Acid Conformation | Polycomb Repressive Complex 2 - chemistry | Polycomb Repressive Complex 2 - metabolism | Dimerization | RNA, Long Noncoding - metabolism | Enhancer of Zeste Homolog 2 Protein
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5. Full Text Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers
by Kogo, Ryunosuke and Shimamura, Teppei and Mimori, Koshi and Kawahara, Kohichi and Imoto, Seiya and Sudo, Tomoya and Tanaka, Fumiaki and Shibata, Kohei and Suzuki, Akira and Komune, Shizuo and Miyano, Satoru and Mori, Masaki
Cancer Research, ISSN 0008-5472, 10/2011, Volume 71, Issue 20, pp. 6320 - 6326
The functional impact of recently discovered long noncoding RNAs (ncRNAs) in human cancer remains to be clarified. One long ncRNA which has attracted attention... 
TARGET | DEVELOPMENTAL REGULATORS | MICROARRAY | ONCOLOGY | EMBRYONIC STEM-CELLS | COMPLEXES | GENES | EXPRESSION | CARCINOMA | Prognosis | RNA, Untranslated - metabolism | Colorectal Neoplasms - genetics | Humans | Middle Aged | Chromatin Assembly and Disassembly | Repressor Proteins - genetics | Male | Polycomb-Group Proteins | RNA, Long Noncoding | Female | Aged | Colorectal Neoplasms - pathology | Liver Neoplasms - secondary | Neoplasm Staging | Colorectal Neoplasms - metabolism | Repressor Proteins - metabolism | Carcinoma - secondary
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6. Full Text Antisense Transcript Long Noncoding RNA (lncRNA) HOTAIR is Transcriptionally Induced by Estradiol
by Bhan, Arunoday and Hussain, Imran and Ansari, Khairul I and Kasiri, Sahba and Bashyal, Aarti and Mandal, Subhrangsu S
Journal of Molecular Biology, ISSN 0022-2836, 10/2013, Volume 425, Issue 19, pp. 3707 - 3722
HOTAIR (HOX antisense intergenic RNA) is a long noncoding RNA (lncRNA) that is transcribed from the antisense strand of homeobox C gene locus in chromosome 12.... 
HOTAIR | long noncoding RNA | MLL histone methylases | estrogen receptors | epigenetics | Keywords | APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HISTONE METHYLASES | ESTROGEN-RECEPTOR | BREAST-CANCER | ROLES | GROWTH | GENE-EXPRESSION | NUCLEAR RECEPTOR COREGULATORS | CELL | XIST GENE | Myeloid-Lymphoid Leukemia Protein - metabolism | Receptors, Estrogen - metabolism | Apoptosis - drug effects | Humans | Breast Neoplasms - metabolism | Gene Knockdown Techniques | CREB-Binding Protein - genetics | DNA-Binding Proteins - metabolism | Microchip Analytical Procedures | CREB-Binding Protein - metabolism | MCF-7 Cells | Antisense Elements (Genetics) - metabolism | Female | Transcription, Genetic | Estradiol - pharmacology | Cell Survival - drug effects | Receptors, Estrogen - genetics | Histone-Lysine N-Methyltransferase | Gene Silencing | RNA, Long Noncoding - genetics | DNA-Binding Proteins - genetics | Response Elements - drug effects | Breast Neoplasms - genetics | Histones - genetics | Myeloid-Lymphoid Leukemia Protein - genetics | Antisense Elements (Genetics) - genetics | Histones - metabolism | RNA, Long Noncoding - metabolism | Phosphates | Leukemia | Genes | Phenols | Development and progression | Antisense RNA | Genetic engineering | Genetic transcription | Binding proteins | Estradiol | RNA polymerases | Protein binding
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7. Full Text Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination
by Yoon, Je-Hyun and Abdelmohsen, Kotb and Kim, Jiyoung and Yang, Xiaoling and Martindale, Jennifer L and Tominaga-Yamanaka, Kumiko and White, Elizabeth J and Orjalo, Arturo V and Rinn, John L and Kreft, Stefan G and Wilson, Gerald M and Gorospe, Myriam
Nature Communications, ISSN 2041-1723, 12/2013, Volume 4, Issue 1, pp. 2939 - 2939
Although mammalian long non-coding (lnc) RNAs are best known for modulating transcription, their post-transcriptional influence on mRNA splicing, stability and... 
INTERACTION NETWORK | HUR | DECAY | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | DIFFERENTIATION | BINDING PROTEIN | IDENTIFICATION | EXPRESSION | ATAXIN-1 | REPLICATIVE SENESCENCE | Cellular Senescence - genetics | RNA-Binding Proteins - genetics | Argonaute Proteins - metabolism | Ataxin-1 | Humans | ELAV Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | RNA Stability | Nerve Tissue Proteins - metabolism | Proteins - genetics | RNA Cap-Binding Proteins - metabolism | Ataxins | Ubiquitination | Proteins - metabolism | HeLa Cells | Ubiquitin-Protein Ligases - genetics | RNA, Long Noncoding - metabolism | RNA-Binding Proteins - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism
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8. Full Text Long Intergenic Noncoding RNA HOTAIR Is Overexpressed and Regulates PTEN Methylation in Laryngeal Squamous Cell Carcinoma
by Li, Dandan and Feng, Jiapeng and Wu, Tianyi and Wang, Yandong and Sun, Yanan and Ren, Jingyuan and Liu, Ming
American Journal of Pathology, The, ISSN 0002-9440, 2013, Volume 182, Issue 1, pp. 64 - 70
Homeobox (HOX) transcript antisense RNA (HOTAIR) is a long intergenic noncoding RNA (lincRNA) that is significantly overexpressed in breast and hepatocellular... 
Pathology | PATHOLOGY | GENE | EXPRESSION | CANCER METASTASIS | Neoplasm Transplantation | Prognosis | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Genes, Neoplasm | Humans | Middle Aged | Apoptosis - genetics | Male | Transplantation, Heterologous | Gene Knockdown Techniques | Laryngeal Neoplasms - pathology | RNA, Long Noncoding - biosynthesis | Female | Tumor Cells, Cultured | Gene Expression Regulation, Neoplastic - genetics | Laryngeal Neoplasms - genetics | PTEN Phosphohydrolase - genetics | Neoplasm Invasiveness | Laryngeal Neoplasms - metabolism | PTEN Phosphohydrolase - metabolism | DNA Methylation - genetics | RNA, Long Noncoding - genetics | Animals | RNA, Neoplasm - genetics | Biomarkers, Tumor - genetics | Mice | Mice, Inbred BALB C | DNA, Neoplasm - genetics | Biomarkers, Tumor - biosynthesis
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9. Full Text Enhanced Expression of Long Non-Coding RNA HOTAIR Is Associated with the Development of Gastric Cancer
by Endo, Hiroyuki and Shiroki, Takeharu and Nakagawa, Takayuki and Yokoyama, Misa and Tamai, Keiichi and Yamanami, Hideaki and Fujiya, Tsuneaki and Sato, Ikuro and Yamaguchi, Kazunori and Tanaka, Nobuyuki and Iijima, Katsunori and Shimosegawa, Tooru and Sugamura, Kazuo and Satoh, Kennichi
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, p. e77070
The long non-coding RNA HOTAIR has been reported to be a poor prognostic biomarker in a variety of malignant tumors. However, little is known about the... 
SURVIVAL | ELEMENTS | PROJECT | MULTIDISCIPLINARY SCIENCES | CARCINOMA PROGRESSION | Stomach Neoplasms - genetics | Peritoneal Cavity - pathology | Humans | Carcinogenesis - genetics | Gene Expression Regulation, Neoplastic | Cell Survival - genetics | Stomach Neoplasms - pathology | RNA, Long Noncoding - genetics | Neoplasm Metastasis | Animals | Cell Line, Tumor | Female | Mice | Liver cancer | Development and progression | Metastasis | RNA | Stomach cancer | Liver | Lung cancer | Genomes | Cancer therapies | Lymph nodes | Metastases | Consortia | Surgery | Gastroenterology | Lesions | Gastric cancer | Deoxyribonucleic acid--DNA | University graduates | Immunodeficiency | Agar | Tumor cell lines | Gene expression | Ribonucleic acid--RNA | Molecular chains | Polymerase chain reaction | Medicine | Correlation analysis | Medical prognosis | Cell lines | Stem cells | Biomarkers | Glyceraldehyde-3-phosphate dehydrogenase | Non-coding RNA | Cancer | Tumors | Peritoneum | Deoxyribonucleic acid | Ribonucleic acid | DNA
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10. Full Text Long non-coding RNA hotair is targeted and regulated by MIR-141 in human cancer cells
by Chiyomaru, Takeshi and Fukuhara, Shinichiro and Saini, Sharanjot and Majid, Shahana and Deng, Guoren and Shahryari, Varahram and Chang, Inik and Tanaka, Yuichiro and Enokida, Hideki and Nakagawa, Masayuki and Dahiya, Rajvir and Yamamura, Soichiro
Journal of Biological Chemistry, ISSN 0021-9258, 1761, Volume 289, Issue 18, pp. 12550 - 12565
Background: Silencing of long non-coding RNA (lncRNA) by microRNA (miRNA) has only been recently observed. Results: miR-141 binds to HOTAIR and suppresses its... 
HOTAIR | TRANSCRIPTIONAL ACTIVITY | CODING REGIONS | Genistein | ALPHA-AMANITIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | MICRORNA TARGETS | MIR-200 FAMILY | REPRESSORS ZEB1 | Invasion | Renal Carcinoma | Gene Regulation | Long Non-coding RNA | EPITHELIAL-MESENCHYMAL TRANSITION | MicroRNA | PROSTATE-CANCER | GENE-EXPRESSION | Cell Growth | Cancer Biology | miR-141 | MAMMALIAN MESSENGER-RNAS | Neoplasms - metabolism | Kidney Neoplasms - genetics | Cell Proliferation | Homeodomain Proteins - metabolism | Humans | Gene Expression Regulation, Neoplastic | Carcinoma, Renal Cell - genetics | Apoptosis - genetics | MicroRNAs - metabolism | Kidney Neoplasms - metabolism | Neoplasms - genetics | RNA Interference | Base Sequence | Cell Line | Argonaute Proteins - metabolism | Argonaute Proteins - genetics | Carcinoma, Renal Cell - pathology | Neoplasm Invasiveness | RNA, Long Noncoding - genetics | Binding Sites - genetics | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Homeodomain Proteins - genetics | HT29 Cells | Transcription Factors - metabolism | Carcinoma, Renal Cell - metabolism | Cell Line, Tumor | Kidney Neoplasms - pathology | MicroRNAs - genetics | Mutation | Neoplasms - pathology | RNA, Long Noncoding - metabolism | Zinc Finger E-box-Binding Homeobox 1 | Cell Biology
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11. Full Text Long non-coding RNA HOTAIR in carcinogenesis and metastasis
by Jinsong Zhang Peijing Zhang Li Wang Hai-long Piao Li Ma
生物化学与生物物理学报：英文版, ISSN 1672-9145, 2014, Volume 46, Issue 1, pp. 1 - 5
Long non-coding RNAs （lncRNAs） have gained massive attention in recent years as a potentially new and crucial layer of gene regulation. LncRNAs are prevalently... 
HOX基因 | 癌变 | 相互作用 | 非编码RNA | 反义RNA | 过度表达 | 基因调控 | 组蛋白H3 | HOTAIR | cancer | lncRNA | carcinogenesis | metastasis | SURVIVAL | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | REVEAL | LUNG-CANCER | HEPATOCELLULAR-CARCINOMA | BIOPHYSICS | MAPS | EXPRESSION | PROGRESSION | EZH2 | Carcinoma, Hepatocellular - physiopathology | Humans | Gene Expression Regulation, Neoplastic | RNA, Long Noncoding - genetics | Carcinogenesis | Carcinoma, Non-Small-Cell Lung - physiopathology | Animals | Breast Neoplasms - pathology | RNA, Long Noncoding - biosynthesis | Liver Neoplasms - physiopathology | Polycomb Repressive Complex 2 - physiology | Female | Histones - metabolism | Pancreatic Neoplasms - physiopathology | Index Medicus | Review
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12. Full Text Long non‐coding RNA HOTAIR is an independent prognostic marker for nasopharyngeal carcinoma progression and survival
by Nie, Yan and Liu, Xiang and Qu, Shaohua and Song, Erwei and Zou, Hua and Gong, Chang
Cancer Science, ISSN 1347-9032, 04/2013, Volume 104, Issue 4, pp. 458 - 464
Identification of new nasopharyngeal carcinoma (NPC) biomarkers is of great clinical value for the diagnosis and treatment of NPC. HOTAIR, a cancer‐related... 
ONCOLOGY | PATIENT SURVIVAL | CANCER | TUMORIGENESIS | EPSTEIN-BARR-VIRUS | Nasopharyngeal Neoplasms - genetics | Up-Regulation | Nasopharyngeal Carcinoma | Carcinoma | Nasopharyngeal Neoplasms - mortality | Prognosis | Neoplasm Invasiveness | Humans | Middle Aged | Male | Disease Progression | Biomarkers, Tumor - metabolism | Cell Line, Tumor | Female | Nasopharyngeal Neoplasms - diagnosis | RNA, Long Noncoding - metabolism | Development and progression | RNA | Analysis | Cancer
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13. Full Text Long Noncoding RNA HOTAIR Is a Prognostic Marker for Esophageal Squamous Cell Carcinoma Progression and Survival
by Lv, Xiao-Bin and Lian, Gui-Yong and Wang, Hao-Ran and Song, Erwei and Yao, Herui and Wang, Ming-Hui
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e63516
Background: It is currently unclear whether the expression of HOX transcript antisense RNA (HOTAIR) correlates with the progression of esophageal cancer. The... 
CANCER | MULTIDISCIPLINARY SCIENCES | RNA, Small Interfering - genetics | Gene Expression | Prognosis | Carcinoma, Squamous Cell - metabolism | Humans | Middle Aged | Kaplan-Meier Estimate | Proportional Hazards Models | Male | Lymphatic Metastasis | RNA, Long Noncoding - genetics | Esophageal Neoplasms - pathology | Gene Knockdown Techniques | Carcinoma, Squamous Cell - mortality | Esophageal Neoplasms - metabolism | Biomarkers, Tumor - metabolism | Cell Line, Tumor | Esophageal Neoplasms - mortality | Carcinoma, Squamous Cell - secondary | Female | Biomarkers, Tumor - genetics | RNA, Long Noncoding - metabolism | Cell Movement | Medical research | Squamous cell carcinoma | Analysis | Medicine, Experimental | DNA polymerases | Development and progression | Antisense RNA | Esophageal cancer | Cell proliferation | Biotechnology | Phosphorylation | RNA-directed DNA polymerase | Transcription | Heart surgery | Metastasis | Tissues | Liver cancer | Cell growth | Cell cycle | Cell survival | Colonies | Breast cancer | Regression analysis | Gene expression | Ribonucleic acid--RNA | Patients | Survival | Esophagus | Studies | Pancreatic cancer | Medical prognosis | Cell lines | Biomarkers | Cell migration | Cancer | Tumors | RNA | Ribonucleic acid
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14. Full Text The Long Noncoding RNA HOTAIR Contributes to Cisplatin Resistance of Human Lung Adenocarcinoma Cells via downregualtion of p21WAF1/CIP1 Expression
by Liu, Zhili and Sun, Ming and Lu, Kaihua and Liu, Jing and Zhang, Meiling and Wu, Weiqin and De, Wei and Wang, Zhaoxia and Wang, Rui
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, p. e77293
HOTAIR, a long intervening non-coding RNA (lincRNA), associates with the Polycomb Repressive Complex 2 (PRC2) and is reported to reprogram chromatin... 
Cell proliferation | Adenocarcinoma | Chromatin | Lung cancer | Chemoresistance | Oncology | Biochemistry | Metastasis | Kinases | Cell growth | Cell cycle | Tumorigenesis | Phenotypes | RNA-mediated interference | siRNA | Gene expression | Ribonucleic acid--RNA | Patients | Cisplatin | Studies | Polycomb group proteins | Sensitivity | Cyclin-dependent kinase inhibitor p21 | Chemotherapy | MicroRNAs | Medical prognosis | Epigenetics | Molecular biology | Non-coding RNA | Apoptosis | RNA | Ribonucleic acid
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