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Epilepsy Research, ISSN 0920-1211, 01/2019, Volume 149, pp. 13 - 16
A combined adult and pediatric population pharmacokinetic model including covariate effects was developed; simulations were subsequently performed to guide... 
Oral | Pharmacokinetics | Epilepsy | NONMEM | CLINICAL NEUROLOGY
Journal Article
Expert Opinion on Biological Therapy, ISSN 1471-2598, 10/2019, Volume 19, Issue 10, pp. 1065 - 1074
Background: PF-06438179/GP1111 (PF-SZ-IFX) is an infliximab (IFX) biosimilar. Pharmacokinetic (PK) similarity of PF-SZ-IFX and reference IFX authorized in the... 
pharmacokinetics | rheumatoid arthritis | infliximab | Biosimilar | PopPK | NONMEM
Journal Article
American Journal of Obstetrics and Gynecology, ISSN 0002-9378, 06/2016, Volume 214, Issue 6, pp. 737.e1 - 737.e9
Background Magnesium sulfate is one of the most commonly prescribed intravenous medications in obstetrics. Despite its widespread use, there are limited data... 
magnesium sulfate | neuroprotection | pregnancy | pharmacokinetics | NONMEM
Journal Article
Journal Article
Journal of Critical Care, ISSN 0883-9441, 02/2020, Volume 55, pp. 116 - 121
The present study aimed to establish a population pharmacokinetic model of vancomycin, including adult critically ill septic patients, with normal and impaired... 
Renal function | Creatinine clearance | Antibiotics | TDM | NONMEM
Journal Article
Journal of clinical pharmacology, ISSN 0091-2700, 5/2018, Volume 58, Issue 5, pp. 628 - 639
Mycophenolic acid (MPA) is an approved immunosuppressive agent widely prescribed to prevent rejection after kidney transplantation. Wide between-subject... 
kidney transplant | pharmacokinetics | Mycophenolic acid | NONMEM | enterohepatic circulation
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 01/2020, Volume 141, p. 105095
The aim of the present study was to develop a population pharmacokinetic model of midazolam, and to evaluate the influence of maturation process and other... 
Population pharmacokinetics | Midazolam | Maturation | Critically ill children | Bronchiolitis | NONMEM
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 12/2002, Volume 54, Issue 6, pp. 592 - 603
Aims Concentrations in the cerebrospinal fluid (CSF) are a useful approximation to the effect site for drugs like morphine. However, CSF samples, are available... 
metabolism | pharmacogenetics | analgtsia | NONMEM | opioids | Pharmacogenetics | Metabolism | Analgtsia | Opioids
Journal Article
Journal of infection and public health, ISSN 1876-0341, 07/2019
Augmented renal clearance (ARC) refers to enhanced renal elimination of circulating solute has attracted attention widely and in recent years increasing... 
Journal Article
European Journal of Clinical Pharmacology, ISSN 0031-6970, 4/2016, Volume 72, Issue 4, pp. 423 - 430
Levodopa is the reference treatment for Parkinson’s disease. However, after several years of treatment, dyskinesia may occur and strategies to overcome this... 
Population pharmacokinetics | Pharmacodynamics | Biomedicine | Levodopa | Pharmacology/Toxicology | Parkinson’s dyskinesia | NONMEM
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 06/2017, Volume 83, Issue 6, pp. 1240 - 1251
Journal Article
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, ISSN 0066-4804, 03/2008, Volume 52, Issue 3, pp. 1052 - 1061
The population pharmacokinetics of piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria treated with two different dosage... 
VIVAX MALARIA | BORDER | ADULTS | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | MODEL | BIOAVAILABILITY | NONMEM | CHILDREN | FOOD
Journal Article
Computer Methods and Programs in Biomedicine, ISSN 0169-2607, 2004, Volume 75, Issue 2, pp. 85 - 94
The NONMEM program is the most widely used nonlinear regression software in population pharmacokinetic/pharmacodynamic (PK/PD) analyses. In this article we... 
Programming | Population | Pharmacodynamics | Perl | Pharmacokinetics | NONMEM | Programming Languages | Pharmacology | Computer Simulation | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, ISSN 0169-2607, 08/2004, Volume 75, Issue 2, pp. 85 - 94
The NONMEM program is the most widely used nonlinear regression software in population pharmacokinetic/pharmacodynamic (PUPD) analyses. In this article we... 
COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | MEDICAL INFORMATICS | ENGINEERING, BIOMEDICAL | pharmacodynamics | pharmacokinetics | COMPUTER SCIENCE, THEORY & METHODS | perl | programming | population | NONMEM
Journal Article
Computer Methods and Programs in Biomedicine, ISSN 0169-2607, 2011, Volume 101, Issue 1, pp. 72 - 79
Abstract Pharmacokinetic–pharmacodynamic modeling using non-linear mixed effects modeling (NONMEM) is a powerful yet challenging technique, as the software is... 
Internal Medicine | Other | Cluster | Distributed computing | Graphical user interface | NONMEM | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | MEDICAL INFORMATICS | ENGINEERING, BIOMEDICAL | PSN | COMPUTER SCIENCE, THEORY & METHODS | User-Computer Interface | Software | Algorithms | Nonlinear Dynamics | Pharmacokinetics | Cluster Analysis
Journal Article
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